Works Published in 2019
Displaying works 1 - 20 of 27 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2019 journal article
Improved transgenic sexing strains for genetic control of the Australian sheep blow fly Lucilia cuprina using embryo-specific gene promoters
Molecular Genetics and Genomics, 295(2), 287–298.
MeSH headings : Animals; Animals, Genetically Modified; Australia; Diptera / genetics; Diptera / pathogenicity; Embryonic Development / genetics; Female; Insect Proteins / genetics; Male; Pest Control, Biological; Promoter Regions, Genetic; Sheep / genetics; Sheep / parasitology; Tetracycline / biosynthesis
TL;DR:
These new embryonic L. cuprina transgenic sexing strains hold great promise for genetic control programs and the system reported here might also be transferable to other major calliphorid livestock pests such as the New World screwworm, Cochliomyia hominivorax.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 30, 2024
2019 journal article
The genome of the migratory nematode, Radopholus similis, reveals signatures of close association to the sedentary cyst nematodes
PLOS ONE, 14(10).
MeSH headings : Animals; DNA, Ribosomal / genetics; Genomics; Nematoda / classification; Phylogeny; Sequence Homology, Nucleic Acid; Tylenchida / classification; Tylenchida / genetics
TL;DR:
The hypothesis that R. similis is evolutionarily closer to the cyst nematodes is supported, however, differences in the effector repertoire delineate ancient divergence of parasitism, probably as a consequence of niche specialization.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 1, 2020
2019 journal article
Lisinopril Preserves Physical Resilience and Extends Life Span in a Genotype-Specific Manner in Drosophila melanogaster
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 74(12), 1844–1852.
author keywords: Angiotensin; Aging; Locomotion; Muscle; Genetic variation
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Drosophila Proteins / metabolism; Drosophila melanogaster / drug effects; Drosophila melanogaster / genetics; Genotype; Lisinopril / pharmacology; Longevity / drug effects; Male; Peptidyl-Dipeptidase A / metabolism; Phenotype; Transcriptome
TL;DR:
It is demonstrated that skeletal muscle-specific Ance, the Drosophila ortholog of ACE, is involved in physical decline and genetic variation in phenotypic responses to an ACE inhibitor is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 30, 2019
2019 article
An improved plant toolset for high-throughput recombineering
Brumos, J., Zhao, C., Gong, Y., Soriano, D., Patel, A. P., Perez-Amador, M. A., … Alonso, J. M. (2019, June 3). (Vol. 6). Vol. 6.
TL;DR:
A recombineering-based tagging system that brings together the convenience of the classical transgenic approaches and the high degree of confidence in the obtained results provided by the direct chromosomal tagging achievable by genome editing strategies is developed.
(via Semantic Scholar)
Source: ORCID
Added: December 19, 2019
2019 journal article
Interplay between Developmental Flexibility and Determinism in the Evolution of Mimetic Heliconius Wing Patterns
Current Biology, 29(23), 3996–4009.e4.
MeSH headings : Animals; Biological Evolution; Biological Mimicry; Butterflies / growth & development; Phenotype; Pigmentation; Selection, Genetic; Wings, Animal / growth & development; Wings, Animal / physiology
TL;DR:
The role that the signaling ligand WntA plays in generating mimetic wing patterns in Heliconius butterflies, a group with extraordinary mimicry-related wing pattern diversity, is explored, highlighting a surprising unpredictability in the developmental paths underlying convergence in a recent radiation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: December 16, 2019
2019 journal article
Structural and functional insights into the Diabrotica virgifera virgifera ATP-binding cassette transporter gene family
BMC GENOMICS, 20(1).
author keywords: ATP-binding cassette (ABC) transporter; Phylogenetic; Transcriptome; RNA interference (RNAi); Corn rootworm
MeSH headings : ATP-Binding Cassette Transporters / genetics; Animals; Coleoptera / classification; Coleoptera / genetics; Coleoptera / growth & development; Computational Biology / methods; Gene Expression Profiling; Gene Ontology; Life Cycle Stages / genetics; Molecular Sequence Annotation; Multigene Family; Phenotype; RNA Interference; Transcriptome
TL;DR:
This study has produced a relatively comprehensive de novo transcriptome assembly for D. v. virgifera and identified 65 members of the ABC transporter family and provided the first insights into the developmental and physiological roles of ABC transporters in this pest species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Source: Web Of Science
Added: December 16, 2019
2019 journal article
Locally Fixed Alleles: A method to localize gene drive to island populations
SCIENTIFIC REPORTS, 9.
MeSH headings : Alleles; Animals; Biodiversity; Islands
TL;DR:
This paper proposes the “Locally Fixed Alleles” approach as a novel means for localizing elimination by a drive to an island population that exhibits significant genetic isolation from neighboring populations and explores the feasibility and degree of localization that can be achieved.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: November 18, 2019
2019 journal article
Epigenetic silencing of a multifunctional plant stress regulator
ELIFE, 8.
