Works Published in 2021
Displaying works 121 - 140 of 248 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2021 journal article
Integrating Bioinformatics Tools Into Inquiry-Based Molecular Biology Laboratory Education Modules
FRONTIERS IN EDUCATION, 6.
author keywords: bioinformatics; science education; molecular biotechnology; software tools; case studies
TL;DR:
This new paradigm for biology laboratory education that embraces bioinformatics as a critical component of inquiry-based learning for undergraduate and graduate students representing the life sciences, the physical sciences, and engineering is described.
(via Semantic Scholar)
www.frontiersin.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 23, 2021
2021 journal article
Pioneer Axons Utilize a Dcc Signaling-Mediated Invasion Brake to Precisely Complete Their Pathfinding Odyssey
JOURNAL OF NEUROSCIENCE, 41(31), 6617–6636.
author keywords: DREZ; invasion; neuron; pathfinding; zebrafish
MeSH headings : Animals; Axon Guidance / physiology; DCC Receptor / metabolism; Ganglia, Spinal / embryology; Signal Transduction / physiology; Zebrafish; Zebrafish Proteins / metabolism
TL;DR:
Time-lapse super-resolution imaging in zebrafish DRG pioneer neurons is used to investigate how embryonic axons control their cytoskeleton to navigate to and invade at the correct anatomic position and reveals a molecularly-controlled brake on invadopodia stabilization until the sensory neuron growth cone is present at the dorsal root entry zone, which is ultimately essential for growth cone entry into the spinal cord and behavioral response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 23, 2021
2021 journal article
Robust projections of future fire probability for the conterminous United States
SCIENCE OF THE TOTAL ENVIRONMENT, 789.
author keywords: Climate change; Pyrome analogs; Fire regime; Fire risk; PC2FM; Wildfire
MeSH headings : Climate Change; Fires; New England; Probability; United States; Wildfires
TL;DR:
This high resolution, continental-scale modeling study of climate change impacts on potential fire probability accounts for shifting background environmental conditions across regions that will interact with topographic drivers to significantly alter future fire probabilities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science; OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 16, 2021
2021 article
Climate change is creating a mismatch between protected areas and suitable habitats for frogs and birds in Puerto Rico
Campos-Cerqueira, M., Terando, A. J., Murray, B. A., Collazo, J. A., & Aide, T. M. (2021, July 27). BIODIVERSITY AND CONSERVATION.
author keywords: Species of greatest conservation need; Passive acoustic monitoring; Climate change; Niche modeling; Species distribution models; Protected areas
TL;DR:
The results indicate that present protected areas will not suffice to safeguard bird and frog species under climate change; however, the establishment of larger protected areas, buffer zones, and connectivity between protected areas may allow species to find suitable niches to withstand environmental changes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 9, 2021
2021 journal article
Understanding Organismal Capacity to Respond to Anthropogenic Change: Barriers and Solutions
Integrative and Comparative Biology, 7.
MeSH headings : Adaptation, Physiological; Animals; Biological Evolution; Genotype; Phenotype; Physical Conditioning, Animal
TL;DR:
The concept of multidimensional phenospace is introduced as an organizing construct to understanding organismal evolutionary responses to environmental change and one or more solutions are suggested that would help to surmount the barrier and improve the ability to predict, and eventually manipulate, organismal capacity to respond to anthropogenic change.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science; OpenAlex)
Source: ORCID
Added: August 3, 2021
2021 article
Pedigree-based and phylogenetic methods support surprising patterns of mutation rate and spectrum in the gray mouse lemur
Campbell, C. R., Tiley, G. P., Poelstra, J. W., Hunnicutt, K. E., Larsen, P. A., Lee, H.-J., … Yoder, A. D. (2021, July 16). HEREDITY.
MeSH headings : Animals; Cheirogaleidae / genetics; Genome; Mice; Mutation Rate; Pedigree; Phylogeny
TL;DR:
This study provides the first direct mutation-rate estimate for a strepsirrhine (i.e., the lemurs and lorises), which comprises nearly half of the primate clade, and finds both the rate and spectrum to be robust to the manipulation of a wide range of computational filtering criteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 2, 2021
2021 journal article
ImputEHR: A Visualization Tool of Imputation for the Prediction of Biomedical Data
FRONTIERS IN GENETICS, 12.
author keywords: electronic health records; imputation; gradient boosting; prediction; decision trees
TL;DR:
A new graphical tool, ImputEHR, is created that allows implementation of a range of simple and sophisticated data imputation approaches and enables data exploration for informed decision-making, as well as implementing machine learning prediction tools for response data selected by the user.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 2, 2021
2021 journal article
Ancestry Studies in Forensic Anthropology: Back on the Frontier of Racism
BIOLOGY-BASEL, 10(7).
author keywords: race; ancestry; population affinity; craniofacial variation; geometric morphometrics
TL;DR:
This work proposes replacing the assumption of continental ancestry with a population structure approach that combines microevolutionary and cultural factors with historical events in the examination of population affinity, and results indicate groups are not patterned by the ancestry trifecta.
