Works Published in 2011
Displaying works 101 - 120 of 124 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 508(1), 31–38.
author keywords: Apoptosis; Caspase activation; Enzyme activity; Protein folding and assembly
MeSH headings : Caspase 3 / chemistry; Caspase 3 / genetics; Caspase 3 / metabolism; Catalytic Domain; Crystallography, X-Ray; Enzyme Stability; Hydrogen Bonding; Models, Molecular; Mutation; Protein Folding; Static Electricity; Structure-Activity Relationship; Thermodynamics
TL;DR:
Results suggest E246 and K242 are important in procaspase-3 for their interaction with neighboring residues, not with one another, and formation of the K242-E246 salt bridge in caspases3 is needed for an accurate, stable conformation of loop L4 and proper active site formation in the mature enzyme.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 4623–4630.
author keywords: antiinflammatory; lactobacilli; Toll-like receptor 2; innate immunity
MeSH headings : Animals; Autoimmunity / immunology; CD4-Positive T-Lymphocytes / immunology; Colitis / chemically induced; Colitis / immunology; Colitis / microbiology; DNA Primers / genetics; Dextran Sulfate / toxicity; Flow Cytometry; Fluorescent Antibody Technique; Gene Deletion; Gene Expression Regulation / immunology; Homeodomain Proteins / genetics; Interleukin-10 / genetics; Lactobacillus acidophilus / metabolism; Lipopolysaccharides / deficiency; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88 / genetics; Polymerase Chain Reaction; Teichoic Acids; Transferases (Other Substituted Phosphate Groups) / genetics
TL;DR:
Directed alteration of cell surface components of L. acidophilus NCFM establishes a potential strategy for the treatment of inflammatory intestinal disorders and significantly mitigated dextran sulfate sodium and CD4+CD45RBhighT cell-induced colitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Leaf-level gas-exchange uniformity and photosynthetic capacity among loblolly pine (Pinus taeda L.) genotypes of contrasting inherent genetic variation
TREE PHYSIOLOGY, 31(1), 78–91.
author keywords: gas exchange; genetic variation; photosynthesis; productivity; water use
MeSH headings : Adaptation, Physiological; Biological Transport; Biomass; Carbon / metabolism; Carbon Dioxide / metabolism; Ecosystem; Genetic Variation / genetics; Genetic Variation / physiology; Genotype; Light; Models, Biological; North Carolina; Phenotype; Photosynthesis / physiology; Photosynthesis / radiation effects; Pinus taeda / genetics; Pinus taeda / growth & development; Pinus taeda / physiology; Pinus taeda / radiation effects; Plant Leaves / genetics; Plant Leaves / growth & development; Plant Leaves / physiology; Plant Leaves / radiation effects; Plant Stomata / physiology; Plant Stomata / radiation effects; Plant Transpiration / physiology; Plant Transpiration / radiation effects; Seasons; Seedlings / genetics; Seedlings / growth & development; Seedlings / physiology; Seedlings / radiation effects; Trees / physiology; Water / metabolism
TL;DR:
It is suggested that uniformity in leaf-level physiological rates is not consistently related to the amount of genetic variation within a given genotype, and δ, A(sat) and R(d) were the leaf- level physiological parameters that were most consistentlyrelated to individual-tree and genotype productivity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Incorporation of secretory immunoglobulin A into biofilms can decrease their resistance to ciprofloxacin
MICROBIOLOGY AND IMMUNOLOGY, 55(3), 174–183.
author keywords: antibiotic; ciprofloxacin; Escherichia coli; host-supported biofilms
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Ciprofloxacin / pharmacology; Culture Media / chemistry; Drug Resistance, Bacterial / drug effects; Drug Resistance, Bacterial / immunology; Escherichia coli / drug effects; Escherichia coli / physiology; Humans; Immunoglobulin A, Secretory / pharmacology; Mice; Milk / immunology
TL;DR:
It is suggested that incorporation of host‐derived molecules into the extracellular matrix of symbiotic biofilms might profoundly alter the properties of thoseBiofilms, including the resistance of those bioFilms to antibiotics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
High-Confidence Discovery of Genetic Network Regulators in Expression Quantitative Trait Loci Data
GENETICS, 187(3), 955–964.
MeSH headings : Algorithms; Bayes Theorem; Chromosome Mapping; Computational Biology; Computer Simulation; Gene Expression Profiling / statistics & numerical data; Gene Regulatory Networks; Genes, Regulator / genetics; Genetic Markers / genetics; Models, Genetic; Quantitative Trait Loci / genetics; Saccharomyces cerevisiae / genetics
TL;DR:
This work introduces the concept of “shielding” in which a specific gene expression variable (the shielder) renders a set of other gene expression variables (the shielded genes) independent of the eQTL, and proposes a novel test for controlling the shielder false-positive rate at a predetermined level by requiring a threshold number of shielded genes per shielder.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
BCR-ABL translocation in a dog with chronic monocytic leukemia
VETERINARY CLINICAL PATHOLOGY, 40(1), 40–47.
