Comparative Medicine Institute

Works Published in 2009

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Displaying works 441 - 460 of 632 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2009 journal article

EVALUATION OF THE SERRATIA MARCESCENS NUCLEASE (NucA) AS A TRANSGENIC CELL ABLATION SYSTEM IN PORCINE

ANIMAL BIOTECHNOLOGY, 20(4), 177–185.

By: I. Caballero n & J. Piedrahita n

author keywords: Ablation; DTA; Fibroblasts; NucA; Porcine
MeSH headings : Animals; Cell Separation / methods; Cells, Cultured; Electroporation / methods; Endodeoxyribonucleases / analysis; Endodeoxyribonucleases / genetics; Endodeoxyribonucleases / metabolism; Endoribonucleases / analysis; Endoribonucleases / genetics; Endoribonucleases / metabolism; Fibroblasts / metabolism; Gene Expression; Gene Transfer Techniques; Rabbits; Serratia / enzymology; Swine
TL;DR: Gene expression analysis of surviving colonies indicated that survival is related to low or absent expression of the toxic genes, and results indicate that the NucA gene, while capable of mammalian cell ablation, is less efficient than DTA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Dune buggies

Natural History Magazine, 118(7), 38–39.

By: R. Dunn 

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Dimension Reduction in Regressions With Exponential Family Predictors

JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS, 18(3), 774–791.

By: R. Cook  n & L. Li n

author keywords: Central subspace; Grassmann manifolds; Inverse regression; Sufficient dimension reduction
TL;DR: This work presents first methodology for dimension reduction in regressions with predictors that, given the response, follow one-parameter exponential families, and proposes a method of estimating the forward regression mean function without requiring an explicit forward regression model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Development of a Robust and High Throughput Method for Profiling N-Linked Glycans Derived from Plasma Glycoproteins by NanoLC-FTICR Mass Spectrometry

JOURNAL OF PROTEOME RESEARCH, 8(7), 3764–3770.

By: M. Bereman n, D. Young n, A. Deiters n & D. Muddiman n 

MeSH headings : Biomarkers, Tumor / metabolism; Blood Proteins / chemistry; Chromatography, Liquid / methods; Detergents / pharmacology; Glycoproteins / chemistry; Humans; Mass Spectrometry / methods; Microwaves; Peptides / chemistry; Polysaccharides / chemistry; Proteome; Proteomics / methods; Spectroscopy, Fourier Transform Infrared / methods; Time Factors
TL;DR: A step-by-step protocol describing a method for N-linked glycan profiling of plasma glycoproteins by nanoflow liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) is presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Development of a Dynamic Pharmacokinetic Model to Estimate Bioconcentration of Xenobiotics in Earthworms

ENVIRONMENTAL MODELING & ASSESSMENT, 14(3), 411–418.

By: H. Henson-Ramsey n, J. Levine n , S. Kennedy-Stoskopf n, S. Taylor*, D. Shea n  & M. Stoskopf n

author keywords: Pharmacokinetic model; Xenobiotic; Earthworm; Soil
TL;DR: A simple and dynamic pharmacokinetic model was developed to predict bioconcentration of organic contaminants in earthworms and was able to accurately predict the bioconentration factor of malathion at steady state. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Design and characterization of a spatially distributed multibeam field emission x-ray source for stationary digital breast tomosynthesis

MEDICAL PHYSICS, 36(10), 4389–4399.

By: X. Qian *, R. Rajaram*, X. Calderon-Colon*, G. Yang *, T. Phan*, D. Lalush n, J. Lu *, O. Zhou *

author keywords: tomosynthesis; breast imaging; x-ray; carbon nanotube; field emission
MeSH headings : Computer-Aided Design; Equipment Design; Equipment Failure Analysis; Mammography / instrumentation; Radiographic Image Enhancement / instrumentation; Radiometry; Reproducibility of Results; Scattering, Radiation; Sensitivity and Specificity; Tomography, X-Ray Computed / instrumentation; Transducers; X-Rays
TL;DR: The authors demonstrate experimentally the feasibility of achieving 11 s scanning time at full detector resolution with 0.3 mm source resolution without motion blur and evaluate the emission current, current variation, lifetime, and focal spot sizes of the source array. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Cross-contamination in the Molecular Detection of Bartonella from Paraffin-embedded Tissues

Veterinary Pathology, 46(5), 940–944.

By: M. Varanat n, R. Maggi n , K. Linder n, S. Horton n & E. Breitschwerdt n 

author keywords: Bartonellosis; cross-contamination; necropsy; paraffin-embedded tissue; PCR contamination
MeSH headings : Animals; Bartonella / genetics; Bartonella / isolation & purification; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Equipment Contamination; Polymerase Chain Reaction / methods
TL;DR: Unless stringent procedures are established and followed to avoid cross-contamination, the molecular detection of Bartonella spp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2009 journal article

Conductive thin film multilayers of gold on glass formed by self-assembly of multiple size gold nanoparticles

THIN SOLID FILMS, 517(24), 6803–6808.