MeSH headings : Arabidopsis / physiology; Arabidopsis Proteins / biosynthesis; Arabidopsis Proteins / metabolism; Epigenesis, Genetic; Ethylenes / metabolism; Gene Expression Regulation, Plant; Nuclear Proteins / metabolism; Receptors, Cell Surface / biosynthesis; Signal Transduction; Transcription Factors / metabolism
TL;DR:
A chromatin-dependent regulatory mechanism at EIN2 requiring two genes is identified, which safeguards the expression of an essential multifunctional plant stress regulator.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 30, 2019
2019 journal article
Specific Gene Disruption in the Major Livestock Pests<i>Cochliomyia hominivorax</i>and<i>Lucilia cuprina</i>Using CRISPR/Cas9
G3 Genes|Genomes|Genetics, 9(9), 3045–3055.
author keywords: Functional genomics; reverse genetics; myiasis; New World Screwworm fly; Australian Sheep Blowfly; gene drive; CRISPR; Cas9; brown body; yellow; transformer
MeSH headings : Animals; Animals, Genetically Modified; CRISPR-Cas Systems; Diptera / embryology; Diptera / genetics; Embryo, Nonmammalian; Female; Insect Proteins / genetics; Male; Mutation; Pest Control / methods; RNA, Guide, Kinetoplastida; Sex Determination Processes
TL;DR:
The CRISPR protocol described here is a significant improvement on the existing toolkit of molecular methods in calliphorids and suggests that Cas9-based systems targeting Chtra and Lctra could be an effective means for controlling natural populations of these important pests.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: September 23, 2019
2019 journal article
Genomic Selection with Allele Dosage in Panicum maximum Jacq.
G3-GENES GENOMES GENETICS, 9(8), 2463–2475.
author keywords: Plant Breeding; Guinea Grass; Quantitative Genotyping; Polyploidy; Genotyping-by-sequencing (GBS); Recurrent Genomic Selection; Genomic Prediction; GenPred; Shared Data Resources
MeSH headings : Algorithms; Alleles; Gene Dosage; Genome, Plant; Genomics / methods; Panicum / genetics; Phenotype; Plant Breeding; Polyploidy; Selection, Genetic
TL;DR:
This work provides bioinformatic and modeling guidelines to consider tetraploid dosage and observed that genomic selection may lead to additional gains in recurrent selection program of P. maximum.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 26, 2019
2019 article
Genes and functions associated with tolerance to fescue toxicosis in Angus cows
Khanal, P., Sanglard, L. P., Mayberry, K., Sommer, J., Poore, M. H., Poole, D. H., & Serao, N. V. L. (2019, July). JOURNAL OF ANIMAL SCIENCE, Vol. 97, pp. 167–167.
author keywords: fescue toxicosis; differentially expressed genes; tolerance
TL;DR:
Enrichment analysis showed that DEG between genetic groups have general functions, such as metabolic, biosynthetic, and catabolic processes, as well as DNA and RNA-related functions,such as translation, transcription, and repair.
(via Semantic Scholar)
Source: Web Of Science
Added: August 12, 2019
2019 journal article
Chromosome-scale assemblies reveal the structural evolution of African cichlid genomes
GIGASCIENCE, 8(4).
author keywords: genome assembly; African cichlids; comparative genomics; genome rearrangements; chromosome evolution; karyotype; inversion; recombination; transposable elements; genetic maps
MeSH headings : Animals; Chromosome Mapping; Cichlids / genetics; Computational Biology / methods; DNA Transposable Elements; Diploidy; Evolution, Molecular; Genetic Linkage; Genome; Genomics / methods; Karyotype; Molecular Sequence Annotation; Recombination, Genetic; Repetitive Sequences, Nucleic Acid
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: July 29, 2019
2019 journal article
Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene
ENVIRONMENTAL HEALTH PERSPECTIVES, 127(6).
MeSH headings : Animals; Collaborative Cross Mice; Glutathione / analogs & derivatives; Glutathione / metabolism; Hepatitis A Virus Cellular Receptor 1 / genetics; Hepatitis A Virus Cellular Receptor 1 / metabolism; Kidney / drug effects; Kidney Diseases / chemically induced; Kidney Diseases / metabolism; Liver / drug effects; Male; Risk Assessment / methods; Species Specificity; Tetrachloroethylene / metabolism; Tetrachloroethylene / pharmacokinetics; Tetrachloroethylene / toxicity; Toxicokinetics
TL;DR:
The utility of the CC mouse population is demonstrated in characterizing metabolism–toxicity interactions and quantifying interindividual variability and the default uncertainty factor for human variability may be marginally adequate to protect 95%, but not more, of the population for kidney toxicity mediated by PERC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 29, 2019
2019 article
From Ethylene-Auxin Interactions to Auxin Biosynthesis and Signal Integration
Stepanova, A. N., & Alonso, J. M. (2019, July). PLANT CELL, Vol. 31, pp. 1393–1394.
MeSH headings : Ethylenes / metabolism; Gene Expression Regulation, Plant; Indoleacetic Acids / metabolism; Models, Biological; Plant Proteins / metabolism; Plant Roots / metabolism; Signal Transduction
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science; OpenAlex)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 29, 2019
2019 journal article
Identification and validation of SNP markers associated with Wz-mediated Phytophthora nicotianae resistance in Nicotiana tabacum L.
