Works Published in 2005
Displaying works 21 - 40 of 113 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2005 journal article
Pharmacokinetics and Safety of Acyclovir in Tragopans (Tragopan species)
Journal of Avian Medicine and Surgery, 19(4), 271–276.
author keywords: herpesvirus; acyclovir; pharmacokinetics; avian; pheasants; tragopans; Tragopan; species
TL;DR:
Results from this study suggest that a dosage of 120 mg/kg PO q12h in tragopans may achieve effective plasma concentrations (1.0 μg/ml) for potential treatment and prevention of herpesviral infections, however, further studies are needed to determine if this dosage is safe for repeated administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: March 2, 2019
2005 journal article
Pharmacokinetics of acyclovir in adult horses
Journal of Veterinary Emergency and Critical Care, 15(3), 174–178.
author keywords: abortion; central nervous system; equine; herpes; respiratory
TL;DR:
IV administration of acyclovir to healthy adult horses achieves concentrations within the sensitivity range described for equine herpes virus-type 1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 2, 2019
2005 journal article
Two-faced cyclins with eyes on the targets
Cell Cycle, 4(1), 125–130.
Contributors: V. Archambault *, N. Buchler* , G. Wilmes, M. Jacobson & F. Cross
author keywords: Clb5; hydrophobic patch; B-type cyclin; RXL; DNA replication
MeSH headings : Amino Acid Motifs; Amino Acid Sequence; Cell Cycle / genetics; Cell Cycle / physiology; Cyclin B / chemistry; Cyclin B / genetics; Cyclin B / physiology; Cyclin-Dependent Kinases / genetics; Cyclin-Dependent Kinases / physiology; Cyclins / genetics; Cyclins / physiology; DNA Replication; Gene Expression Regulation, Fungal; Hydrophobic and Hydrophilic Interactions; Molecular Sequence Data; Origin Recognition Complex / chemistry; Origin Recognition Complex / genetics; Origin Recognition Complex / physiology; Protein Structure, Tertiary; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / physiology; Saccharomyces cerevisiae Proteins / chemistry; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / physiology; Signal Transduction / genetics; Signal Transduction / physiology
TL;DR:
The observations as well as work from other groups suggest that HP-RXL interactions are functionally important for cyclin-Cdk signaling to other targets, and the evolutionary conservation of the HP motif suggests that it allows cyclins to carry out important and specialized functions.
(via Semantic Scholar)
www.tandfonline.com (publisher PDF)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2005 journal article
Transcriptional regulation by the numbers: Models
Current Opinion in Genetics and Development, 15(2), 116–124.
Contributors: L. Bintu *, N. Buchler* , H. Garcia *, U. Gerland *, T. Hwa *, J. Kondev *, R. Phillips *
MeSH headings : Gene Expression Regulation; Humans; Models, Theoretical; Thermodynamics; Transcription, Genetic
TL;DR:
Interactions of activators, repressors, helper molecules and RNAP are described by a single function, the "regulation factor", which culminates in an expression for the probability of RNA polymerase binding at the promoter of interest as a function of the number of regulatory proteins in the cell.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2005 journal article
Transcriptional regulation by the numbers: Applications
Current Opinion in Genetics and Development, 15(2), 125–135.
Contributors: L. Bintu *, N. Buchler* , H. Garcia *, U. Gerland *, T. Hwa *, J. Kondev *, T. Kuhlman *, R. Phillips *
MeSH headings : Animals; Bacteria / genetics; DNA / chemistry; Gene Expression Regulation; Humans; Models, Theoretical; Promoter Regions, Genetic / genetics; Quantitative Trait Loci; Thermodynamics; Transcription, Genetic; Transcriptional Activation
TL;DR:
Thermodynamic models provide a useful framework for the quantitative analysis of bacterial transcription regulation that can facilitate the quantification of vastly different forms of gene expression from several well-characterized bacterial promoters that are regulated by one or two species of transcription factors.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2005 journal article
Nonlinear protein degradation and the function of genetic circuits
Proceedings of the National Academy of Sciences of the United States of America, 102(27), 9559–9564.
Contributors: N. Buchler* , U. Gerland * & T. Hwa *
author keywords: amplification; dimerization; bistability; oscillation
MeSH headings : Bacteria / genetics; Gene Expression Regulation; Models, Biological; Multiprotein Complexes / metabolism; Protein Engineering / methods; Protein Subunits / metabolism; Proteins / metabolism; Transcription Factors / metabolism
TL;DR:
This work examines a simple kinetic source of cooperativity stemming from the nonlinear degradation of multimeric proteins and demonstrates that a few-fold difference between the degradation rate of monomers and dimers can enhance the function of these circuits substantially.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2005 journal article
β<inf>2</inf>-adrenoceptor regulation of the K<sup>+</sup> channel iK<inf>Ca</inf>1 in human mast cells
FASEB Journal, 19(8), 1006–1008.
