Center for Human Health and the Environment

Works Published in 2018

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Displaying works 261 - 280 of 302 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2018 journal article

Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain

SCIENTIFIC REPORTS, 8.

By: N. Muthusamy n, A. Brumm*, X. Zhang n, S. Carmichael * & H. Ghashghaei  n

MeSH headings : Animals; Cell Differentiation / physiology; Ependyma / metabolism; Forkhead Transcription Factors / metabolism; Mice; Neurogenesis / physiology; Neuroglia / metabolism; Neurons / metabolism; Prosencephalon / metabolism; Stem Cells / metabolism; Stroke / metabolism
TL;DR: Using a cell specific genetic approach, Foxj1+ ependymal cells are ruled out as stem cells participating in neurogenesis and gliogenesis in response to acute injury or stroke in the mouse forebrain. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Factors associated with postoperative complications in healthy horses after general anesthesia for ophthalmic versus non-ophthalmic procedures: 556 cases (2012-2014)

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 252(9), 1113–1119.

By: E. Curto, E. Griffith*, L. Posner*, K. Walsh, J. Balko* & B. Gilger* 

MeSH headings : Anesthesia Recovery Period; Anesthesia, General / veterinary; Animals; Colic / veterinary; Eye Diseases / surgery; Eye Diseases / veterinary; Female; Horse Diseases / surgery; Horses; Male; Ophthalmologic Surgical Procedures / veterinary; Postoperative Complications / veterinary; Records / veterinary; Treatment Outcome
TL;DR: In healthy horses, duration of general anesthesia should be minimized to decrease the risk of postanesthetic complications, and judicious use of orally administered fluconazole is recommended. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Direct analysis of terpenes from biological buffer systems using SESI and IR-MALDESI

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410(3), 953–962.

By: M. Nazari  n, A. Malico n, M. Ekeloef, S. Lund n, G. Williams n  & D. Muddiman n 

author keywords: Terpenes; IR-MALDESI; SESI; Direct analysis; Biological buffers; Q Exactive Plus
MeSH headings : Alkenes / analysis; Buffers; Infrared Rays; Ions / analysis; Monocyclic Sesquiterpenes; Sesquiterpenes / analysis; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Terpenes / analysis
TL;DR: By coupling the two techniques and doping the electrospray solvent with silver ions, olefinic terpenes of different classes and varying degrees of volatility were directly analyzed from a biological buffer system with no sample workup steps. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Computation of ancestry scores with mixed families and unrelated individuals

BIOMETRICS, 74(1), 155–164.

By: Y. Zhou n , J. Marron * & F. Wright n

author keywords: Genetic association; Population stratification; Principal components
MeSH headings : Cystic Fibrosis / genetics; Family; Genome; Genotype; Humans; Models, Genetic; Pedigree; Principal Component Analysis
TL;DR: Two main novel strategies are considered: matrix substitution based on decomposition of a target family‐orthogonalized covariance matrix, and using family‐averaged data to obtain loadings using the family‐average method, which shows superior performance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

Cohort profile: Pregnancy and childhood epigenetics (PACE) consortium

International Journal of Epidemiology, 47(1), 22-.

By: J. Felix, B. Joubert, A. Baccarelli, G. Sharp, C. Almqvist, I. Annesi-Maesano, H. Arshad, N. Baiz ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Cohesin SA2 is a sequence-independent DNA-binding protein that recognizes DNA replication and repair intermediates

JOURNAL OF BIOLOGICAL CHEMISTRY, 293(3), 1054–1069.

By: P. Countryman n, Y. Fan *, A. Gorthi*, H. Pan n, J. Strickland n, P. Kaur n, X. Wang  n, J. Lin  n ...

MeSH headings : Cell Cycle Proteins / chemistry; Cell Cycle Proteins / metabolism; Chromosomal Proteins, Non-Histone / chemistry; Chromosomal Proteins, Non-Histone / metabolism; DNA Repair / genetics; DNA Repair / physiology; DNA Replication / physiology; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Fluorescence Polarization; Genomic Instability / genetics; Genomic Instability / physiology; Microscopy, Atomic Force; Microscopy, Fluorescence; Protein Binding / genetics; Protein Binding / physiology
TL;DR: The results suggest that SA2 functions at intermediate DNA structures during DNA transactions in genome maintenance pathways, and has important implications for understanding the function of cohesin in these pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2018 article

Variability in German Cockroach Extract Composition Has A Great Impact On T Cell Potency In Cockroach-Allergic Donors

Schulten, V. M., Birrueta, G., Glesner, J., Filep, S., Schal, C., Jeong, K. Y., … Sci, B. (2018, February). JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol. 141, pp. AB199–AB199.

