Center for Human Health and the Environment

Works Published in 2021

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Displaying works 41 - 60 of 263 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2021 journal article

Identifying the Best Questions for Rapid Screening of Secondhand Smoke Exposure Among Children

NICOTINE & TOBACCO RESEARCH, 23(7), 1217–1223.

MeSH headings : Child; Child, Preschool; Cotinine / analysis; Humans; Nutrition Surveys; Parents; Saliva / chemistry; Tobacco Smoke Pollution / adverse effects
TL;DR: Using saliva cotinine concentration levels as a gold standard for determining SHS exposure, an analysis employing elastic net regression identified two questions that served as good classifier for distinguishing children who might be at risk for secondhand smoking exposure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 3, 2022

2021 journal article

Regulatory status of pesticide residues in cannabis: Implications to medical use in neurological diseases

CURRENT RESEARCH IN TOXICOLOGY, 2, 140–148.

By: D. Pinkhasova*, L. Jameson*, K. Conrow*, M. Simeone*, A. Davis n, T. Wiegers n, C. Mattingly n, M. Leung*

author keywords: Cannabis; Pesticide; Database; Regulation; Seizure; Contaminant
TL;DR: Network analysis reveals potential interactions of insecticides, cannabinoids, and seizure at a functional level in cannabis. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2022

2021 journal article

Predicting molecular mechanisms, pathways, and health outcomes induced by Juul e-cigarette aerosol chemicals using the Comparative Toxicogenomics Database

CURRENT RESEARCH IN TOXICOLOGY, 2, 272–281.

author keywords: E-cigarettes; Vaping; Juul; Respiratory disease; Database; Environmental exposure
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2022

2021 journal article

CTD anatomy: Analyzing chemical-induced phenotypes and exposures from an anatomical perspective, with implications for environmental health studies

CURRENT RESEARCH IN TOXICOLOGY, 2, 128–139.

author keywords: Anatomy; Chemical; Phenotype; Disease; Environmental health; Database
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2022

2021 article

Discovery proteomics of human placental tissue

Mellinger, A. L., McCoy, K., Minior, D. A. T., & Williams, T. I. (2021, December 23). RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol. 9.

By: A. Mellinger n, K. McCoy*, D. Minior* & T. Williams n

Contributors: A. Mellinger n, K. McCoy*, D. Minior* & T. Williams n

TL;DR: A label-free proteomics protocol for the interrogation of the placental proteome is described, which has been applied towards exploring differential protein expression patterns in placentas from women who have been exposed to drugs during pregnancy relative to those who have not. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 3, 2022

2021 journal article

Mapping the residue specificities of epigenome enzymes by yeast surface display

CELL CHEMICAL BIOLOGY, 28(12), 1772-+.

By: A. Waldman n, B. Rao n & A. Keung n

MeSH headings : E1A-Associated p300 Protein / genetics; E1A-Associated p300 Protein / metabolism; Epigenome / genetics; Humans; Saccharomyces cerevisiae / metabolism
TL;DR: The results show that using yeast surface display to study histone modifications is a useful tool that can advance the understanding of chromatin biology by enabling efficient interrogation of the complexity of epigenome modifications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 3, 2022

2021 article

Practical recommendations on double score matching for estimating causal effects

Zhang, Y., Yang, S., Ye, W., Faries, D. E., Lipkovich, I., & Kadziola, Z. (2021, December 26). STATISTICS IN MEDICINE, Vol. 12.

By: Y. Zhang n, S. Yang n, W. Ye*, D. Faries*, I. Lipkovich* & Z. Kadziola*

author keywords: average treatment effect on the treated; causal inference; double robustness; prognostic score; propensity score
MeSH headings : Bias; Causality; Computer Simulation; Humans; Propensity Score
TL;DR: DSM is doubly robust in the sense that the matching estimator is consistent requiring either the propensity score model or the prognostic score model is correctly specified, and this study supports that DSM performs favorably with, if not better than, the two single score matching in terms of bias and variance. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2022

2021 journal article

Night shift schedule alters endogenous regulation of circulating cytokines

Neurobiology of Sleep and Circadian Rhythms, 10, 100063.

