Works Published in 2020
Displaying works 21 - 40 of 143 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2020 article
Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure
Brooks, E. R., Islam, M. T., Anderson, K. V., & Zallen, J. A. (2020, October 13). (Vol. 10). Vol. 10.
TL;DR:
Results reveal a morphogenetic program of patterned apical constriction governed by Shh signaling that generates structural changes in the developing mammalian brain.
(via Semantic Scholar)
doi.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 23, 2022
2020 book
TL;DR:
This chapter overviews the topics covered in this book and thereby sets the stage for understanding the complexity of immune responses to a diversity of emerging engineered nanomaterials.
(via Semantic Scholar)
Source: Crossref
Added: February 5, 2022
2020 journal article
The circadian clock protects against ionizing radiation-induced cardiotoxicity.
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.
Contributors: P. Dakup *, K. Porter *, R. Gajula*, P. Goel*, Z. Cheng * & S. Gaddameedhi*
author keywords: Bmal1; circadian clock; heart; radiation; toxicity
MeSH headings : Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins / genetics; Ataxia Telangiectasia Mutated Proteins / metabolism; BRCA1 Protein / genetics; BRCA1 Protein / metabolism; BRCA2 Protein / genetics; BRCA2 Protein / metabolism; Cell Line; DNA Damage; Mice; Mice, Inbred C57BL; Mutation; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / physiology; Myocytes, Cardiac / radiation effects; Period Circadian Proteins / genetics; Promoter Regions, Genetic; Radiation Injuries, Experimental / genetics; Radiation Injuries, Experimental / metabolism; Radiation, Ionizing; Rats; Systole
TL;DR:
It is suggested that the circadian clock protects from IR‐induced toxicity and potentially impacts RT treatment outcome in cancer patients through IR‐ induced DNA damage responses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2020 journal article
Solar ultraviolet-induced DNA damage response: Melanocytes story in transformation to environmental melanomagenesis.
Environmental and Molecular Mutagenesis.
Contributors: S. Sarkar * & S. Gaddameedhi*
author keywords: circadian clock; DDR signaling; ET-1; melanocytes; NER; solar UVB; alpha MSH
MeSH headings : Animals; DNA Damage / genetics; DNA Damage / radiation effects; DNA Repair / genetics; DNA Repair / radiation effects; Humans; Melanocytes / pathology; Melanocytes / radiation effects; Melanoma / pathology; Skin Neoplasms / pathology; Sunlight / adverse effects; Ultraviolet Rays / adverse effects
TL;DR:
NER is a well-studied DNA repair mechanism in the whole skin, as a tissue, but not much is known about it in melanocytes, so a specific focus on its functional regulators and their cross-talks are focused on, divulging the potential knowledge gap in the field.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2020 journal article
The circadian clock protects against acute radiation-induced dermatitis
Toxicology and Applied Pharmacology, 399, 115040.
Contributors: P. Dakup *, K. Porter * & S. Gaddameedhi*
author keywords: Circadian Rhythm; Radiodermatitis; Toxicity; DNA Damage; BMAL1
MeSH headings : ARNTL Transcription Factors / genetics; Animals; Circadian Clocks / genetics; Circadian Rhythm / genetics; DNA Damage / genetics; DNA Damage / radiation effects; Female; Keratinocytes / radiation effects; Mice; Mice, Hairless; Neoplasms / genetics; Neoplasms / radiotherapy; Radiodermatitis / genetics
TL;DR:
Findings suggest that the circadian clock plays a protective role in IR-induced DNA damage and skin toxicity, possibly through BMAL1-dependent mechanisms, and potentially impacts RT-associated radiodermatitis in cancer patients.
(via Semantic Scholar)
Source: ORCID
Added: December 22, 2021
2020 journal article
Sex differences in the association between tumor growth and T cell response in a melanoma mouse model
Cancer Immunology, Immunotherapy, 69(10), 2157–2162.
