Center for Human Health and the Environment

Works Published in 2018

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Displaying works 161 - 180 of 302 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2018 journal article

SENSITIVITY ANALYSIS FOR UNMEASURED CONFOUNDING IN COARSE STRUCTURAL NESTED MEAN MODELS

STATISTICA SINICA, 28(4), 1703–1723.

By: S. Yang n & J. Lok*

author keywords: Censoring; confounding by indication; estimating equations; HIV/AIDS research; non-ignorable; sequential randomization
TL;DR: This work investigates the sensitivity of G-estimators of coarse SNMMs to unmeasured confounding, and applies this to a sensitivity analysis for the effect of the ART initiation time on the mean CD4 count at year 2 after infection in HIV-positive patients, based on the prospective Acute and Early Disease Research Program. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: December 3, 2018

2018 journal article

Diazotrophs and N-2-Fixation Associated With Particles in Coastal Estuarine Waters

FRONTIERS IN MICROBIOLOGY, 9.

By: J. Pedersen*, D. Bombar*, R. Paerl* & L. Riemann*

author keywords: diazotrophs; nitrogen fixation; marine particles; nifH; estuary
TL;DR: It is indicated that resuspension of sediment material can elevate pelagic N2-fixation, and it is shown that diverse natural diazotrophs can colonize artificial surfaces, but colonization by “pioneer” bacterioplankton that more rapidly associate with surfaces appears to be a prerequisite. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 3, 2018

2018 journal article

IR-MALDESI mass spectrometry imaging of underivatized neurotransmitters in brain tissue of rats exposed to tetrabromobisphenol A

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410(30), 7979–7986.

By: M. Bagley n, M. Ekelof n, K. Rock n, H. Patisaul n & D. Muddiman n

author keywords: IR-MALDESI; Neurotransmitters; Mass spectrometry imaging; Exposomics; Orbitrap
MeSH headings : Animals; Brain; Female; Infrared Rays; Neurotransmitter Agents / chemistry; Polybrominated Biphenyls / toxicity; Rats; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: This study serves as a demonstration of a new application of IR-MALDESI, namely that neurotransmitter distributions can be confidently and rapidly imaged without derivatization, and is used for the analysis of neurotransmitters in the brains of rats exposed to TBBPA in gestation and lactation through their mothers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 3, 2018

2018 review

Sex differences and the effects of estradiol on striatal function

[Review of ]. CURRENT OPINION IN BEHAVIORAL SCIENCES, 23, 42–48.

TL;DR: A brief review of the recent literature reporting on sex differences and effects of the estrogenic hormone 17β-estradiol on behavioral and neural function across all three striatal regions, focusing upon the most prominent striatal neuron type, the medium spiny neuron. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 26, 2018

2018 journal article

Avian response to shade-layer restoration in coffee plantations in Puerto Rico

RESTORATION ECOLOGY, 26(6), 1212–1220.

By: A. Irizarry n, J. Collazo n, K. Pacifici n, B. Reich n & K. Battle n

author keywords: avifauna; coffee cultivation; ecosystem services; local persistence; occupancy; shade restoration
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 26, 2018

2018 journal article

A pilot study documenting increased thrombin generation following abrupt withdrawal of heparin therapy in healthy dogs

Journal of Veterinary Emergency and Critical Care, 28(6), 518–526.

By: E. Mays n, D. Dorman n, C. McKendry n & R. Hanel n

author keywords: hypercoagulable; rebound; thromboelastography
MeSH headings : Animals; Anticoagulants / administration & dosage; Anticoagulants / pharmacology; Dogs; Heparin / administration & dosage; Heparin / pharmacology; Infusions, Intravenous / veterinary; Male; Pilot Projects; Prospective Studies; Thrombelastography / veterinary; Thrombin / biosynthesis; Thrombin / drug effects
TL;DR: Results suggest that a transient increase in thrombin generation developed 12 hours after withdrawal of UFH therapy, which is similar to that seen in healthy dogs following abrupt cessation of unfractionated heparin (UFH) therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: November 26, 2018

2018 journal article

Prevalent reliance of bacterioplankton on exogenous vitamin B1 and precursor availability

