Works Published in 2009
Displaying works 141 - 148 of 148 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2009 journal article
Generation and characterization of novel canine malignant mast cell line CL1
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 127(1-2), 114–124.
author keywords: Mast cell tumor; KIT; Cell line
MeSH headings : Animals; Base Sequence; Cell Degranulation; Cell Line, Tumor; DNA Primers / genetics; DNA, Neoplasm / genetics; Dog Diseases / genetics; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Female; Genome-Wide Association Study; Immunophenotyping; Mast Cells / immunology; Mast Cells / pathology; Mast Cells / physiology; Mastocytosis, Systemic / genetics; Mastocytosis, Systemic / immunology; Mastocytosis, Systemic / pathology; Mastocytosis, Systemic / veterinary; Proto-Oncogene Proteins c-kit / genetics; Proto-Oncogene Proteins c-kit / metabolism
TL;DR:
A novel mast cell line is generated from an 11-year-old spayed female Labrador retriever diagnosed with systemic mastocytosis and neoplastic effusion that possesses phenotypic and functional properties similar to those found in canine BMCMCs, and will likely be a useful tool to study mast cell biology, factors regulating transformation of mast cells, cytogenetic abnormalities in mast cell tumors, and novel preclinical therapies.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Form, function and phylogenetics of NITRs in bony fish
Developmental & Comparative Immunology, 33(2), 135–144.
author keywords: Teleost; Innate immunity; Natural killer receptors; ITIM; ITSM; DAP12; CD8; KIR
MeSH headings : Animals; DNA, Complementary / genetics; Fishes / genetics; Fishes / immunology; Humans; Immunoglobulins / immunology; Ligands; Phylogeny; Receptors, Immunologic / chemistry; Receptors, Immunologic / genetics; Receptors, Immunologic / immunology
TL;DR:
An analysis of all published NITRs demonstrates the conserved nature of multiple residues within the NITR Ig domains permitting the identification of NITr ESTs from salmon, cod, halibut, lake whitefish and stickleback species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunum
EXPERIMENTAL CELL RESEARCH, 315(1), 110–118.
author keywords: Tight junction; Intestinal permeability; Ischemia; ClC-2
MeSH headings : Animals; CLC-2 Chloride Channels; Cell Membrane / metabolism; Chloride Channels / deficiency; Chloride Channels / metabolism; Epithelium / metabolism; Epithelium / pathology; Epithelium / ultrastructure; Fluorescent Antibody Technique; Immunoprecipitation; Ischemia / metabolism; Ischemia / physiopathology; Jejunum / blood supply; Jejunum / pathology; Jejunum / ultrastructure; Mannitol / metabolism; Membrane Proteins / metabolism; Mice; Mice, Knockout; Occludin; Protein Transport; Tight Junctions / metabolism; Tight Junctions / ultrastructure; Wound Healing
TL;DR:
A pivotal role is demonstrated in recovery of the intestinal epithelium barrier by anchoring assembly of tight junctions following ischemic injury in ClC-2(-/-) mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Robe of Cyclin D1 as a Mediator of c-Met- and beta-Catenin-Induced Hepatocarcinogenesis
CANCER RESEARCH, 69(1), 253–261.
MeSH headings : Animals; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cyclin D1 / biosynthesis; Cyclin D1 / genetics; Cyclin D2; Cyclins / biosynthesis; Cyclins / genetics; Disease Models, Animal; Female; Humans; Liver Neoplasms, Experimental / genetics; Liver Neoplasms, Experimental / metabolism; Male; Mice; Mice, Transgenic; Proto-Oncogene Proteins c-met / biosynthesis; Proto-Oncogene Proteins c-met / genetics; Transfection; Up-Regulation; beta Catenin / biosynthesis; beta Catenin / genetics
TL;DR:
The results suggest that CCND1 functions as a mediator of beta-catenin during HCC pathogenesis, although other molecules may be required to fully propagate beta-Catenin signaling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Changes in Ferritin H- and L-Chains in Canine Lenses with Age-Related Nuclear Cataract
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 50(1), 305–310.
MeSH headings : Aging; Animals; Apoferritins / metabolism; Cataract / metabolism; Cataract / veterinary; Dog Diseases / metabolism; Dogs; Electrophoresis, Polyacrylamide Gel / veterinary; Enzyme-Linked Immunosorbent Assay / veterinary; Fluorescent Antibody Technique, Indirect / veterinary; Lens, Crystalline / metabolism; Microscopy, Fluorescence / veterinary
TL;DR:
There are significant differences in the characteristics of ferritin H-chain and its distribution in canine cataractous lenses compared with noncataractsous lenses, which allows this molecule to sequester more iron.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Plasma and ear tissue concentrations of enrofloxacin and its metabolite ciprofloxacin in dogs with chronic end-stage otitis externa after intravenous administration of enrofloxacin
VETERINARY DERMATOLOGY, 20(1), 51–59.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Chronic Disease; Ciprofloxacin / blood; Ciprofloxacin / metabolism; Dog Diseases / drug therapy; Dogs; Dose-Response Relationship, Drug; Ear Canal; Enrofloxacin; Female; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Injections, Intravenous; Male; Otitis Externa / drug therapy; Otitis Externa / veterinary; Skin; Tissue Distribution
TL;DR:
Treating dogs with chronic end-stage otitis undergoing a total ear canal ablation and lateral bulla osteotomy with enrofloxacin would not be recommended for a bacterial organism intermediate or resistant in susceptibility to enro FLX, since appropriate levels of enroFloxac in this study wouldn't be attained.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Pharmacokinetics of butorphanol in horses after intramuscular injection
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 32(1), 62–65.
MeSH headings : Absorption; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacokinetics; Animals; Area Under Curve; Biological Availability; Butorphanol / administration & dosage; Butorphanol / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Cross-Over Studies; Female; Half-Life; Heart Rate / drug effects; Horses / blood; Horses / metabolism; Horses / physiology; Injections, Intramuscular / veterinary; Injections, Intravenous / veterinary; Male; Random Allocation
TL;DR:
No significant differences in any physical parameters were observed after butorphanol administration except for an increase in respiratory rate at 60 and 180 min after IV administration, and administration of 0.08 mg/kg IM every 3 h may be necessary to maintain targeted plasmabutorphanol concentrations above 10 ng/mL.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Light-activation of gene function in mammalian cells via ribozymes
Chem. Commun., (5), 568–570.
MeSH headings : Cell Line; Gene Expression / radiation effects; Humans; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; RNA, Messenger / metabolism; Toyocamycin / chemistry; Toyocamycin / radiation effects; Ultraviolet Rays
TL;DR:
A ribozyme based gene control element enabled the spatio-temporal regulation of gene function in mammalian cell culture with light.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
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