Works Published in 2015
Displaying works 721 - 739 of 739 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 review
Man's best friend: what can pet dogs teach us about non-Hodgkin's lymphoma?
[Review of ]. IMMUNOLOGICAL REVIEWS, 263(1), 173–191.
author keywords: cancer; lymph nodes; comparative oncology; signal transduction; molecular biology; knockout mice
MeSH headings : Animals; Breeding; Chromosome Aberrations; Disease Models, Animal; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dogs; Gene-Environment Interaction; Humans; Lymphoma, Non-Hodgkin / diagnosis; Lymphoma, Non-Hodgkin / drug therapy; Lymphoma, Non-Hodgkin / veterinary; Mice; Molecular Targeted Therapy; Treatment Outcome
TL;DR:
Resources that are currently available to study canine lymphoma, advantages to be gained by exploiting the genetic breed structure in dogs, and current and future challenges and opportunities to take full advantage of this resource for lymphoma studies are described.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons
JOURNAL OF NEUROPHYSIOLOGY, 113(3), 720–729.
author keywords: intrinsic excitability; sex differences; medium spiny neuron; dorsal striatum; mEPSC
MeSH headings : Action Potentials; Animals; Corpus Striatum / cytology; Corpus Striatum / growth & development; Corpus Striatum / physiology; Female; Male; Neurons / physiology; Rats; Rats, Sprague-Dawley; Sex Factors
TL;DR:
It is indicated that MSN excitability is increased in prepubertal females compared with males, providing a new mechanism that potentially contributes to generating sex differences in striatal-mediated processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain
PeerJ, 3, e772.
author keywords: Accelerometry; Dog; Pain; Model; Spontaneous; Accelerometry
TL;DR:
Although accelerometry does not appear to be useful, this model has potential to model the human pain-related nighttime sleep disturbance, and other outcome measures should be explored in this model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2015 journal article
Inferring causal relationships between reproductive and metabolic health disorders and production traits in first-lactation US Holsteins using recursive models
JOURNAL OF DAIRY SCIENCE, 98(4), 2713–2726.
Contributors: K. Dhakal n, F. Tiezzi n, J. Clay * & C. Maltecca n
author keywords: causal effect; health; persistency; structural equation model
MeSH headings : Animals; Bayes Theorem; Cattle; Cattle Diseases / genetics; Female; Lactation / genetics; Metabolic Diseases / genetics; Metabolic Diseases / veterinary; Models, Biological; Pregnancy; Reproduction / genetics; Retrospective Studies
TL;DR:
It is concluded that a health disorder occurring in early lactation has a moderate causal effect on the reproductive or metabolic health disorders occurring in later lactation, and the results obtained suggest that reproductive and metabolic health disorder and culling due to metabolic and reproductive diseases have strong causal relationships.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Histiocytic Sarcoma with Central Nervous System Involvement in Dogs: 19 Cases (2006-2012)
Journal of Veterinary Internal Medicine, 29(2), 607–613.
author keywords: Brain tumor; Malignant histiocytosis; Round cell tumor; Spinal cord tumor
MeSH headings : Animals; Central Nervous System Neoplasms / pathology; Central Nervous System Neoplasms / veterinary; Dog Diseases / pathology; Dogs; Female; Histiocytic Sarcoma / pathology; Histiocytic Sarcoma / veterinary; Male; Retrospective Studies
TL;DR:
Some unique imaging and clinicopathologic characteristics, particularly brain herniation, profound meningeal enhancement, and pleocytosis in combination with 1 or more mass lesions, might help to differentiate this neoplasm from others involving the CNS, although this requires further study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Estimating Monomer Sequence Distributions in Tetrapolyacrylates
MACROMOLECULES, 48(1), 58–63.
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Effect of Chronic Administration of Phenobarbital, or Bromide, on Pharmacokinetics of Levetiracetam in Dogs with Epilepsy
JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(2), 614–619.
