Works Published in 2016
Displaying works 21 - 40 of 49 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2016 journal article
Normalizing oral fluid hydrocodone data using calculated blood volume
Journal of Analytical Toxicology, 40(7), 486–491.
Contributors: O. Cummings, A. Morris, J. Enders* & G. McIntire
MeSH headings : Analgesics, Opioid / metabolism; Humans; Hydrocodone / metabolism; Saliva / metabolism; Substance Abuse Detection / methods
TL;DR:
A retrospective approach to transform and normalize oral fluid testing results to provide a historical picture of patient values in this important test fluid, which parallels the use of creatinine to normalize drug concentration levels in urine and is consistent with the view that oral fluid samples reflect plasma concentrations of the respective drugs.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 11, 2019
2016 journal article
Fentanyl-norfentanyl concentrations during transdermal patch application: LC-MS-MS urine analysis
Journal of Analytical Toxicology, 40(8), 595–600.
Contributors: O. Cummings, J. Enders* , G. McIntire, R. Backer & A. Poklis
MeSH headings : Administration, Cutaneous; Adult; Aged; Chromatography, Liquid; Female; Fentanyl / administration & dosage; Fentanyl / analogs & derivatives; Fentanyl / urine; Humans; Male; Middle Aged; Models, Theoretical; Retrospective Studies; Substance Abuse Detection; Tandem Mass Spectrometry; Transdermal Patch
TL;DR:
This work examines a larger population of patient positives for fentanyl and norfentanyl to determine whether more than a decade later the original report remains accurate in predicting the range and median levels of fentanyl and Norfentanyl concentrations physicians can expect to see from their patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 11, 2019
2016 journal article
A metabolomic, geographic, and seasonal analysis of the contribution of pollen-derived adenosine to allergic sensitization
Metabolomics.
author keywords: NMR; Metabolomics; Pollen; Adenosine; Allergy
TL;DR:
It would be a rare event limited to tree pollen season for concentrations of pollen-derived adenosine to approach physiological levels, and sugar content and other metabolites may be useful in classifying pollens.
(via Semantic Scholar)
Source: ORCID
Added: December 10, 2019
2016 journal article
The Structural Basis of Actin Organization by Vinculin and Metavinculin
Journal of Molecular Biology, 428(1), 10–25.
author keywords: cryo-EM; cytoskeleton; mechanobiology; adhesion; cell motility
MeSH headings : Actins / chemistry; Actins / metabolism; Cryoelectron Microscopy; Humans; Models, Molecular; Protein Binding; Protein Conformation; Protein Multimerization; Vinculin / chemistry; Vinculin / metabolism
TL;DR:
An 8.5-Å-resolution cryo-electron microscopy reconstruction and pseudo-atomic model of the vinculin tail (Vt) domain bound to F-actin is presented, finding that an analogous conformational change also occurs in the H1' helix of the tail domain of metavinculin (MVT) upon actin binding, a muscle-specific splice isoform that suppresses actin bundling by Vt.
(via Semantic Scholar)
Source: ORCID
Added: December 10, 2019
2016 journal article
Role of PIP2-Dependent Membrane Interactions in Vinculin Activation, Motility and Force Transmission
Biophysical Journal, 110(3), 575a.
Source: ORCID
Added: December 10, 2019
2016 journal article
ChemInform Abstract: Synthesis of 7-Norbornenols via Diels-Alder Cycloadditions of Cyclopentadienol Generated by Decomposition of Ferrocenium Cation.
ChemInform, 47(9), no-no.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: November 12, 2019
2016 journal article
1,2,4-Triazolidine-3-thiones as Narrow Spectrum Antibiotics against Multidrug-Resistant Acinetobacter baumannii
ACS Medicinal Chemistry Letters, 8(1), 27–31.
author keywords: antibiotic resistance; antibiotics; Acinetobacter baumannii
TL;DR:
A small molecule with potent antibiotic activity against multiple strains of multidrug-resistant and extensively drug-resistant Acinetobacter baumannii is identified and represents a promising start in the development of a class of drugs that can target this bacterial pathogen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: November 12, 2019
2016 journal article
Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(41), E6080–E6088.
author keywords: allostery; conformational selection; saturation mutagenesis; protein solvation; protein structure
MeSH headings : Allosteric Regulation; Allosteric Site; Amino Acid Substitution; Caspase 3 / chemistry; Caspase 3 / genetics; Caspase 3 / metabolism; Catalytic Domain; Crystallography, X-Ray; Enzyme Activation; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Mutagenesis; Protein Binding; Protein Conformation; Protein Multimerization; Quantitative Structure-Activity Relationship; Solubility; Water / chemistry
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Enhanced Lipidome Coverage in Shotgun Analyses by using Gas-Phase Fractionation
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 27(11), 1735–1744.
