Works Published in 2009
Displaying works 21 - 38 of 38 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2009 journal article
Chiral and structural analysis of biomolecules using mass spectrometry and ion mobility-mass spectrometry
Chirality, 21(1 E).
Contributors: J. Enders* & J. Mclean*
author keywords: chirality; mass spectrometry; ion mobility; ion mobility-mass spectrometry; structural separations; peptide; protein
MeSH headings : Carbohydrates / chemistry; Ions / chemistry; Kinetics; Lipids / chemistry; Mass Spectrometry / methods; Models, Chemical; Molecular Structure; Nucleotides / chemistry; Peptides / chemistry; Stereoisomerism; Thermodynamics
TL;DR:
This report describes the strategies for gas-phase chiral and structural characterization of biomolecules using mass spectrometry (MS) and ion mobility-MS (IM-MS) techniques and methodologies for adding a chiral selector are discussed.
(via Semantic Scholar)
Source: ORCID
Added: December 11, 2019
2009 journal article
Evaluation of the ALiPHAT Method for PC-IDMS and Correlation of Limits-of-Detection with Nonpolar Surface Area
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 20(11), 2006–2012.
MeSH headings : Alkylation; Amino Acid Sequence; Calibration; Carbon Isotopes / chemistry; Chromatography, High Pressure Liquid / methods; Humans; Hydrophobic and Hydrophilic Interactions; Isotope Labeling / methods; Laminin / analysis; Laminin / chemistry; Male; Mass Spectrometry / methods; Nitrogen Isotopes / chemistry; Oligopeptides / analysis; Oligopeptides / chemistry; Prostate-Specific Antigen / chemistry; Reference Standards; Trypsin / analysis; Trypsin / chemistry
TL;DR:
While an increase in hydrophobicity was found to aid in decreasing LOD to an extent, beyond a certain hydrophOBicity, the number of decreases in LOD was observed, the authors observed a decrease.
(via Semantic Scholar)
link.springer.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis
BIOCHEMICAL JOURNAL, 424, 335–345.
author keywords: apoptosis; cancer therapy; conformational switch; co-operative dimer interface; procaspase activation
MeSH headings : Amino Acid Substitution; Apoptosis; Binding Sites / genetics; Blotting, Western; Caspase 3 / chemistry; Caspase 3 / genetics; Caspase 3 / metabolism; Cell Line; Crystallography, X-Ray; Enzyme Activation; Enzyme Precursors / chemistry; Enzyme Precursors / genetics; Enzyme Precursors / metabolism; Humans; Models, Molecular; Mutation; Protein Conformation; Protein Multimerization; Protein Structure, Tertiary; Structure-Activity Relationship; Transfection; X-Linked Inhibitor of Apoptosis Protein / genetics; X-Linked Inhibitor of Apoptosis Protein / metabolism
TL;DR:
It is shown that low concentrations of the pseudo-activated procaspase-3 kill mammalian cells rapidly and, importantly, this protein is not cleaved nor is it inhibited efficiently by the endogenous regulator XIAP (X-linked inhibitor of apoptosis).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Construction of Coordination-Driven Self-Assembled [5+5] Pentagons Using Metal-Carbonyl Dipyridine Ligands
INORGANIC CHEMISTRY, 48(13), 5590–5592.
Contributors: L. Zhao *, K. Ghosh *, Y. Zheng *, M. Lyndon n, T. Williams n & P. Stang *
MeSH headings : Crystallography; Ligands; Magnetic Resonance Spectroscopy; Molecular Structure; Pyridines / chemistry; Spectrometry, Mass, Electrospray Ionization
TL;DR:
The coordination-driven self-assembly of two metal-carbonyl-cluster-coordinated dipyridyl donors, with a linear diplatinum(II) acceptor ligand, resulted in a pentagon-hexagon mixture, which was characterized by electrospray ionization time-of-flight mass spectroscopy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Utilizing Artificial Neural Networks in MATLAB to Achieve Parts-Per-Billion Mass Measurement Accuracy with a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 20(7), 1303–1310.
MeSH headings : Fourier Analysis; Linear Models; Mass Spectrometry / methods; Models, Theoretical; Neural Networks, Computer; Reproducibility of Results; Sensitivity and Specificity
TL;DR:
Artificial neural network calibration in conjunction with automatic gain control (AGC) is utilized in these experiments to formally account for the differences in total ion population in the ICR cell between the external calibration spectra and experimental spectra.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Tandem Mass Spectrometry of Thiolate-Protected Au Nanoparticles NaxAu25(SC2H4Ph)(18-y)(S(C2H4O)(5)CH3)(y)
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131(38), 13844–13851.
MeSH headings : Crystallography, X-Ray; Gold / chemistry; Metal Nanoparticles / chemistry; Sulfhydryl Compounds / chemistry; Tandem Mass Spectrometry
TL;DR:
The first collision-induced dissociation tandem mass spectrometry (CID MS/MS) of a thiolate-protected Au nanoparticle that has a crystallographically determined structure is reported, and previously unreported results show that even soft ionization sources can result in Au nanoparticles fragmentation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Proteomics Characterization of Cell Membrane Blebs in Human Retinal Pigment Epithelium Cells
MOLECULAR & CELLULAR PROTEOMICS, 8(10), 2201–2211.