author keywords: FISH; flow cytometry; monocytosis; myeloproliferative disorder
MeSH headings : Animals; Bone Marrow Cells / pathology; Dog Diseases / diagnosis; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Flow Cytometry / veterinary; Leukemia, Myeloid / diagnosis; Leukemia, Myeloid / genetics; Leukemia, Myeloid / pathology; Leukemia, Myeloid / veterinary; Translocation, Genetic / genetics
TL;DR:
Clinical and laboratory findings and the protracted course supported a diagnosis of chronic monocytic leukemia (CMoL), the first case of CMoL with a BCR-ABL chromosomal abnormalitiy described in dogs, and may have clinical implications for treatment of dogs with chronic leukemias associated with particular genetic mutations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
The Red clover necrotic mosaic virus Capsid as a Multifunctional Cell Targeting Plant Viral Nanoparticle
BIOCONJUGATE CHEMISTRY, 22(1), 67–73.
MeSH headings : Amino Acid Sequence; Biological Availability; Biological Transport; Capsid / chemistry; Capsid / metabolism; Doxorubicin / chemistry; Doxorubicin / pharmacokinetics; Fluorescent Dyes / chemistry; HeLa Cells; Humans; Models, Molecular; Nanoparticles / chemistry; Peptides / chemistry; Peptides / metabolism; Plants / virology; Protein Conformation; Surface Properties; Tombusviridae
TL;DR:
It is shown that targeting peptides (less than 16 amino acids) can be conjugated to the capsid using the heterobifunctional chemical linker sulfosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (Sulfo-SMCC).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Structural characteristics that make chlorophylls green: interplay of hydrocarbon skeleton and substituents
NEW JOURNAL OF CHEMISTRY, 35(1), 76–88.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Natural variation in expression of genes involved in xylem development in loblolly pine (Pinus taeda L.)
TREE GENETICS & GENOMES, 7(1), 193–206.
author keywords: Gene expression; Natural variation; Pinus taeda L; Xylem
TL;DR:
Genes encoding lignin biosynthetic enzymes and arabinogalactan proteins were more variable than those encoding cellulose synthases or those involved in signal transduction, and transcription factors that may be key regulators of xylem development in pine were identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
FLT3 mutations in canine acute lymphocytic leukemia
BMC CANCER, 11.
MeSH headings : Amino Acid Sequence; Animals; Blotting, Western; Carbazoles / pharmacology; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; DNA Mutational Analysis; DNA, Neoplasm / chemistry; DNA, Neoplasm / genetics; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases / metabolism; Furans; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Molecular Sequence Data; Mutation; Phosphorylation / drug effects; Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism; Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology; Reverse Transcriptase Polymerase Chain Reaction; STAT5 Transcription Factor / metabolism; fms-Like Tyrosine Kinase 3 / antagonists & inhibitors; fms-Like Tyrosine Kinase 3 / genetics; fms-Like Tyrosine Kinase 3 / metabolism
TL;DR:
Results show that ALL andFLT3 biology is conserved between canine and human patients, supporting the notion that canine ALL, in conjunction with the GL-1 cell line, will be useful in the development of a relevant large animal model to aid in the study of human FLT3 mutant leukemias.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 article
Computational and phylogenetic validation of nematode horizontal gene transfer
Scholl, E. H., & Bird, D. M. K. (2011, February 22). BMC BIOLOGY, Vol. 9.
MeSH headings : Animals; Cellulase / genetics; Evolution, Molecular; Gene Transfer, Horizontal; Genes, Helminth; Molecular Sequence Data; Nematoda / classification; Nematoda / genetics; Phylogeny
TL;DR:
A detailed phylogenetic analysis of cellulase genes in the free-living nematode Pristionchus pacificus at the species, genus and family levels substantiates the hypothesis that such transfer has been a driving force in the evolution of niche specificity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Abiotic formation of uroporphyrinogen and coproporphyrinogen from acyclic reactants
NEW JOURNAL OF CHEMISTRY, 35(1), 65–75.
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
A genomic map enriched for markers linked to Avr1 in Cronartium quercuum f.sp. fusiforme
FUNGAL GENETICS AND BIOLOGY, 48(3), 266–274.
author keywords: AFLP; Avirulence gene; Cronartium quercuum f.sp fusiforme; Fusiform rust; Linkage map; RAPD; Gene-for-gene interaction
MeSH headings : Basidiomycota / genetics; Basidiomycota / isolation & purification; Basidiomycota / pathogenicity; Chromosome Mapping; Crosses, Genetic; Genes, Fungal; Genome, Fungal; Pinus taeda / microbiology; Virulence
TL;DR:
A novel approach is presented to map avirulence gene Avr1 in the basidiomycete Cronartium quercuum f.sp.fusiforme, the causal agent of fusiform rust disease in pines using DNA markers tightly linked to resistance gene Fr1 in loblolly pine tree 10-5.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Role of the Vacuolar-ATPase in Sindbis Virus Infection
JOURNAL OF VIROLOGY, 85(3), 1257–1266.
