Works Published in 2022
Displaying all 9 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2022 journal article
Flexible sensor patch for continuous carbon dioxide monitoring
FRONTIERS IN CHEMISTRY, 10.
author keywords: CO2; in-line sensor; flexible sensor; process analytical technology; cell culture; biomanufacturing
www.frontiersin.org (publisher PDF)
Source: Web Of Science
Added: March 6, 2023
2022 journal article
Purification of Adeno-Associated Virus (AAV) Serotype 2 from Spodoptera frugiperda (Sf9) Lysate by Chromatographic Nonwoven Membranes
MEMBRANES, 12(10).
author keywords: adeno-associated virus (AAV); viral vector purification; nonwovens; membrane adsorber; anion exchange; cation exchange; membrane chromatography
TL;DR:
A strong anion-exchange membrane was developed by UV grafting glycidyl methacrylate on a polybutylene terephthalate nonwoven followed by functionalization with triethylamine, resulting in a quaternary amine ligand (AEX-TEA membrane) that exhibited a high AAV2 binding capacity and achieved excellent DNA clearance and a recovery of infectivity higher that that reported using ion-ex exchange resin chromatography.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 14, 2022
2022 journal article
Development of peptide ligands for the purification of a-1 antitrypsin from cell culture fluids
JOURNAL OF CHROMATOGRAPHY A, 1679.
author keywords: a-1 antitrypsin; Peptide ligands; Affinity chromatography; Protein purification; CHO cell culture harvest
MeSH headings : Animals; CHO Cells; Cell Culture Techniques; Chromatography, Affinity; Cricetinae; Cricetulus; Ligands; Molecular Docking Simulation; Peptides; alpha 1-Antitrypsin
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 11, 2022
2022 article
Mobile On Demand COVID-19 Vaccine Production Units for Developing Countries
Fahr, S., Pena-Benavides, S. A., Thiel, L., Sengoba, C., Karacasulu, K., Ihling, N., … Roh, K. (2022, August 19). INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, Vol. 61.
Contributors: S. Fahr *, S. Pena-Benavides *, L. Thiel*, C. Sengoba*, K. Karacasulu *, N. Ihling *, J. Sosa-Hernandez *, G. Gilleskie n
TL;DR:
This work designed two MOD vaccine manufacturing units based on a protein antigen expressed in yeast and in vitro transcription of mRNA that can produce on the order of 10,000 vaccine doses daily for competitive prices and in close proximity of their end users.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 14, 2022
2022 article
Towards continuous mAb purification: Clearance of host cell proteins from CHO cell culture harvests via "flow-through affinity chromatography" using peptide-based adsorbents
Sripada, S. A., Chu, W., Williams, T. I., Teten, M. A., Mosley, B. J., Carbonell, R. G., … Menegatti, S. (2022, April 22). BIOTECHNOLOGY AND BIOENGINEERING.
author keywords: CHO; flow-through chromatography; host cell proteins; monoclonal antibodies; peptide-based adsorbents
MeSH headings : Animals; Antibodies, Monoclonal / chemistry; CHO Cells; Cell Culture Techniques; Chromatography, Affinity / methods; Cricetinae; Cricetulus; Peptides / chemistry; Proteomics / methods
TL;DR:
An ensemble of peptide ligands that target the HCPs in Chinese hamster ovary (CHO) cell culture fluids and enable mAb purification via flow‐through affinity chromatography are introduced and their integration into LigaGuard™, an affinity adsorbent featuring an equilibrium binding capacity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 10, 2022
2022 journal article
Epigenome-wide association study of bronchopulmonary dysplasia in preterm infants: results from the discovery-BPD program
CLINICAL EPIGENETICS, 14(1).
author keywords: Preterm infant; Cord blood; DNA methylation; Epigenome-wide association study; Gestational age; Stochastic epimutation; Nucleated red blood cell; cDNA microarray; Bronchopulmonary dysplasia; Lung
MeSH headings : Biomarkers; Birth Weight; Bronchopulmonary Dysplasia / genetics; DNA Methylation; Epigenome; Humans; Infant; Infant, Newborn; Infant, Premature
TL;DR:
Results must be interpreted with caution because of the small size of this study, NRBC content strongly impacted DNA methylation profiles in preterm cord blood and EWAS analysis revealed potential insights into biological pathways involved in BPD pathogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 10, 2022
2022 journal article
Using Proteomic Approaches to Unravel the Response of Ctenocephalides felis felis to Blood Feeding and Infection With Bartonella henselae
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 12.
author keywords: bartonellosis; cat flea; cat scratch disease; flea-pathogen interface; proteome
MeSH headings : Animals; Bartonella henselae / genetics; Cat Diseases; Cats; Ctenocephalides; Felis; Proteomics; Siphonaptera
TL;DR:
Flea-differentially abundant proteins (FDAP) are investigated in unfed fleas, fleas fed on uninfected cats, and flea fed on B. henselae-infected cats to help understand the complex interactions between cat fleas and B. Henselae over an infection time course, thus helping understand the dual effect of vaccine targeting both flea fitness and pathogen competence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 7, 2022
2022 article
A direct comparison between membrane adsorber and packed column chromatography performance (vol 1612, 460629, 2020)
Boi, C., Malavasi, A., Carbonell, R. G., & Gilleskie, G. (2022, March 15). JOURNAL OF CHROMATOGRAPHY A, Vol. 1666.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 21, 2022
2022 journal article
A concept for continuous virus manufacture using a moving bed bioreactor: Growth of MDCK cells to confluence on paper as a model support
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION, 170.
author keywords: Cell culture on paper; Moving bed bioreactor; Continuous virus manufacture; Intensification of vaccine manufacture; MDCK cell growth on paper
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 15, 2021
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