By: V. Schulten*, G. Birrueta*, J. Glesner*, S. Filep*, C. Schal n , K. Jeong *, A. Frazier *, A. Pomes *, A. Sette *, B. Sci

TL;DR: Dramatic variations in T cell reactivity were observed to the different cockroach extract batches, potentially dependent on the donor-specific T cell allergen immunodominance pattern and the aller gen content of the extract tested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models

BMC Bioinformatics, 19.

By: S. Marvel, K. To, F. Grimm, F. Wright, I. Rusyn & D. Reif 

Source: NC State University Libraries
Added: August 6, 2018

2018 personal communication

The NIEHS TaRGET II Consortium and environmental epigenomics

By: T. Wang, E. Pehrsson, D. Purushotham, D. Li, X. Zhuo, B. Zhang, H. Lawson, M. Province ...

Source: NC State University Libraries
Added: August 6, 2018

2018 article

Potency Of German Cockroach Extracts For IgE Reactivity Depends On Allergen Content And Allergen-specific IgE Titers Of The Cockroach Allergic Patient

Glesner, J., Filep, S., Schulten, V. M., Frazier, A., Vailes, L. D., Wunschmann, S., … Pomes, A. (2018, February). JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol. 141, pp. AB108–AB108.

By: J. Glesner*, S. Filep*, V. Schulten*, A. Frazier *, L. Vailes*, S. Wunschmann *, K. Leong*, C. Schal n  ...

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 review

Neurodevelopmental and neurological effects of chemicals associated with unconventional oil and natural gas operations and their potential effects on infants and children

[Review of ]. REVIEWS ON ENVIRONMENTAL HEALTH, 33(1), 3–29.

By: E. Webb*, J. Moon*, L. Dyrszka, B. Rodriguez *, C. Cox *, H. Patisaul n , S. Bushkin, E. London

author keywords: BTEX; children; EDCs; heavy metals; PAHs; particulate matter; UOG
MeSH headings : Adolescent; Air Pollutants / toxicity; Child; Child, Preschool; Congenital Abnormalities / etiology; Environmental Exposure / adverse effects; Humans; Infant; Infant, Newborn; Learning Disabilities / chemically induced; Natural Gas; Neurodevelopmental Disorders / chemically induced; Oil and Gas Industry; Petroleum; Water Pollutants, Chemical / toxicity
TL;DR: Since UOG development has expanded rapidly in recent years, the need for public health prevention techniques, well-designed studies and stronger state and national regulatory standards is becoming increasingly apparent. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Interactive effects of temperature, CO2 and nitrogen source on a coastal California diatom assemblage

JOURNAL OF PLANKTON RESEARCH, 40(2), 151–164.

By: A. Tatters*, A. Schnetzer* , K. Xu *, N. Walworth *, F. Fu*, J. Spackeen, R. Sipler, E. Bertrand * ...

author keywords: global change; diatom community structure; interactive effects
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Inference on phenotype-specific effects of genes using multivariate kernel machine regression

GENETIC EPIDEMIOLOGY, 42(1), 64–79.

By: A. Maity n , J. Zhao  n, P. Sullivan * & J. Tzeng n

author keywords: kernel machine; multivariate regression; mixed models; restricted maximum likelihood; variance components
MeSH headings : Age Factors; Antipsychotic Agents / therapeutic use; Computer Simulation; Genetic Markers / genetics; Humans; Likelihood Functions; Models, Genetic; Phenotype; Sex Factors
TL;DR: An estimation method based on the penalized likelihood approach to estimate phenotype‐specific effects and their corresponding standard errors while accounting for possible correlation among the phenotypes is developed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Impacts of Air-sea Interactions on Regional Air Quality Predictions Using a Coupled Atmosphere-ocean Model in Southeastern US

AEROSOL AND AIR QUALITY RESEARCH, 18(4), 1044–1067.

By: J. He  n, R. He n  & Y. Zhang n

author keywords: O-3; PM2.5; Air-sea interaction; WRF/Chem; ROMS; COAWST; Coupled atmosphere-ocean model
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Endotoxin enhances respiratory effects of phthalates in adults: Results from NHANES 2005-6

ENVIRONMENTAL RESEARCH, 162, 280–286.