Contributors: K. Muñana n , J. Nettifee-Osborne n & M. Papich n
author keywords: Antiepileptic drug; Canine; Drug disposition; Drug interactions; Seizures
MeSH headings : Animals; Anticonvulsants / administration & dosage; Anticonvulsants / pharmacokinetics; Anticonvulsants / therapeutic use; Area Under Curve; Bromides / administration & dosage; Bromides / therapeutic use; Dog Diseases / blood; Dog Diseases / drug therapy; Dog Diseases / metabolism; Dogs; Epilepsy / blood; Epilepsy / drug therapy; Epilepsy / veterinary; Half-Life; Levetiracetam; Phenobarbital / administration & dosage; Phenobarbital / therapeutic use; Piracetam / administration & dosage; Piracetam / analogs & derivatives; Piracetam / pharmacokinetics; Piracetam / therapeutic use
TL;DR:
Significant Dosage increases might be indicated when utilizing LEV as add‐on treatment with phenobarbital in dogs when administered concurrently with conventional AEDs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Designing Peptide Sequences in Flexible Chain Conformations to Bind RNA: A Search Algorithm Combining Monte Carlo, Self-Consistent Mean Field and Concerted Rotation Techniques
JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 11(2), 740–752.
MeSH headings : Algorithms; Amino Acid Sequence; Anti-HIV Agents / chemical synthesis; Anti-HIV Agents / chemistry; Binding Sites; Humans; Molecular Dynamics Simulation; Monte Carlo Method; Peptides / chemical synthesis; Peptides / chemistry; Protein Conformation; RNA / chemistry; RNA, Transfer / chemistry; Rotation; Thermodynamics
TL;DR:
A search algorithm combining Monte Carlo, self-consistent mean field, and concerted rotation techniques was developed to discover peptide sequences that are reasonable HIV drug candidates due to their exceptional binding to human tRNAUUU(Lys3), the primer of HIV replication.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Conditional Control of Alternative Splicing through Light-Triggered Splice-Switching Oligonucleotides
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137(10), 3656–3662.
MeSH headings : Alternative Splicing / radiation effects; Animals; HeLa Cells; Humans; Light; Oligonucleotides / chemistry; Oligonucleotides / genetics; Zebrafish
TL;DR:
This work addressed site-specific installation of light-removable nucleobase-caging groups as well as photocleavable backbone linkers into synthetic SSOs that enables optochemical OFF → ON and ON → OFF switching of their activity and thus precise control of alternative splicing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Complete Effect-Profile Assessment in Association Studies With Multiple Genetic and Multiple Environmental Factors
GENETIC EPIDEMIOLOGY, 39(2), 122–133.
author keywords: factor-set association analysis; kernel machine regression; genetic-environmental interactions; joint and conditional tests
MeSH headings : Computer Simulation; Environment; Gene-Environment Interaction; Genetic Predisposition to Disease; Genome-Wide Association Study / methods; Humans; Models, Genetic; Software
TL;DR:
The issues encountered in constructing kernels for investigating interactions between two factor‐sets are illustrated, and a simple yet intuitive solution to construct the G×E kernel that retains the ease‐of‐interpretation of classic regression is proposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Clinical characteristics of Scottie Cramp in 31 cases
Journal of Small Animal Practice, 56(4), 276–280.
MeSH headings : Animals; Breeding; Cerebellum / pathology; Dog Diseases / drug therapy; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Female; Fluoxetine / therapeutic use; Genetic Predisposition to Disease; Male; Muscle Cramp / drug therapy; Muscle Cramp / genetics; Muscle Cramp / physiopathology; Muscle Cramp / veterinary; Muscle Hypertonia / drug therapy; Muscle Hypertonia / genetics; Muscle Hypertonia / physiopathology; Muscle Hypertonia / veterinary; Selective Serotonin Reuptake Inhibitors / therapeutic use; Severity of Illness Index; Sex Factors; Spinocerebellar Degenerations / genetics; Spinocerebellar Degenerations / physiopathology; Spinocerebellar Degenerations / veterinary
TL;DR:
The disorder recognised as Scottie Cramp by dog owners includes dogs with hind limb spasticity in addition to generalised cramping, which usually improve over time without specific treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2015 journal article
Characterization of discrete equine intestinal epithelial cell lineages
American Journal of Veterinary Research, 76(4), 358–366.
Contributors: L. Gonzalez* , L. Kinnin & A. Blikslager*
MeSH headings : Animals; Cell Lineage; Colic / pathology; Colic / veterinary; Epithelial Cells / cytology; Female; Horse Diseases / pathology; Horses; Intestinal Mucosa / cytology
TL;DR:
The methodology used can enhance detection of stem cells and progenitor cells as well as postmitotic cell lineages in equine intestinal tissues and may have relevance to regenerative potential of intestinal mucosa and survival in horses with colic.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Bartonella spp. Bacteremia in Blood Donors from Campinas, Brazil
PLOS Neglected Tropical Diseases, 9(1), e0003467.
