Works Published in 2008
Displaying works 41 - 60 of 67 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2008 journal article
Genomic analysis of post-mating changes in the honey bee queen (Apis mellifera)
BMC GENOMICS, 9.
MeSH headings : Animals; Base Sequence; Bees / genetics; Bees / growth & development; Bees / physiology; Brain / metabolism; DNA Primers / genetics; Drosophila / genetics; Drosophila / physiology; Female; Gene Expression Profiling; Genomics; Male; Oligonucleotide Array Sequence Analysis; Ovary / growth & development; Ovary / metabolism; RNA / genetics; RNA / metabolism; Reproduction / genetics; Reproduction / physiology; Sex Attractants / metabolism; Sexual Behavior, Animal; Species Specificity; Sperm Count; Vitellogenins / genetics; Vitellogenins / metabolism
TL;DR:
Studying the underlying molecular mechanisms of post-mating changes in honey bee queens will not only give insight into how molecular mechanisms regulate physiological and behavioral changes, but they may also lead to important insights into the evolution of social behavior.
(via Semantic Scholar)
bmcgenomics.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants
BMC Genomics, 9.
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Biochemical and functional evidence of p53 homology is inconsistent with molecular phylogenetics for distant sequences
JOURNAL OF MOLECULAR EVOLUTION, 67(1), 51–67.
author keywords: p53; p63; p73; beta-Sandwich; transcription factor; p731
MeSH headings : Animals; Arthropods / genetics; DNA-Binding Proteins / classification; Evolution, Molecular; Genes, p53; Mollusca / genetics; Nematoda / genetics; Nuclear Proteins / classification; Phylogeny; Sequence Homology, Amino Acid; Tumor Protein p73; Tumor Suppressor Protein p53 / chemistry; Tumor Suppressor Protein p53 / classification; Tumor Suppressor Proteins / classification; Urochordata / genetics
TL;DR:
The study shows that the biochemical and functional evidence of p53 homology for nematodes, arthropods, and protists is inconsistent with their implied phylogenetic relationship within the overall family, and suggests that p63 is a far more appropriate protein for comparison.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
The drosophila gap gene giant has an anterior segment identity function mediated through disconnected and teashirt
GENETICS, 179(1), 441–453.
MeSH headings : Animals; Body Patterning / genetics; DNA Primers / genetics; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / embryology; Gene Expression Regulation, Developmental / genetics; Microscopy, Confocal; Mutation / genetics; Repressor Proteins / genetics; Repressor Proteins / metabolism; Transcription Factors / metabolism
TL;DR:
The regulatory effects of gap genes on the spatial expression of disco, disco-r, and tsh during Drosophila embryogenesis are reported, shedding new light on how mutations in giant (gt) affect patterning within the anterior gt domain, demonstrating homeotic function in this domain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Hepatic endopolyploidy as a cellular consequence of age-specific selection for rate of development in mice
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION, 310B(5), 385–397.
MeSH headings : Aging / genetics; Aging / pathology; Animals; Female; Flow Cytometry; Growth; Liver / metabolism; Liver / pathology; Male; Mice; Mice, Inbred ICR; Polyploidy
TL;DR:
This work searches for endopolyploidy in the liver in response to age-specific restricted index selection for the rate of development in mice, finding lines selected for divergence in early growth and late growth are divergent in frequency of polyploid cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Phenotypic plasticity and genotype by environment interaction for olfactory behavior in Drosophila melanogaster
GENETICS, 179(2), 1079–1088.