Contributors: S. Duffy*, G. Cruse* , W. Lawley* & P. Bradding *
author keywords: salbutamol; ICI 118551; K(Ca)3.1; lung; G protein
MeSH headings : Adrenergic beta-Agonists / pharmacology; Albuterol / pharmacology; Antibodies / pharmacology; Benzimidazoles / pharmacology; Cells, Cultured; Electric Conductivity; GTP-Binding Protein alpha Subunits, Gs; Humans; Immunoglobulin E / immunology; Immunoglobulin E / physiology; Intermediate-Conductance Calcium-Activated Potassium Channels / drug effects; Intermediate-Conductance Calcium-Activated Potassium Channels / physiology; Ion Channel Gating / drug effects; Lung / cytology; Mast Cells / chemistry; Mast Cells / drug effects; Mast Cells / physiology; Propanolamines / pharmacology; Receptors, Adrenergic, beta-2 / physiology
TL;DR:
This is the first demonstration that gating of the iKCa1 channel is regulated by a G protein‐coupled receptor and provides a clearly defined mechanism for the mast cell “stabilizing” effect of β2‐agonists.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2005 journal article
Activation of human lung mast cells by monomeric immunoglobulin E (multiple letters) [2]
European Respiratory Journal, 26(4), 744–746.
MeSH headings : Centrifugation; Chromatography; Humans; Immunoglobulin E / chemistry; Immunoglobulin E / immunology; Immunoglobulin E / pharmacology; Immunologic Factors / chemistry; Immunologic Factors / immunology; Immunologic Factors / pharmacology; Lung / immunology; Mast Cells / drug effects; Mast Cells / immunology
TL;DR:
Immunoglobulin preparations contain variable proportions of Ig aggregates 1, which behave like true immune complexes and are able to activate inflammatory cells by crosslinking Fc receptors 2.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2005 journal article
Activation of human lung mast cells by monomeric immunoglobulin E
European Respiratory Journal, 25(5), 858–863.
Contributors: G. Cruse* , D. Kaur, W. Yang, S. Duffy, C. Brightling & P. Bradding
author keywords: asthma; calcium; human; mast cell; mediators; monomeric immunoglobulin E
MeSH headings : Calcium / metabolism; Cells, Cultured; Culture Media, Conditioned; Histamine / metabolism; Humans; Immunoglobulin E / metabolism; Interleukin-8 / metabolism; Leukotriene C4 / metabolism; Lung / cytology; Lung / immunology; Mast Cells / immunology; Mast Cells / metabolism; Reference Values; Stem Cell Factor
TL;DR:
The hypothesis that immunoglobulin E loading of mast cells within the asthmatic airway contributes to the disordered airway physiology of this disease is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2005 conference paper
Fish Health Management. Continuing Education Course, June 21-23, 2005
Raleigh, NC: North Carolina State University, College of Veterinary Medicine.
Source: NC State University Libraries
Added: August 6, 2018
2005 article
Human Neutrophil Elastase provokes mucin secretion by NHBE cells via a Protein Kinase C delta (PKC?)?mediated mechanism.
404nOtfound, Vol. 2, p. A110.
Source: NC State University Libraries
Added: August 6, 2018
2005 article
Cysteine String Protein is involved in mucin secretion from normal human bronchial epithelial (NHBE) cells in vitro.
404nOtfound, Vol. 2, p. A215.
Source: NC State University Libraries
Added: August 6, 2018
2005 article
A peptide directed against the N-terminus of MARCKS protein attenuates release of myeloperoxidase (MPO) from human and canine neutrophils in vitro.
404nOtfound, Vol. 2, p. A633.
Source: NC State University Libraries
Added: August 6, 2018
2005 article
?2-adrenergic receptor activation with (R)-albuterol attenuates GM-CSF expression via an iNOS-mediated pathway in human bronchial epithelial cells in vitro.
404nOtfound, Vol. 2, p. A757.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Assessment of a von Frey device for evaluation of the antinociceptive effects of morphine and its application in pharmacodynamic modeling of morphine in dogs
American Journal of Veterinary Research, 66(9), 1616–1622.
MeSH headings : Analgesics / therapeutic use; Animals; Chromatography, High Pressure Liquid / veterinary; Dogs / metabolism; Drug Design; Evaluation Studies as Topic; Morphine / blood; Morphine / therapeutic use; Pain / drug therapy; Pain Measurement / instrumentation; Pain Measurement / methods; Pain Measurement / veterinary; Statistics, Nonparametric
TL;DR:
Data suggest that, in dogs, evaluation of the antinociceptive effect and pharmacodynamic modeling of a dose of morphine sulfate (1 mg/kg, i.v.) can be successfully achieved by use of a von Frey device.
(via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2005 chapter
Plants poisonous to animals
In C. M. Kahn & S. Line (Eds.), Merck veterinary manual. Whitehouse Station, N.J. : Merck.
Ed(s): C. Kahn & S. Line
Source: NC State University Libraries
Added: August 6, 2018
2005 patent
Culture system for mouse tracheal epithelial cells
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Thermal dose is related to duration of local control in canine sarcomas treated with thermoradiotherapy
Clinical Cancer Research, 11(14), 5206–5214.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Pathology of end-stage remodeling in a family of cats with hypertrophic cardiomyopathy
VETERINARY PATHOLOGY, 42(4), 458–467.
author keywords: burned-out phase; dilated phase; end stage; feline; hypertrophic cardiomyopathy; myocardial fibrosis
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / pathology; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / pathology; Cats; Fatal Outcome; Female; Histological Techniques / veterinary; In Situ Nick-End Labeling / veterinary; Male; Myocardium / pathology; Ventricular Remodeling / physiology
TL;DR:
The objectives were to describe the pathologic alterations associated with ES-HCM and investigate the pathogenesis in three of the four cats, and to exclude apoptosis or coronary vessel spasm on the basis of the data presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Modeling the airway epithelium in allergic asthma: Interleukin-13-induced effects in differentiated murine tracheal epithelial cells
In Vitro Cellular & Developmental Biology. Animal, 41(7), 217–224.
Source: NC State University Libraries
Added: August 6, 2018
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