Works Published in 2008
Displaying works 321 - 340 of 637 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2008 journal article
Crop Immune Response Post-Salmonella Enteritidis Challenge in Eight Commercial Egg-Layer Strains and Specific-Pathogen-Free White Leghorn Chickens
AVIAN DISEASES, 52(1), 79–87.
author keywords: Salmonella Enteritidis; chicken; crop; ingluvies; mucosal immune system; gut-associated lymphoid tissue; IgA; enzyme-linked immunosorbent assay
MeSH headings : Animals; Chickens / genetics; Chickens / immunology; Chickens / microbiology; Crop, Avian / anatomy & histology; Crop, Avian / immunology; Crop, Avian / microbiology; Female; Genetic Predisposition to Disease; Immunoglobulin A / metabolism; Lymphoid Tissue / immunology; Oviposition; Salmonella Infections, Animal / genetics; Salmonella Infections, Animal / microbiology; Salmonella enteritidis / immunology; Specific Pathogen-Free Organisms; Time Factors
TL;DR:
Crop SE-LPS-specific IgA response remained elevated above day 0 baseline for the duration of the experiment and well-defined score 3 to 5 lymphoid tissue aggregates were observed in crop tissue sections harvested at day 34 PI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Coxiella-Like Infection in Psittacines and a Toucan
Avian Diseases, 52(3), 426–432.
author keywords: avian; psittacines; toucan; hepatitis; splenitis; Coxiella
MeSH headings : Animals; Base Sequence; Bird Diseases / microbiology; Bird Diseases / pathology; Coxiella / genetics; DNA Primers / genetics; Fatal Outcome; Gram-Negative Bacterial Infections / pathology; Gram-Negative Bacterial Infections / veterinary; Immunohistochemistry; Liver / ultrastructure; Microscopy, Electron; Molecular Sequence Data; Psittaciformes; RNA, Ribosomal, 16S / genetics; Sequence Analysis, DNA
TL;DR:
This is the first documentation of disease presumptively associated with Coxiella-like bacteria in birds, based on polymerase chain reaction and bacterial 16S rRNA gene sequence obtained from each bird's liver tissue.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling
Blood, 112(12), 4694–4698.
MeSH headings : Antineoplastic Agents / therapeutic use; Cells, Cultured; Enzyme Inhibitors / therapeutic use; Farnesyltranstransferase / antagonists & inhibitors; Female; Humans; Hypertension, Pulmonary / drug therapy; Hypertension, Pulmonary / etiology; K562 Cells; Leukemia, Large Granular Lymphocytic / complications; Leukemia, Large Granular Lymphocytic / drug therapy; Leukemia, Large Granular Lymphocytic / genetics; Middle Aged; Quinolones / therapeutic use; Receptors, Natural Killer Cell / genetics; Signal Transduction / genetics; Treatment Outcome
TL;DR:
A genetic approach demonstrated that killing of pulmonary endothelial cells by patient NK cells was mediated by dysregulated balance in activating and inhibitory NK-receptor signaling, and suggested a causal relationship between the expanded lymphocyte population and these clinical manifestations.
(via Semantic Scholar)
www.bloodjournal.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
A Killer-Rescue system for self-limiting gene drive of anti-pathogen constructs
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 275(1653), 2823–2829.
author keywords: gene drive; selfish genes; Aedes; Anopheles; dengue; malaria
MeSH headings : Alleles; Animals; Culicidae / genetics; Culicidae / parasitology; Culicidae / virology; Disease Transmission, Infectious / prevention & control; Gene Frequency; Genes, Lethal; Genetic Engineering / methods; Genotype; Inheritance Patterns; Insect Vectors / genetics; Insect Vectors / parasitology; Insect Vectors / virology; Models, Genetic; Transgenes
TL;DR:
A gene-drive mechanism that can be self-limiting over time and space, and is simpler to build is proposed, which involves one gene that codes for toxicity (killer) and a second that confers immunity to the toxic effects (rescue).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2008 journal article
A Disease-causing Point Mutation in Human Mitochondrial tRNA(Met) Results in tRNA Misfolding Leading to Defects in Translational Initiation and Elongation
JOURNAL OF BIOLOGICAL CHEMISTRY, 283(49), 34445–34456.
