Works Published in 2023
Displaying all 19 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2023 article
Toward the quantification of adeno-associated virus titer by electrochemical impedance spectroscopy
2023 IEEE BIOSENSORS CONFERENCE, BIOSENSORS.
author keywords: adeno-associated virus; AAV2; immunosensor; electrochemical impedance spectroscopy; viral vector
TL;DR:
The preliminary development of an immunosensor for measuring the titer of adeno-associated virus 2 (AAV2), which may be deployed for rapid quantification of product yield during AAV biomanufacturing.
(via Semantic Scholar)
Source: Web Of Science
Added: December 4, 2023
2023 journal article
The downstream bioprocess toolbox for therapeutic viral vectors
JOURNAL OF CHROMATOGRAPHY A, 1709.
author keywords: Viral vectors; Gene therapy; Affinity ligands; Chromatography; Adsorbents; AAV
TL;DR:
This study presents a comprehensive overview of the downstream bioprocess toolbox for viral vectors established in the last decade, and discusses present efforts and future directions contributing to the success of this promising class of biological medicines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Web Of Science
Added: October 30, 2023
2023 journal article
Pseudo-affinity capture of <i>K. phaffii</i> host cell proteins in flow-through mode: Purification of protein therapeutics and proteomic study
SEPARATION AND PURIFICATION TECHNOLOGY, 326.
author keywords: Komagataella phaffii; Chromatography; Protein purification; Monoclonal antibodies; Antibody fragment; Proteomics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 23, 2023
2023 journal article
Draft genome sequences of a historical collection of Listeria monocytogenes from humans and other sources, 1926-1964
MICROBIOLOGY RESOURCE ANNOUNCEMENTS.
author keywords: Listeria monocytogenes; food-borne pathogens; listeriosis; DNA sequencing; genomes; intracellular pathogens; historical strains
TL;DR:
It is shown that listeria monocytogenes can persistently contaminate food processing environments and tolerate sanitizers, and a diverse panel of 83 strains from 1926 to 1964 are reported.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 16, 2023
2023 article
Rational design and experimental evaluation of peptide ligands for the purification of adeno-associated viruses via affinity chromatography
Shastry, S., Chu, W., Barbieri, E., Greback-Clarke, P., Smith, W. K., Cummings, C., … Menegatti, S. (2023, September 28). BIOTECHNOLOGY JOURNAL, Vol. 9.
author keywords: adeno-associated virus; affinity chromatography; gene therapy; peptide ligands; transduction activity
TL;DR:
This study introduces a cohort of peptide ligands that mimic the biorecognition activity of the AAV receptor (AAVR) and anti-AAV antibody A20, enable product elution under near-physiological conditions (pH 6.0) and grant extended reusability by withstanding multiple regenerations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 10, 2023
2023 chapter
Digital Twins in Pilot Scale Fermentation: Non-Linear State Estimation for Improving Induction Timing
In Computer Aided Chemical Engineering (pp. 2637–2642).
Sources: ORCID, Crossref, NC State University Libraries
Added: September 6, 2023
2023 article
Peptide ligands for the affinity purification of adeno-associated viruses from HEK 293 cell lysates
Chu, W., Shastry, S., Barbieri, E., Prodromou, R., Greback-Clarke, P., Smith, W., … Menegatti, S. (2023, July 12). BIOTECHNOLOGY AND BIOENGINEERING, Vol. 7.
author keywords: adeno-associated virus; affinity chromatography; HEK 293 lysate; peptide ligands; virus purification
MeSH headings : Humans; Dependovirus / genetics; HEK293 Cells; Ligands; Peptides / genetics; Peptides / metabolism; Amino Acid Sequence; Genetic Vectors
TL;DR:
Peptide ligands that selectively capture AAVs and release them under mild conditions are introduced, affording high recovery, high recovery of host cell proteins (HCPs), and high transduction activity of the purified viruses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 7, 2023
2023 article
Advances in high-throughput, high-capacity nonwoven membranes for chromatography in downstream processing: A review
Lavoie, J., Fan, J., Pourdeyhimi, B., Boi, C., & Carbonell, R. G. (2023, May 31). BIOTECHNOLOGY AND BIOENGINEERING.
author keywords: downstream purification; fibrous systems; membrane adsorbers; membrane chromatography; nonwovens; product capture and polishing
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 19, 2023
2023 article
Draft Genome Sequences of 158 Listeria monocytogenes Strains Isolated from Black Bears (Ursus americanus) in the United States
Brown, P., Chen, Y., Ivanova, M., Leekitcharoenphon, P., Parsons, C., Niedermeyer, J., … Kathariou, S. (2023, June 5). MICROBIOLOGY RESOURCE ANNOUNCEMENTS.
TL;DR:
The draft genome sequences of 158 L. monocytogenes strains isolated from black bears (Ursus americanus) in the southeastern United States between 2014 and 2017 are reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 19, 2023
2023 article
Draft Genome Sequences of Closely Related Listeria monocytogenes Lineage III Strains Isolated from a Food Processing Environment and a Case of Human Listeriosis
Brown, P., Kanenaka, R., Chen, Y., Ivanova, M., Leekitcharoenphon, P., Elhanafi, D., & Kathariou, S. (2023, May 22). MICROBIOLOGY RESOURCE ANNOUNCEMENTS.
