Works Published in 2013
Displaying works 101 - 120 of 241 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2013 review
Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence
[Review of ]. FUTURE MEDICINAL CHEMISTRY, 5(11), 1265–1284.
MeSH headings : Bacteria / metabolism; Bacteria / pathogenicity; Bacterial Infections / drug therapy; Bacterial Proteins / antagonists & inhibitors; Bacterial Proteins / metabolism; Biofilms / drug effects; Drug Resistance, Multiple, Bacterial / drug effects; Histidine Kinase; Humans; Protein Kinases / chemistry; Protein Kinases / metabolism; Signal Transduction / drug effects; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology; Small Molecule Libraries / therapeutic use; Virulence / drug effects
TL;DR:
An overview of TCS that are potential targets for such a strategy, small-molecules inhibitors of T CS identified to date are described, and assays for the identification of novel inhibitors are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Interface kinetic diffusion reaction leading to fast and continuous generation of AgCl nanocubes in NaCl solution
Dalton Transactions (Cambridge, England : 2003), 42(42), 15219–15225.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Understanding the Role of Proteolytic Digestion on Discovery and Targeted Proteomic Measurements Using Liquid Chromatography Tandem Mass Spectrometry and Design of Experiments
JOURNAL OF PROTEOME RESEARCH, 12(12), 5820–5829.
author keywords: design of experiments; proteolytic digestion; LC-MS/MS; Populus trichocarpa
MeSH headings : Amino Acid Sequence; Animals; Cattle; Chromatography, Liquid / standards; Factor Analysis, Statistical; Hydrogen-Ion Concentration; Isotope Labeling; Molecular Sequence Annotation; Molecular Sequence Data; Peptide Fragments / chemistry; Peptide Fragments / isolation & purification; Plant Proteins / chemistry; Plant Proteins / isolation & purification; Populus / chemistry; Protein Stability; Proteolysis; Proteomics / methods; Proteomics / standards; Research Design; Swine; Tandem Mass Spectrometry / standards; Trypsin / chemistry; Xylem / chemistry
TL;DR:
The tryptic digest optimization described here has eliminated this previously observed peptide decay as well as provided a greater understanding and standardization for a common but critical sample treatment used across the field of proteomics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Tyrosyl radicals in dehaloperoxidase how nature deals with evolving an oxygen-binding globin to a biologically relevant peroxidase
Journal of Biological Chemistry, 288(46), 33470–33482.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Synthesis, Structure, Photophysics, and a DFT Study of Phosphorescent C*(NN)-N-boolean AND- and (CNN)-N-boolean AND-N-boolean AND-Coordinated Platinum Complexes
INORGANIC CHEMISTRY, 52(20), 11711–11722.
MeSH headings : Crystallography, X-Ray; Luminescent Agents / chemical synthesis; Luminescent Agents / chemistry; Models, Molecular; Molecular Structure; Organoplatinum Compounds / chemical synthesis; Organoplatinum Compounds / chemistry; Photochemical Processes; Quantum Theory
TL;DR:
The calculations suggested that lowest singlet and triplet excited states are characteristic of a mixed state involving one or more charge-transfer transitions such as ILCT, MLCT, and LLCT.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Synthesis and Optical Properties of Ag(I), Pb(II), and Bi(III) Tantalate-Based Photocatalysts
ACS CATALYSIS, 3(12), 2943–2953.
author keywords: photocatalysis; lead exchange; layered tantalate; solar energy; band engineering
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Synthesis and Characterization of MnCrO4, a New Mixed-Valence Antiferromagnet
INORGANIC CHEMISTRY, 52(20), 11850–11858.
TL;DR:
Both the magnetic susceptibility and the specific heat data indicate an onset of a three-dimensional antiferromagnetic order at TN ≈ 42 K, which was confirmed also by calculating the spin exchange interactions on the basis of first principles density functional calculations.
(via Semantic Scholar)
hdl.handle.net (repository)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Lengthening the Intersubunit Linker of Procaspase 3 Leads to Constitutive Activation
BIOCHEMISTRY, 52(36), 6219–6231.
MeSH headings : Apoptosis / physiology; Caspase 3 / chemistry; Caspase 3 / genetics; Caspase 3 / metabolism; Caspase Inhibitors / pharmacology; Catalytic Domain; Enzyme Activation; Enzyme Precursors / chemistry; Models, Chemical; Models, Molecular; Molecular Dynamics Simulation; Protein Conformation; Protein Multimerization
TL;DR:
The data show that releasing the strain of the short IL is not sufficient to populate the active conformer of the native ensemble, and it is shown that increasing the length of the IL by introducing 3-5 alanines results in constitutively active procaspases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
In Situ Electrode Calibration Strategy for Voltammetric Measurements In Vivo
ANALYTICAL CHEMISTRY, 85(23), 11568–11575.