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(44), E10447–E10456.

author keywords: vitamin B1; thiamin; bacterioplankton; metagenomics; growth limitation
MeSH headings : Bacteria / genetics; Bacteria / metabolism; Fresh Water; Gene Expression Regulation, Bacterial; Genome, Bacterial; Genomics / methods; Genotype; Plankton; Seawater; Thiamine / metabolism; Transcriptome
TL;DR: It is shown that B1 auxotrophy, the need for exogenous B1 or precursors for survival, is widespread among wild bacterioplankton, and a hitherto overlooked influence of B1/precursor availability on aquatic biochemical cycling is suggested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 19, 2018

2018 journal article

Machine Learning Reveals Protein Signatures in CSF and Plasma Fluids of Clinical Value for ALS

SCIENTIFIC REPORTS, 8(1).

By: M. Bereman n, J. Beri n, J. Enders n & T. Nash n

Contributors: M. Bereman n, J. Beri n, J. Enders n & T. Nash n

MeSH headings : Amyotrophic Lateral Sclerosis / blood; Amyotrophic Lateral Sclerosis / cerebrospinal fluid; Amyotrophic Lateral Sclerosis / metabolism; Humans; Machine Learning; Multivariate Analysis; Proteomics
TL;DR: The potential of a panel of targeted proteins for objective measurements of clinical value in ALS is demonstrated, and three proteins composed a prognostic model that explained 49% of the variation in the ALS-FRS scores. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 19, 2018

2018 journal article

SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh

NATURE COMMUNICATIONS, 9.

MeSH headings : Animals; CRISPR-Cas Systems / genetics; CRISPR-Cas Systems / physiology; Endometrium / metabolism; Female; GATA2 Transcription Factor / genetics; GATA2 Transcription Factor / metabolism; HMGB Proteins / genetics; HMGB Proteins / metabolism; Hedgehog Proteins / genetics; Hedgehog Proteins / metabolism; Hepatocyte Nuclear Factor 3-beta / genetics; Hepatocyte Nuclear Factor 3-beta / metabolism; Leukemia Inhibitory Factor / genetics; Leukemia Inhibitory Factor / metabolism; Mice; SOXF Transcription Factors / genetics; SOXF Transcription Factors / metabolism; Transcriptome / genetics; Uterus / metabolism
TL;DR: The authors show that SOX17 is upstream of Indian hedgehog to regulate mouse uterine receptivity, and their analysis of uterine tissue from endometriosis patients suggests the same function in humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 5, 2018

2018 journal article

Estrous cycle-induced sex differences in medium spiny neuron excitatory synaptic transmission and intrinsic excitability in adult rat nucleus accumbens core

JOURNAL OF NEUROPHYSIOLOGY, 120(3), 1356–1373.

By: S. Proano n, H. Morris n, L. Kunz n, D. Dorris n & J. Meitzen n

author keywords: estrous cycle; excitability; medium spiny neurons; nucleus accumbens; sex steroid hormones
MeSH headings : Action Potentials; Animals; Castration; Estrous Cycle; Excitatory Postsynaptic Potentials; Female; Male; Neurons / physiology; Nucleus Accumbens / physiology; Rats, Sprague-Dawley; Sex Characteristics
TL;DR: It is the first demonstration that medium spiny neuron electrophysiological properties change across adult female hormone cycle phases in any striatal region and indicates that adultFemale hormone cycles are an important factor for neurophysiology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 5, 2018

2018 journal article

Palmitoylation of caveolin-1 is regulated by the same DHHC acyltransferases that modify steroid hormone receptors

JOURNAL OF BIOLOGICAL CHEMISTRY, 293(41), 15901–15911.