MeSH headings : Animals; Cells, Cultured; Cricetinae; Enzyme Inhibitors / metabolism; Host-Pathogen Interactions; Macrolides / metabolism; Sindbis Virus / physiology; Vacuolar Proton-Translocating ATPases / metabolism; Virus Internalization; Virus Replication
TL;DR:
The results suggest that in BHK cells in the presence of bafilomycin A1, virus RNA enters the cell and is translated, but replication and proper folding of the product proteins requires the function of the V-ATPase.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Population Genetic Analysis of Tomato spotted wilt virus on Peanut in North Carolina and Virginia
PHYTOPATHOLOGY, 101(1), 147–153.
author keywords: population diversity
MeSH headings : Arachis / virology; Genetic Variation; Haplotypes; North Carolina; Plant Diseases / virology; RNA, Viral; Tospovirus / genetics; Virginia
TL;DR:
Estimates of the population mutation rate suggest that mutation has had a significant effect on the shaping of this population and, together with purifying selection, these forces have been the predominant evolutionary forces influencing the TSWV population in peanut in North Carolina and Virginia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Glycine and a Glycine Dehydrogenase (GLDC) SNP as Citalopram/Escitalopram Response Biomarkers in Depression: Pharmacometabolomics-Informed Pharmacogenomics
CLINICAL PHARMACOLOGY & THERAPEUTICS, 89(1), 97–104.
MeSH headings : Biomarkers, Pharmacological / blood; Cell Line; Chromosomes, Human, Pair 9 / genetics; Citalopram / therapeutic use; DNA-Binding Proteins / metabolism; Depressive Disorder, Major / blood; Depressive Disorder, Major / drug therapy; Depressive Disorder, Major / genetics; Drug Monitoring / methods; Female; Genetic Association Studies; Glycine / blood; Glycine / metabolism; Glycine Dehydrogenase (Decarboxylating) / genetics; Humans; Introns / genetics; Linkage Disequilibrium; Male; Metabolome / drug effects; Nuclear Proteins / metabolism; Polymorphism, Single Nucleotide; Selective Serotonin Reuptake Inhibitors / therapeutic use
TL;DR:
A possible role for glycine in SSRI response is highlighted and the use of pharmacometabolomics‐informed pharmacogenomic research strategy to identify citalopram/escitaloprams treatment outcome biomarkers is illustrated to “inform” pharmacogenomics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Functional Analysis of a Novel Motif Conserved across Geminivirus Rep Proteins
JOURNAL OF VIROLOGY, 85(3), 1182–1192.
MeSH headings : Amino Acid Motifs; Amino Acid Sequence; Conserved Sequence; DNA Helicases / genetics; DNA Helicases / metabolism; DNA, Viral / metabolism; Geminiviridae / enzymology; Geminiviridae / genetics; Geminiviridae / physiology; Molecular Sequence Data; Mutation, Missense; Plant Diseases / virology; Protein Binding; Sequence Alignment; Tobacco / virology; Trans-Activators / genetics; Trans-Activators / metabolism; Viral Proteins / genetics; Viral Proteins / metabolism; Virulence; Virus Replication
TL;DR:
It is established that the GRS is a conserved, essential motif characteristic of an ancient lineage of rolling-circle initiators and support the idea that geminiviruses may have evolved from plasmids associated with phytoplasma or algae.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(OpenAlex)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Fatal Aortic Endocarditis Associated with Community-Acquired Serratia marcescens Infection in a Dog
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 47(2), 133–137.
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Community-Acquired Infections / diagnosis; Community-Acquired Infections / drug therapy; Community-Acquired Infections / veterinary; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dogs; Endocarditis, Bacterial / diagnosis; Endocarditis, Bacterial / drug therapy; Endocarditis, Bacterial / veterinary; Fatal Outcome; Male; Serratia Infections / diagnosis; Serratia Infections / drug therapy; Serratia Infections / veterinary; Serratia marcescens
TL;DR:
A 12 yr old Dalmatian was referred for evaluation of acute lethargy, fever, neurologic signs, and a recently ausculted heart murmur and found to have nonhospital-acquired Serratia marcescens bacteremia and aortic valve endocarditis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Autocrine Effects of Interleukin-6 Mediate Acute-Phase Proinflammatory and Tissue-Reparative Transcriptional Responses of Canine Bladder Mucosa
INFECTION AND IMMUNITY, 79(2), 708–715.
MeSH headings : Acute-Phase Reaction / metabolism; Animals; Dogs; Humans; Interleukin-6 / metabolism; Mucous Membrane / metabolism; Mucous Membrane / microbiology; Signal Transduction; Tissue Culture Techniques; Urinary Bladder / metabolism; Urinary Bladder / microbiology; Uropathogenic Escherichia coli; Urothelium / metabolism
TL;DR:
It is demonstrated that uropathogenic Escherichia coli infection stimulates the synthesis of IL-6 by all urothelial cell layers, with the u rothelial cells alone representing the only site of unequivocal IL- 6 receptor expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Tapping the near-infrared spectral region with bacteriochlorin arrays
NEW JOURNAL OF CHEMISTRY, 35(3), 511–516.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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