MeSH headings : Animals; Behavior, Animal; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Environment; Female; Gene Expression Profiling; Genes, Insect; Genetic Complementation Test; Genetic Variation; Genotype; Male; Mutation; Oligonucleotide Array Sequence Analysis; Phenotype; Phylogeny; Quantitative Trait Loci; Reverse Transcriptase Polymerase Chain Reaction; Smell / genetics; Smell / physiology; Transferrin / genetics
TL;DR:
It is found that ∼50% of phenotypic variation in adult olfactory behavior is attributable to GEI, and transcriptional analysis revealed that only 20 genes show GEI at the level of gene expression [false discovery rate (FDR) < 0.05], some of which are associated with physiological responses to environmental chemicals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Failure to replicate effect of Kibra on human memory in two large cohorts of European origin
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 147B(5), 667–668.
author keywords: neurocognition; phenotype; cognitive task; replication; neurogenetics
MeSH headings : Cohort Studies; Europe; Humans; Intracellular Signaling Peptides and Proteins; Memory / physiology; Phosphoproteins; Polymorphism, Single Nucleotide; Proteins / genetics; Proteins / physiology; Reproducibility of Results; White People
TL;DR:
It is suggested that Kibra does not have a strong and general effect on human memory.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
A new branch of endoplasmic reticulum stress signaling and the osmotic signal converge on plant-specific asparagine-rich proteins to promote cell death
JOURNAL OF BIOLOGICAL CHEMISTRY, 283(29), 20209–20219.
MeSH headings : Asparagine / metabolism; Cell Death; Cells, Cultured; Endoplasmic Reticulum / metabolism; Gene Expression Regulation, Plant; Genes, Reporter / genetics; Osmosis; Plant Leaves / cytology; Plant Leaves / genetics; Plant Leaves / growth & development; Plant Leaves / metabolism; Plant Proteins / genetics; Plant Proteins / metabolism; Protein Folding; Signal Transduction; Soybeans / cytology; Soybeans / genetics; Soybeans / growth & development; Soybeans / metabolism; Up-Regulation
TL;DR:
The results indicate that ER stress induces leaf senescence through activation of plant-specific NRPs via a novel branch of the ER stress response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
A gene expression signature of confinement in peripheral blood of red wolves (Canis rufus)
MOLECULAR ECOLOGY, 17(11), 2782–2791.
author keywords: conservation genetics; heterologous microarray; Illumina; pro-inflammatory response
MeSH headings : Animals; Biomarkers / blood; Coyotes / genetics; Female; Gene Expression Profiling; Male; Models, Genetic; North Carolina; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Stress, Physiological / genetics; Wolves / genetics
TL;DR:
Characterization of differential transcript abundance in an accessible tissue such as peripheral blood identifies biomarkers that could be useful in animal management practices and for evaluating the impact of habitat changes on population health, particularly as attention turns to the effect of climate change on physiology and in turn species distributions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
13. Climate Action
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
TAA1-mediated auxin biosynthesis is essential for hormone crosstalk and plant development
CELL, 133(1), 177–191.
Contributors: A. Stepanova n , J. Robertson-Hoyt n, J. Yun n, L. Benavente n, D. Xie n, K. Doležal *, A. Schlereth*, G. Jürgens *, J. Alonso n
MeSH headings : Amino Acid Sequence; Arabidopsis / drug effects; Arabidopsis / embryology; Arabidopsis / genetics; Arabidopsis / metabolism; Biosynthetic Pathways; Ethylenes / pharmacology; Indoleacetic Acids / metabolism; Indoles / metabolism; Molecular Sequence Data; Mutation; Plant Roots / drug effects; Seedlings / metabolism; Sequence Alignment; Tryptophan Transaminase / chemistry; Tryptophan Transaminase / genetics; Tryptophan Transaminase / metabolism
TL;DR:
By characterizing the Arabidopsis wei8 mutant, it is found that a small family of genes mediates tissue-specific responses to ethylene, and the IPA route of auxin production is key to generating robust auxin gradients in response to environmental and developmental cues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Sustaining public plant breeding to meet future national needs
HortScience, 43(2), 298–299.
