Works Published in 2018
Displaying works 21 - 40 of 64 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 journal article
Cardiovascular Mechanisms of Action of Anthocyanins May Be Associated with the Impact of Microbial Metabolites on Heme Oxygenase-1 in Vascular Smooth Muscle Cells
Molecules, 23(4), 898.
author keywords: anthocyanin; smooth muscle cells; metabolism; antioxidant; atherosclerosis
MeSH headings : Animals; Anthocyanins / chemistry; Anthocyanins / pharmacology; Aorta; Cell Proliferation / drug effects; Cells, Cultured; Gene Expression Regulation / drug effects; Heme Oxygenase (Decyclizing) / metabolism; Molecular Structure; Muscle, Smooth, Vascular / cytology; Muscle, Smooth, Vascular / drug effects; Muscle, Smooth, Vascular / metabolism; Phenols / chemistry; Phenols / pharmacology; Rats; Rats, Sprague-Dawley
TL;DR:
It is demonstrated that phenolic metabolites of anthocyanins differentially affect HO-1 activity, often having additive, synergistic or nullifying effects.
(via Semantic Scholar)
www.mdpi.com (publisher PDF)
Sources: Crossref, NC State University Libraries
Added: December 5, 2019
2018 article
Increased Plasma Levels of Gut-Derived Phenolics Linked to Walking and Running Following 2-Weeks Flavonoid Supplementation
Nieman, D. C., Kay, C. D., Rathore, A. S., Grace, M. H., Strauch, R. C., Stephan, E. H., … Lila, M. A. (2018, October 15). (Vol. 10). Vol. 10.
Source: ORCID
Added: November 13, 2019
2018 journal article
Increased Plasma Levels of Gut-Derived Phenolics Linked to Walking and Running Following Two Weeks of Flavonoid Supplementation
Nutrients, 10(11).
Contributors: D. Nieman *, C. Kay n , A. Rathore n, M. Grace n , R. Strauch n, E. Stephan*, C. Sakaguchi *, M. Lila n
author keywords: exercise; polyphenol; metabolite; hippurate; intestinal tract; colon
TL;DR:
Data indicate that acute exercise bouts (brisk walking, intensive running) are linked to an increased translocation of gut-derived phenolics into circulation, an effect that is amplified when combined with a two-week period of increased flavonoid intake or chronic training as a runner.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: November 12, 2019
2018 journal article
In vitro mineral nutrition of Curcuma longa L. affects production of volatile compounds in rhizomes after transfer to the greenhouse
BMC Plant Biology, 18(1).
Contributors: R. El-Hawaz *, M. Grace n , A. Janbey n, M. Lila n & J. Adelberg*
author keywords: Bioreactor; Sesquiterpenes; GC-MS; Curcuma longa rhizome; Response surface methods; Fed-batch technique
MeSH headings : Bioreactors; Calcium / metabolism; Curcuma / drug effects; Curcuma / metabolism; Fertilizers; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Magnesium / metabolism; Minerals / pharmacology; Nitrates / metabolism; Phosphates / metabolism; Potassium Compounds / metabolism; Rhizome / drug effects; Rhizome / metabolism; Volatile Organic Compounds / metabolism
TL;DR:
Mining in the in vitro bioreactor medium during rhizome development affected biosynthesis of turmeric volatile components after transfer to the greenhouse six months later, and the varied phytochemical profiles were maintained with integrity during the greenhouse growth in high fertility conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: ORCID, NC State University Libraries
Added: November 12, 2019
2018 journal article
Analytical Profiling of Proanthocyanidins from Acacia mearnsii Bark and In Vitro Assessment of Antioxidant and Antidiabetic Potential
Molecules, 23(11), 2891.
Contributors: X. Chen *, J. Xiong n , S. Huang *, X. Li *, Y. Zhang *, L. Zhang *, F. Wang *
author keywords: proanthocyanidins; HPLC/MS; MALDI-TOF/MS; antidiabetic; antioxidant; degree of polymerization
MeSH headings : Acacia / chemistry; Antioxidants / chemistry; Chromatography, High Pressure Liquid; Ethanol / chemistry; Hep G2 Cells; Humans; Hypoglycemic Agents / chemistry; Plant Bark / chemistry; Plant Extracts / chemistry; Polyphenols / chemistry; Proanthocyanidins / chemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
TL;DR:
Results of combined antioxidant activity assays, as well as carbolytic enzyme inhibitory activities of proanthocyanidins from A. mearnsii bark, indicated an encouraging antioxidant capacity for the high polyphenol content and a potential for use as alternative drugs for lowering the glycemic response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 12, 2019
2018 journal article
Simultaneous LC-MS quantification of anthocyanins and non-anthocyanin phenolics from blueberries with widely divergent profiles and biological activies
Food Chemistry, 10.
