Works Published in 2004
Displaying works 61 - 80 of 102 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2004 review
Role of neurosteroids in catamenial epilepsy
[Review of ]. EPILEPSY RESEARCH, 62(2-3), 99–118.
author keywords: neurosteroid; GABA(A) receptor; progesterone; ganaxolone; catamenial epilepsy
MeSH headings : Animals; Anticonvulsants / therapeutic use; Brain Chemistry / physiology; Disease Models, Animal; Epilepsy / classification; Epilepsy / drug therapy; Epilepsy / etiology; Epilepsy / metabolism; Female; Humans; Menstruation Disturbances / complications; Menstruation Disturbances / therapy; Models, Molecular; Pregnanolone / analogs & derivatives; Pregnanolone / therapeutic use; Progesterone / analogs & derivatives; Progesterone / metabolism; Progesterone / therapeutic use; Receptors, GABA-A / metabolism; Steroids / chemistry; Steroids / physiology
TL;DR:
Synthetic neuroactive steroids, such as ganaxolone, which are orally active and devoid of hormonal side effects, represent a novel treatment strategy for catamenial epilepsy, however, their clinical efficacy in catamenian epilepsy has yet to be explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Pharmacokinetics of sulfadimethoxine and ormetoprim in a 5 : 1 ratio following intraperitoneal and oral administration, in the hybrid striped bass (Morone chrysops x Morone saxitalis)
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 27(1), 1–6.
MeSH headings : Administration, Oral; Aeromonas / drug effects; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacokinetics; Anti-Infective Agents / pharmacology; Area Under Curve; Bass / metabolism; Crosses, Genetic; Drug Therapy, Combination; Edwardsiella / drug effects; Escherichia coli / drug effects; Injections, Intraperitoneal / veterinary; Microbial Sensitivity Tests; Pseudomonas / drug effects; Pyrimidines / administration & dosage; Pyrimidines / pharmacokinetics; Pyrimidines / pharmacology; Sulfadimethoxine / administration & dosage; Sulfadimethoxine / pharmacokinetics; Sulfadimethoxine / pharmacology; Yersinia / drug effects
TL;DR:
The single 50 mg/kg oral dose of the 5:1 combination of sulfadimethoxine and ormetoprim appears to provide plasma concentrations high enough to inhibit the growth of Yersinia ruckeri, Edwardsiella tarda, and Escherichia coli.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Pharmacokinetics of oxytetracycline in loggerhead sea turtles (Caretta caretta) after single intravenous and intramuscular injections
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 35(4), 477–488.
author keywords: biologic marker; Caretta caretta; loggerhead sea turtle; oxytetracycline; pharmacokinetics
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Cross-Over Studies; Half-Life; Injections, Intramuscular / veterinary; Injections, Intravenous / veterinary; Metabolic Clearance Rate; Oxytetracycline / administration & dosage; Oxytetracycline / pharmacokinetics; Turtles / blood; Turtles / metabolism
TL;DR:
The pharmacokinetics of oxytetracycline in 2-yr-old loggerhead sea turtles (Caretta caretta) after single i.v. and i.m. injections indicates that an infrequent dosing interval may be effective for sensitive bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science; OpenAlex)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Nuclear localization signal and cell synchrony enhance gene targeting efficiency in primary fetal fibroblasts
Nucleic Acids Research, 32(3), e25–e28.
MeSH headings : Animals; Azaguanine / pharmacology; Base Sequence; Cattle; Cell Division / drug effects; Cell Division / physiology; Cells, Cultured; Drug Resistance; Fetus; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Gene Targeting / methods; Genetic Vectors / genetics; Hypoxanthine Phosphoribosyltransferase / genetics; Male; Molecular Sequence Data; Mutagenesis, Insertional; Nuclear Localization Signals / genetics
TL;DR:
It was determined that while no targeted colonies were identified using a conventional targeting construct, an average of 1 per million targeted cells were identified when a nuclear localization signal (nls) was added to the construct and targeting efficiency increased 7-fold.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2004 article
Evaluation of the bioavailability and pharmacokinetics of two extended-release theophylline formulations in dogs
Bach, J. F., Kukanich, B., Papich, M. G., & McKiernan, B. C. (2004, April 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 224, pp. 1113–1119.