Contributors: P. Dakup *, K. Porter *, A. Little *, H. Zhang * & S. Gaddameedhi*
author keywords: Melanoma; Sex differences; Male; Female; Immunity
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / pathology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; Disease Models, Animal; Female; Lymphocytes, Tumor-Infiltrating / immunology; Male; Melanoma, Experimental / immunology; Melanoma, Experimental / pathology; Mice; Mice, Inbred C57BL; Skin Neoplasms / immunology; Skin Neoplasms / secondary; T-Lymphocytes, Cytotoxic / immunology; T-Lymphocytes, Cytotoxic / pathology; Tumor Burden; Tumor Cells, Cultured
TL;DR:
The results highlight a mouse model that represents melanoma progression in the human population and displays a higher immune response to melanoma in females compared to males, suggesting that the immune system may be one of the mechanisms responsible for sex differences in melanoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 22, 2021
2020 journal article
Cohesin SA1 and SA2 are RNA binding proteins that localize to RNA containing regions on DNA
Nucleic Acids Research.
Source: ORCID
Added: September 23, 2021
2020 journal article
Single-molecule level structural dynamics of DNA unwinding by human mitochondrial Twinkle helicase
Journal of Biological Chemistry, 295(17), 5564–5576.
Source: ORCID
Added: September 23, 2021
2020 article
Interaction of Nanomaterials with the Immune System Introduction
INTERACTION OF NANOMATERIALS WITH THE IMMUNE SYSTEM, pp. 1–14.
author keywords: Nanotechnology; Immune system; Immunotoxicity
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 16, 2021
2020 article
Macrophages: First Innate Immune Responders to Nanomaterials
INTERACTION OF NANOMATERIALS WITH THE IMMUNE SYSTEM, pp. 15–34.
author keywords: Macrophage; Nanomaterial; Toll-like receptors; Scavenger receptors; Reactive oxygen species; Inflammasome; Polarization
TL;DR:
The immune response of macrophages to ENMs, including inflammasome activation and alternative polarization, plays important roles in immune-mediated diseases such as fibrosis, asthma, and cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 16, 2021
2020 article
Molecular mechanisms that activate convergent oncogenic pathway in genomically complex angiosarcoma
Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Schulte, A. J., Wang, C., … Modiano, J. F. (2020, August). CANCER RESEARCH, Vol. 80.
TL;DR:
The data suggests that genomic instability induced by TP53 mutations might create a predisposition for fusion events that may contribute to tumor progression by promoting selection and/or enhancing fitness through activation of convergent angiogenic pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: March 8, 2021
2020 article
A comparative oncology approach to biomarker and drug discovery for cancer diagnosis and treatment in dogs and humans
LeBlanc, A. K., Mazcko, C. N., Breen, M., Thomas, R., & Thamm, D. H. (2020, August). CANCER RESEARCH, Vol. 80.
TL;DR:
This work exemplifies the type of approach meant to further establish the comparative relevance of canine to human cancer and provide opportunities to explore hypotheses related to detection and treatment in both species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: March 8, 2021
2020 article
Heterozygous mutation of Sonic Hedgehog receptor (Ptch) drives cerebellar overgrowth and sex-specifically alters hippocampal and cortical layer structure, activity, and social behavior in female mice
Jackson, T. W., Bendfeldt, G. A., Beam, K. A., Rock, K. D., & Belcher, S. M. (2020, January 25). (Vol. 1). Vol. 1.
TL;DR:
Neuroanatomical changes related to deficient SHH signaling may alter social behavior and activity in Ptch1+/- females was explored, suggesting some behavioral abnormalities could be inherent to the medulloblastoma sequalae rather than treatment.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2020 journal article
Rapid Hazard Characterization of Environmental Chemicals Using a Compendium of Human Cell Lines from Different Organs
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 37(4), 623–638.
TL;DR:
The potential of this in vitro screening model for rapidly evaluating potential hazards of chemicals using a small number of human cells is demonstrated to inform rapid risk-based decision-making through ranking, clustering, and assessment of both hazard and risks of diverse environmental chemicals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: February 15, 2021
2020 journal article
Gestational Cd Exposure in the CD-1 Mouse Induces Sex-Specific Hepatic Insulin Insensitivity, Obesity, and Metabolic Syndrome in Adult Female Offspring
TOXICOLOGICAL SCIENCES, 178(2), 264–280.
