Works Published in 2006
Displaying works 61 - 80 of 85 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2006 journal article
Kinetic characterization of the inhibition of acyl coenzyme A: Steroid acyltransferases by tributyltin in the eastern mud snail (Ilyanassa obsoleta)
AQUATIC TOXICOLOGY, 78(3), 233–242.
author keywords: tributyltin; imposex; acyl coenzyme A; steroid acyltransferase; testosterone; 17 beta-estradiol; endocrine; snail
MeSH headings : Acyltransferases / antagonists & inhibitors; Acyltransferases / drug effects; Acyltransferases / pharmacokinetics; Animals; Esterification / drug effects; Estradiol / metabolism; Female; Kinetics; Microsomes / enzymology; Palmitoyl Coenzyme A / metabolism; Snails / drug effects; Snails / enzymology; Testosterone / metabolism; Trialkyltin Compounds / toxicity; Water Pollutants, Chemical / toxicity
TL;DR:
The results of this study supply the much-needed mechanistic support for the hypothesis that TBT elevates free testosterone in neogastropods by inhibiting their major regulatory process for maintaining free testosterone homeostasis-the fatty acid esterification of testosterone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells
INTERNATIONAL IMMUNOLOGY, 18(10), 1405–1411.
author keywords: IBD; regulatory T cells; signal transduction; TCR
MeSH headings : Aging / genetics; Aging / immunology; Aging / pathology; Animals; B-Lymphocytes / immunology; B-Lymphocytes / pathology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; Colitis / genetics; Colitis / immunology; Colitis / pathology; Colitis / prevention & control; Humans; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / immunology; MAP Kinase Signaling System / genetics; MAP Kinase Signaling System / immunology; Mice; Mice, Knockout; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / pathology; Thymus Gland / immunology; Thymus Gland / pathology
TL;DR:
The results show that TAK1, by controlling the generation of central Treg cells, is important for preventing spontaneously developing colitis.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis
JOURNAL OF BIOLOGICAL CHEMISTRY, 281(28), 19610–19617.
MeSH headings : Animals; Apoptosis; Cytokines / metabolism; Epidermis / metabolism; Gene Deletion; Homeostasis; Inflammation; Keratinocytes / cytology; Keratinocytes / metabolism; MAP Kinase Kinase 4 / metabolism; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Inbred C57BL; NF-kappa B / metabolism; Skin / pathology
TL;DR:
It is demonstrated that TAK1 is the major regulator of skin inflammation as well as keratinocyte death in vivo and is a master regulator of TNF signaling in skin and regulates skin inflammation and keratinocytes death.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish
Immunogenetics, 58(1), 31–40.
author keywords: C-type lectin; ITIM; natural killer cells; signaling motifs
MeSH headings : Amino Acid Sequence; Animals; Cell Survival / physiology; Chromosomes; Chromosomes, Artificial, Bacterial; Killer Cells, Natural / metabolism; Lectins, C-Type / chemistry; Lectins, C-Type / genetics; Lectins, C-Type / metabolism; Lectins, C-Type / physiology; Lymphocytes / metabolism; Models, Molecular; Molecular Sequence Data; Myeloid Cells / metabolism; Phylogeny; Zebrafish / genetics; Zebrafish / immunology; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
A multi-gene family of Group II immune-related, lectin-like receptors (illrs) whose members possess inhibiting and/or activating signaling motifs typical of Group V NK receptors are identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2006 personal communication
Chemical mixtures: Greater-than-additive effects?
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Use of probabilistic modeling within a physiologically based pharmacokinetic model to predict sulfamethazine residue withdrawal times in edible tissues in swine
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 50(7), 2344–2351.
MeSH headings : Animals; Animals, Domestic / metabolism; Drug Residues / pharmacokinetics; Female; Legislation, Drug; Legislation, Veterinary; Meat; Models, Statistical; Monte Carlo Method; Predictive Value of Tests; Sulfamethazine / administration & dosage; Sulfamethazine / pharmacokinetics; Swine / metabolism; Time Factors; Tissue Distribution; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR:
Probabilistic modeling techniques incorporated into a physiologically based pharmacokinetic (PBPK) model were used to predict the amounts of sulfamethazine residues in edible tissues in swine to calculate the withdrawal time by using the tolerance limit algorithm designed by FDA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Role of juvenile hormone esterase and epoxide hydrolase in reproduction of the cotton bollworm, Helicoverpa zea
JOURNAL OF INSECT PHYSIOLOGY, 52(7), 669–678.
