Works Published in 2020
Displaying works 421 - 440 of 779 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2020 journal article
PTPN11mutations in canine and human disseminated histiocytic sarcoma
INTERNATIONAL JOURNAL OF CANCER, 147(6), 1657–1665.
author keywords: histiocytic sarcoma; dog; spontaneous model; PTPN11
MeSH headings : Adult; Aged; Aged, 80 and over; Animals; Biopsy; Cell Line, Tumor; Cell Proliferation / drug effects; Child; Child, Preschool; DNA Mutational Analysis; Disease Models, Animal; Dog Diseases / blood; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Drug Screening Assays, Antitumor / methods; Female; Histiocytes / pathology; Histiocytic Sarcoma / drug therapy; Histiocytic Sarcoma / genetics; Histiocytic Sarcoma / pathology; Histiocytic Sarcoma / veterinary; Humans; Infant; MAP Kinase Signaling System / drug effects; MAP Kinase Signaling System / genetics; Male; Middle Aged; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / metabolism; Mutation; Protein Kinase Inhibitors / pharmacology; Protein Kinase Inhibitors / therapeutic use; Protein Tyrosine Phosphatase, Non-Receptor Type 11 / antagonists & inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 11 / genetics; Ribonucleases; Tumor Suppressor Proteins; Young Adult
TL;DR:
Results illustrate the relevance of naturally affected dogs in deciphering genetic mechanisms and selecting efficient targeted therapies for such rare and aggressive cancers in humans, by testing drugs targeting the MAPK pathway in eight canine HS cell lines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 10, 2020
2020 journal article
Semiparametric estimation of the cure fraction in population-based cancer survival analysis
STATISTICS IN MEDICINE, 39(26), 3787–3805.
author keywords: Breslow estimator; EM algorithm; mixture cure model; perturbation; population-based study; semiparametric regression
MeSH headings : Aged; Algorithms; Computer Simulation; Female; Humans; Models, Statistical; Neoplasms / mortality; Proportional Hazards Models; Survival Analysis
TL;DR:
Real data analysis shows that the proposed semiparametric MCPH+BM model may provide more accurate estimation in population‐level cancer study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 10, 2020
2020 article
Clinical xenotransplantation of the heart: At the watershed
Platt, J. L., Piedrahita, J. A., & Cascalho, M. (2020, August). JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol. 39, pp. 758–760.
MeSH headings : Animals; Heart; Heart Transplantation; Primates; Swine; Transplantation, Heterologous
www.jhltonline.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 10, 2020
2020 article
Shared Multidrug Resistance Patterns in Chicken-Associated Escherichia coli Identified by Association Rule Mining (vol 10, 687, 2019)
Cazer, C. L., Al-Mamun, M. A., Kaniyamattam, K., Love, W. J., Booth, J. G., Lanzas, C., & Grohn, Y. T. (2020, June 30). FRONTIERS IN MICROBIOLOGY, Vol. 11.
author keywords: association rule mining; antimicrobial resistance; Escherichia coli; machine learning; multidrug resistance; foodborne bacteria
TL;DR:
This research presents a novel probabilistic procedure that allows for direct measurement of the response of the immune system to earthquake-triggered landsliding.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 10, 2020
2020 journal article
Salicylanilide Analog Minimizes Relapse of Clostridioides difficile Infection in Mice
JOURNAL OF MEDICINAL CHEMISTRY, 63(13), 6898–6908.
MeSH headings : Animals; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Clostridioides difficile / drug effects; Clostridioides difficile / physiology; Clostridium Infections / drug therapy; Female; Male; Mice; Mice, Inbred C57BL; Recurrence; Safety; Salicylanilides / chemistry; Salicylanilides / pharmacokinetics; Salicylanilides / pharmacology; Salicylanilides / therapeutic use; Tissue Distribution
TL;DR:
A new series of known membrane-targeting compounds was synthesized and the most potent analog was selected through an in vitro inhibitory assay to evaluate its pharmacokinetic parameters and potency in a CDI mouse model, revealing reduced recurrence of CDI and disturbance of the microbiota in mice compared to standard-of-care vancomycin, thus paving the way for novel therapy that can potentially target the cell membrane of C. difficile.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 10, 2020
2020 journal article
Chitosan Hydrogels for Synergistic Delivery of Chemotherapeutics to Triple Negative Breast Cancer Cells and Spheroids
PHARMACEUTICAL RESEARCH, 37(7).