MOLECULAR BREEDING, 39(7).
author keywords: Nicotiana; Tobacco; RNA-seq; Black shank; Phytophthora nicotianae
TL;DR:
The utility of a subset of derived Kompetitive Allele Specific PCR (KASP) and Cleaved Amplified Polymorphic Sequence (CAPS) markers for predicting the presence of Wz was verified using segregating populations and F3:4 families that were evaluated for field black shank resistance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: July 22, 2019
2019 journal article
Interferon-λ3 Promotes Epithelial Defense and Barrier Function Against Cryptosporidium parvum Infection
Cellular and Molecular Gastroenterology and Hepatology, 8(1), 1–20.
author keywords: Cryptosporidiosis; Cytokine; Enterocyte; Protozoa
MeSH headings : Animals; Cell Line; Cryptosporidiosis / genetics; Cryptosporidiosis / immunology; Cryptosporidiosis / parasitology; Cryptosporidium parvum / physiology; Cytokines / genetics; Cytokines / metabolism; Disease Models, Animal; Gene Expression Profiling; Intestinal Mucosa / immunology; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Swine; Up-Regulation
TL;DR:
These studies identify IFN-λ2/3 as a key epithelial defense mechanism against C parvum infection and Priming of IECs with recombinant human IFn-λ3 promoted cellular defense against CParvum infections and abrogated C parVum–induced loss of barrier function by decreasing paracellular permeability to sodium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: July 15, 2019
2019 article
RiboStreamR: a web application for quality control, analysis, and visualization of Ribo-seq data
Perkins, P., Mazzoni-Putman, S., Stepanova, A., Alonso, J., & Heber, S. (2019, June 6). BMC GENOMICS, Vol. 20.
author keywords: Ribo-seq; Next-generation sequencing; Data analysis; Web application
MeSH headings : Computer Graphics; Genomics / methods; High-Throughput Nucleotide Sequencing / methods; Humans; Protein Biosynthesis; Quality Control; RNA, Messenger / genetics; RNA, Messenger / metabolism; Ribosomes / metabolism; Sequence Analysis, RNA; Software; Transcriptome; Web Browser
TL;DR:
RiboStreamR is presented, a comprehensive Ribo-seq quality control (QC) platform in the form of an R Shiny web application that provides visualization and analysis tools for various Ribe-seq QC metrics, including read length distribution, read periodicity, and translational efficiency.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 1, 2019
2019 journal article
Genetics of cocaine and methamphetamine consumption and preference in Drosophila melanogaster
PLOS GENETICS, 15(5).
MeSH headings : Animals; Central Nervous System Stimulants / metabolism; Cocaine / metabolism; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins / antagonists & inhibitors; Dopamine Plasma Membrane Transport Proteins / genetics; Dopamine Plasma Membrane Transport Proteins / metabolism; Dopaminergic Neurons / metabolism; Drosophila Proteins / antagonists & inhibitors; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / drug effects; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Feeding Behavior; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Genome, Insect; Male; Methamphetamine / metabolism; Mushroom Bodies / metabolism; Mushroom Bodies / physiopathology; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism; Sex Characteristics; Substance-Related Disorders / genetics; Substance-Related Disorders / metabolism; Substance-Related Disorders / physiopathology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 24, 2019
2019 journal article
Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse
CHEMICAL RESEARCH IN TOXICOLOGY, 32(5), 887–898.
MeSH headings : Animals; Butadienes / toxicity; Carcinogens, Environmental / toxicity; DNA Adducts / chemistry; DNA Adducts / genetics; DNA Adducts / metabolism; DNA Methylation / drug effects; Epigenesis, Genetic / drug effects; Guanine / analogs & derivatives; Guanine / chemistry; Histones / metabolism; Kidney / drug effects; Liver / drug effects; Lung / drug effects; Male; Mice; Mutagens / toxicity
TL;DR:
1,3-butadiene is used to demonstrate how the Collaborative Cross mouse population can be used to identify the mechanisms for and quantify the degree of interindividual variability in tissue-specific effects that are relevant to chemically induced carcinogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 17, 2019
2019 journal article
Variation in pigmentation gene expression is associated with distinct aposematic color morphs in the poison frog Dendrobates auratus
BMC EVOLUTIONARY BIOLOGY, 19.
author keywords: Aposematism; Coloration; Color variation; Poison frog
MeSH headings : Animals; Anura / genetics; Color; Gene Expression Regulation; Gene Ontology; Melanins / metabolism; Phenotype; Principal Component Analysis; Skin Pigmentation / genetics; Transcriptome / genetics
TL;DR:
This work has taken a transcriptomics-based approach to elucidate the underlying genetic mechanisms affecting color and pattern in a highly polytypic poison frog, and finds differential expression of a suite of genes that control melanogenesis, melanocyte differentiation, and melanocyte proliferation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 6, 2019
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