Center for Human Health and the Environment

Works Published in 2011

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Displaying works 141 - 160 of 225 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2011 journal article

Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomes

CHROMOSOME RESEARCH, 19(6), 685–708.

author keywords: B chromosomes; fragile breakage model; breakpoint reuse theory; fluorescence in situ hybridization; phylogenetic; Canidae
MeSH headings : Animals; Biological Evolution; Canidae / genetics; Chromosome Mapping; Chromosome Painting; Chromosomes, Artificial, Bacterial; Chromosomes, Mammalian / genetics; Cytogenetics; Dogs / genetics; Foxes / genetics; Genome; In Situ Hybridization, Fluorescence; Raccoon Dogs / genetics
TL;DR: This work suggests that the complex karyotype rearrangements associated with speciation of the Canidae reflect unstable chromosome regions described by the fragile breakage model and provides evidence that these breakpoints are also recurrently associated with spontaneous canine cancers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2011 review

Regulation of mucin secretion and inflammation in asthma: A role for MARCKS protein?

[Review of ]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1810(11), 1110–1113.

By: T. Green n, A. Crews n, J. Park n, S. Fang n & K. Adler n

author keywords: MARCKS; Mucin; Secretion; Asthma
MeSH headings : Animals; Asthma / etiology; Humans; Inflammation / etiology; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / physiology; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate
TL;DR: The properties of MARCKS and how the protein may regulate mucin secretion at a cellular level will be discussed and the roles ofMARCKS in airway inflammation related to both influx of inflammatory cells into the lung and release of granules containing inflammatory mediators by these cells will be explored. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Listeria monocytogenes Strains Selected on Ciprofloxacin or the Disinfectant Benzalkonium Chloride Exhibit Reduced Susceptibility to Ciprofloxacin, Gentamicin, Benzalkonium Chloride, and Other Toxic Compounds

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 77(24), 8714–8721.

By: M. Rakic-Martinez n, D. Drevets*, V. Dutta n, V. Katic* & S. Kathariou n

MeSH headings : Anti-Bacterial Agents / pharmacology; Benzalkonium Compounds; Biological Transport, Active / genetics; Ciprofloxacin / pharmacology; Culture Media / chemistry; Disinfectants / pharmacology; Drug Resistance, Bacterial; Gentamicins / pharmacology; Listeria monocytogenes / drug effects; Listeria monocytogenes / isolation & purification; Microbial Sensitivity Tests; Mutation
TL;DR: Data suggest that mutations in efflux systems are responsible for the multidrug resistance phenotype of strains selected on ciprofloxacin or BC. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Field Observations of Oviposition by a Specialist Herbivore on Plant Parts and Plant Species Unsuitable as Larval Food

Environmental Entomology, 40(6), 1478–1486.

By: N. Benda n, C. Brownie n, C. Schal n & F. Gould n

author keywords: Heliothis subflexa; Physalis; oviposition mistakes; nonhost oviposition; neonate movement
MeSH headings : Animals; Female; Genetic Fitness; Larva / genetics; Larva / physiology; Moths / genetics; Moths / physiology; Movement; North Carolina; Oviposition; Physalis; Plant Leaves; Seasons
TL;DR: Where a female places her eggs can have a major impact on the fitness of her offspring, especially for insects in which the winged adults are far more mobile than the neonates, and the fitness cost of oviposition on nonhosts may be balanced by fitness benefits of such behavior. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2011 journal article

Evaluation of Normalization Methods on GeLC-MS/MS Label-Free Spectral Counting Data to Correct for Variation during Proteomic Workflows

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 22(12), 2199–2208.

By: E. Gokce n, C. Shuford n, W. Franck n, R. Dean n & D. Muddiman n

author keywords: Label-free; Proteomics; Mass spectrometry; Total spectral count normalization; Normalized spectral abundance factor; Quantification; Spectral counting; Significance test; Fold-change; GeLC-MS/MS; nanoLC-MS; Orbitrap XL
TL;DR: The correlation between SpCs of the same proteins across the different data sets was investigated and it was reported that TSpC normalization and NSAF normalization yielded almost ideal slopes of unity for normalized SpC versus average normalized SpCs, while NSP did not afford effective corrections of the unnormalized data. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Characterization of Canine Osteosarcoma by Array Comparative Genomic Hybridization and RT-qPCR: Signatures of Genomic Imbalance in Canine Osteosarcoma Parallel the Human Counterpart

GENES CHROMOSOMES & CANCER, 50(11), 859–874.