MeSH headings : Aged; Animals; Antioxidants / pharmacology; Basigin / analysis; Cell Line; Cell Membrane / chemistry; Cell Membrane / drug effects; Cell Membrane / ultrastructure; Cell Surface Extensions / chemistry; Cell Surface Extensions / drug effects; Cell Surface Extensions / ultrastructure; Chromatography, Liquid; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Epithelial Cells / chemistry; Epithelial Cells / cytology; Epithelial Cells / drug effects; Extracellular Matrix / chemistry; Extracellular Matrix / metabolism; Eye Proteins / analysis; Humans; Hydroquinones / pharmacology; Macular Degeneration / pathology; Matrix Metalloproteinase 14 / analysis; Matrix Metalloproteinase 2 / analysis; Molecular Sequence Data; Proteomics / methods; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Retinal Pigment Epithelium / chemistry; Retinal Pigment Epithelium / cytology; Smoke; Smoking / adverse effects; Tandem Mass Spectrometry; Tobacco / chemistry
TL;DR:
Basigin and matrix metalloproteinase-14, key proteins involved in extracellular matrix remodeling, were identified in RPE blebs and shown to be more prevalent in AMD patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 article
Mass Spectrometry-Based Biomarker Discovery: Toward a Global Proteome Index of Individuality
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, Vol. 2, pp. 265–277.
author keywords: biological variability; analytical variability; longitudinal sampling
MeSH headings : Animals; Biomarkers / analysis; Humans; Mass Spectrometry / instrumentation; Mass Spectrometry / methods; Proteome / analysis; Proteomics / instrumentation; Proteomics / methods
TL;DR:
The purpose of this review is to discuss the analytical methods and strategies that have been developed for mass spectrometry-based biomarker-discovery platforms and to place them in the context of the many challenges and opportunities yet to be addressed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Development of a Robust and High Throughput Method for Profiling N-Linked Glycans Derived from Plasma Glycoproteins by NanoLC-FTICR Mass Spectrometry
JOURNAL OF PROTEOME RESEARCH, 8(7), 3764–3770.
MeSH headings : Biomarkers, Tumor / metabolism; Blood Proteins / chemistry; Chromatography, Liquid / methods; Detergents / pharmacology; Glycoproteins / chemistry; Humans; Mass Spectrometry / methods; Microwaves; Peptides / chemistry; Polysaccharides / chemistry; Proteome; Proteomics / methods; Spectroscopy, Fourier Transform Infrared / methods; Time Factors
TL;DR:
A step-by-step protocol describing a method for N-linked glycan profiling of plasma glycoproteins by nanoflow liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Synthesis of Six-Component Metallodendrimers via [3+3] Coordination-Driven Self-Assembly
JOURNAL OF ORGANIC CHEMISTRY, 74(9), 3524–3527.
MeSH headings : Dendrimers / chemical synthesis; Dendrimers / chemistry; Models, Molecular; Molecular Conformation; Organometallic Compounds / chemical synthesis; Organometallic Compounds / chemistry
TL;DR:
A new class of 120 degrees dendritic di-Pt(II) acceptor subunits has been designed and synthesized, from which six-component hexagonal metallodendrimers were easily formed with 120 degreesdendritic dipyridine donors via [3 + 3] coordination-driven self-assembly.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Multiple solvent crystal structures of ribonuclease A: An assessment of the method
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 76(4), 861–881.
author keywords: organic solvents; solvent mapping; plasticity; hydration; protein binding sites
MeSH headings : Animals; Catalytic Domain; Cattle; Computer Simulation; Crystallography, X-Ray; Models, Molecular; Pancreas / enzymology; Protein Binding; Protein Conformation; Ribonuclease, Pancreatic / chemistry; Ribonuclease, Pancreatic / metabolism; Solvents / chemistry; Solvents / metabolism; Water / chemistry; Water / metabolism
TL;DR:
Comparison of the MSCS structures with inhibitor‐bound crystal structures of RNAse A reveals that the organic solvent molecules identify key interactions made by inhibitor molecules, highlighting ligand binding hot‐spots in the active site.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Characterization of Charge Separation in the Array of Micromachined UltraSonic Electrospray (AMUSE) Ion Source for Mass Spectrometry
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 20(9), 1684–1687.
MeSH headings : Equipment Design; Equipment Failure Analysis; Radiation Dosage; Radiometry; Sonication; Spectrometry, Mass, Electrospray Ionization / instrumentation; Static Electricity
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Atmospheric pressure infrared (10.6 mu m) laser desorption electrospray ionization (IR-LDESI) coupled to a LTQ Fourier transform ion cyclotron resonance mass spectrometer
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 23(13), 1989–1992.