TL;DR: The results indicate that night shift work compromises host defense by creating cytokine conditions that initially impede anti-viral immunity (lower TNF-α) and may eventually promote autoimmunity (mistimed rise in IL-6). (via Semantic Scholar)
Source: ORCID
Added: December 22, 2021

2021 journal article

Potential Human Health Hazard of Post-Hurricane Harvey Sediments in Galveston Bay and Houston Ship Channel: A Case Study of Using In Vitro Bioactivity Data to Inform Risk Management Decisions

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 18(24).

author keywords: new approach methods (NAMs); environmental mixtures; disaster research
MeSH headings : Bays; Cyclonic Storms; Disasters; Environmental Monitoring; Geologic Sediments; Humans; Polycyclic Aromatic Hydrocarbons / analysis; Risk Management; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / toxicity
TL;DR: It is found that in vitro bioactivity can be used as a comprehensive indicator of potential hazards and is an example of a new approach method (NAM) to inform risk management decisions on site cleanup. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 20, 2021

2021 article

Per- and polyfluoroalkyl substances (PFAS)-contaminants of emerging concern

Baker, E. S., & Knappe, D. R. U. (2021, December 2). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 12.

By: E. Baker n & D. Knappe*

MeSH headings : Anthropogenic Effects; Environmental Pollutants / analysis; Environmental Pollutants / pharmacokinetics; Fluorocarbons / analysis; Fluorocarbons / pharmacokinetics; Humans; Tissue Distribution; United States; United States Environmental Protection Agency
TL;DR: It was imperative to assemble this PFAS topical collection to be a critical resource as Published in the topical collection Perand Polyfluoroalkyl Substances (PFAS) – Contaminants of Emerging Concern with guest editors Erin Baker and Detlef Knappe. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: December 13, 2021

2021 journal article

Does Irrigation with Treated and Untreated Wastewater Increase Antimicrobial Resistance in Soil and Water: A Systematic Review

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH.

By: S. Slobodiuk n, C. Niven n, G. Arthur n, S. Thakur n & A. Ercumen n

author keywords: antimicrobial resistance; resistance genes; resistant bacteria; persistent organic pollutants; wastewater irrigation; wastewater reuse; water scarcity; water insecurity; untreated municipal wastewater; treated municipal wastewater
MeSH headings : Agricultural Irrigation; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Bacterial Agents / pharmacology; Drug Resistance, Bacterial; Genes, Bacterial; Humans; Soil; Wastewater / analysis; Water
TL;DR: It is demonstrated that irrigation with untreated wastewater increases AMR in soil and call for precautionary action by field workers, their families, and consumers when untreated wastewater is used to irrigate crops. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 13, 2021

2021 article

Water use behaviors and water access in intermittent and continuous water supply areas during the COVID-19 pandemic

Kumpel, E., Billava, N., Nayak, N., & Ercumen, A. (2021, November 24). JOURNAL OF WATER AND HEALTH, Vol. 11.

By: E. Kumpel*, N. Billava*, N. Nayak* & A. Ercumen n

author keywords: COVID-19 pandemic; drinking water; handwashing; intermittent water supply; piped water; water access
MeSH headings : COVID-19; Humans; Pandemics / prevention & control; SARS-CoV-2; Water Quality; Water Supply
Sources: Web Of Science, NC State University Libraries
Added: December 6, 2021

2021 journal article

Responsible innovation of nano-agrifoods: Insights and views from U.S. stakeholders

NanoImpact, 24, 100365.

author keywords: Food and agriculture; Nanotechnology; Responsible innovation; Stakeholder engagement
MeSH headings : Agriculture; Environmental Health; Humans; Nanotechnology / methods; Risk Assessment; Stakeholder Participation
TL;DR: Overall, participants indicated they held relatively neutral views on research and innovation for nano-agrifoods being conducted responsibly, and they identified key challenges to ensuring their responsible innovation that were related to uncertainties in EHS studies, the need for public understanding and acceptance, and adequate regulation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: December 6, 2021

2021 article

Salicylate coordination in metal-protochelin complexes

Doydora, S. A., Baars, O., Harrington, J. M., & Duckworth, O. W. (2021, November 27). BIOMETALS, Vol. 11.

author keywords: Siderophore; Molybdophore; Coordination chemistry; Trace metals
MeSH headings : Coordination Complexes / chemistry; Molybdenum / chemistry; Salicylates; Siderophores / chemistry; Trace Elements
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: December 6, 2021

2021 journal article

An Integrative Co-localization (INCO) Analysis for SNV and CNV Genomic Features With an Application to Taiwan Biobank Data

FRONTIERS IN GENETICS, 12.

By: Q. Yu*, T. Lu*, T. Hsiao*, C. Lin*, C. Wu*, J. Tzeng n, C. Hsiao*

author keywords: co-localization; gene-level; integrative analysis; Taiwan Biobank; CNV; SNV; CNV-SNV cross-platform interaction; rare variant
TL;DR: This study proposes an integrative approach that combines both single nucleotide variants (SNVs) and copy number variations (CNVs) in the same genomic unit to co-localize the concurrent effect and to deal with the sparsity due to rare variants. (via Semantic Scholar)
Source: Web Of Science
Added: December 6, 2021

2021 journal article

Beyond Cholinesterase Inhibition: Developmental Neurotoxicity of Organophosphate Ester Flame Retardants and Plasticizers

ENVIRONMENTAL HEALTH PERSPECTIVES, 129(10).