MeSH headings : Animals; Bone Neoplasms / genetics; Bone Neoplasms / veterinary; Comparative Genomic Hybridization; Core Binding Factor Alpha 1 Subunit / genetics; DNA Copy Number Variations; Dog Diseases / genetics; Dogs; Female; Gene Dosage; Genomic Instability; Humans; In Situ Hybridization, Fluorescence; Male; Membrane Proteins / genetics; Osteosarcoma / genetics; Osteosarcoma / veterinary; PTEN Phosphohydrolase / genetics; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Tumor Suppressor Proteins / genetics
TL;DR: Large scale screening of genomic imbalance in canine OS further validates the use of the dog as a suitable model for human cancers, supporting the idea that dysregulation discovered in canine cancers will provide an avenue for complementary study in human counterparts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Cadmium exposure route affects antioxidant responses in the mayfly Centroptilum triangulifer

AQUATIC TOXICOLOGY, 105(3-4), 199–205.

By: L. Xie n & D. Buchwalter n

author keywords: Cadmium; Exposure route; Antioxidant enzymes; Glutathione; Periphyton; Mayfly
MeSH headings : Animals; Antioxidants / metabolism; Cadmium / analysis; Cadmium / toxicity; Catalase / metabolism; Dose-Response Relationship, Drug; Environmental Exposure / adverse effects; Food Contamination; Glutathione Transferase / metabolism; Insecta / chemistry; Insecta / drug effects; Insecta / enzymology; Larva / chemistry; Larva / drug effects; Larva / enzymology; Random Allocation; Superoxide Dismutase / metabolism; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / toxicity
TL;DR: Dietary Cd is potentially more toxic than aqueously derived Cd in this mayfly and the effect of dietary Cd tissue loading rates on antioxidant enzyme suppression is examined and found that absolute tissue load appeared more important than loading rate. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Spectral Accuracy and Sulfur Counting Capabilities of the LTQ-FT-ICR and the LTQ-Orbitrap XL for Small Molecule Analysis

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 22(12), 2269–2275.

author keywords: Electrospray ionization; FT-ICR-MS; Orbitrap-MS; Forensic analysis; Textiles; Trace evidence
MeSH headings : Chi-Square Distribution; Coloring Agents / chemistry; Forensic Sciences; Fourier Analysis; Mass Spectrometry / methods; Polyesters / chemistry; Sensitivity and Specificity; Sulfur / analysis; Textiles / analysis
TL;DR: DY42, a high-volume disperse dye for polyester, was used to compare the capabilities of the LTQ-Orbitrap XL and theLTQ-FT-ICR with respect to mass measurement accuracy (MMA), spectral accuracy, and sulfur counting. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

One-year plasma N-linked glycome intra-individual and inter-individual variability in the chicken model of spontaneous ovarian adenocarcinoma

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 305(2-3), 79–86.

By: R. Dixon n, M. Bereman n, J. Petitte n, A. Hawkridge n & D. Muddiman n

author keywords: N-linked glycans; HILIC; FTMS; Longitudinal sampling
TL;DR: The initial interrogation of longitudinally-procured samples provides evidence that supports the value of this strategy in the search for glycomic biomarkers, and identifies 35 N-linked glycans identified in this study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 book

Genomes of foodborne and waterborne pathogens

By: Y. Pina Fratamico & S. Kathariou*

TL;DR: Genomic and Postgenomic Approaches To Understand the Pathogenesis of the Enteric Protozoan Parasite Entamoeba histolytica Kumiko Nakada-Tsukui and Tomoyoshi Nozaki. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Effect of direct-fed microbials on performance and Clostridium perfringens colonization of turkey poults

POULTRY SCIENCE, 90(11), 2656–2662.