By: K. Eisinger*, K. Woolfrey*, S. Swanson*, S. Schnell*, J. Meitzen n, M. Dell'Acqua*, P. Mermelstein*

author keywords: estrogen receptor; post-translational modification (PTM); protein palmitoylation; caveolin; membrane protein; DHHC
MeSH headings : Acetyltransferases; Acyltransferases / genetics; Acyltransferases / metabolism; Animals; Caveolin 1 / metabolism; Cyclic AMP Response Element-Binding Protein / metabolism; Female; Gene Knockdown Techniques; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / metabolism; Lipoylation; Protein Processing, Post-Translational; Rats, Sprague-Dawley
TL;DR: Findings provide additional information about the overall influence of palmitoylation on the membrane-initiated estrogen signaling pathway and highlight the importance of considering the influence ofPalmitoylated proteins on other CAV1-dependent processes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: October 29, 2018

2018 journal article

C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event

Cell Death & Disease, 9(11).

By: Z. Messenger*, J. Hall*, D. Jima*, J. House*, H. Tam, D. Tokarz*, R. Smart*

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / administration & dosage; Animals; Apoptosis / drug effects; Apoptosis / genetics; CCAAT-Enhancer-Binding Protein-beta / deficiency; CCAAT-Enhancer-Binding Protein-beta / genetics; Cell Differentiation; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Gene Expression Regulation, Neoplastic; Genes, Lethal; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Mice; Mice, Knockout; Receptors, Death Domain / genetics; Receptors, Death Domain / metabolism; Signal Transduction; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / genetics; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate / administration & dosage; Tetradecanoylphorbol Acetate / analogs & derivatives; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism; ras Proteins / genetics; ras Proteins / metabolism
TL;DR: The results show that oncogenic Ras tumors display a significant DNA damage/replicative stress phenotype and these tumors have acquired a dependence on C/EBPβ for their survival, making it a promising target for future potential anticancer therapies. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: October 29, 2018

2018 journal article

The GEOTRACES Intermediate Data Product 2017

CHEMICAL GEOLOGY, 493, 210–223.

By: R. Schlitzer*, R. Anderson*, E. Dodas*, M. Lohan*, W. Geibere, A. Tagliabue*, A. Bowie*, C. Jeandel* ...

author keywords: GEOTRACES; Trace elements; Isotopes; Electronic atlas; IDP2017
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 19, 2018

2018 review

Enhancing and Extending Biological Performance and Resilience

[Review of ]. DOSE-RESPONSE, 16(3).

By: R. Leak*, E. Calabrese*, W. Kozumbo*, J. Gidday*, T. Johnson*, J. Mitchell*, C. Ozaki*, R. Wetzker* ...

author keywords: preconditioning; conditioning; adaptation; hormesis; stress; tolerance; biphasic; dose-response; U-shaped; J-shaped; fitness; endurance; epigenetics; dietary restriction; caloric restriction
TL;DR: A path forward is proposed for researchers hoping to optimize protocols that support human health and longevity, whether in civilians, soldiers, athletes, or the elderly patients, by recommending approaches to control and exploit endogenous defense mechanisms to enhance the structure and function of biological tissues. (via Semantic Scholar)
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Relationship Between Sequence Homology, Genome Architecture, and Meiotic Behavior of the Sex Chromosomes in North American Voles

GENETICS, 210(1), 83–97.

By: B. Dumont n, C. Williams n, B. Ng*, V. Horncastle*, C. Chambers*, L. McGraw n, D. Adams*, T. Mackay n, M. Breen n

author keywords: pseudoautosomal region; Microtus heterochromatin; telomeric repeats; meiotic synapsis
MeSH headings : Animals; Arvicolinae / genetics; Chromosome Segregation / genetics; Genomics / methods; Meiosis / genetics; North America; Pseudoautosomal Regions / genetics; Sequence Analysis, DNA / methods; Sequence Homology, Nucleic Acid; Sex Chromosomes / genetics; Telomere / genetics; Telomere-Binding Proteins / genetics; X Chromosome / genetics; Y Chromosome / genetics
TL;DR: Key conditions required to sustain the standard program of X/Y synapsis at meiosis are suggested and an intriguing connection between heterochromatic repeat architecture and noncanonical, asynaptic mechanisms of sex chromosome segregation in voles is revealed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: October 19, 2018

2018 journal article

MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network

SCIENTIFIC REPORTS, 8.