MeSH headings : Animals; Base Sequence; Binding Sites; Cattle; Escherichia coli / enzymology; Humans; Mitochondria / enzymology; Mitochondria / metabolism; Mutation; Nucleic Acid Conformation; Nucleic Acid Denaturation; Optic Atrophy, Hereditary, Leber / genetics; Point Mutation; Protein Biosynthesis; RNA, Transfer, Met / chemistry; Thermodynamics
TL;DR:
It is shown that the single 8U→C mutation leads to a failure of the tRNA to respond conformationally to Mg2+.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 article
A Bipodal-Tethered Porphyrin for Attachment to Silicon Surfaces in Studies of Molecular Information Storage
Schmidt, I., Jiao, J., Bocian, D. F., & Lindsey, J. S. (2008, September). JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, Vol. 8, pp. 4813–4817.
author keywords: Porphyrin; Bipod; Silicon; Memory; DRAM
MeSH headings : Amino Acid Motifs; Electrochemistry / methods; Electronics; Information Storage and Retrieval; Materials Testing; Models, Chemical; Nanotechnology / methods; Oxidation-Reduction; Porphyrins / chemistry; Pyrroles / chemistry; Semiconductors; Silicon / chemistry; Software
TL;DR:
The observation that the bipodal anchor does not provide enhanced stability is surprising given that attachment is achieved via two versus one covalent linkage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
'Smooth' inference for survival functions with arbitrarily censored data
Statistics in Medicine, 27(26), 5421–5439.
MeSH headings : Clinical Trials as Topic / methods; Computer Simulation; Data Interpretation, Statistical; Disease Progression; Endpoint Determination; Humans; Likelihood Functions; Statistics, Nonparametric; Survival Analysis
TL;DR:
The method is predicated on the mild assumption that the distribution of the random variable has a density that lies in a class of 'smooth' densities whose elements can be represented by an infinite Hermite series, and can result in gains in efficiency over traditional nonparametric methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2008 journal article
The antimicrobial peptides piscidins are stored in the granules of professional phagocytic granulocytes of fish and are delivered to the bacteria-containing phagosome upon phagocytosis
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 32(12), 1531–1538.
author keywords: mast cells; acidophilic granulocytes; piscidins; phagocytosis; evolution
MeSH headings : Animals; Antimicrobial Cationic Peptides / metabolism; Bacteria / immunology; Cytoplasmic Granules / metabolism; Cytoplasmic Granules / microbiology; Fish Proteins / immunology; Fish Proteins / metabolism; Granulocytes / cytology; Granulocytes / metabolism; Granulocytes / microbiology; Immunohistochemistry; Mast Cells / cytology; Mast Cells / metabolism; Mast Cells / microbiology; Phagocytes / cytology; Phagocytes / metabolism; Phagocytes / microbiology; Phagocytosis / immunology; Phagosomes / metabolism; Phagosomes / microbiology; Sea Bream / immunology; Sea Bream / metabolism; Sea Bream / microbiology
TL;DR:
It is found by immunoelectron microscopy that piscidins were delivered to the bacteria-containing phagosome of granulocytes upon phagocytosis, suggesting a role for these AMPs in the killing of both extracellular and intracellular pathogenic bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Synthesis of Anthracene and Azaanthracene Fluorophores via [2+2+2] Cyclotrimerization Reactions
ORGANIC LETTERS, 10(20), 4661–4664.
MeSH headings : Anthracenes / chemical synthesis; Anthracenes / chemistry; Aza Compounds / chemical synthesis; Aza Compounds / chemistry; Benzene / chemistry; Cell Line; Cyclization; Fluorescent Dyes / chemical synthesis; Fluorescent Dyes / chemistry; Humans; Molecular Structure; Pyridines / chemistry
TL;DR:
A highly convergent [2-2+2] cyclotrimerization approach to anthracenes and 2-azaanthracenes has been developed that allows for the facile introduction of the anthracene moiety on alkyne and nitrile bearing molecules and the rapid construction of compound arrays.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Serological and Molecular Prevalence of Borrelia burgdorferi, Anaplasma phagocytophilum, and Ehrlichia Species in Dogs from Minnesota
Vector-Borne and Zoonotic Diseases, 8(4), 455–464.
author keywords: tick(s)
MeSH headings : Anaplasma phagocytophilum / isolation & purification; Animals; Antibodies, Bacterial / blood; Borrelia burgdorferi / isolation & purification; Dog Diseases / blood; Dog Diseases / epidemiology; Dog Diseases / microbiology; Dogs; Ehrlichia / isolation & purification; Ehrlichiosis / epidemiology; Ehrlichiosis / veterinary; Female; Lyme Disease / epidemiology; Lyme Disease / veterinary; Male; Minnesota / epidemiology; Prevalence; Time Factors
TL;DR:
A population of 731 naturally exposed pet dogs examined at a private practice in Baxter, Minnesota, an area endemic for Lyme disease and anaplasmosis, was tested by serological and molecular methods for evidence of exposure to or infection with selected vector-borne pathogens, finding A. phagocytophilum DNA was more prevalent in suspected cases of anaplasmsosis or borreliosis than in healthy dogs from the same region.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Role of bacteria in the pathogenesis of recurrent uveitis in horses from the southeastern United States
American Journal of Veterinary Research, 69(10), 1329–1335.
