Works Published in 2012
Displaying works 41 - 60 of 112 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
A Nestin-cre transgenic mouse is insufficient for recombination in early embryonic neural progenitors
Biology Open, 1(12), 1200–1203.
TL;DR:
It is found that the rate of Nestin-cre driven recombination only reaches sufficiently high levels in NSCs and NPCs during late embryonic and early postnatal periods, which is important when commercially available cre lines are considered for directing recombination to embryonic NSCS and NPCs.
(via Semantic Scholar)
bio.biologists.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: July 20, 2019
2012 journal article
A new approach to bias correction in RNA-Seq
Bioinformatics, 28(7), 921–928.
MeSH headings : Bayes Theorem; Computational Biology / methods; Humans; Models, Statistical; Molecular Sequence Annotation; RNA / genetics; Sequence Analysis, RNA / methods; Software
TL;DR:
This work presents a new method to measure and correct for protocol-specific sequence bias in RNA-Seq experiments using a simple graphical model that effectively decreases bias and increases uniformity.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2012 journal article
Compression of next-generation sequencing reads aided by highly efficient de novo assembly
Nucleic Acids Research, 40(22), e171–e171.
MeSH headings : Algorithms; Data Compression / methods; High-Throughput Nucleotide Sequencing / methods; Probability; Software
TL;DR:
Quip is presented, a lossless compression algorithm for next-generation sequencing data in the FASTQ and SAM/BAM formats and the first assembly-based compressor, using a novel de novo assembly algorithm.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2012 journal article
The non-human primate reference transcriptome resource (NHPRTR) for comparative functional genomics
Nucleic Acids Research, 41(D1), D906–D914.
MeSH headings : Animals; Databases, Nucleic Acid; Genome, Human; Genomics; Humans; Internet; Primates / genetics; Primates / metabolism; Sequence Alignment; Sequence Analysis, RNA; Transcriptome
TL;DR:
A large-scale RNA-Seq data and analysis infrastructure is described, the NHP reference transcriptome resource, which presently hosts data from 12 species of primates and is to be expanded to 15 species/subspecies spanning great apes, old world monkeys, new world monkeys and prosimians.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2012 journal article
HSULF-1 inhibits ERK and AKT signaling and decreases cell viability in vitro in human lung epithelial cells
Respiratory Research, 13(1), 69.
author keywords: Human endosulfatase 1; Heparan sulfate proteoglycans
MeSH headings : Apoptosis / genetics; Cell Line, Tumor; Cell Survival; Epithelial Cells / enzymology; Humans; In Situ Nick-End Labeling; Lung / enzymology; Lung Neoplasms / enzymology; MAP Kinase Signaling System / genetics; Proto-Oncogene Proteins c-akt / metabolism; Real-Time Polymerase Chain Reaction; Signal Transduction; Sulfotransferases / metabolism
TL;DR:
It is indicated that HSULF-1 is expressed at lower levels in H292 lung cancer cells than in normal human alveolar cells and that its over-expression reduced cell viability in H 292 cells by inducing apoptotic pathways, at least in part by inhibiting ERK/Akt signaling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: July 20, 2019
2012 journal article
Solvent effects in the hydrogenation of 2-butanone
Journal of Catalysis, 289, 30–41.
Contributors: B. Akpa* , . C. D'Agostino, L. Gladden *, K. Hindle*, H. Manyar *, J. McGregor *, R. Li*, M. Neurock *
author keywords: Solvent effects; Mixed solvents; Mass transfer; Heterogeneous catalysis; Hydrogenation; 2-Butanone; Ru; DFT
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: July 20, 2019
2012 chapter
Solubility criteria for veterinary drugs
In Stimuli Article. http://www.usp.org/sites/default/files/usp_pdf/en/s200600.pdf
Source: NC State University Libraries
Added: April 5, 2019
2012 journal article
Neutrophil and monocyte function in neonatal dairy calves fed fresh or frozen colostrum
International Journal of Applied Research in Veterinary Medicine, 10(4), 328–334.
Source: NC State University Libraries
Added: February 18, 2019
2012 journal article
Development and Characterization of Anti-Nitr9 Antibodies
Advances in Hematology, 2012, 1–9.
TL;DR:
Anti-Nitr9 monoclonal antibodies were generated and evaluated for the ability to recognize the three Nitr9 isoforms and should prove to be useful for identifying the specific lymphocyte lineages that express Nitr9 and may permit the isolation of Nitr9-expressing cells that can be directly assessed for cytotoxic function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 13, 2019
2012 conference paper
Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) Protein Plays A Critical Role In Production Of Proinflammatory Cytokines By Isolated Canine Neutrophils
A67. ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME: BIOLOGICAL MECHANISMS.
Source: ORCID
Added: February 13, 2019
2012 journal article
Programming stress-induced altruistic death in engineered bacteria
Molecular Systems Biology, 8.
Contributors: Y. Tanouchi, A. Pai*, N. Buchler* & L. You *
author keywords: altruistic death; antibiotic response; eagle effect; programmed cell death; synthetic biology
MeSH headings : Apoptosis; Escherichia coli / cytology; Escherichia coli / growth & development; Genetic Engineering; Microbial Viability; Models, Biological; Reproducibility of Results; Stress, Physiological
TL;DR:
Using a mathematical model, the existence of an optimal programmed death rate that maximizes population growth under stress is predicted and the ‘Eagle effect’, a counter‐intuitive phenomenon where bacteria appear to grow better when treated with higher antibiotic concentrations is predicted.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2012 journal article
Productive thyroid follicular carcinoma in a wild barred owl (Strix varia)
Journal of Veterinary Diagnostic Investigation, 24(6), 1145–1150.