author keywords: Pink-fruited; Blueberries; LC-IT-TOF-MS; Quantification; Antioxidant; Anti-inflammatory; PCA
MeSH headings : Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Anti-Inflammatory Agents / analysis; Anti-Inflammatory Agents / pharmacology; Antioxidants / analysis; Antioxidants / pharmacology; Biological Assay; Blueberry Plants / chemistry; Cell Survival / drug effects; Chromatography, Liquid; Color; Flavonoids / analysis; Flavonoids / pharmacology; Flavonols / analysis; Flavonols / pharmacology; Fruit / chemistry; Hydroxybenzoates / analysis; Hydroxybenzoates / pharmacology; Limit of Detection; Mass Spectrometry; Mice; Nitric Oxide / metabolism; Phenols / analysis; Phenols / pharmacology; Plant Extracts / analysis; Plant Extracts / pharmacology; RAW 264.7 Cells; Reactive Oxygen Species / metabolism; Reproducibility of Results; Resveratrol / analysis; Resveratrol / pharmacology
TL;DR:
A sensitive and straightforward LC-IT-TOF-MS method was validated for the profiling and simultaneous quantification of anthocyanins, flavan-3-ols, flavonols, phenolic acids, and resveratrol in blueberry genotypes with fruit color ranging from deep purple to various shades of pink.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: November 12, 2019
2018 journal article
Effects of In Vitro Digestion on the Content and Biological Activity of Polyphenols from Acacia mearnsii Bark
Molecules, 23(7), 1804.
Contributors: X. Chen *, J. Xiong n , L. He*, Y. Zhang *, X. Li *, L. Zhang *, F. Wang *
author keywords: Acacia mearnsii; proanthocyanidins; in vitro digestion; antioxidant; antidiabetic; HPLC; MS
MeSH headings : Acacia / chemistry; Antioxidants / chemistry; Antioxidants / pharmacokinetics; Chromatography, High Pressure Liquid; Gastrointestinal Tract / metabolism; Hypoglycemic Agents / chemistry; Hypoglycemic Agents / pharmacokinetics; In Vitro Techniques; Mass Spectrometry; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Plant Extracts / metabolism; Plant Extracts / pharmacokinetics; Polyphenols / chemistry; Polyphenols / isolation & purification; Polyphenols / metabolism; Polyphenols / pharmacokinetics; Proanthocyanidins / chemistry; Proanthocyanidins / pharmacokinetics; Solid Phase Extraction
TL;DR:
Findings show that PAs from A. mearnsii bark as a native plant source may be particularly beneficial for human health as a natural nutritional supplement.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 12, 2019
2018 journal article
Dynamic DNA Methylation in Plant Growth and Development
International Journal of Molecular Sciences, 19(7), 2144.
author keywords: DNA methylation; methylome; seed; development; gene expression; dynamics; epigenetics; transposable element; plant
MeSH headings : DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Plant Development / genetics
TL;DR:
DNA methylation patterns in angiosperms are complex, dynamic, and an integral part of genome diversity after millions of years of evolution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2018 journal article
Plasma proteins associated with circulating carotenoids in Nepalese school-aged children.
Archives of Biochemistry and Biophysics.
author keywords: Proteomics; Plasma proteins; beta-cryptoxanthin; Antioxidants; Carotenoids; Nepal
MeSH headings : Biomarkers / blood; Biomarkers / metabolism; Blood Proteins / analysis; Blood Proteins / metabolism; Carotenoids / blood; Carotenoids / metabolism; Child; Humans; Linear Models; Mass Spectrometry / methods; Nepal; Proteomics / methods
TL;DR:
Carotenoids are naturally occurring pigments that function as vitamin A precursors, antioxidants, anti-inflammatory agents or biomarkers of recent vegetable and fruit intake, and are thus important for population health and nutritional assessment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: May 4, 2019
2018 journal article
Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
Nature Communications, 9(1), 53.
MeSH headings : Aged; Animals; Antineoplastic Agents; Benzamides / pharmacology; Cell Line, Tumor; Cell Proliferation; Co-Repressor Proteins / antagonists & inhibitors; Co-Repressor Proteins / metabolism; Drug Design; Drug Screening Assays, Antitumor; Female; Histone Deacetylase Inhibitors / pharmacology; Histone Deacetylases / chemistry; Humans; Male; Melanoma / drug therapy; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Nerve Tissue Proteins / antagonists & inhibitors; Nerve Tissue Proteins / metabolism; Oligonucleotide Array Sequence Analysis; Pyridines / pharmacology; Repressor Proteins / antagonists & inhibitors; Repressor Proteins / metabolism; Skin Neoplasms / drug therapy; Tranylcypromine / pharmacology; Xenograft Model Antitumor Assays
TL;DR:
A bifunctional small molecule inhibitor that simultaneously targets the deacetylase (HDAC1) and demethylase (LSD1) activities of the CoREST complex is reported, highlighting the promise of a new class of two-pronged hybrid agents that may show preferential targeting of particular epigenetic regulatory complexes and offer unique therapeutic opportunities.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: February 8, 2019
2018 journal article
Plasma proteome correlates of lipid and lipoprotein: biomarkers of metabolic diversity and inflammation in children of rural Nepal
Journal of Lipid Research, 60(1), 149–160.