By: S. Rahimi*, S. Kathariou*, J. Grimes n & R. Siletzky*

author keywords: Clostridium; turkey; enteritis; probiotic; direct-fed microbial
MeSH headings : Animals; Carrier State; Clostridium Infections / microbiology; Clostridium Infections / prevention & control; Clostridium Infections / veterinary; Clostridium perfringens; Intestinal Diseases / microbiology; Intestinal Diseases / veterinary; Intestines / microbiology; Probiotics / pharmacology; Turkeys; Weight Gain
TL;DR: Evaluating the effectiveness of a direct-fed microbial (DFM), Primalac, in preventing intestinal colonization of turkey poults with C. perfringens found that among the inoculated groups, birds fed the DFM-supplemented diet had significantly lower cecal C. perfume counts than the birds feeding the diet without the D FM. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Sufficient Dimension Reduction via Bayesian Mixture Modeling

BIOMETRICS, 67(3), 886–895.

By: B. Reich n, H. Bondell n & L. Li n

author keywords: Central subspace; Directional regression; Probit link function; Sliced inverse regression; Sufficient dimension reduction
MeSH headings : Bayes Theorem; Data Interpretation, Statistical; HIV; Humans; Models, Statistical
TL;DR: A Bayesian solution for sufficient dimension reduction is proposed that directly model the response density in terms of the sufficient predictors using a finite mixture model and offers a unified framework to handle categorical predictor, missing predictors, and Bayesian variable selection. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Sexually dimorphic expression of hypothalamic estrogen receptors α and β and kiss1 in neonatal male and female rats

The Journal of Comparative Neurology, 519(15), 2954–2977.

By: J. Cao n & H. Patisaul n

author keywords: development; anteroventral periventricular nucleus (AVPV); medial preoptic area (MPOA); arcuate nucleus (ARC); kisspeptin; sex differences
MeSH headings : Animals; Autoradiography; Estrogen Receptor alpha / genetics; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / genetics; Estrogen Receptor beta / metabolism; Female; Hypothalamus / anatomy & histology; Hypothalamus / metabolism; Kisspeptins / genetics; Kisspeptins / metabolism; Male; Neurons / cytology; Neurons / metabolism; Pregnancy; Rats; Sex Characteristics; Signal Transduction / physiology
TL;DR: Detailed profiles of neonatal Kiss1 and ERs mRNA levels will help elucidate the relative roles each plays in the sex‐specific, estrogen‐dependent organization of gonadotropin signaling pathways and provide evidence that Kiss1 may play a role in the sexual dimorphic organization of the neonatal brain. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2011 journal article

Expression Strategy of Densonucleosis Virus from the German Cockroach, Blattella germanica

Journal of Virology, 85(22), 11855–11870.

By: T. Kapelinskaya*, E. Martynova*, C. Schal n & D. Mukha

MeSH headings : Animals; Cockroaches / virology; Densovirus / growth & development; Densovirus / physiology; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation, Viral; Mass Spectrometry; Molecular Weight; Protein Biosynthesis; RNA Splicing; RNA, Messenger / metabolism; RNA, Viral / metabolism; Transcription, Genetic; Viral Proteins / biosynthesis; Viral Proteins / chemistry
TL;DR: BgDNV is characterized by two additional NS transcripts overlapping by more than 1,650 nt with VP-coding transcripts, which reveal an uneven pattern of NS1 expression resembling a halo within the nuclear membrane. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2011 journal article

DNA methylation profiling in nanochannels

Biomicrofluidics, 5(3).

By: S. Lim, A. Karpusenko, J. Sakon, J. Hook, T. Lamar & R. Riehn

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Two Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Paralogs are Required for Normal Development in Zebrafish

The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 294(9), 1511–1524.

By: L. Ott n, Z. Mcdowell n, P. Turner n, J. Law n, K. Adler n, J. Yoder n, S. Jones n

author keywords: MARCKS; zebrafish; development
MeSH headings : Amino Acid Sequence; Animals; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / metabolism; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / genetics; Membrane Proteins / metabolism; Molecular Sequence Data; Morpholinos / pharmacology; Multigene Family; Myristoylated Alanine-Rich C Kinase Substrate; Phenotype; Phylogeny; Sequence Homology, Amino Acid; Zebrafish / genetics; Zebrafish / growth & development
TL;DR: It is demonstrated that Marcksa and Marcksb are required for normal zebrafish development and suggested that zebra fish are a suitable model to further study MARCKS function. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2011 journal article

Transformation kinetics of biochemically active compounds in low-pressure UV Photolysis and UV/H2O2 advanced oxidation processes

WATER RESEARCH, 45(15), 4531–4543.