MeSH headings : Animals; Calibration; Electrochemical Techniques / methods; Electrodes, Implanted; Flow Injection Analysis / methods; Male; Rats; Rats, Sprague-Dawley
TL;DR:
A model that utilizes information contained in the background charging current to predict electrode sensitivity to dopamine, ascorbic acid, hydrogen peroxide, and pH shifts at any point in an electrochemical experiment is developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Hydrogen Sensing under Ambient Conditions Using SnO2 Nanowires: Synergetic Effect of Pd/Sn Codeposition
NANO LETTERS, 13(12), 5938–5943.
author keywords: Room-temperature hydrogen sensor; SnO2 nanowire; synergetic effect of Pd/Sn codeposition
MeSH headings : Hydrogen / chemistry; Hydrogen / isolation & purification; Metal Nanoparticles / chemistry; Nanowires / chemistry; Semiconductors; Tin Compounds / chemistry
TL;DR:
It is indicated that in the presence of Pd the oxidation of Sn nanoparticles on the surface of the SnO2 nanowire is incomplete leading only to suboxides SnOx (1 ≤ x < 2), and thesurface of the Pd/Sn-deposited SnO1 nanowires is almost perfectly hydrophobic.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Highly Active Modulators of Indole Signaling Alter Pathogenic Behaviors in Gram-Negative and Gram-Positive Bacteria
CHEMISTRY-A EUROPEAN JOURNAL, 19(51), 17595–17602.
author keywords: desformylflustrabromine; mechanistic probes; natural products; phenotype control; structure-activity relationships
MeSH headings : Bacterial Proteins / antagonists & inhibitors; Bacterial Proteins / metabolism; Biofilms / drug effects; Gram-Negative Bacteria / drug effects; Gram-Negative Bacteria / physiology; Gram-Positive Bacteria / drug effects; Gram-Positive Bacteria / physiology; Hydrocarbons, Brominated / chemical synthesis; Hydrocarbons, Brominated / chemistry; Hydrocarbons, Brominated / pharmacology; Indole Alkaloids / chemical synthesis; Indole Alkaloids / chemistry; Indole Alkaloids / pharmacology; Indoles / chemical synthesis; Indoles / chemistry; Indoles / pharmacology; Phenotype; Structure-Activity Relationship; Temperature; Trans-Activators / antagonists & inhibitors; Trans-Activators / metabolism; Tryptophanase / antagonists & inhibitors; Tryptophanase / metabolism
TL;DR:
This investigation demonstrates that molecules based on the dFBr scaffold can alter pathogenic behaviors by mimicking indole-signaling pathways and develop non-microbicidal dF Br derivatives that are 27-2000 times more active than indole in modulating biofilm formation, motility, acid resistance, and antibiotic resistance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Functional Consequences of the Open Distal Pocket of Dehaloperoxidase-Hemoglobin Observed by Time-Resolved X-ray Crystallography
BIOCHEMISTRY, 52(45), 7943–7950.
MeSH headings : Binding Sites; Carbon Monoxide / chemistry; Carbon Monoxide / metabolism; Crystallography, X-Ray / methods; Hemoglobins / chemistry; Hemoglobins / metabolism; Peroxidases / chemistry; Peroxidases / metabolism
TL;DR:
Using time-resolved X-ray crystallography, a bifunctional dehaloperoxidase-hemoglobin (DHP) is contrasted with previously studied examples of myoglobin and hemoglobin to understand the functional role of the distal pocket of globins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Experimental Determination of the Crystallization Phase-Boundary Velocity in the Halozeotype CZX-1
Chemistry of Materials, 25(20), 3932–3940.
author keywords: crystallization kinetics; Avrami; DSC kinetics; XRD kinetics; phase-boundary velocity; time-resolved diffraction; synchrotron
UN Sustainable Development Goal Categories
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Evidence of Entropy-Driven Bistability through N-15 NMR Analysis of a Temperature- and Solvent-Induced, Chiroptical Switching Polycarbodiimide
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135(51), 19292–19303.
