Works Published in 2014

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Displaying works 221 - 240 of 270 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2014 article

Status and access to the Collaborative Cross population (vol 23, pg 706, 2012)

Welsh, C. E., Miller, D. R., Manly, K. F., Wang, J., McMillan, L., Morahan, G., … Villena, F. P.-M. (2014, April). MAMMALIAN GENOME, Vol. 25, pp. 192–192.

By: C. Welsh*, D. Miller*, K. Manly*, J. Wang*, L. McMillan*, G. Morahan*, R. Mott*, F. Iraqi*, D. Threadgill n, F. Villena*

UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2014 article

Sex-specific Esr2 mRNA expression in the rat hypothalamus and amygdala is altered by neonatal bisphenol A exposure

Cao, J., Joyner, L., Mickens, J. A., Leyrer, S. M., & Patisaul, H. B. (2014, April). REPRODUCTION, Vol. 147, pp. 537–554.

By: J. Cao*, L. Joyner, J. Mickens*, S. Leyrer & H. Patisaul*

MeSH headings : Amygdala / drug effects; Amygdala / growth & development; Amygdala / metabolism; Animals; Animals, Newborn; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Receptor beta / genetics; Estrogen Receptor beta / metabolism; Female; Gene Expression Regulation, Developmental / drug effects; Hypothalamus / drug effects; Hypothalamus / growth & development; Hypothalamus / metabolism; Male; Phenols / toxicity; Rats; Rats, Long-Evans; Sex Factors; Sexual Behavior, Animal / drug effects; Social Behavior
TL;DR: Testing the hypothesis that neonatal bisphenol A exposure can alter sex-specific postnatal Esr2 (Erβ) expression in brain regions fundamental to sociosexual behavior in rat demonstrates that region- and sex- specific EsR2 expression is vulnerable to neonatal BPA exposure in regions of the developing brain critical to socIosexual behavior. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Replication of Many Human Viruses Is Refractory to Inhibition by Endogenous Cellular MicroRNAs

JOURNAL OF VIROLOGY, 88(14), 8065–8076.

By: H. Bogerd*, R. Skalsky*, E. Kennedy*, Y. Furuse*, A. Whisnant*, O. Flores*, K. Schultz*, N. Putnam* ...

MeSH headings : Animals; Cell Line; Gene Silencing; Host-Pathogen Interactions; Humans; Immune Evasion; MicroRNAs / genetics; MicroRNAs / immunology; Virus Replication; Viruses / genetics; Viruses / growth & development; Viruses / immunology
TL;DR: It is demonstrated that the replication of a wide range of pathogenic viruses is not enhanced in human cells engineered to be unable to produce mi RNAs, indicating that viruses have evolved to be resistant to inhibition by miRNAs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse

ENVIRONMENTAL HEALTH PERSPECTIVES, 122(5), 456–463.

By: W. Chiu*, J. Campbell*, H. Clewell*, Y. Zhou n, F. Wright n, K. Guyton*, I. Rusyn*

MeSH headings : Animals; Bayes Theorem; Dichloroacetic Acid / metabolism; Humans; Male; Mice; Trichloroethylene / metabolism; Trichloroethylene / pharmacokinetics
TL;DR: When extrapolated to lower doses more relevant to environmental exposures, mouse population-derived variability estimates for TCE metabolism closely matched population variability estimates previously derived from human toxicokinetic studies with TCE, highlighting the utility of mouse interstrain metabolism studies for addressing toxicokinetics variability. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Phenotypic Characterization of Transgenic Japanese Medaka (Oryzias latipes) That Express a Red Fluorescent Protein in Hepatocytes

TOXICOLOGIC PATHOLOGY, 42(3), 616–621.

By: A. Van Wettere n, J. Mac Law n, D. Hinton* & S. Kullman n

author keywords: transgenic medaka; Oryzias latipes; liver fatty acid binding protein; inclusion; red fluorescent protein
MeSH headings : Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / metabolism; Cloning, Molecular; Embryo, Nonmammalian; Fatty Acid-Binding Proteins / genetics; Female; Hepatocytes / chemistry; Hepatocytes / metabolism; Liver / chemistry; Liver / metabolism; Luminescent Proteins / chemistry; Luminescent Proteins / genetics; Luminescent Proteins / metabolism; Male; Oryzias / genetics; Oryzias / metabolism; Phenotype
TL;DR: The phenotype of a transgenic medaka strain that expresses a red fluorescent protein (RFP) in hepatocytes was characterized using light and fluorescence microscopy, immunohistochemistry, and transmission electron microscopy (TEM). (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Obesity and the cardiovascular health effects of fine particulate air pollution

Obesity, 22(7), 1580–1589.

