Works Published in 2022
Displaying works 21 - 40 of 151 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2022 journal article
143-OR: Mapping Genetic Determinants of Blood Glucose Control in the Action to Control Cardiovascular Risk in Diabetes Study Group (ACCORD)
Diabetes, 71(Supplement_1).
TL;DR:
This work identified and replicated variants that merit further study in the development of precision medicine for treatment of T2D and stratified analyses highlight the potential importance of heterogeneity in these efforts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 21, 2023
2022 journal article
Questionnaire-Based Polyexposure Assessment Outperforms Polygenic Scores for Classification of Type 2 Diabetes in a Multiancestry Cohort
Diabetes Care, 11, dc220295.
MeSH headings : Humans; Diabetes Mellitus, Type 2 / epidemiology; Diabetes Mellitus, Type 2 / genetics; Hypertension / complications; Environmental Exposure; Multifactorial Inheritance / genetics; Surveys and Questionnaires; Genome-Wide Association Study; Risk Factors
TL;DR:
The findings in a multiancestry cohort elucidate how type 2 diabetes odds can be attributed to clinical, genetic, and environmental factors and emphasize the need for exposome data in disease-risk association studies.
(via Semantic Scholar)
doi.org (repository)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023
2022 journal article
Abstract PR011: Characterization of the precancerous and cancer microenvironment in a zebrafish sarcoma model
Clinical Cancer Research, 28(18_Supplement), PR011–PR011.
TL;DR:
Using RNA-seq, the transcriptomes of microenvironmental cells from the zebrafish MPNST model are profiled and it is determined that the precancerous and cancerous microenvironments exhibit broad activation of inflammatory and immune-associated signaling networks.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023
2022 journal article
Longitudinal Serological Surveillance for COVID-19 Antibodies after Infection and Vaccination
Microbiology Spectrum, 10(5).
Ed(s): O. Laeyendecker
MeSH headings : Humans; COVID-19 / prevention & control; Pandemics; Ad26COVS1; Vaccination; Antibodies; Antibodies, Viral
TL;DR:
It is concluded that, in a real-life setting, vaccination and social distancing behavior are positively correlated and the observed effect of vaccination in preventing COVID-19 may include both vaccine-mediated protection and the associated more cautious behavior exhibited by vaccinated individuals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023
2022 journal article
LBMON114 Enrichment Of Rare Sequence Variants In Genes That Communicate Metabolic Signals To The GnRH System In Hypothalamic Amenorrhea
Journal of the Endocrine Society, 6(Supplement_1), A466–A467.
TL;DR:
These data suggest that RSVs in genes involved in phenotypes or signaling pathways that link metabolism to GnRH secretion may predispose to development of HA in the setting of decreased energy balance, but not for stress-related genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023
2022 journal article
Social isolation exacerbates acute ozone inhalation induced pulmonary and systemic health outcomes
Toxicology and Applied Pharmacology, 457, 116295.
TL;DR:
Collectively, psychosocial stressors, especially SI, affected the neuroendocrine system and induced adverse metabolic and inflammatory effects that were exacerbated by ozone exposure.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023
2022 journal article
Stress Drivers of Glucose Dynamics during Ozone Exposure Measured Using Radiotelemetry in Rats
Environmental Health Perspectives, 130(12).
MeSH headings : Rats; Male; Animals; Glucose; Receptors, Glucocorticoid; Blood Glucose Self-Monitoring; Irritants; Blood Glucose; Rats, Inbred WKY; Corticosterone; Ozone / toxicity; Air Pollutants / toxicity; Adrenergic Agents
TL;DR:
The temporality of neuroendocrine-stress–mediated biological sequalae responsible for ozone-induced glucose metabolic dysfunction and mechanism in a rodent model is demonstrated and may be useful in identifying interactions among irritant pollutants and stress-related illnesses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023
2022 journal article
Maternal Periconceptional Stressors, Mediterranean Diet Adherence, and Child Outcomes
Current Developments in Nutrition, 6, 650.
TL;DR:
The data suggest that maternal Mediterranean diet adherence provides a potent avenue by which effects of prenatal stressors on maternal and fetal outcomes can be mitigated to reduce ethnic disparities in childhood obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023
2022 journal article
Adrenal Stress Hormone Regulation of Hepatic Homeostatic Function After an Acute Ozone Exposure in Wistar-Kyoto Male Rats
Toxicological Sciences, 189(1), 73–90.
MeSH headings : Animals; Corticosterone; Homeostasis; Insulin; Male; Ozone / toxicity; RNA, Messenger; Rats; Rats, Inbred WKY
TL;DR:
The critical role of adrenal stress hormones in ozone-induced hepatic homeostasis is demonstrated and necessitate further research elucidating their role in propagating environmentally driven diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 11, 2023
2022 journal article
Questionnaire-based exposome-wide association studies (ExWAS) reveal expected and novel risk factors associated with cardiovascular outcomes in the Personalized Environment and Genes Study
Environmental Research, 212, 113463.
MeSH headings : Cardiovascular Diseases / epidemiology; Cardiovascular Diseases / etiology; Coronary Artery Disease; Exposome; Heart Failure; Humans; Myocardial Infarction; Risk Factors; Stroke / epidemiology; Surveys and Questionnaires
TL;DR:
ExWAS analyses revealed novel associations that include blood type A (Rh-) with heart attack, and significant nonlinear effects of sleep disorder, regular intake of grapefruit, and a family history of blood clotting problems for multiple CVD outcomes, highlighting the importance of considering multiple exposures when examining CVD outcome.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 11, 2023
2022 dataset
Cestode infection facilitates co-infection by other parasites in a metapopulation of threespine stickleback
Dryad.