(via Semantic Scholar)
Source: Web Of Science
Added: August 2, 2021
2021 journal article
Data Processing Workflow to Identify Structurally Related Compounds in Petroleum Substances Using Ion Mobility Spectrometry-Mass Spectrometry
ENERGY & FUELS, 35(13), 10529–10539.
TL;DR:
This work demonstrates how rapid untargeted IMS-MS analysis and the proposed data processing workflow can be used to provide confident compositional characterization of hydrocarbon-containing substances.
(via Semantic Scholar)
Source: Web Of Science
Added: July 26, 2021
2021 journal article
Multiomic Big Data Analysis Challenges: Increasing Confidence in the Interpretation of Artificial Intelligence Assessments
ANALYTICAL CHEMISTRY, 93(22), 7763–7773.
MeSH headings : Artificial Intelligence; Big Data; Data Analysis
TL;DR:
The present and future capabilities of AI techniques in multiomic studies are discussed while introducing analytical checks and balances to validate the computational conclusions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 19, 2021
2021 journal article
DNA Methylation in Babies Born to Nonsmoking Mothers Exposed to Secondhand Smoke during Pregnancy: An Epigenome-Wide Association Study
ENVIRONMENTAL HEALTH PERSPECTIVES, 129(5).
MeSH headings : DNA Methylation; Epigenesis, Genetic; Epigenome; Female; Fetal Blood / chemistry; Humans; Infant, Newborn; Maternal Exposure / adverse effects; Pregnancy; Tobacco Smoke Pollution / adverse effects
TL;DR:
It is suggested that even low levels of smoke exposure during pregnancy may be sufficient to alter DNA methylation in distinct sites of mixed umbilical cord blood leukocytes in pathways that are known to be altered in cord blood from pregnant active smokers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 19, 2021
2021 journal article
Evaluation of UBE3A antibodies in mice and human cerebral organoids
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Angelman Syndrome / genetics; Angelman Syndrome / pathology; Animals; Antibodies / genetics; Antibodies / immunology; Autistic Disorder / genetics; Autistic Disorder / pathology; Cerebellum / cytology; Disease Models, Animal; Genomic Imprinting; Humans; Mice; Neural Stem Cells / metabolism; Neurons / metabolism; Neurons / pathology; Organoids / cytology; Pluripotent Stem Cells; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / immunology
TL;DR:
While four antibodies show specific localization patterns in both mouse brain sections and human cerebral organoids, these antibodies varied significantly in background signals and staining patterns in undifferentiated human pluripotent stem cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 19, 2021
2021 journal article
Polymorphic tandem DNA repeats activate the human telomerase reverse transcriptase gene
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(26).
Contributors: T. Xu *, D. Cheng*, Y. Zhao*, J. Zhang *, X. Zhu *, F. Zhang *, G. Chen *, Y. Wang *
author keywords: telomere and telomerase; hTERT gene; repetitive DNA elements; polymorphism and genetic diversities; human longevity
MeSH headings : Black or African American / genetics; Aged, 80 and over; Animals; Base Sequence; Cell Differentiation / genetics; Cell Line; Cell Proliferation / genetics; Chromosomes, Artificial, Bacterial / genetics; E-Box Elements / genetics; Genome, Human; Human Embryonic Stem Cells / metabolism; Humans; Mice, Nude; Minisatellite Repeats / genetics; Neoplasms / genetics; Neoplasms / pathology; Polymorphism, Genetic; Promoter Regions, Genetic; Protein Binding / genetics; Sequence Deletion / genetics; Telomerase / genetics; Telomere Homeostasis / genetics; Transcriptional Activation
TL;DR:
An intronic variable number tandem repeat element, VNTR2-1, is identified as an enhancer-like element, which activated hTERT transcription in a cell in a chromatin-dependent manner, and is likely a missing link in the telomerase regulatory network and a molecular basis for genetic diversities of telomere homeostasis and age-related disease susceptibilities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 19, 2021
2021 journal article
Implications of Regionalizing Care in the Developing World: Impact of Distance to Referral Center on Compliance to Biopsy Recommendations in a Brazilian Prostate Cancer Screening Cohort
PROSTATE CANCER, 2021.