By: S. Weichenthal*, J. Hoppin n & F. Reeves*

Contributors: S. Weichenthal*, J. Hoppin n & F. Reeves*

MeSH headings : Air Pollution / adverse effects; Air Pollution / statistics & numerical data; Cardiovascular Diseases / mortality; Causality; Cause of Death; Cohort Studies; Comorbidity; Environmental Monitoring / statistics & numerical data; Female; Humans; Longitudinal Studies; Male; Obesity / mortality; Particulate Matter / toxicity; Prospective Studies; Public Health; Weather
TL;DR: This review examines evidence related to the potential impact of obesity on the cardiovascular health effects of fine particulate air pollution (PM2.5). (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Nickel Nanoparticles cause exaggerated lung and airway remodeling in mice lacking the T-box transcription factor, TBX21 (T-bet)

Particle and Fibre Toxicology, 11.

By: E. Glista-Baker, A. Taylor, B. Sayers, E. Thompson & J. Bonner

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

Genome Research, 24(7), 1193–1208.

By: W. Huang, A. Massouras, Y. Inoue, J. Peiffer, M. Ramia, A. Tarone, L. Turlapati, T. Zichner ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Multiple vitellogenins and product yolk proteins in striped bass, Morone saxatilis: molecular characterization and processing during oocyte growth and maturation

FISH PHYSIOLOGY AND BIOCHEMISTRY, 40(2), 395–415.

By: V. Williams n, B. Reading n, N. Hiramatsu*, H. Amano*, N. Glassbrook n, A. Hara*, C. Sullivan n

author keywords: Striped bass; Vitellogenin; Yolk; Post-vitellogenic oocytes; Ovulated eggs; Maturation; Mass spectrometry
MeSH headings : Amino Acid Sequence; Animals; Bass / genetics; Bass / growth & development; Bass / metabolism; Blotting, Western; Cloning, Molecular; DNA, Complementary / genetics; Egg Proteins / genetics; Egg Proteins / metabolism; Female; Fish Proteins / genetics; Fish Proteins / metabolism; Male; Molecular Sequence Data; Oocytes / growth & development; Oocytes / metabolism; Peptide Fragments / genetics; Peptide Fragments / metabolism; Phylogeny; Protein Processing, Post-Translational; Sequence Homology, Amino Acid; Tandem Mass Spectrometry; Vitellogenesis; Vitellogenins / genetics; Vitellogenins / metabolism
TL;DR: The detailed characterization of Vtgs and their proteolytic fate(s) during oocyte growth and maturation establishes striped bass as a freshwater model for investigating teleost multiple Vtg systems. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Modulation of innate immune signaling by the secreted form of the West Nile virus NS1 glycoprotein

VIROLOGY, 458, 172–182.

By: K. Crook n, M. Miller-Kittrell n, C. Morrison n & F. Scholle n

author keywords: West Nile virus; Flaviviridae; Nonstructural protein; Toll like receptor; Innate immunity
MeSH headings : Animals; HeLa Cells; Humans; Immunity, Innate; Luciferases / metabolism; Macrophages / immunology; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Myeloid Cells / immunology; Myeloid Cells / metabolism; Poly I-C / pharmacology; Signal Transduction / immunology; Specific Pathogen-Free Organisms; Toll-Like Receptor 3 / antagonists & inhibitors; Viral Nonstructural Proteins / immunology; Viral Nonstructural Proteins / physiology; West Nile virus / immunology; West Nile virus / metabolism
TL;DR: Investigating whether the secreted form of NS1 inhibits innate immune signaling pathways in uninfected cells reduces TLR3 signaling and WNV replicon particle-mediated cytokine transcription in popliteal lymph nodes found the protein associated predominantly with macrophages and dendritic cells in the draining lymph node. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Interactions in a warmer world: effects of experimental warming, conspecific density, and herbivory on seedling dynamics

ECOSPHERE, 5(1).

author keywords: active warming; climatic warming; insect herbivory; interspecific interaction; intraspecific interaction; Quercus alba; warming experiment; white oak
TL;DR: The results indicate species responses to climatic warming may be contingent on intra- and interspecific interactions, sometimes in complicated and counter-intuitive ways. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts

Particle and Fibre Toxicology, 11.

By: S. Hussain, S. Sangtian, S. Anderson, R. Snyder, J. Marshburn, A. Rice, J. Bonner, S. Garantziotis

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

In vitro assessment of human nuclear hormone receptor activity and cytotoxicity of the flame retardant mixture FM 550 and its triarylphosphate and brominated components

Toxicology Letters, 228(2), 93–102.