MeSH headings : Administration, Oral; Animals; Biological Availability; Bronchodilator Agents / administration & dosage; Bronchodilator Agents / blood; Bronchodilator Agents / pharmacokinetics; Capsules; Computer Simulation; Cross-Over Studies; Delayed-Action Preparations; Dogs / blood; Dogs / metabolism; Drug Administration Schedule / veterinary; Female; Half-Life; Injections, Intravenous / veterinary; Male; Random Allocation; Tablets; Theophylline / administration & dosage; Theophylline / blood; Theophylline / pharmacokinetics
TL;DR:
Results of these single-dose studies indicated that administration of the specific brand of extended-release theophylline tablets or capsules used in this study at a dosage of 10 mg x kg(-1), PO, every 12 hours would maintain plasma concentrations within the desired therapeutic range in healthy dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Comparison of amikacin pharmacokinetics in a killer whale (Orcinus orca) and a beluga whale (Delphinapterus leucas)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 35(2), 179–184.
author keywords: aminoglycoside; amikacin; Delphinapterus leucas; pharmacokinetics; whale; Orcinus orca
MeSH headings : Amikacin / adverse effects; Amikacin / pharmacokinetics; Animals; Anti-Bacterial Agents / adverse effects; Anti-Bacterial Agents / pharmacokinetics; Dolphins / metabolism; Dose-Response Relationship, Drug; Female; Gram-Negative Bacterial Infections / drug therapy; Gram-Negative Bacterial Infections / veterinary; Half-Life; Injections, Intramuscular / veterinary; Metabolic Clearance Rate; Microbial Sensitivity Tests; Treatment Outcome; Whales / metabolism
TL;DR:
Both whales exhibited a prolonged elimination half-life and decreased clearance when compared with other animal species despite normal renal parameters on biochemistry panels, and allometric principles and therapeutic drug monitoring were used to accurately determine the doses and to avoid toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 310(1), 230–239.
MeSH headings : Animals; Anticonvulsants / therapeutic use; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors / pharmacology; Female; Finasteride / pharmacology; Kindling, Neurologic / drug effects; Male; Mice; Mice, Knockout; Mutation; Pregnanolone / blood; Progesterone / antagonists & inhibitors; Progesterone / therapeutic use; Receptors, Progesterone / deficiency; Receptors, Progesterone / genetics; Seizures / prevention & control; Steroids / therapeutic use
TL;DR:
These studies provide strong evidence that the PR is not required for the antiseizure effects of progesterone, which mainly occurs through its conversion to the neurosteroid allopregnanolone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Urinary bladder incarceration and infarction by an intra-abdominal fat pad in a Virginia opossum (Didelphis virginiana)
VETERINARY RADIOLOGY & ULTRASOUND, 45(4), 312–314.
author keywords: hydronephrosis; hydroureter; infarction; marsupial; opossum; ultrasound; urinary bladder
MeSH headings : Abdomen / pathology; Adipose Tissue / pathology; Animals; Diagnosis, Differential; Female; Opossums; Radiography, Abdominal / veterinary; Ultrasonography; Urinary Bladder Neck Obstruction / diagnostic imaging; Urinary Bladder Neck Obstruction / pathology; Urinary Bladder Neck Obstruction / veterinary
TL;DR:
A 2.5-year-old, female opossum had acute stranguria and cystic structure identified in the caudal abdomen associated with bilateral hydroureter and hydronephrosis, which contained a neutrophilic fluid, determined to be urine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Ultrasonographic appearance of Dandy Walker-like Syndrome in a Boston terrier
Veterinary Radiology & Ultrasound, 45(4), 336–339.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3 alpha-androstanediol and 17 beta-estradiol
NEUROSCIENCE, 129(1), 195–207.
author keywords: neurosteroid; testosterone; epilepsy; 3 alpha-androstanediol; 17 beta-estradiol; GABA(A) receptor
MeSH headings : Androstane-3,17-diol / metabolism; Animals; Aromatase Inhibitors / pharmacology; Chromatography; Convulsants / pharmacology; Dose-Response Relationship, Drug; Enzyme Inhibitors / pharmacology; Estradiol / metabolism; Finasteride / pharmacology; Hippocampus / drug effects; Hippocampus / physiology; Letrozole; Male; Mass Spectrometry; Mice; Nitriles / pharmacology; Organ Culture Techniques; Patch-Clamp Techniques; Pentylenetetrazole / pharmacology; Rats; Receptors, GABA-A / drug effects; Receptors, GABA-A / metabolism; Seizures / chemically induced; Seizures / prevention & control; Testosterone / metabolism; Testosterone / pharmacology; Triazoles / pharmacology
TL;DR:
Testosterone-derived neurosteroids 3α-Diol and 17β-estradiol could contribute to the net cellular actions of testosterone on neural excitability and seizure susceptibility.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and Gob-5
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 170(3), 306–312.