Source: NC State University Libraries
Added: August 6, 2018
2008 review
Diverse inhibitors of aflatoxin biosynthesis
[Review of ]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 78(4), 559–572.
author keywords: aspergillus; secondary metabolism; oxidative stress; host resistance
MeSH headings : Aflatoxins / antagonists & inhibitors; Aflatoxins / biosynthesis; Alkaloids / pharmacology; Anti-Bacterial Agents / pharmacology; Antimetabolites / pharmacology; Antitoxins / isolation & purification; Antitoxins / metabolism; Aspergillus flavus / metabolism; Calcium Signaling; Food Contamination; Food Preservation; Oxidative Stress; Plants / metabolism; Terpenes / pharmacology
TL;DR:
Instrained compounds may be amenable to pathway engineering for tissue-specific expression in susceptible host plants as a defense against aflatoxin contamination and show promise as protectants during crop storage.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2008 article
Darwinian selection on a selfing locus (vol 306, pg 2081, 2004)
Science, Vol. 320, pp. 176–176.
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
A Markov chain Monte Carlo expectation maximization algorithm for statistical analysis of DNA sequence evolution with neighbor-dependent substitution rates
JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS, 17(1), 138–162.
author keywords: EM-algorithm; Gibbs sampling; likelihood inference; molecular evolution; neighbor-dependence; path sampling
TL;DR:
This work describes statistical inference of neighbor-dependent models using a Markov chain Monte Carlo expectation maximization (MCMC-EM) algorithm and estimates the high-dimensional integrals required in the EM algorithm are estimated using MCMC sampling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 patent
Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
From classical genetics to quantitative genetics to systems biology: Modeling epistasis
PLoS Genetics, 4(3).
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Comparative genetics of sex determination: Masculinizing mutations in Caenorhabditis briggsae
GENETICS, 178(3), 1415–1429.
MeSH headings : Alleles; Animals; Caenorhabditis / genetics; Caenorhabditis elegans; Cell Lineage; Female; Germ Cells; Gonads / cytology; Gonads / growth & development; Helminth Proteins / isolation & purification; Helminth Proteins / metabolism; Male; Mutant Proteins / isolation & purification; Mutant Proteins / metabolism; Mutation / genetics; Phenotype; Sex Determination Processes; Species Specificity; Zygote / metabolism
TL;DR:
This work has taken an unbiased forward mutagenesis approach to isolating zygotic mutations that masculinize all tissues of C. briggsae hermaphrodites and shows that in both C. elegans large C-terminal truncations of TRA-1 that retain the DNA-binding domain affect sex determination more strongly than somatic gonad development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan amazighs
PLoS Genetics, 4(4).
Source: NC State University Libraries
Added: August 6, 2018
2008 review
Targeting mucosal dendritic cells with microbial antigens from probiotic lactic acid bacteria
[Review of ]. EXPERT REVIEW OF VACCINES, 7(2), 163–174.
MeSH headings : Administration, Oral; Antigens, Bacterial / genetics; Antigens, Bacterial / immunology; Antigens, Bacterial / metabolism; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / genetics; Bacterial Vaccines / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Genetic Vectors / administration & dosage; Genetic Vectors / genetics; Genetic Vectors / metabolism; Gram-Positive Bacteria / genetics; Gram-Positive Bacteria / metabolism; Humans; Immunity, Mucosal; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Lactic Acid / metabolism; Probiotics / administration & dosage; Probiotics / metabolism
TL;DR:
This overview of mucosal immunity and how its cellular component(s), particularly dendritic cells, can be specifically targeted to deliver immunogenic subunits, such as the protective antigen from Bacillus anthracis (the causative agent of anthrax) is focused on.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Quantitative genetic analysis of sleep in Drosophila melanogaster
GENETICS, 178(4), 2341–2360.
MeSH headings : Alleles; Analysis of Variance; Animals; Drosophila melanogaster / genetics; Energy Metabolism / genetics; Female; Gene Expression Regulation; Male; Mutagenesis, Insertional; Phenotype; Quantitative Trait, Heritable; RNA, Messenger / genetics; RNA, Messenger / metabolism; Sex Characteristics; Sleep / genetics; Time Factors; Wakefulness / genetics
TL;DR:
Mutational genetic correlations among sleep parameters revealed that the genetic basis of the transition between sleep and waking states in males and females may be different, suggesting that sleep may serve a number of different functions rather than a single purpose.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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