Contributors: D. Bolnick & M. Rodgers
Source: ORCID
Added: April 6, 2023
2022 journal article
The AGMK1-9T7 cell model of neoplasia: Evolution of DNA copy-number aberrations and miRNA expression during transition from normal to metastatic cancer cells
PLOS ONE, 17(10).
MeSH headings : Animals; Humans; Chlorocebus aethiops; MicroRNAs / genetics; MicroRNAs / metabolism; Neoplasms / genetics; Carcinogenesis / genetics; DNA Copy Number Variations / genetics; Chromosome Aberrations; Neoplasms, Second Primary / genetics; DNA; Gene Expression Regulation, Neoplastic; Gene Expression Profiling
TL;DR:
The evolution of chromosomal DNA copy-number aberrations and miRNA expression in this cell line from passage 1 to the acquisition of a tumorigenic phenotype at passage 40 is examined and it is proposed that the evolution of AGMK1-9T7 cells represents a detailed model of neoplasia in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 27, 2023
2022 journal article
Gestational exposure to neighborhood police-reported crime and early childhood blood pressure in Durham, NC
HEALTH & PLACE, 75.
author keywords: Crime; Violence; Policing; Neighborhood environment; Early childhood health; Blood pressure
MeSH headings : Blood Pressure; Child; Child, Preschool; Crime; Humans; Infant, Newborn; Police; Residence Characteristics; Violence
TL;DR:
It is demonstrated that violence and drug policing are consistently associated with increased blood pressure among children born to Black participants but not White or Latinx participants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(Web of Science)
Source: Web Of Science
Added: February 27, 2023
2022 journal article
Maternal Mediterranean Diet Adherence and Its Associations with Maternal Prenatal Stressors and Child Growth
CURRENT DEVELOPMENTS IN NUTRITION, 6(11).
author keywords: Mediterranean diet; stressors; child weight; birth outcomes; maternal diet
TL;DR:
If replicated in larger studies, the data suggest that MDA provides a potent avenue by which effects of prenatal stressors on maternal and fetal outcomes can be mitigated to reduce ethnic disparities in childhood obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 20, 2023
2022 journal article
Confirmation of high-throughput screening data and novel mechanistic insights into FXR-xenobiotic interactions by orthogonal assays
CURRENT RESEARCH IN TOXICOLOGY, 3.
author keywords: ToxCast; Farnesoid X receptor; High -throughput screening; Teleost models; Medaka
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 23, 2023
2022 journal article
MagicalRsq: Machine-learning-based genotype imputation quality calibration
AMERICAN JOURNAL OF HUMAN GENETICS, 109(11), 1986–1997.
MeSH headings : Humans; Genome-Wide Association Study / methods; Polymorphism, Single Nucleotide / genetics; Calibration; Genotype; Machine Learning
TL;DR:
MagicalRsq is proposed, a machine-learning-based method that integrates variant-level imputation and population genetics statistics, to provide a better calibrated imputation quality metric and will benefit downstream analysis by better distinguishing well-imputed variants from those poorly imputed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 17, 2023
2022 journal article
A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior
Frontiers in Toxicology, 4.
TL;DR:
Evaluation of the available human epidemiological, experimental, and wildlife data indicates heightened accumulation of perfluoroalkyl acids in the brain after environmental exposure, in comparison to the experimental studies, and highlights the need for additional experimental analysis of neurodevelopmental impacts of environmentally relevant concentrations and complex mixtures of PFAS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
15. Life on Land
(OpenAlex)
Source: ORCID
Added: January 6, 2023
2022 journal article
Blood concentrations of per- and polyfluoroalkyl substances are associated with autoimmune-like effects in American alligators from Wilmington, North Carolina
FRONTIERS IN TOXICOLOGY, 4.
author keywords: autoantibodies; autoimmune; crocodilian; immune toxicity; lupus; one health; PFAS
TL;DR:
The association of increased PFAS exposure with disrupted immune functions is interpreted to suggest that PFAS broadly alters immune activities resulting in autoimmune-like pathology in American alligators.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 6, 2023
2022 article
A chromosome level genome assembly of longnose gar,Lepisosteus osseus
Mallik, R., Carlson, K. B., Wcisel, D. J., Fisk, M., Yoder, J. A., & Dornburg, A. (2022, December 22).
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: December 23, 2022
2022 article
TCDD alters essential transcriptional regulators of osteogenic differentiation in multipotent mesenchymal stem cells
Watson, A. L. T. D., Carmona Baez, A., Jima, D., Reif, D., Ding, J., Roberts, R., & Kullman, S. W. (2022, November 12). TOXICOLOGICAL SCIENCES, Vol. 11.
author keywords: mesenchymal stem cell; AhR; cell differentiation
MeSH headings : Humans; Osteogenesis / genetics; Polychlorinated Dibenzodioxins / toxicity; Cell Differentiation; Fibroblast Growth Factors / metabolism; Mesenchymal Stem Cells / metabolism; Cells, Cultured; Osteoblasts
TL;DR:
A global transcriptomic landscape during early, intermediate, and apical stages of osteogenic differentiation in vitro in response to TCDD is established to identify novel pathways and transcription factors that may facilitate a better understanding of the osteoblast differentiation process, perturbation by exogenous agents, and potential intervention strategies targeting those specific pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 19, 2022
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