By: R. Gerber n, D. Leonard* & S. Franzen n 

author keywords: Colloidal self-assembly; Atomic force microscopy; Selected area diffraction; Gold nanoparticles
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Comparative Efficacy of BioUD to Other Commercially Available Arthropod Repellents against the Ticks Amblyomma americanum and Dermacentor variabilis on Cotton Cloth

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 81(4), 685–690.

By: B. Bissinger*, J. Zhu*, C. Apperson*, D. Sonenshine, D. Watson & R. Roe* 

MeSH headings : Animals; Cotton Fiber; Insect Repellents / pharmacology; Ixodidae / drug effects; Textiles; Time Factors
TL;DR: Repellency of BioUD was compared with five commercially available arthropod repellents against the ticks Amblyomma americanum (L.) and Dermacentor variabilis in two-choice bioassays on treated versus untreated cotton cheesecloth. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Co-isolation of Bartonella henselae and Bartonella vinsonii subsp. berkhoffii from blood, joint and subcutaneous seroma fluids from two naturally infected dogs

Veterinary Microbiology, 138(3-4), 368–372.

By: P. Diniz n, M. Wood n, R. Maggi n , S. Sontakke n, M. Stepnik n & E. Breitschwerdt n 

author keywords: Alpha Proteobacteria; Culture; Arthritis; Seroma; Co-infection; Bartonella
MeSH headings : Animals; Bartonella / isolation & purification; Bartonella Infections / microbiology; Bartonella Infections / veterinary; DNA, Bacterial; Dog Diseases / microbiology; Dogs; Female; Male; Serologic Tests; Seroma / microbiology; Synovial Fluid / microbiology
TL;DR: Dogs can be co-infected with two Bartonella spp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2009 article

Characterization of eversion syndrome in captive Scyphomedusa jellyfish

Freeman, K. S., Lewbart, G. A., Robarge, W. P., Harms, C. A., Law, J. M., & Stoskopf, M. K. (2009, September). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 70, pp. 1087–1093.

By: K. Freeman n, G. Lewbart* , W. Robarge*, C. Harms* , J. Law & M. Stoskopf*

MeSH headings : Animal Feed; Animals; Digestive System Abnormalities / pathology; Digestive System Abnormalities / veterinary; Scyphozoa / anatomy & histology; Scyphozoa / physiology; Syndrome
TL;DR: It is suggested that eversion syndrome is a complex phenomenon associated with degenerative changes of the bell matrix and Striated muscle degeneration and necrosis and extracellular matrix (mesoglea) degeneration were evident on histologic examination of affected jellyfish. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Characterization of Conserved and Nonconserved Imprinted Genes in Swine

BIOLOGY OF REPRODUCTION, 81(5), 906–920.

By: S. Bischoff n, S. Tsai n, N. Hardison n, A. Motsinger-Reif n, B. Freking *, D. Nonneman*, G. Rohrer *, J. Piedrahita n

author keywords: assisted reproductive technology; comparative genomic imprinting; epigenetics; gene regulation; genomic imprinting; parthenogenesis; placenta; swine parthenote
MeSH headings : Animals; Female; Fetus / anatomy & histology; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genomic Imprinting / genetics; Oligonucleotide Array Sequence Analysis; Organ Size; Parthenogenesis / genetics; Placenta / anatomy & histology; Polymorphism, Single Nucleotide; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; Staining and Labeling; Swine / genetics
TL;DR: To increase the understanding of imprinted genes in swine, a comprehensive analysis of this gene family was carried out using two complementary approaches: expression and phenotypic profiling of parthenogenetic fetuses, and analysis of imprinting by pyrosequencing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Canine cutaneous epitheliotropic T-cell lymphoma with vesiculobullous lesions resembling human bullous mycosis fungoides

Veterinary Dermatology, 20(4), 281–288.

By: P. Bizikova*, K. Linder*, S. Suter*, A. Van Wettere* & T. Olivry* 

Contributors: P. Bizikova*, K. Linder*, S. Suter*, A. Van Wettere* & T. Olivry* 

MeSH headings : Animals; Dog Diseases / pathology; Dogs; Lymphoma, T-Cell / pathology; Lymphoma, T-Cell / veterinary; Male; Skin Neoplasms / pathology; Skin Neoplasms / veterinary
TL;DR: Clonal rearrangement analysis of antigen receptor genes in samples from skin and lung lesions using primers specific for canine T- cell receptor gamma produced a single-sized amplicon of identical sequence, indicating that both lesions resulted from the expansion of the same neoplastic T-cell population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2009 journal article

Bayesian variable selection using an adaptive powered correlation prior

JOURNAL OF STATISTICAL PLANNING AND INFERENCE, 139(8), 2665–2674.

By: A. Krishna n, H. Bondell n & S. Ghosh n 

Contributors: A. Krishna n, H. Bondell n & S. Ghosh n 

author keywords: Bayesian variable selection; Collinearity; Powered correlation prior; Zellner's g-prior
TL;DR: An extension of the Zellner's prior is proposed in this article which allow for a power parameter on the empirical covariance of the predictors which helps control the degree to which correlated predictors are smoothed towards or away from one another. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Acute sodium tungstate inhalation is associated with minimal olfactory transport of tungsten (W-188) to the rat brain

NEUROTOXICOLOGY, 30(3), 445–450.