Ed(s): D. Walker
MeSH headings : Adult; Bacteremia / epidemiology; Bartonella Infections / epidemiology; Bartonella Infections / transmission; Bartonella henselae / genetics; Bartonella henselae / immunology; Bartonella henselae / isolation & purification; Blood Donors; Brazil / epidemiology; Cross-Sectional Studies; Female; Humans; Male; Polymerase Chain Reaction; Sequence Analysis, DNA
TL;DR:
Bartonella species are blood-borne, re-emerging organisms, capable of causing prolonged infection with diverse disease manifestations, from asymptomatic bacteremia to chronic debilitating disease and death, and screening of blood supplies for this pathogen is not routinely performed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2015 article
Answering the Call for Improved Chemical Alternatives Assessments (CAA)
Tickner, J. A., Dorman, D. C., & Sheton-Davenport, M. (2015, February 17). ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol. 49, pp. 1995–1996.
MeSH headings : Chemical Industry; Green Chemistry Technology / methods; Green Chemistry Technology / standards; Humans; Research; Risk Assessment
TL;DR:
It is critical that CAA processes be flexible so they can be adapted to varied decision contexts and avoid “paralysis by analysis”, and that emerging developments in toxicity testing be able to support the evaluation, comparison and design of safer chemicals and materials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research
American Journal of Physiology-Gastrointestinal and Liver Physiology, 308(2), G63–G75.
Contributors: L. Gonzalez n , A. Moeser n & A. Blikslager n
author keywords: animal model; intestine; ischemia; mucosal injury; reperfusion
MeSH headings : Animals; Disease Models, Animal; Humans; Intestines / injuries; Intestines / pathology; Ischemia / complications; Ischemia / pathology; Oxygen / metabolism; Reperfusion Injury / complications; Reperfusion Injury / metabolism; Reperfusion Injury / pathology; Translational Research, Biomedical / methods
TL;DR:
This review assesses animal models of ischemia-reperfusion injury as well as the knowledge that has been derived from each to aid selection of appropriate research models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
A comparison of pet and purpose-bred research dog (Canis familiaris) performance on human-guided object-choice tasks
BEHAVIOURAL PROCESSES, 110, 60–67.
author keywords: Domestic dog; Object-choice task; Social cognition; Purpose-bred dog
MeSH headings : Animals; Behavior, Animal / physiology; Choice Behavior / physiology; Cues; Dogs / physiology; Gestures; Human-Animal Bond; Humans; Male
TL;DR:
It is found that while pet dogs followed the momentary distal point above chance levels, research dogs did not, and the results indicate that ontogenetic experiences may influence a domestic dog's ability to use human gestures, highlighting the importance of testing different sub-populations of domestic dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
3D hydrodynamic focusing microfluidics for emerging sensing technologies
Biosensors and Bioelectronics, 67, 25–34.
author keywords: Microfluidics; Sensors; Hydrodynamic focusing; Flow cytometry; Microfluidic fabrication
MeSH headings : Biosensing Techniques / instrumentation; Biosensing Techniques / methods; Cell Separation; Flow Cytometry; Hydrodynamics; Microfluidics
TL;DR:
The underlying principles for hydrodynamic focusing in three dimensions (3D) using miscible fluids and the application of these principles for creation of bios Sensors, separation of cells and particles for sample manipulation, and fabrication of materials that could be used for biosensors are explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2015 journal article
Mapping burn severity in a disease-impacted forest landscape using Landsat and MASTER imagery
INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION, 40, 91–99.
author keywords: Burn severity; Forest fire; Disease invasion; MASTER; Landsat; Sudden oak death; Interacting disturbances
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Molecular recognition mechanism of peptide chain bound to the tRNA(Lys3) anticodon loop in silico
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 33(1), 14–27.
author keywords: molecular recognition; binding free energy; atomistic molecular dynamics simulation; binding affinity and specificity; peptide and tRNA(Lys3)
MeSH headings : Algorithms; Amino Acid Sequence; Amino Acids / chemistry; Amino Acids / metabolism; Anticodon / chemistry; Anticodon / genetics; Anticodon / metabolism; Computer Simulation; Humans; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Peptides / chemistry; Peptides / metabolism; Phenylalanine / chemistry; Phenylalanine / metabolism; Protein Binding; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; RNA, Transfer, Lys / chemistry; RNA, Transfer, Lys / metabolism; Static Electricity; Thermodynamics
TL;DR:
The metastable folded peptide was found to bind to hASLLys3 much easier than the stable Folded peptide in the binding simulations, and an energetic analysis reveals that the VDW energy favors the binding, whereas the ELE + EGB energies disfavor the binding.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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