author keywords: mucin; MUC5ac; gob-5; respiratory syncytial virus
MeSH headings : Animals; Chloride Channels / metabolism; Cytokines / metabolism; Disease Models, Animal; Female; Interleukin-17 / metabolism; Lung / pathology; Mice; Mice, Inbred BALB C; Mucin 5AC; Mucins / metabolism; Mucoproteins / metabolism; Ovalbumin; Respiratory Hypersensitivity / complications; Respiratory Hypersensitivity / metabolism; Respiratory Hypersensitivity / pathology; Respiratory Hypersensitivity / virology; Respiratory Syncytial Virus Infections / complications; Respiratory Syncytial Virus Infections / metabolism; Respiratory Syncytial Virus Infections / pathology; Respiratory Syncytial Viruses
TL;DR:
There was significantly increased staining for gob-5 and Muc5ac in the airways of OVA/RSV mice compared with either OVA mice or allergically sensitized mice that were challenged with inactivated RSV, and virtually no detectable staining in the RSV group.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Pharmacokinetics of tramadol and the metabolite O-desmethyl tramadol in dogs
Journal of Veterinary Pharmacology and Therapeutics, 27(4), 1–8.
MeSH headings : Administration, Oral; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacokinetics; Animals; Area Under Curve; Cross-Over Studies; Dogs / metabolism; Female; Injections, Intravenous / veterinary; Male; Tramadol / administration & dosage; Tramadol / analogs & derivatives; Tramadol / pharmacokinetics
TL;DR:
Simulated oral dosing regimens predict tramadol and M1 plasma concentrations consistent with analgesia in humans; however, studies are needed to establish the safety and efficacy of these doses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2004 journal article
Moxifloxacin pharmacokinetics in horses and disposition into phagocytes after oral dosing
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 27(1), 57–60.
MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Aza Compounds / administration & dosage; Aza Compounds / blood; Aza Compounds / pharmacokinetics; Female; Fluoroquinolones; Horses / metabolism; Moxifloxacin; Phagocytes / metabolism; Quinolines / administration & dosage; Quinolines / blood; Quinolines / pharmacokinetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Malignant tumor formation in dogs previously irradiated for acanthomatous epulis
Veterinary Radiology & Ultrasound, 45(4), 357–361.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Light-chain myeloma in a dog
JOURNAL OF VETERINARY INTERNAL MEDICINE, 18(1), 119–121.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 article
In vivo hyperglycemia and its effect on Glut-1 expression in the embryonic heart
Joyner, N. T., & Smoak, I. W. (2004, July). BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, Vol. 70, pp. 438–448.
author keywords: Glut-1; mouse; embryo; hyperglycemia; heart
MeSH headings : Animals; Female; Gene Expression / physiology; Glucose / metabolism; Glucose Transporter Type 1; Heart / embryology; Hyperglycemia / metabolism; Mice; Monosaccharide Transport Proteins / genetics; Monosaccharide Transport Proteins / metabolism; Pregnancy; RNA, Messenger / metabolism
TL;DR:
Hyperglycemia-induced alterations in Glut-1 expression likely interfere with balance of glucose available to the embryonic heart that may affect cardiac morphogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 personal communication
Enhanced factor VIII activity measurements using ROTEG and factor VIII-/- mice whole blood
Source: NC State University Libraries
Added: August 6, 2018
2004 article
Effects of continuous rate intravenous infusion of butorphanol on physiologic and outcome variables in horses after celiotomy
JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 18, pp. 555–563.
author keywords: behavior; colic; cortisol; pain management; stress
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Arginine stimulates intestinal cell migration through a focal adhesion kinase dependent mechanism
GUT, 53(4), 514–522.
MeSH headings : Animals; Arginine / pharmacology; Cell Movement / drug effects; Cells, Cultured; Dietary Supplements; Dose-Response Relationship, Drug; Enterocytes / drug effects; Enterocytes / physiology; Enzyme Inhibitors / pharmacology; Focal Adhesion Protein-Tyrosine Kinases; Nitric Oxide / metabolism; Ornithine Decarboxylase / physiology; Ornithine Decarboxylase Inhibitors; Phosphorylation / drug effects; Polyamines / pharmacology; Protein-Tyrosine Kinases / physiology; Swine; Transfection; Tyrosine / physiology
TL;DR:
Results showed that l-arginine stimulates cell migration through NO and FAK dependent pathways and that combination therapy with arginine and BSC may enhance intestinal restitution via separate and convergent pathways.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Prevalence of and risk factors for feline Tritichomonas foetus and Giardia infection
JOURNAL OF CLINICAL MICROBIOLOGY, 42(6), 2707–2710.
MeSH headings : Animals; Cat Diseases / epidemiology; Cat Diseases / etiology; Cats; Female; Giardiasis / epidemiology; Giardiasis / etiology; Giardiasis / veterinary; Male; Prevalence; Protozoan Infections / etiology; Protozoan Infections, Animal; Risk Factors; Tritrichomonas foetus
TL;DR:
Catteries in which T. foetus was identified were more likely to have had a recent history of diarrhea, historical diagnosis of coccidia infection in adult cats, and a decreased number of square feet of facility per cat.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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