By: J. Brudvig*, J. Cain*, R. Sears*, G. Schmidt-Grimminger*, E. Wittchen*, K. Adler n, H. Ghashghaei n, J. Weimer*

MeSH headings : Actins / metabolism; Animals; Cytoskeleton / metabolism; Female; Male; Mice; Mice, Inbred C57BL; Microtubules / metabolism; Myristoylated Alanine-Rich C Kinase Substrate / metabolism; Neurites / metabolism; Neurons / cytology; Neurons / metabolism; Phosphorylation; Primary Cell Culture; Protein Binding; Pseudopodia / metabolism; Signal Transduction; cdc42 GTP-Binding Protein / metabolism
TL;DR: It is proposed that MARCKS is uniquely positioned to regulate CDC42 localization and interactions within specialized cellular compartments, such as nascent neurites. (via Semantic Scholar)
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Leptin Stimulates Cellular Glycolysis Through a STAT3 Dependent Mechanism in Tilapia

FRONTIERS IN ENDOCRINOLOGY, 9.

By: J. Douros n, D. Baltzegar n, B. Reading n, A. Seale*, D. Lerner*, E. Grau*, R. Borski n

author keywords: leptin; prolactin cell; hepatocytes; pituitary; RNAseq; fishes; phosphofructokinase-1
TL;DR: It is suggested that one of leptin's ancient, highly-conserved functions among vertebrates may be stimulation of glycolysis to facilitate the energetic needs associated with various stressors in a teleost fish. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Qualitative and quantitative analysis of chemicals emitted from the pheromone gland of individual Heliothis subflexa females

PLOS ONE, 13(8), e0202035.

Ed(s): J. Hull

MeSH headings : Animals; Female; Gas Chromatography-Mass Spectrometry; Moths / chemistry; Moths / metabolism; Reproducibility of Results; Scent Glands / chemistry; Scent Glands / metabolism; Sex Attractants / chemistry; Sex Attractants / metabolism; Volatile Organic Compounds / chemistry; Volatile Organic Compounds / metabolism
TL;DR: The chemicals emitted from the sex pheromone gland of individual Heliothis subflexa females were sampled using a short section of thick-film megabore fused silica capillary column, and the phersomone glands of the same females were extracted after the effluvia collection. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 19, 2018

2018 journal article

Changes in the Peripheral Chemosensory System Drive Adaptive Shifts in Food Preferences in Insects

Frontiers in Cellular Neuroscience, 12.

By: A. Wada-Katsumata n, H. Robertson*, J. Silverman n & C. Schal n

author keywords: chemoreception; gustation; sensilla; nutrient sensing; glucose-aversion
TL;DR: The peripheral gustatory neural mechanisms of glucose-aversion are reviewed and how the rapid emergence of taste polymorphisms can impede pest control efforts and affect foraging and mate-choice in adapted cockroach populations are discussed. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: October 19, 2018

2018 journal article

Proximity to Other Commercial Turkey Farms Affects Colonization Onset, Genotypes, and Antimicrobial Resistance Profiles of Campylobacter spp. in Turkeys: Suggestive Evidence from a Paired-Farm Model

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 84(18).

By: J. Niedermeyer n, L. Ring n, W. Miller*, S. Genger n, C. Lindsey n, J. Osborne n, S. Kathariou n

author keywords: Campylobacter; antimicrobial resistance; colonization; genotype; turkey
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Campylobacter / drug effects; Campylobacter / genetics; Campylobacter / growth & development; Campylobacter / isolation & purification; Campylobacter Infections / economics; Campylobacter Infections / microbiology; Campylobacter Infections / veterinary; Drug Resistance, Bacterial; Farms / economics; Genotype; Models, Biological; Multilocus Sequence Typing; North Carolina; Poultry Diseases / economics; Poultry Diseases / microbiology; Turkeys / microbiology
TL;DR: A paired-farm design was used to concurrently investigate Campylobacter colonization and strain types in two turkey breeds at two farms in eastern North Carolina, highlighting the need to further characterize the impact of farm-specific factors and host genetics on antimicrobial resistance and genotypes of C. jejuni and C. coli that colonize turkeys. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 19, 2018

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