Works Published in 2017
Displaying works 281 - 300 of 321 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2017 journal article
Local Government Capacity to Respond to Environmental Change: Insights from Towns in New York State
Environmental Management, 60(1), 118–135.
author keywords: Climate change; Environmental policy; Local government; Natural gas development; Open space development; Social capital
MeSH headings : Climate Change; Conservation of Natural Resources / legislation & jurisprudence; Conservation of Natural Resources / methods; Conservation of Natural Resources / trends; Environmental Policy / legislation & jurisprudence; Environmental Policy / trends; Humans; Local Government; New York; Policy Making; Rural Population; Urban Population
TL;DR:
It was found that towns confronted with climate change were at a much earlier stage in the policy process and were generally less likely to display the essential resources, social support, and political legitimacy needed for an effective policy response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Linking physiological mechanisms to thermally driven life history outcomes in the Mayfly Neocloeon triangulifer
Integrative and Comparative Biology, 57, E225–225.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Keep breathing: Linking respiration to thermally regulated life history outcomes in the Mayfly Neocloeon triangulifer
Integrative and Comparative Biology, 57, E225–225.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
House Dust Endotoxin Levels Are Associated with Adult Asthma in a U.S. Farming Population
Annals of the American Thoracic Society, 14(3), 324–331.
author keywords: pulmonary function; atopy; wheeze; CD14; TLR4
MeSH headings : Aged; Agriculture / statistics & numerical data; Asthma / epidemiology; Asthma / genetics; Case-Control Studies; Dust / analysis; Endotoxins / analysis; Environmental Exposure / adverse effects; Female; Gene-Environment Interaction; Humans; Lipopolysaccharide Receptors / genetics; Logistic Models; Male; Middle Aged; Odds Ratio; Respiratory Sounds; Surveys and Questionnaires; Toll-Like Receptor 4 / genetics; United States / epidemiology
TL;DR:
House dust endotoxin was associated with current atopic and nonatopic asthma in a U.S. farming population and was associatedwith lower pulmonary function in patients with asthma, and the degree of the association with asthma depended on early‐life farm exposures.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Genomic profiling of canine mast cell tumors identifies DNA copy number aberrations associated with KIT mutations and high histological grade
CHROMOSOME RESEARCH, 25(2), 129–143.
author keywords: Cancer; Comparative genomic hybridization; Digital PCR; Dog; Mastocytosis; Pug
MeSH headings : Animals; Comparative Genomic Hybridization; DNA Copy Number Variations / genetics; Dogs; Genome / genetics; Mastocytosis, Cutaneous / diagnosis; Mastocytosis, Cutaneous / genetics; Mastocytosis, Cutaneous / pathology; Mutation; Predictive Value of Tests; Proto-Oncogene Proteins c-kit / genetics; Sensitivity and Specificity
TL;DR:
Characterization of genomic alterations in canine MCTs may identify genomic regions and/or genes responsible for their development and progression, facilitating the discovery of new therapeutic targets and improved clinical management of this heterogeneous cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Generation of LIF-independent induced pluripotent stem cells from canine fetal fibroblasts
THERIOGENOLOGY, 92, 75–82.
author keywords: iPSC; Canine; Stem cells; Pluripotency; Cellular reprogramming
MeSH headings : Animals; Dogs; Fetus / cytology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / physiology; Gene Expression Regulation / physiology; Leukemia Inhibitory Factor / pharmacology; Mice; Mice, Inbred BALB C; Mice, Nude; Pluripotent Stem Cells / physiology; Polymerase Chain Reaction / veterinary
TL;DR:
This report is the first to describe the ability to reprogram canine somatic cells via lentiviral vectors without supplementation and with resistance to enzymatic action, thereby demonstrating the pluripotency of these cell lines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Electrical Cell-Substrate Impedance Spectroscopy Can Monitor Age-Grouped Human Adipose Stem Cell Variability During Osteogenic Differentiation
STEM CELLS TRANSLATIONAL MEDICINE, 6(2), 502–511.
