Molecular Education, Technology and Research Innovation Center

Works Published in 2015

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Displaying works 41 - 52 of 52 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2015 journal article

Assessing drug and metabolite detection in liver tissue by UV-MALDI and IR-MALDESI mass spectrometry imaging coupled to FT-ICR MS

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 377, 448–455.

By: J. Barry n, M. Groseclose*, G. Robichaud n, S. Castellino* & D. Muddiman n 

author keywords: MALDI; IR-MALDESI; Mass spectrometry imaging; Drug distribution
TL;DR: The detection of lapatinib as well as several of its metabolites in liver tissue was determined by MSI using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) coupled to high resolving power Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Synthesis, Structure, and Thermal Instability of the Cu2Ta4O11 Phase

CRYSTAL GROWTH & DESIGN, 15(2), 552–558.

By: N. King n, R. Sommer n , P. Watkins-Curry*, J. Chan * & P. Maggard n 

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Synthesis of Unsupported d(1)-d(x) dx Oxido-Bridged Heterobimetallic Complexes Containing V-IV: A New Direction for Metal-to-Metal Charge Transfer

INORGANIC CHEMISTRY, 54(11), 5322–5328.

By: X. Wu n, T. Huang n, T. Lekich n, R. Sommer n  & W. Weare n

TL;DR: This work reports the first report of visible-light induced MMCT in a heterobimetallic oxido-bridged molecule where the electron originates on a d(1) metal center. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Mass Spectrometry Imaging Reveals Heterogeneous Efavirenz Distribution within Putative HIV Reservoirs

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 59(5), 2944–2948.

By: C. Thompson*, M. Bokhart n, C. Sykes *, L. Adamson*, Y. Fedoriw*, P. Luciw*, D. Muddiman n , A. Kashuba *, E. Rosen n

MeSH headings : Alkynes; Animals; Anti-Retroviral Agents / pharmacokinetics; Benzoxazines / pharmacokinetics; Cyclopropanes; Gray Matter / metabolism; Lymph Nodes / metabolism; Macaca; Mass Spectrometry / methods
TL;DR: Intratissue efavirenz distribution was heterogeneous, with the drug concentrating in the lamina propria of the colon, the primary follicles of lymph nodes, and the brain gray matter, the first imaging data of an antiretroviral drug in active viral reservoirs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Crystalline and Liquid Structure of Zinc Chloride Trihydrate: A Unique Ionic Liquid

INORGANIC CHEMISTRY, 54(3), 1109–1119.

By: R. Wilcox n, B. Losey n, J. Folmer n, J. Martin n , M. Zeller * & R. Sommer n 

TL;DR: The water/ZnCl(2) phase diagram in the vicinity of the 75 mol % water composition is reported, demonstrating the existence of a congruently melting phase and a novel nonpolar, hydrogen-bonding, ionic liquid solvent. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Cellular-level mass spectrometry imaging using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) by oversampling

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407(8), 2265–2271.

By: M. Nazari n & D. Muddiman n 

author keywords: Mass spectrometry imaging; Infrared; MALDESI; Cellular analysis; Oversampling; Tissue analysis; Lipids
MeSH headings : Cells / chemistry; Cells / metabolism; Cervix Uteri / chemistry; Cervix Uteri / metabolism; Cholesterol / metabolism; Female; Humans; Microtomy; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: Infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) imaging of cervical tissue sections was performed using a spot-to-spot distance of 10 μm by utilizing the method of oversampling, where the target plate is moved by a distance that is less than the desOrption radius of the laser. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Quantitative mass spectrometry imaging of emtricitabine in cervical tissue model using infrared matrix-assisted laser desorption electrospray ionization

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407(8), 2073–2084.

By: M. Bokhart n, E. Rosen n, C. Thompson*, C. Sykes *, A. Kashuba * & D. Muddiman n 

author keywords: Mass spectrometry imaging; IR-MALDESI; Absolute quantification; Drug distribution; HIV; Selected reaction monitoring
MeSH headings : Diagnostic Imaging / instrumentation; Diagnostic Imaging / methods; Female; Humans; Papillomavirus Vaccines / chemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Uterine Cervical Neoplasms / chemistry; Uterine Cervical Neoplasms / diagnosis
TL;DR: A quantitative mass spectrometry imaging technique using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) is demonstrated for the antiretroviral (ARV) drug emtricitabine in incubated human cervical tissue, leading to a gain in sensitivity and removal of interferences for several ARV drugs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Analysis of trace fibers by IR-MALDESI imaging coupled with high resolving power MS

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407(3), 813–820.

By: K. Cochran n, J. Barry n, G. Robichaud n & D. Muddiman n 

author keywords: Mass spectrometry imaging; Forensic science; Trace evidence; Polarity switching imaging; MALDESI
TL;DR: IR-MALDESI was used as a source for mass spectrometry imaging (MSI) of a dyed nylon fiber cluster and single fiber to yield more quantitative structural information about the dye and polymer that can be used for more conclusive comparisons. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 personal communication

Michael Gross: 25 Years of Dedication and Leadership of JASMS (1990-2015)

Muddiman, D. C. (2015, January).

By: D. Muddiman n 

Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

4-Coumaroyl and Caffeoyl Shikimic Acids Inhibit 4-Coumaric Acid: Coenzyme A Ligases and Modulate Metabolic Flux for 3-Hydroxylation in Monolignol Biosynthesis of Populus trichocarpa

MOLECULAR PLANT, 8(1), 176–187.

By: C. Lin n, J. Wang n , Q. Li *, H. Chen n, J. Liu  n, P. Loziuk n, J. Song  n, C. Williams n  ...

author keywords: monolignol biosynthesis; Populus trichocarpa; metabolic flux; reaction and inhibition kinetics; LC-MS/MS; 4-coumaroyl and caffeoyl shikimic acids
MeSH headings : Acyl Coenzyme A / metabolism; Coenzyme A Ligases / metabolism; Coumaric Acids / metabolism; Coumaric Acids / pharmacology; Hydroxylation / drug effects; Plant Proteins / metabolism; Populus / drug effects; Populus / enzymology; Populus / metabolism; Propionates; Shikimic Acid / pharmacology
TL;DR: 4-coumaroyl and caffeoyl shikimic acids are inhibitors of Ptr4CL3 and Ptr 4CL5, which can reduce lignin content in a number of plant species and play significant regulatory roles when these inhibitors accumulate. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

ortho-C-H Activation of Thiobenzoic Acid: Synthesis, Characterization, and Reactivity of Iridium Thiobenzoate Complexes

ORGANOMETALLICS, 34(1), 275–279.

By: D. Frasco n, R. Sommer n  & E. Ison n 

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Oxyfunctionalization with Cp*Ir-III(NHC)(Me)(CI) with O-2: Identification of a Rare Bimetallic Ir-IV mu-Oxo Intermediate

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137(10), 3574–3584.

By: M. Lehman n, D. Pahls *, J. Meredith*, R. Sommer n , D. Heinekey*, T. Cundari *, E. Ison n 

TL;DR: Isotope labeling studies confirmed the origin of the methyl group in the methanol product is the iridium-methyl bond in the [Cp*Ir(NHC)Me(CD2Cl2)][BAr(F)4] starting material, and DFT and MCSCF calculations reveal several important features of the electronic structure of 3. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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