author keywords: juvenile harmone; juvenile harmone esterase; juvenile harmone epoxide hydrolase; cotton bollworm; Helicoverpa zea
MeSH headings : Acetone / analogs & derivatives; Animals; Carboxylic Ester Hydrolases / antagonists & inhibitors; Carboxylic Ester Hydrolases / metabolism; Carboxylic Ester Hydrolases / physiology; Epoxide Hydrolases / metabolism; Epoxide Hydrolases / physiology; Female; Male; Metamorphosis, Biological; Moths / enzymology; Ovary / metabolism; Oviposition / physiology; Reproduction / physiology; Sesquiterpenes / metabolism; Sexual Behavior, Animal / physiology
TL;DR:
The role of juvenile hormone (JH) esterase (JHE) and epoxide hydrolase (EH) in reproduction of the cotton bollworm, Helicoverpa zea, was investigated and the highest levels of JHE and JH EH activity/min/mg protein in d2 virgin and mated females was found in ovaries followed by the carcass and then haemolymph.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Pharmacokinetics of flunixin meglumine in swine after intravenous dosing
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 29(5), 437–440.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / metabolism; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Area Under Curve; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / metabolism; Clonixin / pharmacokinetics; Half-Life; Injections, Intravenous; Metabolic Clearance Rate; Protein Binding; Swine
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappa B activation - TAO2 regulates TAK1 pathways
Journal of Biological Chemistry, 281(39), 28802–28810.
Source: NC State University Libraries
Added: August 6, 2018
2006 article
Influence of water quality and associated contaminants on survival and growth of the endangered Cape Fear shiner (Notropis mekistocholas)
Hewitt, A. H., Cope, W. G., Kwak, T. J., Augspurger, T., Lazaro, P. R., & Shea, D. (2006, September). ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, Vol. 25, pp. 2288–2298.
author keywords: biomonitoring; in situ toxicity; endangered species; water quality; Cape Fear shiner
MeSH headings : Animals; Biodiversity; Conservation of Natural Resources; Cyprinidae / growth & development; Cyprinidae / physiology; North Carolina; Population Dynamics; Rivers; Water Pollutants, Chemical / adverse effects; Water Pollutants, Chemical / analysis; Water Pollution / adverse effects; Water Pollution / analysis
TL;DR:
A generalized hazard assessment showed that certain sites exhibited trends in cumulative contaminant presence with reduced fish survival and growth, thereby enabling the identification of the existing riverine habitat most suitable for reintroduction or population augmentation of this endangered fish.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Hemin-mediated regulation of an antioxidant-responsive element of the human ferritin H gene and role of Ref-1 during erythroid differentiation of K562 cells
MOLECULAR AND CELLULAR BIOLOGY, 26(7), 2845–2856.
MeSH headings : Antioxidants / metabolism; Antioxidants / pharmacology; Basic-Leucine Zipper Transcription Factors / metabolism; Cell Differentiation; Cells, Cultured; DNA-(Apurinic or Apyrimidinic Site) Lyase / metabolism; Erythroid Cells / cytology; Ferritins / genetics; Gene Expression Regulation / drug effects; Gene Expression Regulation / genetics; Glutathione S-Transferase pi / metabolism; Hemin / pharmacology; Humans; K562 Cells; NAD(P)H Dehydrogenase (Quinone) / metabolism; Protein Binding; RNA, Messenger / genetics; RNA, Messenger / metabolism; Response Elements / genetics; Transcriptional Activation / genetics
TL;DR:
Results suggest that hemin activates the transcription of the ferritin H gene during K562 erythroid differentiation by Ref-1-mediated activation of these b-zip transcription factors to the ARE.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Fate of chemical warfare agents and toxic industrial chemicals in landfills
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 40(13), 4219–4225.
Contributors: S. Bartelt-Hunt n, M. Barlaz n , D. Knappe n & P. Kjeldsen n
MeSH headings : Biodegradation, Environmental; Chemical Warfare Agents / chemistry; Environmental Pollution; Half-Life; Hazardous Waste; Industrial Waste; Kinetics; Models, Chemical; Refuse Disposal
TL;DR:
Model results showed that hydrolysis and gas-phase advection were the principal fate pathways for CWAs and TICs, respectively, and CWA hydrolysates were more persistent than the parent CWAs, but limited information is available on abiotic or biotic transformation rates for these chemicals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Aldo-keto reductase 1 family B7 is the gene induced in response to oxidative stress in the livers of Long-Evans Cinnamon rats
International Journal of Oncology, 29(4), 829–838.