By: C. Baeza* & D. Knappe n

Contributors: C. Baeza* & D. Knappe n

author keywords: Antibiotics; Endocrine disrupting chemicals; Pharmaceuticals; Photooxidation; Quantum yield
MeSH headings : Diclofenac / chemistry; Hydrogen Peroxide / chemistry; Hydrogen-Ion Concentration; Hydroxyl Radical / chemistry; Kinetics; North Carolina; Oxidation-Reduction; Photolysis; Trimethoprim / chemistry; Ultraviolet Rays; Water Pollutants, Chemical / chemistry; Water Purification / methods; Water Supply / standards
TL;DR: Quantum yields and second order rate constants describing the reaction between the hydroxyl radical and BACs were determined and used together with background water quality data to predict fluence-based BAC transformation rate constants (k'). (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Studying Gene and Gene-Environment Effects of Uncommon and Common Variants on Continuous Traits: A Marker-Set Approach Using Gene-Trait Similarity Regression

AMERICAN JOURNAL OF HUMAN GENETICS, 89(2), 277–288.

MeSH headings : Chromosomes, Human, Pair 21 / genetics; Computer Simulation; Databases, Genetic; Environment; Genes / genetics; Genetic Markers; Humans; Models, Genetic; Mutation / genetics; Quantitative Trait, Heritable; Regression Analysis
TL;DR: A similarity-based regression method for assessing the main genetic and interaction effects of a group of markers on quantitative traits and is an ideal tool for evaluating associations between phenotype and marker sets defined by linkage disequilibrium blocks, genes, or pathways in whole-genome analysis. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Stable-Isotope Labeled Hydrophobic Hydrazide Reagents for the Relative Quantification of N-Linked Glycans by Electrospray Ionization Mass Spectrometry

ANALYTICAL CHEMISTRY, 83(17), 6738–6745.

MeSH headings : Carbon Isotopes / chemistry; Glycopeptides / analysis; Glycosylation; Hydrazones / chemistry; Hydrophobic and Hydrophilic Interactions; Isotope Labeling; Polysaccharides / analysis; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR: It is shown that these reagents are capable of quantifying changes in glycosylation in simple mixtures, and the analytical variability of the reagents in pooled plasma samples is shown to be less than ±30%. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 review

PULMONARY ENDPOINTS (LUNG CARCINOMAS AND ASBESTOSIS) FOLLOWING INHALATION EXPOSURE TO ASBESTOS

[Review of ]. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS, 14(1-4), 76–121.

By: B. Mossman*, M. Lippmann*, T. Hesterberg*, K. Kelsey*, A. Barchowsky* & J. Bonner n

MeSH headings : Animals; Asbestos / administration & dosage; Asbestos / chemistry; Asbestos / pharmacokinetics; Asbestos / toxicity; Asbestosis / metabolism; Biological Transport; Body Burden; Carcinogens, Environmental / administration & dosage; Carcinogens, Environmental / chemistry; Carcinogens, Environmental / pharmacokinetics; Carcinogens, Environmental / toxicity; Carcinoma / chemically induced; Carcinoma / genetics; Carcinoma / metabolism; Chemical Phenomena; Humans; Inhalation Exposure / adverse effects; Lung / drug effects; Lung / metabolism; Lung Neoplasms / chemically induced; Lung Neoplasms / genetics; Lung Neoplasms / metabolism; Mineral Fibers / analysis; Mineral Fibers / toxicity; Mutagens / administration & dosage; Mutagens / chemistry; Mutagens / pharmacokinetics; Mutagens / toxicity; Particulate Matter / administration & dosage; Particulate Matter / chemistry; Particulate Matter / pharmacokinetics; Particulate Matter / toxicity; Tissue Distribution
Source: Web Of Science
Added: August 6, 2018

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