Contributors: T. Jackson n, G. Ryherd n, C. Scheibly n, A. Sasser n, T. Guillette n & S. Belcher n
author keywords: cadmium; diabetes mellitus type 2; endocrine disruption; insulin resistance; metabolic; nonalcoholic fatty liver disease; retinoic acid
MeSH headings : Animals; Cadmium / toxicity; Cadmium Chloride / toxicity; Diabetes Mellitus, Type 2 / chemically induced; Female; Insulin Resistance; Liver / physiopathology; Male; Metabolic Syndrome / chemically induced; Mice; Obesity / chemically induced; Pregnancy; Prenatal Exposure Delayed Effects; Sex Factors
TL;DR:
The observed steatosis and metabolic syndrome-like phenotypes resulting from exposure to 500 ppb CdCl2 during the pre- and perinatal period of development equivalent to human gestation indicate that Cd acts developmentally as a sex-specific delayed obesogen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 15, 2021
2020 journal article
Endocrine Disruption in Invertebrates: A Survey of Research Progress
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(21), 13365–13369.
MeSH headings : Animals; Ecosystem; Endocrine Disruptors / analysis; Endocrine Disruptors / toxicity; Endocrine System; Invertebrates; Surveys and Questionnaires; Vertebrates
TL;DR:
Experts in this field were surveyed on the current state of the science and many of the recommendations matched those made over two decades ago, indicating that the field has not advanced as much as one might have expected.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 1, 2021
2020 journal article
Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies
REPRODUCTIVE TOXICOLOGY, 98, 29–60.
Contributors: J. Heindel*, S. Belcher n , J. Flaws *, G. Prins *, S. Ho*, J. Mao*, H. Patisaul n , W. Ricke*
author keywords: CLARITY-BPA; Guideline study; Bisphenol A; EDC; Endocrine disruptor; GLP; Systemic effects
MeSH headings : Animals; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; DNA Methylation; Endocrine Disruptors / toxicity; Female; Gene Expression Regulation, Developmental / drug effects; Heart / drug effects; Heart / growth & development; Male; Mammary Glands, Animal / drug effects; Mammary Glands, Animal / growth & development; Maternal-Fetal Exchange; Ovary / drug effects; Ovary / growth & development; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Prostate / drug effects; Prostate / growth & development; Rats, Sprague-Dawley; Reproducibility of Results; Thyroid Gland / drug effects; Thyroid Gland / growth & development; Urethra / drug effects; Urethra / growth & development
TL;DR:
The goal of this collaboration was to provide a more comprehensive dataset upon which to base safety standards and to determine whether industry-standard tests are as sensitive and predictive as molecular and disease-associated endpoints.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
9. Industry, Innovation and Infrastructure
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 19, 2021
2020 journal article
Associations between Maternal Cadmium Exposure with Risk of Preterm Birth and Low after Birth Weight Effect of Mediterranean Diet Adherence on Affected Prenatal Outcomes
TOXICS, 8(4).
Contributors: S. Gonzalez-Nahm *, K. Nihlani*, J. House* , R. Maguire n, H. Skinner n & C. Hoyo n
author keywords: cadmium; heavy metals; birth weight; preterm birth; diet pattern; Mediterranean diet; pregnancy
TL;DR:
The findings suggest that adherence to a Mediterranean dietary pattern during pregnancy may not mitigate cadmium exposure effects, and that larger studies are required to clarify these findings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: January 19, 2021
2020 journal article
Thyroid Receptor Antagonism of Chemicals Extracted from Personal Silicone Wristbands within a Papillary Thyroid Cancer Pilot Study
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(23), 15296–15312.
MeSH headings : Adult; Antithyroid Agents; Case-Control Studies; Environmental Monitoring; Flame Retardants / analysis; HEK293 Cells; Halogenated Diphenyl Ethers / analysis; Humans; North Carolina; Pilot Projects; Prospective Studies; Silicones; Thyroid Cancer, Papillary; Thyroid Neoplasms
TL;DR:
The results suggest that personal passive samplers may be useful in evaluating the bioactivities of mixtures that people contact on a daily basis and tentative associations between thyroid receptor antagonism, chemical concentrations, and papillary thyroid cancer case status are reported.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 19, 2021
2020 journal article
Systematic Comparisons for Composition Profiles, Taxonomic Levels, and Machine Learning Methods for Microbiome-Based Disease Prediction
FRONTIERS IN MOLECULAR BIOSCIENCES, 7.
author keywords: phenotype prediction; machine learning method; k-mers; operational taxonomic unit (OTU); amplicon sequence variant (ASV); phylogenetic analysis
TL;DR:
The use of short k-mers, which have computational advantages and conceptual simplicity, is shown to be effective as a source for microbiome-based prediction, among machine-learning approaches, and tree-based methods show consistent, though modest, advantages in prediction accuracy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 19, 2021
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