MeSH headings : Animals; Cattle; Molecular Weight; Proteins / chemistry; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Spectroscopy, Fourier Transform Infrared / instrumentation; Spectroscopy, Fourier Transform Infrared / methods
TL;DR:
The implementation of a CO(2) laser emitting infrared laser irradiation at 10.6 microm onto the versatile atmospheric pressure ionization platform is presented and Multiply charged proteins ranging in molecular mass from 8.6 to 17 kDa were detected from liquid-state samples without the addition of matrix.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Coupling of a vented column with splitless nanoRPLC-ESI-MS for the improved separation and detection of brain natriuretic peptide-32 and its proteolytic peptides
Journal of Chromatography B, 877(10), 948–954.
author keywords: Vented column; BNP-32; Splitless nanoLC; Tryptic digestion
MeSH headings : Amino Acid Sequence; Brain Chemistry; Chromatography, Liquid / methods; Molecular Sequence Data; Natriuretic Peptide, Brain / chemistry; Natriuretic Peptide, Brain / isolation & purification; Natriuretic Peptide, Brain / pharmacokinetics; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
It is demonstrated that the use of free cysteine as an alkylation quenching agent and a secondary digestion within the digestion scheme can provide targeted tryptic peptides with increased abundances, which will serve to further augment the detection of BNP-32 by LC-MS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Intact and Top-Down Characterization of Biomolecules and Direct Analysis Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Coupled to FT-ICR, Mass Spectrometry
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 20(4), 667–673.
MeSH headings : Amino Acid Sequence; Animals; Carbohydrates / chemistry; Cattle; Chickens; Egg Yolk / chemistry; Horses; Lipids / chemistry; Milk / chemistry; Molecular Sequence Data; Mucins / chemistry; Mucins / metabolism; Myoglobin / chemistry; Polysaccharides / chemistry; Polysaccharides / metabolism; Proteins / chemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectroscopy, Fourier Transform Infrared / methods
TL;DR:
Three of the four classes of biological macromolecules have been ionized and detected using MALDESI with minimal sample preparation and Sequencing of O-linked glycans, cleaved from mucin using reductive β-elimination chemistry, is also demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Generation of Multiply Charged Peptides and Proteins by Radio Frequency Acoustic Desorption and Ionization for Mass Spectrometric Detection
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 20(4), 597–600.
MeSH headings : Electrodes; Equipment Design; Mass Spectrometry / instrumentation; Mass Spectrometry / methods; Natriuretic Peptide, Brain / chemistry; Peptides / chemistry; Proteins / chemistry; Quartz / chemistry; Ubiquitin / chemistry
TL;DR:
The design and implementation of a radio frequency acoustic desorption ionization (RADIO) source has been demonstrated and intact and dissociated species observed during MS and MS/MS experiments, respectively are confirmed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Absolute Quantification of C-Reactive Protein in Human Plasma Derived from Patients with Epithelial Ovarian Cancer Utilizing Protein Cleavage Isotope Dilution Mass Spectrometry
JOURNAL OF PROTEOME RESEARCH, 8(2), 1085–1090.
author keywords: absolute quantification; C-reactive protein; ovarian cancer; single reaction monitoring
MeSH headings : Amino Acid Sequence; C-Reactive Protein / chemistry; C-Reactive Protein / metabolism; Chromatography, Liquid / methods; Female; Humans; Isotope Labeling / methods; Mass Spectrometry / methods; Molecular Sequence Data; Ovarian Neoplasms / blood; Ovarian Neoplasms / chemistry; Peptides / chemistry; Peptides / genetics; Peptides / metabolism; Reproducibility of Results
TL;DR:
Interestingly, the PC-IDMS method provided concentration values that were approximately 10x the concentration reported by the ELISA method, which demonstrated that the method of detection is an important consideration when determining reference ranges of a particular analyte.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Development of a nanoLC LTQ Orbitrap Mass Spectrometric Method for Profiling Glycans Derived from Plasma from Healthy, Benign Tumor Control, and Epithelial Ovarian Cancer Patients
ANALYTICAL CHEMISTRY, 81(3), 1130–1136.
Contributors: M. Bereman n, T. Williams n & D. Muddiman n
MeSH headings : Biomarkers, Tumor / blood; Biomarkers, Tumor / chemistry; Carcinoma / diagnosis; Chromatography, Liquid / methods; Female; Genital Neoplasms, Female / chemistry; Genital Neoplasms, Female / diagnosis; Glycoproteins / blood; Glycoproteins / chemistry; Humans; Hydrophobic and Hydrophilic Interactions; Lectins / blood; Lectins / chemistry; Male; Ovarian Neoplasms / diagnosis; Polysaccharides / blood; Polysaccharides / chemistry; ROC Curve; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR:
A split-less nano-flow liquid chromatography mass spectrometric analysis of glycans chemically cleaved from glycoproteins in plasma shows similar column efficiencies and excellent retention time reproducibility without an internal standard to correct for retention time shift.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
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