Works Published in 2018
Displaying works 21 - 40 of 46 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 journal article
International collaborative study to assess cardiovascular risk and evaluate long-term health in cats with preclinical hypertrophic cardiomyopathy and apparently healthy cats: The REVEAL Study
Journal of Veterinary Internal Medicine, 32(3), 930–943.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi
BIODATA MINING, 11(1).
author keywords: Chemical prioritization; ToxPi; ToxCast; Missing data; Imputation; Multiple imputation; Simulation
TL;DR:
Simulation studies around high-throughput screening data generated by the ToxCast and Tox21 programs on chemicals highlighted by the Agency for Toxic Substances and Disease Registry’s Substance Priority List (SPL) can augment confidence in the robustness of decisions regarding the health and ecological effects of environmental chemicals.
(via Semantic Scholar)
biodatamining.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2018 journal article
Animal models of endocrine disruption
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 32(3), 283–297.
author keywords: vole; peromyscus; toxicology; neurosciences; collaborative cross; PFOA
MeSH headings : Animals; Disease Models, Animal; Endocrine Disruptors / toxicity; Endocrine System / drug effects; Endocrine System Diseases / chemically induced; Endocrine System Diseases / pathology; Environmental Exposure / adverse effects; Environmental Illness / chemically induced; Environmental Illness / pathology; Humans; Reproducibility of Results; Reproduction / drug effects; Reproduction / physiology
TL;DR:
Advances in genomics, neuroimaging and other tools are making a wider range of animal models more widely available to EDC researchers, and a greater diversity of species are used to effectively model more subtle but significant outcomes such as changes in pubertal timing, mammary gland development, and social behaviors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
An empirical Bayes approach for multiple tissue eQTL analysis
Biostatistics (Oxford, England), 19(3), 391–406.
MeSH headings : Bayes Theorem; Biostatistics / methods; Gene Expression; Genomics / methods; Genotyping Techniques / methods; Humans; Models, Statistical; Quantitative Trait Loci
TL;DR:
A hierarchical Bayesian model (MT‐eQTL) for multi‐tissue eQTL analysis that explicitly captures patterns of variation in the presence or absence of eQ TL, as well as the heterogeneity of effect sizes across tissues is developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
A zero-inflated beta-binomial model for microbiome data analysis
STAT, 7(1).
author keywords: count data; penalized generalized linear model; zero-inflated beta-binomial modelling
TL;DR:
A zero‐inflated beta‐binomial is introduced to model the distribution of microbiome count data and to determine association with a continuous or categorical phenotype of interest and has higher power than competing methods to detect taxa associated with phenotype.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2018 journal article
Janus kinase inhibitors differ in their affinity to the TRPV1 receptor - implications for their use in itch and pain
Journal of Veterinary Pharmacology and Therapeutics, 41, 160–160.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
In silico Predicted Glucose-1-phosphate Uridylyltransferase (GalU) Inhibitors Block a Key Pathway Required for Listeria Virulence
Molecular Informatics, 37(6-7), 1800004.
author keywords: drug design; molecular modeling; structure-activity relationships; virtual screening; antibiotics
MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Bacterial Proteins / antagonists & inhibitors; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Benzamides / chemistry; Drug Discovery; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / pharmacology; Listeria monocytogenes / drug effects; Listeria monocytogenes / enzymology; Listeria monocytogenes / pathogenicity; Pyrimidines / chemistry; Quantitative Structure-Activity Relationship; UTP-Glucose-1-Phosphate Uridylyltransferase / antagonists & inhibitors; UTP-Glucose-1-Phosphate Uridylyltransferase / chemistry; UTP-Glucose-1-Phosphate Uridylyltransferase / metabolism
TL;DR:
A series of in silico predicted GalU inhibitors identified using structure‐based virtual screening and experimentally validated to be effective in blocking the WTA galactosylation pathway in vitro are reported on.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018
2018 journal article
Genetic variants in CPA6 and PRPF31 are associated with variation in response to metformin in individuals with type 2 diabetes
Diabetes, 67(7), 1428–1440.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Gene set analysis methods: A systematic comparison
Biodata Mining, 11.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Gene expression and linkage analysis implicate as a mediator of rituximab resistance
PHARMACOGENOMICS JOURNAL, 18(3), 467–473.
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Antibodies, Monoclonal / administration & dosage; Antibodies, Monoclonal / adverse effects; Antibodies, Monoclonal / genetics; Antigens, CD20 / drug effects; Antigens, CD20 / immunology; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm / drug effects; Drug Resistance, Neoplasm / genetics; Female; Gene Expression Regulation, Neoplastic / drug effects; Genetic Linkage; Genome, Human / genetics; Humans; Leukemia, Lymphocytic, Chronic, B-Cell / complications; Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell / genetics; Male; Proto-Oncogene Proteins c-cbl / genetics; Rituximab / administration & dosage; Rituximab / adverse effects
TL;DR:
This study developed a strategy to genetically map in vitro drug sensitivity, identifying genes that alter responsiveness to rituximab, a therapeutic anti-CD20 MAb that provides significant benefit to patients with B-cell malignancies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Cheminformatics Analysis of Dynamic WNK-Inhibitor Interactions
Molecular Informatics, 37(6-7), 1700138.
author keywords: drug design; kinases; medicinal chemistry; structure-activity relationships; molecular modeling
MeSH headings : Binding Sites; Humans; Molecular Docking Simulation; Protein Binding; Protein Kinase Inhibitors / chemistry; Protein Kinase Inhibitors / pharmacology; WNK Lysine-Deficient Protein Kinase 1 / antagonists & inhibitors; WNK Lysine-Deficient Protein Kinase 1 / chemistry; WNK Lysine-Deficient Protein Kinase 1 / metabolism
TL;DR:
This study reports on the first, cheminformatics‐powered analysis of the entire chemical space of known WNK inhibitors and discusses the conservation of critical WNK‐inhibitor interactions and the existence of isoform‐specific interactions that could enable the rational design of more potent and selective WNK binders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018
2018 journal article
A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure
Cell Reports, 23(2), 327–336.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups.