Contributors: J. Brandão *, B. Manickam*, U. Blas-Machado*, E. Cohen* , J. Mejia-Fava*, S. Divers *, J. Mayer*
author keywords: Carcinoma; barred owls; immunohistochemistry; productive; Strigiformes; thyroid
MeSH headings : Adenocarcinoma, Follicular / pathology; Adenocarcinoma, Follicular / veterinary; Animals; Bird Diseases / pathology; Male; Strigiformes; Thyroid Neoplasms / pathology; Thyroid Neoplasms / veterinary
TL;DR:
Findings are indicative of a productive thyroid follicular carcinoma in an adult male barred owl found unable to fly on a pasture during the day.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2012 journal article
Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions
New England Journal of Medicine, 366(4), 330–338.
Contributors: M. Ombrello *, E. Remmers*, G. Sun *, A. Freeman *, S. Datta*, P. Torabi-Parizi *, N. Subramanian*, T. Bunney *
MeSH headings : Autoimmune Diseases / genetics; Cold Temperature / adverse effects; Cryopyrin-Associated Periodic Syndromes / genetics; DNA, Complementary / analysis; DNA, Complementary / isolation & purification; Female; Humans; Immunologic Deficiency Syndromes / genetics; Male; Pedigree; Phenotype; Phospholipase C gamma / genetics; Phospholipase C gamma / metabolism; Polymorphism, Single Nucleotide; Sequence Analysis, DNA; Sequence Deletion
TL;DR:
Genomic deletions in PLCG2 cause gain of PLCγ(2) function, leading to signaling abnormalities in multiple leukocyte subsets and a phenotype encompassing both excessive and deficient immune function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2012 journal article
Clinical and Pathological Effects of the Polyopisthocotylean Monogenean, Gamacallum macroura in White Bass
JOURNAL OF AQUATIC ANIMAL HEALTH, 24(4), 251–257.
MeSH headings : Animals; Bass; Fish Diseases / parasitology; Fish Diseases / pathology; Platyhelminths / classification; Platyhelminths / isolation & purification; Trematode Infections / parasitology; Trematode Infections / veterinary
TL;DR:
Pale-gilled and healthy white bass were selected with no particular attention to condition for venipuncture and euthanasia for postmortem examination, including parasite counts from gills, and monogeneans, identified as Gamacallum macroura, were found on the gills.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Nitric oxide and superoxide mediate diesel particle effects in cytokine-treated mice and murine lung epithelial cells - implications for susceptibility to traffic-related air pollution
Particle and Fibre Toxicology, 9.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Limited yield of diagnoses of intrahepatic infectious causes of canine granulomatous hepatitis from archival liver tissue
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 24(5), 888–894.
author keywords: Copper hepatopathy; dogs; fluorescent in situ hybridization; granulomatous hepatitis; polymerase chain reaction
MeSH headings : Animals; Bartonella / isolation & purification; Bartonella Infections / diagnosis; Bartonella Infections / microbiology; Bartonella Infections / pathology; Bartonella Infections / veterinary; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Female; Formaldehyde; Granuloma / pathology; Granuloma / veterinary; Hepatitis, Animal / diagnosis; Hepatitis, Animal / pathology; Liver / pathology; Male; Paraffin Embedding; Retrospective Studies; Tissue Preservation / veterinary
TL;DR:
It was concluded that investigation of infectious etiologies within FFPE liver specimens using these diagnostic approaches may be of low yield.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Selection of antibiotics for meticillin-resistant Staphylococcus pseudintermedius: time to revisit some old drugs?
Veterinary Dermatology, 23(4), 352–360.
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Methicillin Resistance; Staphylococcal Skin Infections / drug therapy; Staphylococcal Skin Infections / microbiology; Staphylococcal Skin Infections / veterinary; Staphylococcus / classification; Staphylococcus / drug effects
TL;DR:
The aim of this review is to consider systemic therapy options for meticillin-resistant Staphylococcus pseudintermedius (MRSP), which is, by definition, resistant to all β-lactam antibiotics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Neurological impacts from inhalation of pollutants and the nose-brain connection
NeuroToxicology, 33(4), 838–841.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Florfenicol pharmacokinetics in healthy adult alpacas after subcutaneous and intramuscular injection
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(4), 382–388.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Camelids, New World / blood; Cross-Over Studies; Female; Injections, Intramuscular; Injections, Subcutaneous; Male; Thiamphenicol / administration & dosage; Thiamphenicol / analogs & derivatives; Thiamphenicol / pharmacokinetics
TL;DR:
The lowest effective dose of florfenicol should be used in alpacas and limited to treatment of highly susceptible pathogens, using a randomized, cross-over design, and 28-day washout period.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Directed migration of mouse macrophages in vitro involves myristoylated alanine-rich C-kinase substrate (MARCKS) protein
JOURNAL OF LEUKOCYTE BIOLOGY, 92(3), 633–639.
author keywords: cytoplasmic translocation; J774A.1 cells; monocyte chemotactic protein 1; chemotaxis
MeSH headings : Actin Cytoskeleton / immunology; Actin Cytoskeleton / metabolism; Animals; Blotting, Western; Chemotaxis, Leukocyte / physiology; Intracellular Signaling Peptides and Proteins / immunology; Intracellular Signaling Peptides and Proteins / metabolism; Macrophages / immunology; Macrophages / metabolism; Membrane Proteins / immunology; Membrane Proteins / metabolism; Mice; Microscopy, Confocal; Myristoylated Alanine-Rich C Kinase Substrate; Protein Transport / physiology
TL;DR:
Results suggest that MARCKS is involved in directed migration of macrophages via a process involving its phosphorylation, cytoplasmic translocation, and interaction with actin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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