author keywords: Electrical cell-substrate impedance spectroscopy; Adipose stem cells; Osteogenesis; Bioimpedance
MeSH headings : Adipose Tissue / cytology; Adult; Age Factors; Aged; Aged, 80 and over; Bone and Bones / cytology; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dielectric Spectroscopy / methods; Electric Impedance; Humans; Middle Aged; Osteogenesis; Phenotype; Stem Cells / metabolism; Stem Cells / physiology; Time Factors; Young Adult
TL;DR:
This is the first study to use ECIS to predict osteogenic potential of multiple hASC populations and to show that donor age may temporally control onset of osteogenesis, which could be critical for development of patient‐specific bone tissue engineering and regenerative medicine therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies
LEUKEMIA & LYMPHOMA, 58(7), 1702–1710.
author keywords: Diffuse large B-cell lymphoma; alternative NF-kappa B pathway; canine model; targeting therapy; comparative pathology
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Cell Line, Tumor; Cell Survival / drug effects; Disease Models, Animal; Dogs; Gene Expression; Genes, Reporter; Humans; Lymphoma, Large B-Cell, Diffuse / drug therapy; Lymphoma, Large B-Cell, Diffuse / metabolism; Lymphoma, Large B-Cell, Diffuse / pathology; Molecular Targeted Therapy; NF-kappa B / metabolism; Signal Transduction / drug effects
TL;DR:
It is demonstrated that dogs with spontaneous DLBCL can provide a useful large animal model to study therapies targeting the ANFκBP and that a small interfering RNA inhibits the activation of the NFκB pathway and induces apoptosis in canineDLBCL cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Arsenic-Induced Activation of the Homeodomain-Interacting Protein Kinase 2 (HIPK2) to cAMP-Response Element Binding Protein (CREB) Axis
JOURNAL OF MOLECULAR BIOLOGY, 429(1), 64–78.
author keywords: ATF1; HIPK1; CCNA1; CBP; TAF4
MeSH headings : Arsenic / metabolism; Carrier Proteins / metabolism; Cell Line; Cyclic AMP Response Element-Binding Protein / metabolism; Gene Expression Profiling; Humans; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases / metabolism; Serine / metabolism; Transcriptional Activation
TL;DR:
The results suggest that the HIPK2-phospho-Ser271 CREB axis is a new arsenic-responsive CREB activation mechanism in parallel with the PKA-ph phosphate-based activation mechanism of Ser133 CREB.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 review
Applying evolutionary genetics to developmental toxicology and risk assessment
[Review of ]. REPRODUCTIVE TOXICOLOGY, 69, 174–186.
author keywords: Evolutionary genetics; Developmental toxicology; Systems toxicology; Birth defects; Signaling pathways; High-throughput screening; Evo-Devo
MeSH headings : Animals; Computational Biology; Evolution, Molecular; Humans; Phylogeny; Risk Assessment; Systems Biology; Teratology
TL;DR:
This synthesis can lead to novel applications in developmental toxicity and risk assessment, but also can pave the way for applying an evo-devo perspective to the study of developmental origins of health and disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
A note on multiple imputation under complex sampling
Biometrika, 104(1), 221–228.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
The Comparative Toxicogenomics Database: update 2017
NUCLEIC ACIDS RESEARCH, 45(D1), D972–D978.
MeSH headings : Computational Biology / methods; Databases, Chemical; Databases, Genetic; Gene Ontology; Humans; Search Engine; Signal Transduction; Toxicogenetics / methods; User-Computer Interface; Web Browser
TL;DR:
This update describes the new exposure module (that harmonizes exposure science information with core toxicogenomic data) and introduces a novel dataset of GO-disease inferences (that identify common molecular underpinnings for seemingly unrelated pathologies).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis
MOLECULAR CANCER RESEARCH, 15(2), 165–178.