TL;DR:
The genome sequences of three closely related lineage III strains from Hawaii are reported, namely, one isolated from a human case and twoisolated from a produce storage facility.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 12, 2023
2023 journal article
Purification of a monoclonal antibody using a novel high-capacity multimodal cation exchange nonwoven membrane
SEPARATION AND PURIFICATION TECHNOLOGY, 317.
author keywords: Salt-tolerant multimodal ligand; Membrane adsorber; Membrane chromatography; Nonwoven membranes; Monoclonal antibodies (mAbs); High-risk HCPs
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 5, 2023
2023 article
Rational design and experimental evaluation of peptide ligands for the purification of adeno-associated viruses via affinity chromatography
Shastry, S., WENNING, C. H. U., Barbieri, E., Greback-Clarke, P., Smith, W., Cummings, C., … Menegatti, S. (2023, May 23).
Source: ORCID
Added: May 23, 2023
2023 review
Development and Delivery of a Hands-On Short Course in Adeno-Associated Virus Manufacturing to Support Growing Workforce Needs in Gene Therapy
[Review of ]. HUMAN GENE THERAPY, 34(7-8), 259–272.
author keywords: viral vectors; AAV; gene therapy; biomanufacturing; training; short course
MeSH headings : Humans; Dependovirus / genetics; Genetic Therapy; Commerce; Genetic Vectors / genetics
TL;DR:
The design of the course, the backgrounds of the nearly 80 students who have participated in the seven offerings held since March 2019, and feedback from the course participants are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 19, 2023
2023 journal article
Investigation of a Listeria monocytogenes Chromosomal Immigration Control Region Reveals Diverse Restriction Modification Systems with Complete Sequence Type Conservation
MICROORGANISMS, 11(3).
author keywords: Listeria; restriction modification system; immigration control region; whole genome sequencing; chromosomal hotspot
TL;DR:
Analysis of L. monocytogenes genomes indicates that the ICR has a high propensity for RM systems which are intraclonaly conserved and may impact bacteriophage susceptibility as well as ST emergence and stability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 17, 2023
2023 journal article
Membrane-localized expression, production and assembly of Vibrio parahaemolyticus T3SS2 provides evidence for transertion
NATURE COMMUNICATIONS, 14(1).
MeSH headings : Vibrio parahaemolyticus; Membranes; Membrane Proteins; Bacterial Proteins; Bile Acids and Salts
TL;DR:
Evidence is provided that Vibrio parahaemolyticus uses transertion to assemble a transmembrane complex (type III secretion system) used to inject virulence factors into host cells, and it is hypothesize that the proposed transertions process may be used by other enteric bacteria for efficient assembly of membrane-bound molecular complexes in response to extracellular signals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 17, 2023
2023 journal article
Immunological and Oxidative Biomarkers in Bovine Serum from Healthy, Clinical, and Sub-Clinical Mastitis Caused by Escherichia coli and Staphylococcus aureus Infection
ANIMALS, 13(5).
author keywords: mastitis; E; coli; S; aureus; oxidative; antioxidant molecules; APP; inflammatory cytokines
TL;DR:
The study aimed to investigate the mastitis’ emerging causative agents and their antimicrobial sensitivity, in addition to the hematological, biochemical indicators, oxidative biomarkers, acute phase protein (APP), and inflammatory cytokine changes in dairy farms in Gamasa, Dakahlia Governorate, Egypt.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: April 4, 2023
2023 article
Peptide ligands for the affinity purification of adeno-associated viruses from HEK 293 cell lysates
Chu, W., Barbieri, E., Prodromou, R., Greback-Clarke, P., Smith, W. K., Moore, B. D., … Menegatti, S. (2023, February 21).
Source: ORCID
Added: February 22, 2023
2023 journal article
Development of peptide affinity ligands for the purification of polyclonal and monoclonal Fabs from recombinant fluids
JOURNAL OF CHROMATOGRAPHY A, 1687.
author keywords: Peptide ligands; Affinity chromatography; Fragment antigen binding; Monoclonal antibodies; Cell culture harvests
MeSH headings : Cricetinae; Animals; Humans; Cricetulus; Ligands; CHO Cells; Molecular Docking Simulation; Protein Binding; Peptides / chemistry; Antibodies, Monoclonal; Chromatography, Affinity
TL;DR:
The de novo discovery of peptide ligands that target different regions of human Fab and enable product release under mild conditions are discovered and afforded values of yield and purity comparable to those provided by Protein L resins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 17, 2023
2023 journal article
Integrated in silico and experimental discovery of trimeric peptide ligands targeting Butyrylcholinesterase
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 102.
author keywords: Acetylcholinesterase; Butyrylcholinesterase; Purification; Molecular docking; Affinity ligands
MeSH headings : Butyrylcholinesterase / metabolism; Cholinesterase Inhibitors / chemistry; Ligands; Molecular Docking Simulation; Peptides
TL;DR:
A marked anti-correlated conformational movement governed by the ionic strength and pH of the aqueous environment is revealed, which ultimately controls BChE binding and release during chromatographic purification and provides useful guidance for ligand design and affinity maturation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 17, 2023
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