MeSH headings : Acetylation; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / chemistry; Antineoplastic Combined Chemotherapy Protocols / pharmacology; Cell Line, Tumor; Cell Survival / drug effects; Chitosan / chemistry; Deoxycytidine / administration & dosage; Deoxycytidine / analogs & derivatives; Deoxycytidine / chemistry; Deoxycytidine / pharmacology; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers; Drug Compounding; Drug Liberation; Drug Synergism; Female; Humans; Hydrogels; Kinetics; Spheroids, Cellular; Triple Negative Breast Neoplasms / drug therapy; Triple Negative Breast Neoplasms / pathology; Gemcitabine
TL;DR:
The ACS hydrogel delivery system accomplishes drug release kinetics and molar ratio that affords strong therapeutically synergism and provides a strong pre-clinical demonstration of the potential of the proposed system for complementing surgical resection of aggressive solid tumors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 10, 2020
2020 journal article
A Novel Cecropin-LL37 Hybrid Peptide Protects Mice Against EHEC Infection-Mediated Changes in Gut Microbiota, Intestinal Inflammation, and Impairment of Mucosal Barrier Functions
FRONTIERS IN IMMUNOLOGY, 11.
author keywords: enrofloxacin; Escherichia coli; hybrid peptide; inflammation; microflora; mucosal barrier; O157; H7
MeSH headings : Animals; Antimicrobial Cationic Peptides / pharmacology; Cecropins / pharmacology; Escherichia coli Infections / pathology; Escherichia coli O157; Female; Gastrointestinal Microbiome / drug effects; Inflammation / microbiology; Inflammation / pathology; Intestinal Diseases / microbiology; Intestinal Diseases / pathology; Intestinal Mucosa / drug effects; Mice; Mice, Inbred C57BL; Recombinant Proteins / pharmacology; Cathelicidins
TL;DR:
Findings suggest that the novel hybrid peptide C-L could be developed into a new anti-inflammatory agent for use in animals or humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 10, 2020
2020 journal article
High-Throughput Manufacture of 3D Fiber Scaffolds for Regenerative Medicine
TISSUE ENGINEERING PART C-METHODS, 26(7), 364–374.
author keywords: 3D printing; melt blowing; fibers; scaffolds
MeSH headings : Animals; Biocompatible Materials / chemistry; Dogs; Hernia / therapy; Herniorrhaphy / methods; Polymers / chemistry; Printing, Three-Dimensional / instrumentation; Regenerative Medicine; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR:
The 3DMB system described in this study is modified from larger nonwovens manufacturing machinery to accommodate the lower volume, high-cost polymers used for tissue engineering and implantable biomedical devices and has a fiber collection component that uses adaptable robotics to create scaffolds with predetermined geometries.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 10, 2020
2020 journal article
Dermal exosomes containing miR-218-5p promote hair regeneration by regulating beta-catenin signaling
SCIENCE ADVANCES, 6(30).
MeSH headings : Cells, Cultured; Exosomes; Hair; Hair Follicle; MicroRNAs / genetics; Regeneration; beta Catenin / genetics
TL;DR:
Results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment, and it was demonstrated that miR-218-5p was notably up-regulated in DP spheroid–derived exosomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 10, 2020
2020 journal article
Preliminary Evaluation of a Wearable Sensor System for Heart Rate Assessment in Guide Dog Puppies
IEEE SENSORS JOURNAL, 20(16), 9449–9459.
author keywords: ECG; heart rate variability; electrodes; machine learning; 3D printing; wearable
TL;DR:
A novel wireless heart rate sensing system for puppies in training as guide dogs that includes a harness with on-board electrocardiography front-end circuit, inertial measurement unit and a micro-computer with wireless capability is developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 10, 2020
2020 book
Spectroscopic Tools for Food Analysis
In SPECTROSCOPIC TOOLS FOR FOOD ANALYSIS (pp. 1–87).
TL;DR:
Food quality analysis is an area of interest that has always attracted the attention of everyone, and making suitable tools for food analysis is especially important.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 10, 2020
2020 journal article
Novel peptide ligands for antibody purification provide superior clearance of host cell protein impurities
JOURNAL OF CHROMATOGRAPHY A, 1625.
author keywords: Peptide affinity ligands; Protein A; mAb purification; Affinity chromatography; Peptide design
MeSH headings : Amino Acid Sequence; Animals; Antibodies, Monoclonal / isolation & purification; Antibodies, Monoclonal / metabolism; CHO Cells; Chromatography, Affinity / methods; Cricetinae; Cricetulus; Immunoglobulin G / isolation & purification; Immunoglobulin G / metabolism; Ligands; Peptides / chemical synthesis; Peptides / chemistry; Peptides / metabolism; Protein Binding; Staphylococcal Protein A / chemistry; Staphylococcal Protein A / metabolism
TL;DR:
WQRHGI-WorkBeads resin was finally characterized by purification of a monoclonal antibody from a Chinese Hamster Ovary cell culture harvest, affording a remarkable HCP LRV of 2.7, and consistent product yield and purity over 100 chromatographic cycles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 10, 2020
2020 journal article
Algorithmically Controlled Electroporation: A Technique for Closed Loop Temperature Regulated Pulsed Electric Field Cancer Ablation
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 67(8), 2176–2186.