MeSH headings : Animals; Aqueous Humor / microbiology; Horse Diseases / microbiology; Horses; Leptospira / genetics; Leptospira / isolation & purification; Leptospirosis / microbiology; Leptospirosis / veterinary; Polymerase Chain Reaction; RNA, Ribosomal / genetics; Recurrence; Reference Values; Southeastern United States; Uveitis / microbiology; Uveitis / veterinary; Vitreous Body / microbiology
TL;DR:
In horses from the southeastern United States, Leptospira organisms may have helped initiate ERU in some, but the continued presence of the organisms did not play a direct role in the pathogenesis of this recurrent disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2008 journal article
Prophylactic ovariosalpingectomy using a prefemoral approach in eastern box turtles (Terrapene carolina carolina)
VETERINARY RECORD, 163(16), 487–488.
MeSH headings : Abscess / surgery; Abscess / veterinary; Animals; Ear Diseases / surgery; Ear Diseases / veterinary; Ear, Middle / surgery; Fallopian Tubes / surgery; Female; Hindlimb Suspension / methods; North Carolina; Ovariectomy / methods; Ovariectomy / veterinary; Turtles / surgery
TL;DR:
Surgical access to the coelomic cavity of captive chelonians is restricted due to concerns over the integrity of the encomium and the location of the eggs in the body.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Ocular toxicity and distribution of subconjunctival and intravitreal rapamycin in horses
Journal of Veterinary Pharmacology and Therapeutics, 31(6), 511–516.
MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Chromatography, High Pressure Liquid; Dermatitis, Phototoxic; Horses; Sirolimus / adverse effects; Sirolimus / pharmacokinetics; Sirolimus / therapeutic use; Tissue Distribution; Uveitis / drug therapy; Uveitis / veterinary
TL;DR:
Drug could be detected in both the aqueous and vitreous humor after intravitreal injection and no evidence of ocular toxicity was noted on ophthalmic examination or histopathology, suggesting a lack of RAPA phototoxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2008 journal article
Metabolomic analyses of body fluids after subchronic manganese inhalation in rhesus monkeys
TOXICOLOGICAL SCIENCES, 106(1), 46–54.
author keywords: metabolomics; metal; neurotoxicity
MeSH headings : Air Pollutants / blood; Air Pollutants / toxicity; Air Pollutants / urine; Animals; Biomarkers / blood; Biomarkers / urine; Chromatography, Liquid; Cluster Analysis; Environmental Monitoring; Globus Pallidus / drug effects; Globus Pallidus / metabolism; Inhalation Exposure; Macaca mulatta; Male; Manganese Compounds / blood; Manganese Compounds / urine; Metabolomics / methods; Principal Component Analysis; Sulfates / blood; Sulfates / toxicity; Sulfates / urine; Tandem Mass Spectrometry
TL;DR:
Biochemical changes identified in manganese-exposed monkeys included endpoints relate to oxidative stress and neurotransmission (aminobutyrate, glutamine, phenylalanine), and 27 metabolites with statistically significant expression differences were structurally confirmed by MS-MS methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 review
Life in hot acid: Pathway analyses in extremely thermoacidophilic archaea
[Review of ]. CURRENT OPINION IN BIOTECHNOLOGY, 19(5), 445–453.
MeSH headings : Acids / metabolism; Archaea / physiology; Archaeal Proteins / metabolism; Cell Survival; Ecosystem; Hot Temperature; Hydrogen-Ion Concentration; Models, Biological; Signal Transduction / physiology
TL;DR:
New insights into the metabolic pathways and physiological features that define extreme thermoacidophily have been obtained, in some cases suggesting prospects for biotechnological opportunities.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Induction of arginase II by intestinal epithelium promotes the uptake of L-arginine from the lumen of Cryptosporidium parvum-infected porcine ileum
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 47(4), 417–427.