By: P. Radcliffe*, A. Olabisi*, D. Wagner*, T. Leavens n , B. Wong*, M. Struve n, G. Chapman*, E. Wilfong*, D. Dorman n

author keywords: Inhalation; Olfactory transport; Brain; Tungsten; Single-dose; Rat
MeSH headings : Administration, Inhalation; Aerosols; Animals; Corpus Striatum / metabolism; Male; Olfactory Pathways / metabolism; Pituitary Gland / metabolism; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tungsten Compounds / administration & dosage; Tungsten Compounds / blood; Tungsten Compounds / pharmacokinetics
TL;DR: The data suggest that olfactory transport plays a minimal role in delivering tungsten to the rat brain, i.e., approximately 1-3% of the amount ofTungsten seen in the olf factory epithelium suggesting that o aroma transport plays an important role in transporting metals to the CNS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

A role for hydrophobicity in a DielsAlder reaction catalyzed by pyridyl-modified RNA

NUCLEIC ACIDS RESEARCH, 37(9), 3074–3082.

By: K. Gagnon n, S. Ju n, M. Goshe n, E. Maxwell n & S. Franzen n 

MeSH headings : Anthracenes / metabolism; Base Sequence; Catalysis; Ethylene Glycols / metabolism; Hydrophobic and Hydrophilic Interactions; Lactones; Molecular Sequence Data; Nucleic Acid Conformation; Pyridines / chemistry; RNA / chemistry; RNA / metabolism; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; Sesquiterpenes
TL;DR: It is shown that DA_TR96, the most active member of the DA22 RNA sequence family, which was selected with pyridyl-modified nucleotides, accelerates a cycloaddition reaction between anthracene and maleimide derivatives with high turnover, and suggests a key role for the hydrophobic effect in the catalytic mechanism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

A Bipolar Clamp Mechanism for Activation of Jak-Family Protein Tyrosine Kinases

PLOS COMPUTATIONAL BIOLOGY, 5(4).

By: D. Barua n, J. Faeder * & J. Haugh n 

Ed(s): N. Kannan

MeSH headings : Adaptor Proteins, Signal Transducing / chemistry; Adaptor Proteins, Signal Transducing / metabolism; Binding Sites; Computer Simulation; Enzyme Activation; Janus Kinases / chemistry; Janus Kinases / metabolism; Models, Biological; Models, Chemical; Phosphorylation; Protein Binding; Signal Transduction / physiology
TL;DR: Analysis of the results revealed a unique mechanism whereby SH2-B and receptor dimers constitute a bipolar ‘clamp’ that stabilizes the active configuration of two Jak2 molecules in the same macro-complex. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium

JOURNAL OF CLINICAL INVESTIGATION, 119(9), 2702–2713.

By: D. Lee*, M. Yu *, E. Lee *, H. Kim*, Y. Yang *, K. Kim *, C. Pannicia*, J. Kurie*, D. Threadgill n

MeSH headings : Animals; Apoptosis / genetics; Apoptosis / physiology; Base Sequence; Caspase 3 / metabolism; Cell Line, Tumor; Colorectal Neoplasms / enzymology; Colorectal Neoplasms / genetics; Colorectal Neoplasms / pathology; ErbB Receptors / antagonists & inhibitors; ErbB Receptors / genetics; Female; Genes, APC; Genes, erbB; Humans; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Male; Mice; Mice, Knockout; Mice, Transgenic; Models, Biological; RNA, Small Interfering / genetics; Receptor, ErbB-3 / antagonists & inhibitors; Receptor, ErbB-3 / deficiency; Receptor, ErbB-3 / genetics; Receptor, ErbB-4
TL;DR: It is shown that the intestinal epithelium of mice with intestine-specific genetic ablation of Erbb3 exhibits no cytological abnormalities but does exhibit loss of expression of ERBB4 and sensitivity to intestinal damage, and this results indicate that the ERBB3 pseudo-kinase has essential roles in supporting intestinal tumorigenesis and suggest that ER BB3 may be a promising target for the treatment of colorectal cancers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Tritrichomonas foetus: A new agent of feline diarrhea

Compendium-Continuing Education for Veterinarians, 31(8), 374-.

By: M. Tolbert & J. Gookin 

Source: NC State University Libraries
Added: August 6, 2018

2009 review

The gastrointestinal microbiome: a malleable, third genome of mammals

[Review of ]. MAMMALIAN GENOME, 20(7), 395–403.

By: I. Carroll *, D. Threadgill* & D. Threadgill n

MeSH headings : Animals; Bacteria / genetics; Bacteria / isolation & purification; Bacterial Infections / microbiology; Gastrointestinal Tract / microbiology; Genome, Bacterial; Humans; Mammals / microbiology; Metagenome
TL;DR: The current knowledge of the gastrointestinal microbiome, its relationship to human health and disease with a particular focus on mammalian physiology, and efforts to alter its composition as a novel therapeutic approach are reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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