author keywords: Shotgun lipidomics; Gas-phase fractionation; Lipids; Hen model; Lipid metabolism; Polarity switching; Q Exactive Plus
MeSH headings : Animals; Chickens; Female; Glycerophospholipids; Ions; Lipids / chemistry; Tandem Mass Spectrometry
TL;DR:
This comprehensive analysis of the lipidome can serve as a species- and tissue-specific database for confident identification of other MS-based datasets, such as mass spectrometry imaging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Design and validation of the mounting structure for BETTII balloon-based telescope with thin-walled optics
JOURNAL OF ASTRONOMICAL TELESCOPES INSTRUMENTS AND SYSTEMS, 2(2).
author keywords: light-weight optics; diamond turning optics; optical mounting; kinematic coupling; Balloon Experimental Twin Telescope for Infrared Interferometry
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Reductive Carbonylation of Oxorhenium Hydrides Induced by Lewis Acids
ORGANOMETALLICS, 35(17), 2822–2829.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
7. Affordable and Clean Energy
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Mechanism for the Reaction of CO with Oxorhenium Hydrides: Migratory Insertion of CO into Rhenium Hydride and Formyl Bonds leads to Migration from Rhenium to the Oxo Ligand
ORGANOMETALLICS, 35(17), 3060–3068.
UN Sustainable Development Goal Categories
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 review
Infrared matrix-assisted laser desorption electrospray ionization mass spectrometry imaging analysis of biospecimens
[Review of ]. ANALYST, 141(18), 5236–5245.
MeSH headings : Histocytological Preparation Techniques; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
TL;DR:
Challenges and limitations of MSI using IR-MALDESI are addressed in the context of the bioimaging field and valuable information is provided for targeted, label-free drug distribution studies and untargeted metabolomic datasets.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Examining ubiquitinated peptide enrichment efficiency through an epitope labeled protein
ANALYTICAL BIOCHEMISTRY, 512, 114–119.
author keywords: Ubiquitination; Gly-Gly enrichment; Enrichment efficiency
MeSH headings : Antibodies, Monoclonal, Murine-Derived / chemistry; Epitopes / chemistry; Muramidase / chemistry; Ubiquitinated Proteins / chemistry; Ubiquitination
TL;DR:
It is shown that when conjugated to a lysine containing protein, such as lysozyme, it can be applied as a standard protein to examine ubiquitinated peptide enrichment within a complex background.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Effect of the Ancillary Ligand on the Mechanism for CO Migratory Insertion in High-Valent Oxorhenium Complexes
ORGANOMETALLICS, 35(20), 3530–3537.
UN Sustainable Development Goal Categories
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Nondirected C-H Activation of Arenes with Cp*Ir(III) Acetate Complexes: An Experimental and Computational Study
ORGANOMETALLICS, 35(15), 2435–2445.
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
TransOmic analysis of forebrain sections in Sp2 conditional knockout embryonic mice using IR-MALDESI imaging of lipids and LC-MS/MS label-free proteomics
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 408(13), 3453–3474.
author keywords: IR-MALDESI; Proteomics; Lipidomics; Mass spectrometry imaging; Embryonic brain
MeSH headings : Animals; Chromatography, Liquid / methods; Lipids / analysis; Mass Spectrometry / methods; Mice; Mice, Knockout; Prosencephalon / embryology; Prosencephalon / metabolism; Sp2 Transcription Factor / genetics; Spectrophotometry, Infrared / methods; Transcriptome
TL;DR:
An integrated approach for systematic analysis of the “lipidome” in tissue revealed many specific changes to fundamental cellular processes and biosynthetic pathways in the cerebral cortices of Sp2-cKO embryos.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 review
Optimizing Mass Spectrometry Analyses: A Tailored Review on the Utility of Design of Experiments
[Review of ]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 27(5), 767–785.
author keywords: Design of experiments; Mass spectrometry; Tutorial; Optimization; Modeling
MeSH headings : Mass Spectrometry; Models, Statistical; Research Design
TL;DR:
This review provides a tutorial-like guide into the selection of DOE for MS experiments, the practices for modeling and optimization of response variables, and the available software tools that support DOE implementation in any laboratory.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Whole-body Mass Spectrometry Imaging by Infrared Matrix-assisted Laser Desorption Electrospray Ionization (IR-MALDESI)
Journal of Visualized Experiments, 3(109).
author keywords: Bioengineering; Issue 109; Mass spectrometry imaging; IR-MALDESI; Tissue analysis; Whole-body imaging; Metabolites; Lipids
MeSH headings : Histocytological Preparation Techniques / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR:
A robust IR-MALDESI imaging source has been developed, where a tunable mid-IR laser is synchronized with a computer controlled XY translational stage and a high resolving power mass spectrometer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2016 journal article
Transition-Metal Oxos as the Lewis Basic Component of Frustrated Lewis Pairs
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 138(14), 4832–4842.
TL;DR:
It is demonstrated for the first time that the incorporation of a transition-metal oxo in a frustrated Lewis pair can have a synergistic effect and results in enhanced catalytic activity at olefin hydrogenation.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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