TL;DR:
The results indicate conclusively that in LEC rat liver, akr1b7 might be up-regulated by oxidative stress mediated through NF-kappaB, but not that mediated directly by copper.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
A procedure to quantify organic antistrip additives in asphalt binders and mixes
Journal of Testing and Evaluation, 34(4), 269–274.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Role for retinoid signaling in left–right asymmetric digestive organ morphogenesis
Developmental Dynamics, 235(8), 2266–2275.
author keywords: retinoic acid; RALDH2; CYP26A1; gut; looping; malrotation; Xenopus; biliary atresia; annular pancreas
MeSH headings : Aldehyde Dehydrogenase 1 Family; Aldehyde Oxidase / genetics; Animals; Body Patterning; Cytochrome P-450 Enzyme System / genetics; Digestive System / growth & development; Digestive System / metabolism; Morphogenesis; Oxidoreductases / genetics; Receptors, Retinoic Acid / metabolism; Retinal Dehydrogenase; Retinoic Acid 4-Hydroxylase; Retinoids / metabolism; Signal Transduction; Xenopus Proteins / genetics; Xenopus laevis / genetics; Xenopus laevis / growth & development; Xenopus laevis / metabolism
TL;DR:
It is shown that the genes for retinaldehyde dehydrogenase and a retinoic acid hydroxylase are expressed in complementary patterns in the Xenopus gut during looping, likely to play a critical role in asymmetric gut tube morphogenesis and may underlie the etiology of several clinically relevant defects in the digestive system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2006 journal article
Application of risk assessment and management principles to the extralabel use of drugs in food-producing animals
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 29(1), 5–14.
MeSH headings : Animals; Decision Trees; Drug Labeling; Drug Residues / adverse effects; Europe; Humans; Legislation, Food; Meat / analysis; Risk Assessment; United States; Veterinary Drugs / administration & dosage; Veterinary Drugs / adverse effects; Veterinary Drugs / analysis
TL;DR:
This review describes how risk assessment principles can be extended to evaluate the risks posed by different classes of extralabel drug use and risk management practices in the United States and Europe are summarized and contrasted to illustrate the application of these principles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
A candidate juvenoid hormone receptor cis-element in the Daphnia magna hb2 hemoglobin gene promoter
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 247(1-2), 91–102.
author keywords: methyl farnesoate; juvenoid; crustacean; response element; sex determination
MeSH headings : Animals; Base Sequence; Cycloheximide / pharmacology; Daphnia / genetics; Daphnia / physiology; Fatty Acids, Unsaturated / metabolism; Hemoglobins / biosynthesis; Hemoglobins / genetics; Hemoglobins / physiology; Juvenile Hormones / metabolism; Molecular Sequence Data; Promoter Regions, Genetic; Pyridines / metabolism; RNA, Messenger / biosynthesis; Receptors, Cytoplasmic and Nuclear / genetics; Receptors, Cytoplasmic and Nuclear / metabolism; Response Elements; Signal Transduction
TL;DR:
Induction of hb2 by juvenoids was not dependent upon the synthesis of secondary transcription factors that bound the JRE but was likely due to activation of the gene directly by the juvenoid-receptor complex.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Nonchemical dielectric barrier discharge treatment as a method of insect control
IEEE TRANSACTIONS ON PLASMA SCIENCE, 34(1), 55–62.
author keywords: dielectric barrier discharge (DBD); insect control; neutral bremsstrahlung continuum
TL;DR:
The study has shown the DBD treatment does not always induce instant mortality: however, the mortality increases over a 24-h period after treatment, and the treatment is more rapid when the ambient gas temperature is elevated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Methylation of tRNAAsp by the DNA Methyltransferase Homolog Dnmt2
Science, 311(5759), 395–398.
MeSH headings : Animals; Anticodon; Arabidopsis / genetics; Arabidopsis / physiology; Arabidopsis Proteins / genetics; Catalytic Domain; Cytosine / metabolism; DNA (Cytosine-5-)-Methyltransferases / chemistry; DNA (Cytosine-5-)-Methyltransferases / genetics; DNA (Cytosine-5-)-Methyltransferases / metabolism; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Evolution, Molecular; Humans; Mass Spectrometry; Methylation; Mice; Mutation; NIH 3T3 Cells; RNA, Plant / metabolism; RNA, Transfer, Asp / chemistry; RNA, Transfer, Asp / metabolism; Transfection
TL;DR:
The sequence and the structure of DNA methyltransferase-2 (DnMT2) bear close affinities to authentic DNA cytosine methyltransferases, and human DNMT2 protein restored methylation in vitro to tRNAAsp from Dnmt2-deficient strains of mouse, Arabidopsis thaliana, and Drosophila melanogaster in a manner that was dependent on preexisting patterns of modified nucleosides.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2006 journal article
Conditional ablation of C/EBP beta demonstrates its keratinocyte-specific requirement for cell survival and mouse skin tumorigenesis
ONCOGENE, 25(8), 1272–1276.
author keywords: C/EBP; apoptosis; carcinogenesis
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / physiology; Carcinogens / toxicity; Female; Integrases / metabolism; Keratin-15; Keratin-5; Keratinocytes / metabolism; Keratinocytes / pathology; Keratins / genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Promoter Regions, Genetic; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate / toxicity
TL;DR:
It is demonstrated that C/EBPβ exerts an essential, keratinocyte-intrinsic role in cell survival in response to carcinogen treatment and the elimination of C/ EBPβ in keratinocytes is sufficient to confer complete resistance of the skin to chemical carcinogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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