author keywords: plasma proteomics; high density lipoprotein-cholesterol; low density lipoprotein-cholesterol; triglycerides
MeSH headings : Biomarkers / blood; Biomarkers / metabolism; Child; Female; Humans; Inflammation / blood; Inflammation / metabolism; Lipoproteins / blood; Lipoproteins / metabolism; Male; Nepal; Proteomics; Rural Population
TL;DR:
Relative abundance of two-thirds of the HDL proteome varied with inflammation, with acute phase reactants higher by 4∼40%, and proteins involved in HDL biosynthesis, cholesterol efflux, vitamin transport, angiogenesis, and tissue repair lower by 3∼20%.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 8, 2019
2018 journal article
A plasma proteome is associated with carotenoid status and dietary intake of food sources of carotenoids in Nepalese school aged children
Archives of Biochemistry and Biophysics, 646, 153–160.
Source: NC State University Libraries
Added: February 8, 2019
2018 chapter
Sexual and Non-sexual Reproduction
In Advances in Botanical Research (Vol. 88, pp. 117–163).
TL;DR:
With the advance in epigenome profiling techniques, dissection of epigenetic-based complex traits, and the development of molecular tools for locus-specific epigenome editing, the effects of epigenetics for underlying phenotypic traits can be unequivocally elucidated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries, Web Of Science
Added: January 7, 2019
2018 journal article
The Good, the Bad, and the Lethal: Gene Expression and Metabolomics Reveal Physiological Mechanisms Underlying Chronic Thermal Effects in Mayfly Larvae (Neocloeon triangulifer)
FRONTIERS IN ECOLOGY AND EVOLUTION, 6.
author keywords: aquatic insects; mayfly; thermal limits; metabolomics; temperature
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: December 17, 2018
2018 journal article
Grafting the Indeterminate Tomato Cultivar Moneymaker onto Multifort Rootstock Improves Cold Tolerance
HORTSCIENCE, 53(11), 1610–1617.
author keywords: Solanum habrochaites; Solanum lycopersicum; herbaceous grafts; root system morphology; suboptimal temperature
TL;DR:
The ability for ‘Multifort’ to maintain root growth at suboptimal temperatures may improve root system sink strength, thereby promoting movement of photosynthate from leaf to root even under cold conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: December 17, 2018
2018 journal article
SR-B1 involvement in keratinocytes in vitro wound closure
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 658, 1–6.
author keywords: Wound healing; Skin; Proliferation; Migration
MeSH headings : Cell Line, Transformed; Cell Movement / physiology; Cell Proliferation / physiology; Cyclin D1 / metabolism; Gene Knockout Techniques; Humans; Keratinocytes / cytology; Keratinocytes / physiology; Matrix Metalloproteinase 9 / metabolism; NF-kappa B p50 Subunit / metabolism; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / physiology; Skin / metabolism; Wound Healing / physiology
TL;DR:
In vitro data demonstrated that SR-B1 influenced keratinocyte proliferation and migration through a downregulation of nuclear cyclin D1 levels and active MMP9 expression respectively possibly in an NF-kB-dependent mechanism, and suggests a new role of SRB1 as a possible new key player in cutaneous wound healing mechanism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 26, 2018
2018 article
Inflammasome involvement in Rett syndrome subclinical inflammation
Pecorelli, A., Cordone, V., Falone, S., Romani, A., Benedusi, M., Hayek, J., … Valacchi, G. (2018, November 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 128, pp. S108–S109.
TL;DR:
The results suggest a possible basal activation of inflammasome in RTT cells that, on the other hand, appear to be unable to respond properly at the inflammatory stimulus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 19, 2018
2018 review
Viability of commercial cucumber fermentation without nitrogen or air purging
[Review of ]. TRENDS IN FOOD SCIENCE & TECHNOLOGY, 81, 185–192.
author keywords: Cucumber fermentation; Bloater; Microbiota; Carbon dioxide; Purging; Pickling industry
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 19, 2018
2018 article
Scavenger receptor B1 as a possible new player in cutaneous tissue proliferation and differentiation
Valacchi, G., Muresan, X., Belmonte, G., Pecorelli, A., & Gruber, F. (2018, September). JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 138, pp. B25–B25.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 19, 2018
2018 article
AtmO(3)spheric skin damage: The oxInflammation phenomena
Valacchi, G., Pecorelli, A., Pambianchi, E., Ferrara, F., & Lila, M. (2018, September). JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 138, pp. B15–B15.
Sources: Web Of Science, NC State University Libraries
Added: October 19, 2018
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