author keywords: epithelial transport; nitric oxide; polyamines
MeSH headings : Animals; Animals, Newborn; Arginase / genetics; Arginase / metabolism; Arginine / metabolism; Atrophy; Biological Transport / genetics; Carrier Proteins / metabolism; Cationic Amino Acid Transporter 1 / genetics; Cationic Amino Acid Transporter 1 / metabolism; Cationic Amino Acid Transporter 2 / genetics; Cationic Amino Acid Transporter 2 / metabolism; Chromatography, High Pressure Liquid; Cryptosporidiosis / enzymology; Cryptosporidiosis / physiopathology; Cryptosporidium parvum; Ileum / metabolism; Ileum / parasitology; Ileum / physiopathology; Intestinal Mucosa / enzymology; Intestinal Mucosa / metabolism; Nitric Oxide / antagonists & inhibitors; Nitric Oxide / biosynthesis; Nitric Oxide Synthase / metabolism; Swine
TL;DR:
Intracellular catabolism by arginase II, the induction of which has not been described previously for intestinal epithelium, facilitates uptake of L-arginine by infected epithelia using transport systems that do not differ from those of uninfected cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Immunophenotypic and cytomorphologic subclassification of T-cell lymphoma in the boxer breed
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 125(1-2), 102–110.
author keywords: boxer; lymphoma; immunophenotype; cytomorphology
MeSH headings : Animals; Biopsy, Fine-Needle / veterinary; CD4 Antigens / blood; CD4 Antigens / immunology; CD8 Antigens / blood; CD8 Antigens / immunology; Dog Diseases / classification; Dog Diseases / drug therapy; Dog Diseases / immunology; Dogs; Female; Genetic Predisposition to Disease; Immunohistochemistry / veterinary; Immunophenotyping / veterinary; Kaplan-Meier Estimate; Lymphoma, T-Cell / classification; Lymphoma, T-Cell / drug therapy; Lymphoma, T-Cell / immunology; Lymphoma, T-Cell / veterinary; Male; Prospective Studies; Receptors, Antigen, T-Cell, alpha-beta / blood; Receptors, Antigen, T-Cell, alpha-beta / immunology; Receptors, Antigen, T-Cell, gamma-delta / blood; Receptors, Antigen, T-Cell, gamma-delta / immunology; Retrospective Studies
TL;DR:
The results of this study indicate that lymphoma in the boxer breed is a disease comprised predominantly of TCRalphabeta+, CD4+ (helper) T-cells with lymphoblastic (high-grade) morphology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 article
Evaluation of perinuclear anti-neutrophilic cytoplasmic autoantibodies as an early marker of protein-losing enteropathy and protein-losing nephropathy in Soft Coated Wheaten Terriers
Allenspach, K., Lomas, B., Wieland, B., Harris, T., Pressler, B., Mancho, C., … Vaden, S. L. (2008, October). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 69, pp. 1301–1304.
MeSH headings : Animals; Antibodies, Antineutrophil Cytoplasmic / blood; Autoantibodies / blood; Dog Diseases / blood; Dog Diseases / immunology; Dogs; Kidney Diseases / etiology; Kidney Diseases / immunology; Kidney Diseases / veterinary; Protein-Losing Enteropathies / complications; Protein-Losing Enteropathies / immunology; Protein-Losing Enteropathies / veterinary; Species Specificity
TL;DR:
Most dogs in this study affected with PLE, PLN, or both had positive results for pANCAs before clinicopathologic evidence of disease was detected and may be useful as an early noninvasive test of disease in SCWTs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 article
Equine lymphoma: What are the prospects for cellular differentiation, early diagnosis and intervention strategies?
Roberts, M. C. (2008, September). EQUINE VETERINARY EDUCATION, Vol. 20, pp. 464–466.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Endothelial cell suppression of peripheral blood mononuclear cell trafficking in vitro during acute exposure to feline immunodeficiency virus
CELL AND TISSUE RESEARCH, 334(1), 55–65.
author keywords: HIV; astrocytes; microglia; monocyte; T cell; feline
MeSH headings : Animals; Astrocytes / immunology; Astrocytes / virology; B-Lymphocytes / immunology; B-Lymphocytes / virology; Brain / cytology; Brain / immunology; Brain / virology; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / virology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / virology; Cats; Cell Movement / immunology; Cells, Cultured; Endothelial Cells / immunology; Endothelial Cells / virology; Immunodeficiency Virus, Feline; Leukocytes, Mononuclear / immunology; Leukocytes, Mononuclear / virology; Microglia / immunology; Microglia / virology
TL;DR:
Initial exposure of PBMCs to FIV is sufficient to induce a general increase in trafficking, whereas initial exposure of endothelial cells to Fiv tends to down-regulate this effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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