TL;DR:
In Brazil, where distances to referral centers can be large, greater distance was related to reduced biopsy compliance in a PC screening cohort, and among men who lived within 150 km, distance was unrelated to compliance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 19, 2021
2021 article
The toughest animals of the Earth versus global warming: Effects of long-term experimental warming on tardigrade community structure of a temperate deciduous forest
Vecchi, M., Kossi Adakpo, L., Dunn, R. R., Nichols, L. M., Penick, C. A., Sanders, N. J., … Guidetti, R. (2021, June 29). ECOLOGY AND EVOLUTION.
author keywords: climate change; experimental; global warming; Tardigrades; water bears
TL;DR:
Results are in line with previous experimental studies, indicating that tardigrades may not be directly affected by ongoing global warming, possibly due to their thermotolerance and cryptobiotic abilities to avoid negative effects of stressful temperatures, and the buffering effect on temperature of the soil litter substrate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 12, 2021
2021 article
Circadian clock protein BMAL1 regulates melanogenesis through MITF in melanoma cells
Sarkar, S., Porter, K. I., Dakup, P. P., Gajula, R. P., Koritala, B. S. C., Hylton, R., … Gaddameedhi, S. (2021, July 6). PIGMENT CELL & MELANOMA RESEARCH, Vol. 34.
Contributors: S. Sarkar *, K. Porter *, P. Dakup *, R. Gajula*, B. Koritala *, R. Hylton *, M. Kemp *, K. Wakamatsu *, S. Gaddameedhi*
author keywords: BMAL1; melanin; melanogenesis; MITF; ultraviolet radiation
MeSH headings : ARNTL Transcription Factors / genetics; ARNTL Transcription Factors / metabolism; Animals; Gene Expression Regulation, Neoplastic; Humans; Melanoma / genetics; Melanoma / metabolism; Melanoma / pathology; Mice; Microphthalmia-Associated Transcription Factor / genetics; Microphthalmia-Associated Transcription Factor / metabolism; Neoplasm Proteins / genetics; Neoplasm Proteins / metabolism
TL;DR:
Novel insights are provided to the mechanistic role of the circadian clock in melanin synthesis and protection against UVB mediated DNA damage and genomic instability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 12, 2021
2021 journal article
Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 9.
author keywords: dopa decarboxylase; knock-out; imprinting; heart; mouse; human
TL;DR:
Comparative studies in the human developing heart reveal a paternal expression bias with polymorphic imprinting patterns between individual human hearts at DDC_EXON1a, a finding consistent with other imprinted genes in human.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 12, 2021
2021 journal article
Sex-specific Disruption of the Prairie Vole Hypothalamus by Developmental Exposure to a Flame Retardant Mixture
ENDOCRINOLOGY, 162(8).
Contributors: S. Gillera n, W. Marinello n , K. Cao n, B. Horman n, H. Stapleton * & H. Patisaul n
author keywords: Social; anxiety; neurodevelopment; neural; endocrine disruptors; endocrine disrupting chemicals; oxytocin; vasopressin; dopamine
MeSH headings : Animals; Arginine Vasopressin / metabolism; Arvicolinae; Endocrine Disruptors / toxicity; Female; Flame Retardants / toxicity; Male; Neurons / drug effects; Neurons / metabolism; Oxytocin / metabolism; Paraventricular Hypothalamic Nucleus / drug effects; Sex Factors; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
Results expand on previous work showing evidence of endocrine disruption of OT/AVP pathways, including to subpopulations of PVN AVP neurons that coordinate osmoregulatory functions in the periphery, by testing the hypothesis that FM 550 sex-specifically alters AVP and OT neuronal populations in critical nuclei.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 12, 2021
2021 journal article
TAK1 inhibition elicits mitochondrial ROS to block intracellular bacterial colonization
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(25).
author keywords: TAK1; ROS; mitochondria; intracellular bacteria
MeSH headings : Animals; Bacteria / growth & development; Caspase 3 / metabolism; Colony Count, Microbial; Hydrogen Sulfide / pharmacology; Intracellular Space / microbiology; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; Mice; Mitochondria / metabolism; Reactive Oxygen Species / metabolism; Receptor-Interacting Protein Serine-Threonine Kinases / metabolism; Salmonella / drug effects; Salmonella / growth & development; Yersinia / drug effects
TL;DR:
A previously unrecognized host defense mechanism is revealed, which is initiated by host recognition of pathogen-induced impairment in a host protein, TAK1, but not directly of pathogens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 12, 2021
2021 journal article
Survival and Contaminants in Imperiled and Common Riverine Fishes Assessed with an In Situ Bioassay Approach
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 40(8), 2206–2219.
author keywords: Polychlorinated biphenyls; Mercury; Kaplan-Meier; Endocrine disruption; Robust redhorse
MeSH headings : Animals; Bass; Biological Assay; Cyprinidae; Cypriniformes; Ecosystem; Rivers; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / toxicity
TL;DR:
Contaminants and other water quality stressors in this river system appear to detrimentally impact juvenile fish survival with presumed effects at the fish assemblage and community levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2021
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