ALTEX, 35(1), 51–64.
Contributors: W. Chiu *, K. Guyton*, M. Martin*, D. Reif n & I. Rusyn *
author keywords: carcinogenicity; high throughput screening; in vitro; mechanisms
MeSH headings : Animals; Biological Assay; Carcinogenicity Tests; Carcinogens / toxicity; High-Throughput Screening Assays / methods; Humans; International Agencies; Publications; United States; United States Environmental Protection Agency
TL;DR:
ToxCast HTS data were useful both in evaluating specific mechanistic hypotheses and in contributing to the overall evaluation of mechanistic evidence, however, additional HTS assays are needed to provide more comprehensive coverage of the 10 key characteristics of carcinogens that form the basis of current IARC mechanistic evaluations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2018 journal article
Modulation of GLP-1 Levels by a Genetic Variant That Regulates the Cardiovascular Effects of Intensive Glycemic Control in ACCORD
DIABETES CARE, 41(2), 348–355.
MeSH headings : Aged; Blood Glucose / genetics; Blood Glucose / metabolism; Diabetes Mellitus, Type 2 / blood; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / genetics; Diabetic Angiopathies / blood; Diabetic Angiopathies / genetics; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Glucagon-Like Peptide 1 / blood; Humans; Hypoglycemic Agents / therapeutic use; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors
TL;DR:
Differences in GLP-1 axis activation may mediate the modulatory effect of variant rs57922 on the cardiovascular response to intensive glycemic control, and highlight the importance of GLp-1 as a cardioprotective factor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Pharmacogenetic Analysis of the Model-Based Pharmacokinetics of Five Anti-HIV Drugs: How Does This Influence the Effect of Aging?
CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 11(2), 226–236.
MeSH headings : ATP Binding Cassette Transporter, Subfamily B / genetics; Adult; Age Factors; Aged; Aging / genetics; Anti-HIV Agents / administration & dosage; Anti-HIV Agents / pharmacokinetics; Anti-HIV Agents / therapeutic use; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; Cytochrome P-450 CYP2B6 / genetics; Drug Combinations; Drug Therapy, Combination / methods; Female; Frail Elderly; HIV Infections / drug therapy; HIV Infections / genetics; Humans; Male; Middle Aged; Multidrug Resistance-Associated Proteins / genetics; Pharmacogenomic Testing / methods; Prospective Studies; Young Adult
TL;DR:
Both age and p16INK4a expression interacted with PGx on ATV and TFV disposition, implying potential dose adjustment based on aging may depend on genetic background.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Computation of ancestry scores with mixed families and unrelated individuals
BIOMETRICS, 74(1), 155–164.
author keywords: Genetic association; Population stratification; Principal components
MeSH headings : Cystic Fibrosis / genetics; Family; Genome; Genotype; Humans; Models, Genetic; Pedigree; Principal Component Analysis
TL;DR:
Two main novel strategies are considered: matrix substitution based on decomposition of a target family‐orthogonalized covariance matrix, and using family‐averaged data to obtain loadings using the family‐average method, which shows superior performance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Adverse drug reactions triggered by the common HLA-B*57:01 variant: Virtual screening of DrugBank using 3D molecular docking
Journal of Cheminformatics, 10.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models.
BMC Bioinformatics, 3(1).
Contributors: S. Marvel n, K. To n, F. Grimm*, F. Wright n, I. Rusyn * & D. Reif n
author keywords: Visual analytics; Software; systems biology; Risk assessment; Data integration; Graphical user interface
MeSH headings : Cluster Analysis; Information Dissemination; Information Storage and Retrieval; Models, Theoretical; Software; User-Computer Interface
TL;DR:
A new graphical user interface for ToxPi (Toxicological Prioritization Index) is detailed, that provides interactive visualization, analysis, reporting, and portability and introduces several features, from flexible data import formats to similarity-based clustering.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2018 personal communication
The NIEHS TaRGET II Consortium and environmental epigenomics
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 7(1).
author keywords: blood pressure; lipid metabolites; metabolomics; pharmacogenetics; thiazide diuretics
MeSH headings : Adult; Blood Pressure; Female; Genomics; Humans; Hydrochlorothiazide / therapeutic use; Hypertension / drug therapy; Lipid Metabolism; Male; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Nitriles; Pharmacogenetics; Prognosis; Serine C-Palmitoyltransferase / genetics; Siloxanes; Sodium Chloride Symporter Inhibitors / therapeutic use; Sphingolipids / metabolism; Treatment Outcome
TL;DR:
This study provides insight into potential pharmacometabolomic and genetic mechanisms underlying HCTZ BP response and suggests that SPTLC3 is a potential determinant of the BP response to HCTz.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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