By: H. Patisaul n, M. Behl*, L. Birnbaum*, A. Blum*, M. Diamond*, S. Fernandez*, H. Hogberg*, C. Kwiatkowski n ...

MeSH headings : Acetylcholinesterase; Child; Environmental Monitoring; Esters; Female; Flame Retardants / analysis; Humans; Organophosphates / urine; Placenta / metabolism; Plasticizers / analysis; Plasticizers / metabolism; Plasticizers / toxicity; Pregnancy
TL;DR: It is demonstrated that OPEs can alter neurodevelopmental processes by interfering with noncholinergic pathways at environmentally relevant doses and may have implications for the development of cognitive and social skills in children. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: November 29, 2021

2021 journal article

SEAGLE: A Scalable Exact Algorithm for Large-Scale Set-Based Gene-Environment Interaction Tests in Biobank Data

FRONTIERS IN GENETICS, 12.

By: J. Chi*, I. Ipsen n, T. Hsiao*, C. Lin, L. Wang*, W. Lee*, T. Lu*, J. Tzeng n

author keywords: gene-based GxE test for biobank data; GxE collapsing test for biobank data; GxE test for large-scale sequencing data; scalable GEI test; gene-environment variance component test; gene-environment kernel test; regional-based gene-environment test
TL;DR: SEAGLE, a Scalable Exact AlGorithm for Large-scale set-based G×E tests, is presented to permit GxE VC tests for biobank-scale data to explore the interaction of gene and physical activity status on body mass index and demonstrates its utility by conducting genome-wide gene-basedG×E analysis on the Taiwan Biobank data. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: November 29, 2021

2021 journal article

Intra- and Inter-Species Variability in Urinary N7-(1-Hydroxy-3-buten-2-yl)guanine Adducts Following Inhalation Exposure to 1,3-Butadiene

CHEMICAL RESEARCH IN TOXICOLOGY, 34(11), 2375–2383.

MeSH headings : Animals; Butadienes / administration & dosage; Butadienes / metabolism; Butadienes / urine; Chromatography, Liquid; DNA Adducts / administration & dosage; DNA Adducts / metabolism; DNA Adducts / urine; Female; Inhalation Exposure; Male; Mice; Mice, Inbred Strains; Nanotechnology; Spectrometry, Mass, Electrospray Ionization
TL;DR: Urinary EB-GII levels, particularly from human studies, may be useful for quantitative characterization of human variability in cancer risks to butadiene, and are largely consistent with UFH estimates for other chemicals based on human data for non-cancer endpoints. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 29, 2021

2021 journal article

HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 321(5), G588–G602.

author keywords: epithelial repair; HOPX; ischemia; large animal models; stem cell
MeSH headings : Animals; Cell Proliferation; Disease Models, Animal; Epithelial Cells / metabolism; Epithelial Cells / pathology; Female; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Male; Mesenteric Ischemia / genetics; Mesenteric Ischemia / metabolism; Mesenteric Ischemia / pathology; Phenotype; Re-Epithelialization; Severity of Illness Index; Stem Cells / metabolism; Stem Cells / pathology; Sus scrofa; Tissue Culture Techniques
TL;DR: It is demonstrated that during early in vivo recovery, injury-resistant HOPX+cells maintain quiescence, suggesting that HopX may serve a functional role in ISC mediated regeneration after injury and could be a target to control ISC proliferation. (via Semantic Scholar)
Source: Web Of Science
Added: November 23, 2021

2021 article

Bayesian nonparametric quantile process regression and estimation of marginal quantile effects

Xu, S. G., & Reich, B. J. (2021, November 10). BIOMETRICS, Vol. 11.

By: S. Xu n & B. Reich n

author keywords: density regression; Hamiltonian Monte Carlo; interpretable machine learning; simultaneous quantile estimation
MeSH headings : Female; Pregnancy; Humans; Regression Analysis; Birth Weight; Bayes Theorem; Computer Simulation; Neural Networks, Computer
TL;DR: A Bayesian nonparametric method to simultaneously estimate noncrossing, nonlinear quantile curves and expands the conditional distribution function of the response in I‐spline basis functions where the covariate‐dependent coefficients are modeled using neural networks. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 23, 2021

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