By: P. Strassle *, L. Smit * & J. Hoppin n 

author keywords: Allergy; Asthma; Wheeze; Dust endotoxin; Phthalates
MeSH headings : Adult; Asthma / chemically induced; Cross-Sectional Studies; Dust; Endotoxins / toxicity; Environmental Exposure; Humans; Nutrition Surveys; Phthalic Acids / toxicity; Respiratory Sounds / drug effects
TL;DR: The lack of an association between wheeze or asthma and phthalate when endotoxin exposure was low suggests that phthalates alone may not increase these symptoms, whereas this cross‐sectional study cannot address key temporal issues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Effects of Cadmium Exposure on DNA Methylation at Imprinting Control Regions and Genome-Wide in Mothers and Newborn Children.

Environmental Health Perspectives, 3(3).

By: M. Cowley n , D. Skaar n, D. Jima n, R. Maguire n, K. Hudson n, S. Park n, P. Sorrow n, C. Hoyo n

MeSH headings : Cadmium / toxicity; DNA Methylation / drug effects; DNA Methylation / genetics; Epigenesis, Genetic / drug effects; Epigenesis, Genetic / ethics; Female; Genomic Imprinting / drug effects; Genomic Imprinting / genetics; Humans; Infant, Newborn; Male; Mothers
TL;DR: The findings suggest that ICRs may be hot spots for perturbation by Cadmium, motivating further study of these loci to investigate potential mechanisms of cadmium action and suggest that epigenetic changes may contribute to the etiology of cad mium-associated diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2018 journal article

EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain

ENDOCRINE CONNECTIONS, 7(2), 305–324.

By: K. Rock n, B. Horman n, A. Phillips *, S. McRitchie*, S. Watson *, J. Deese-Spruill*, D. Jima n, S. Sumner n ...

author keywords: endocrine disruptors; flame retardants; behavior; serotonin; sexually dimorphic; EDC; brain
TL;DR: It is demonstrated that environmental contaminants, like FM 550, have the potential to impact the developing brain by disrupting normal placental functions. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Demonstration of hydrazide tagging for O-glycans and a central composite design of experiments optimization using the INLIGHT (TM) reagent

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410(5), 1409–1415.

By: S. King n, E. Hecht n & D. Muddiman n 

author keywords: O-glycosylation; Hydrazide tag; Rapid derivatization; Design of experiments
MeSH headings : Chromatography, Liquid; Glycoproteins / chemistry; Hydrazines / chemistry; Mass Spectrometry; Polysaccharides / chemistry
TL;DR: This work has taken the INLIGHT™ strategy for N-linked glycan derivatization and adopted it for use with O-linked glycans, demonstrating successful hydrazide tagging of O-glycans for the first time. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 review

Algal Blooms and Cyanotoxins in Jordan Lake, North Carolina

[Review of ]. TOXINS, 10(2).

By: D. Wiltsie n, A. Schnetzer n , J. Green *, M. Vander Borgh* & E. Fensin*

author keywords: freshwater blooms; cyanobacteria; cyanotoxins; microcystin; anatoxin-alpha; BMAA; North Carolina; SPATT; water quality
MeSH headings : Alkaloids; Amino Acids, Diamino / analysis; Bacterial Toxins / analysis; Cyanobacteria / isolation & purification; Cyanobacteria Toxins; Environmental Monitoring; Harmful Algal Bloom; Lakes / microbiology; Microcystins / analysis; North Carolina; Tropanes / analysis; Uracil / analogs & derivatives; Uracil / analysis; Water Pollutants / analysis; Water Supply
TL;DR: This study is the first to document the presence of dissolved microcystin, anatoxin-a, cylindrospermopsin, and β-N-methylamino-l-alanine in Jordan Lake, a major drinking water reservoir in North Carolina. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

A novel integrated strategy for the detection and quantification of the neurotoxin beta-N-methylamino-l-alanine in environmental samples

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410(10), 2597–2605.

By: J. Beri n, K. Kirkwood n, D. Muddiman n  & M. Bereman n

author keywords: BMAA; CZE; Isomer separation; Quantification; HRAM MS/MS; Seafood
MeSH headings : Amino Acids, Diamino / analysis; Animals; Cyanobacteria Toxins; Environmental Monitoring / methods; Environmental Pollutants / analysis; Fishes / metabolism; Food Analysis / methods; Humans; Limit of Detection; Neurotoxins / analysis; Seafood / analysis; Tandem Mass Spectrometry / methods
TL;DR: Interestingly, BMAA was not identified in the free protein fraction but only detected after protein hydrolysis which suggests that BMAA is tightly bound by and/or incorporated into proteins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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