TL;DR:
The thermo- and solvo-driven chiroptical switching process observed in specific polycarbodiimides occurs in a concerted fashion with large deviations in specific optical rotation and CD Cotton effect as a consequence of varying populations of two distinct polymer conformations, and it is proposed that the increased entropy in the system is a direct consequence of increased disorder in the solvent as the switching occurs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Efficient Separation of Photogenerated Electron-Hole Pairs by the Combination of a Heterolayered Structure and Internal Polar Field in Pyroelectric BiOIO3 Nanoplates
CHEMISTRY-A EUROPEAN JOURNAL, 19(44), 14777–14780.
author keywords: BiOIO3; electron-hole separation; heterolayered structure; photocatalysts; polar field; semiconducters
TL;DR:
Heterolayered bismuth-based layered semiconductors, BiOIO3, are studied to find that it is an efficient photocatalyst under ultraviolet (UV) light irradiation, far superior to that of TiO2 (P25).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Crystal Growth Simulations To Establish Physically Relevant Kinetic Parameters from the Empirical Kolmogorov–Johnson–Mehl–Avrami Model
Chemistry of Materials, 25(20), 3941–3951.
author keywords: crystallization simulation; nucleation rate; Avrami; crystallization kinetics; phase boundary velocity; size-effect; shape-effect
UN Sustainable Development Goal Categories
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Cellular Delivery and Photochemical Activation of Antisense Agents through a Nucleobase Caging Strategy
ACS CHEMICAL BIOLOGY, 8(10), 2272–2282.
MeSH headings : Base Sequence; Gene Transfer Techniques; HeLa Cells; Humans; Light; Models, Biological; Molecular Structure; Oligonucleotides, Antisense / chemistry; Oligonucleotides, Antisense / genetics; Oligonucleotides, Antisense / metabolism; Polymerase Chain Reaction; tat Gene Products, Human Immunodeficiency Virus / chemistry; tat Gene Products, Human Immunodeficiency Virus / genetics
TL;DR:
The conjugation of multiple HIV TAT peptides to a hairpin-protected antisenseAgent through a light-cleavable nucleobase caging group allows for the facile delivery of the antisense agent without a transfection reagent, and photochemical activation offers precise control over gene expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Biologically inspired strategies for combating bacterial biofilms
CURRENT OPINION IN PHARMACOLOGY, 13(5), 699–706.
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Bacterial Infections / drug therapy; Bacterial Infections / metabolism; Bacterial Physiological Phenomena / drug effects; Biofilms / drug effects; Humans; Quorum Sensing / drug effects; Signal Transduction / drug effects
TL;DR:
Small molecule interference with bacterial communication and signaling pathways, including quorum sensing and two-component signal transduction systems are focused on, focusing firstly on enzymatic approaches to the degradation of extracellular matrix components to effect biofilm dispersal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
The UDP-diacylglucosamine Pyrophosphohydrolase LpxH in Lipid A Biosynthesis Utilizes Mn2+ Cluster for Catalysis
JOURNAL OF BIOLOGICAL CHEMISTRY, 288(38), 26987–27001.
Contributors: H. Young*, M. Donohue n, T. Smirnova n , A. Smirnov n & P. Zhou *
MeSH headings : Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / isolation & purification; Bacterial Proteins / metabolism; Catalysis; Cloning, Molecular; Gene Expression; Haemophilus influenzae / enzymology; Haemophilus influenzae / genetics; Lipid A / biosynthesis; Lipid A / chemistry; Lipid A / metabolism; Manganese / chemistry; Manganese / metabolism; Pyrophosphatases / chemistry; Pyrophosphatases / genetics; Pyrophosphatases / isolation & purification; Pyrophosphatases / metabolism
TL;DR:
Overall, this work unambiguously establishes LpxH as a calcineurin-like phosphoesterase containing a Mn2+ cluster coordinated by conserved residues, which sets the scene for further structural investigation of the enzyme and for design of novel antibiotics targeting lipid A biosynthesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Structural Refinement of Ladder-Type Perylenediimide Dimers: A Classical Tale of Conformational Dynamics
JOURNAL OF ORGANIC CHEMISTRY, 78(17), 8634–8644.
Contributors: M. Myahkostupov *, V. Prusakova*, D. Oblinsky *, G. Scholes * & F. Castellano*
MeSH headings : Dimerization; Imides / chemistry; Molecular Structure; Perylene / analogs & derivatives; Perylene / chemistry; Quantum Theory
TL;DR:
Rational two-dimensional NMR approaches based on both homo- and heteronuclear couplings, in conjunction with high-level structural DFT calculations, were readily applied to these structures, producing well-defined analytical characterization, and the associated methodology is described in detail.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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