By: S. Belcher*, C. Cookman*, H. Patisaul n & H. Stapleton*

Contributors: S. Belcher*, C. Cookman*, H. Patisaul n & H. Stapleton*

author keywords: Apoptosis Endocrine disruptor; Flame retardant; Nuclear receptors; Obesity; Peroxisome proliferator-activated receptor
MeSH headings : Adipocytes / drug effects; Animals; CHO Cells; Caspase 3 / metabolism; Cell Survival / drug effects; Cricetinae; Cricetulus; Endocrine Disruptors / toxicity; Flame Retardants / toxicity; Humans; Ligands; Organophosphates / chemistry; Organophosphates / toxicity; Organotin Compounds / toxicity; PPAR gamma / drug effects; PPAR gamma / metabolism; Receptors, Cytoplasmic and Nuclear / drug effects; Transcriptional Activation / drug effects
TL;DR: The resulting data indicated that the primary metabolic disruptive effects of FM 550 were likely mediated by the activity of the triarylphosphates at PPARγ, and have identified TPP as a candidate metabolic disruptor that also acts as a cytotoxicant. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2014 journal article

Implementation of Statistical Process Control for Proteomic Experiments Via LC MS/MS

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 25(4), 581–587.

By: M. Bereman n, R. Johnson*, J. Bollinger*, Y. Boss*, N. Shulman*, B. MacLean*, A. Hoofnagle*, M. MacCoss*

author keywords: Quality control; Statistical process control; Proteomics; Mass spectrometry; Shewhart control charts
MeSH headings : Chromatography, Liquid / methods; Models, Statistical; Peptides / analysis; Peptides / chemistry; Proteomics / methods; Tandem Mass Spectrometry / methods
TL;DR: A tool has been developed termed Statistical Process Control in Proteomics (SProCoP) which implements aspects of SPC (e.g., control charts and Pareto analysis) into the Skyline proteomics software, which monitors five quality control metrics in a shotgun or targeted proteomic workflow. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Fungal endophyte increases the allelopathic effects of an invasive forb

Oecologia, 175(1), 285–291.

By: E. Aschehoug, R. Callaway, G. Newcombe, N. Tharayil & S. Chen

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Evolutionary change in continuous reaction norms

American Naturalist, 183(4), 453–467.

By: C. Murren, H. Maclean, S. Diamond, U. Steiner, M. Heskel, C. Handelsman, C. Ghalambor, J. Auld ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Estimating reef fish discard mortality using surface and bottom tagging: effects of hook injury and barotrauma

CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES, 71(4), 514–520.

By: P. Rudershausen n, J. Buckel n & J. Hightower n

TL;DR: The tag-return approach using a control group with no fishery-associated trauma represents a method to accurately estimate absolute discard survival of physoclistous reef species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Estimating movement and survival rates of a small saltwater fish using autonomous antenna receiver arrays and passive integrated transponder tags

Marine Ecology Progress Series, 499, 177–192.

By: P. Rudershausen*, J. Buckel*, T. Dubreuil, M. O'Donnell, J. Hightower*, S. Poland, B. Letcher

TL;DR: The utility of PIT tags and continuously oper- ating autonomous detection systems for tracking fish at fine temporal scales, and improving esti- mates of demographic parameters in salt marsh creeks that are difficult or impractical to sample with active fishing gear is demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (Web of Science; OpenAlex)
15. Life on Land (Web of Science)
Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 306(5), G370–G381.

By: L. Scheving*, X. Zhang*, O. Garcia*, R. Wang*, M. Stevenson*, D. Threadgill n, W. Russell*

author keywords: liver; epidermal growth factor; Dsk5; cholesterol; hepatomegaly; low-density lipoprotein receptor
MeSH headings : Adipose Tissue / anatomy & histology; Alleles; Animals; Chondroitin Sulfates; Dermatan Sulfate; ErbB Receptors / genetics; ErbB Receptors / metabolism; Female; Gene Expression Regulation, Developmental / physiology; Heparitin Sulfate; Kidney / anatomy & histology; Lipid Metabolism / physiology; Lipids / blood; Liver / anatomy & histology; Liver / metabolism; Male; Mice; Sarcoma, Small Cell; Signal Transduction; Spleen / anatomy & histology; Testis / anatomy & histology
TL;DR: It is suggested that the EGFR may play a regulatory role in hepatocyte proliferation and lipid metabolism in adult male mice, explaining why elevated levels of EGF or EGF-like peptides have been positively correlated to increased cholesterol levels in human studies. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Chemical shift assignments and secondary structure prediction of the master biofilm regulator, SinR, from Bacillus subtilis

BIOMOLECULAR NMR ASSIGNMENTS, 8(1), 155–158.

By: S. Stowe n, A. Olson n, R. Losick* & J. Cavanagh n

author keywords: NMR; SinR; Bacillus subtilis; Biofilm regulation
MeSH headings : Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Biofilms; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary
TL;DR: The full-length backbone and side chain chemical shift values in addition to the experimentally derived secondary structure predictions are reported as the first step towards directly studying the complex interaction dynamics between SinR and SinI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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