author keywords: Temperature control; Temperature measurement; Temperature sensors; Electric fields; Protocols; Temperature dependence; In vitro; Non-thermal high frequency irreversible electroporation; electro-thermal therapy; pulsed electric field; bioelectric; electroporation
MeSH headings : Electricity; Electroporation; Humans; Models, Theoretical; Neoplasms; Temperature
TL;DR:
The results of this study indicate ablative outcomes due to exposure to pulses on the order of one microsecond may be thermally mediated and dependent on local tissue temperatures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 10, 2020
2020 journal article
Serum procalcitonin concentrations in dogs with induced endotoxemia
Journal of Veterinary Internal Medicine.
author keywords: animal model; biomarker; lipopolysaccharide; sepsis
MeSH headings : Animals; Cross-Over Studies; Dog Diseases / blood; Dog Diseases / chemically induced; Dogs; Endotoxemia / blood; Endotoxemia / chemically induced; Endotoxemia / veterinary; Lipopolysaccharides / toxicity; Male; Procalcitonin / blood
TL;DR:
Procalcitonin expression is likely to be a clinically useful biomarker for sepsis in dogs and might have an additional role in prognostication and therapeutic decision‐making.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: August 6, 2020
2020 journal article
Second illness due to subsequent Cytauxzoon felis infection in a domestic cat
Journal of Feline Medicine and Surgery Open Reports.
author keywords: Cytauxzoonosis; schizont; piroplasm; vector-borne disease
TL;DR:
A castrated male domestic shorthair cat from a wooded area in Missouri had recovered from typical severe cytauxzoonosis at 4 years of age, after intensive in-hospital supportive care and administration of atovaquone and azithromycin and then developed a subsequent clinical illness typical of cytauxZoonosis, which was accompanied not only by intraerythrocytic piroplasms, but also by schizont-laden tissue macrophages pathognomonic of clinical cyt
(via Semantic Scholar)
Source: ORCID
Added: August 6, 2020
2020 journal article
Avian Satellite Cell Plasticity
Animals, 10(8), 1322.
author keywords: satellite cells; plasticity; stem cells; chicken; embryo
TL;DR:
The results of this study proved the high myogenicity of chicken Pectoralis thoracicus cell isolates, as well as provided new information about their migration pathways following introduction into the blastocyst.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: August 5, 2020
2020 journal article
Lily steroidal glycoalkaloid promotes early inflammatory resolution in wounded human fibroblasts
Journal of Ethnopharmacology.
author keywords: Steroidal glycoalkaloid; Lilium longiflorum Thunb.; Scratch migration assay; Gene expression; Easter lily; Human dermal fibroblast cells
MeSH headings : Alkaloids / isolation & purification; Alkaloids / pharmacology; Cell Movement / drug effects; Cells, Cultured; Chromatography, Liquid; Fibroblasts / drug effects; Fibroblasts / pathology; Flowers; Gene Expression Regulation / drug effects; Glycosides / isolation & purification; Glycosides / pharmacology; Humans; Inflammation / drug therapy; Inflammation / pathology; Lilium / chemistry; Plant Roots; Wound Healing / drug effects
TL;DR:
It is demonstrated that a glycoalkaloid present in lilies promoted fibroblast migration in vitro and affected inflammatory, remodeling and growth factor gene expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: August 4, 2020
2020 journal article
Editorial: Cosmeceuticals From Medicinal Plants
Frontiers in Pharmacology.
author keywords: cosmeceutials; medicinal plant; anti-inflammatory; acne (acne vulgaris); skin aging
TL;DR:
This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, as to provide real-time information about the phytochemical properties of manure and its applications in agriculture and animal welfare.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
15. Life on Land
(Web of Science)
Source: ORCID
Added: August 4, 2020
2020 journal article
Experimental Characterization and Finite Element Modeling of the Effects of 3D Bioplotting Process Parameters on Structural and Tensile Properties of Polycaprolactone (PCL) Scaffolds
Applied Sciences, 10(15), 5289.
author keywords: 3D Bioplotting; scaffolds; finite element analysis; tensile strength; PCL
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: August 4, 2020
2020 journal article
Pharmacokinetics, sedation and hemodynamic changes following the administration of oral transmucosal detomidine gel in cats
JOURNAL OF FELINE MEDICINE AND SURGERY, 22(12), 1184–1190.
author keywords: Detomidine gel; alpha-2 agonist; buccal; oral transmucosal; pharmacokinetics
MeSH headings : Administration, Oral; Animals; Blood Pressure / drug effects; Cats / physiology; Conscious Sedation / veterinary; Female; Gels; Heart Rate / drug effects; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / pharmacokinetics; Imidazoles / administration & dosage; Imidazoles / pharmacokinetics; Male; Respiratory Rate / drug effects
TL;DR:
The pharmacokinetic profile supports short-term, minimally invasive sedation in this species and is warranted for use in debilitated cats, or prior to general anesthesia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 3, 2020
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