MeSH headings : Animals; Breast Neoplasms / genetics; Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Carcinogenesis / genetics; Carcinogenesis / metabolism; Carcinogenesis / pathology; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Female; Heterografts; Humans; Mice; Receptors, LDL / biosynthesis; Receptors, LDL / genetics; Receptors, LDL / metabolism
TL;DR:
Results show that nuclear LSR alters gene expression and may promote aggressive cancer phenotypes through differential subcellular localization to alter cell signaling, bioenergetics, and gene expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Novel Cadmium Resistance Determinant in Listeria monocytogenes
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 83(5).
author keywords: Listeria monocytogenes; cadmium resistance; cadA; biofilm; virulence
MeSH headings : Animals; Bacterial Proteins / genetics; Biofilms / drug effects; Biofilms / growth & development; Cadmium / toxicity; DNA Transposable Elements / genetics; Disease Models, Animal; Drug Resistance, Bacterial; Food Microbiology; Gene Expression Regulation, Bacterial / genetics; Genes, Bacterial; Larva / microbiology; Lepidoptera / microbiology; Listeria monocytogenes / drug effects; Listeria monocytogenes / genetics; Listeria monocytogenes / growth & development; Listeria monocytogenes / physiology; Listeriosis / microbiology; Metals, Heavy; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Sequence Alignment; Virulence / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Marine snow formation by the toxin-producing diatom, Pseudo-nitzschia australis
HARMFUL ALGAE, 61, 23–30.
author keywords: Marine snow; Domoic acid; Pseudo-nitzschia; Toxin flux; Food web
TL;DR:
This study confirms that MS functions as a major vector for toxin flux to depth, that Pseudo-nitzschia -derived aggregates should be considered ‘toxic snow’ for MS-associated organisms, and that effects of MS toxicity on interactions with aggregate-associated microbes and zooplankton consumers warrant further consideration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 article
Imaging antiretroviral distribution within gastrointestinal tissues across pre-clinical species: implications for hiv eradication
Clinical Pharmacology & Therapeutics, Vol. 101, pp. S17–17.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Generation of a stable transgenic swine model expressing a porcine histone 2b-egfp fusion protein for cell tracking and chromosome dynamics studies
PLoS One, 12(1).
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury
SCIENTIFIC REPORTS, 7.
MeSH headings : Animals; Astrocytes / physiology; Cell Differentiation; Cicatrix / physiopathology; Disease Models, Animal; Ependyma / physiopathology; Mice; Mice, Transgenic; Neural Stem Cells / physiology; Spinal Cord Injuries / physiopathology
TL;DR:
It is shown that ependyma contribution of progeny after SCI is minimal, local and dependent on direct ependymal injury, indicating that ependedyma are not a major source of endogenous neural stem cells or neuroprotective astrocytes afterSCI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Effect of Cranberry Extract on the Frequency of Bacteriuria in Dogs with Acute Thoracolumbar Disk Herniation: A Randomized Controlled Clinical Trial
JOURNAL OF VETERINARY INTERNAL MEDICINE, 31(1), 60–68.
author keywords: Escherichia coli; Incontinence; Proanthocyanidins; Spinal cord injury
MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / therapeutic use; Bacteriuria / complications; Bacteriuria / drug therapy; Bacteriuria / urine; Bacteriuria / veterinary; Dog Diseases / drug therapy; Dogs; Female; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / veterinary; Male; Plant Extracts / administration & dosage; Plant Extracts / therapeutic use; Prospective Studies; Single-Blind Method; Thoracic Vertebrae; Treatment Outcome; Urinary Tract Infections / complications; Urinary Tract Infections / drug therapy; Urinary Tract Infections / urine; Urinary Tract Infections / veterinary; Vaccinium macrocarpon
TL;DR:
This clinical trial did not show a benefit of oral cranberry extract but had low power, but a possible association between urine AAA and lower risk of E. coli bacteriuria was identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
TAK1 regulates resident macrophages by protecting lysosomal integrity
CELL DEATH & DISEASE, 8.
MeSH headings : Animals; Cell Death / physiology; Cell Survival / physiology; Embryonic Development / physiology; Lung / metabolism; Lysosomes / metabolism; MAP Kinase Kinase Kinases / metabolism; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Protective Agents / metabolism; Receptors, Tumor Necrosis Factor, Type I / metabolism; Signal Transduction / physiology; Thymocytes / physiology; Thymus Gland / metabolism; Toll-Like Receptors / metabolism
TL;DR:
The results suggest that autocrine and potentially paracrine TNF kills Tak1-deficient macrophages during development, and reveal that TAK1 signaling maintains proper macrophage populations through protecting lysosomal integrity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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