Works Published in 2019
Displaying works 61 - 80 of 113 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2019 journal article
Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways
Computational Toxicology, 12, 100094.
Contributors: M. Kosnik n, A. Planchart n , S. Marvel n, D. Reif n & C. Mattingly n
doi.org (publisher)
Sources: ORCID, Crossref, NC State University Libraries
Added: August 30, 2019
2019 journal article
Overall gestational weight gain mediates the relationship between maternal and child obesity
BMC PUBLIC HEALTH, 19(1).
author keywords: Obesity; Gestational weight gain; Child obesity; Mediation; Causal inference
MeSH headings : Adult; Child, Preschool; Female; Gestational Weight Gain; Humans; Male; Mothers / statistics & numerical data; Obesity / epidemiology; Pediatric Obesity / epidemiology; Pregnancy; Risk Factors
TL;DR:
GWG mediated the relationship between maternal BMI and childhood adiposity and highlighted an important public health education opportunity to stress the impact of a pre-pregnancy weight and excessive GWG on the risk of child obesity for all mothers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 26, 2019
2019 journal article
Does cesarean delivery impact infant weight gain and adiposity over the first year of life?
INTERNATIONAL JOURNAL OF OBESITY, 43(8), 1549–1555.
MeSH headings : Adiposity; Adult; Birth Weight; Body Size; Body-Weight Trajectory; Cesarean Section / adverse effects; Cesarean Section / methods; Delivery, Obstetric / methods; Female; Gestational Age; Humans; Infant; Infant, Newborn; Linear Models; Male; Pediatric Obesity / pathology; Pregnancy; Prospective Studies; Skinfold Thickness; Socioeconomic Factors; Time Factors; Weight Gain; Young Adult
TL;DR:
Compared to vaginal delivery, cesarean delivery was associated with greater offspring rate of weight gain over the first year and differences in adiposity that appear as early as 3 months of age.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 26, 2019
2019 journal article
Transgenerational Bisphenol A Causes Deficits in Social Recognition and Alters Postsynaptic Density Genes in Mice
ENDOCRINOLOGY, 160(8), 1854–1867.
MeSH headings : Animals; Benzhydryl Compounds / toxicity; Brain / drug effects; Brain / metabolism; Female; Fetus / drug effects; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins / physiology; Phenols / toxicity; Post-Synaptic Density / drug effects; Social Behavior
TL;DR:
Transgenerational BPA exposure disrupted social interactions in mice and dysregulated normal expression of PSD genes during neural development, suggesting that BPA may contribute, in a transgenerational manner, to neurodevelopmental diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 19, 2019
2019 journal article
Inhalation exposure to multi-walled carbon nanotubes alters the pulmonary allergic response of mice to house dust mite allergen
INHALATION TOXICOLOGY, 31(5), 192–202.
author keywords: Carbon nanotubes; house dust mite allergen; asthma; inhalation; atopy; nanoparticles
MeSH headings : Animals; Antigens, Dermatophagoides / immunology; Bronchoalveolar Lavage Fluid; Dose-Response Relationship, Immunologic; Fibrosis; Hypersensitivity / physiopathology; Immunoglobulin E / blood; Inhalation Exposure / adverse effects; Interleukin-13 / analysis; Lung / physiology; Male; Mice; Nanotubes, Carbon / toxicity; Th2 Cells / immunology
TL;DR:
Inhalation pre-exposure to MWCNTs inhibited HDM-induced TH2 immune responses, yet this combined exposure resulted in vascular inflammation and airway fibrosis, indicating that M WCNT pre-Exposure alters the immune response to allergens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 19, 2019
2019 journal article
Exome sequencing of family trios from the National Birth Defects Prevention Study: Tapping into a rich resource of genetic and environmental data
BIRTH DEFECTS RESEARCH, 111(20), 1618–1632.
author keywords: birth defects; gene-environment interaction; genetics; intestinal atresia; sequence analysis
MeSH headings : Congenital Abnormalities / genetics; Congenital Abnormalities / prevention & control; Family; Gene-Environment Interaction; Humans; Exome Sequencing
TL;DR:
Successful sequencing of exomes from well-characterized NBDPS families indicated that this unique collection can be used to investigate the roles of genetic variation and gene-environment interaction effects in birth defect etiologies, providing a valuable resource for birth defect researchers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 12, 2019
2019 journal article
Integration of Food Animal Residue Avoidance Databank (FARAD) empirical methods for drug withdrawal interval determination with a mechanistic population-based interactive physiologically based pharmacokinetic (iPBPK) modeling platform: example for flunixin meglumine administration
ARCHIVES OF TOXICOLOGY, 93(7), 1865–1880.
author keywords: Flunixin; Interactive physiologically based pharmacokinetic (iPBPK) model; Food safety; Drug residues; Withdrawal intervals (WDIs); Food Animal Residue Avoidance Databank (FARAD)
MeSH headings : Animals; Animals, Domestic / metabolism; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Databases, Factual; Drug Residues / pharmacokinetics; Food Contamination / analysis; Food Contamination / prevention & control; Food Safety / methods; Models, Biological; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR:
A new PBPK model for both cattle and swine after administration of flunixin meglumine was developed and it can be applied to develop new models for other drugs in other food animal species, thereby facilitating the application of P BPK modeling in WDI estimation and food safety assessment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 12, 2019
2019 journal article
Growth, Condition, and Trophic Relations of Stocked Trout in Southern Appalachian Mountain Streams
TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY, 148(4), 771–784.
TL;DR:
Evaluated the growth, condition, and trophic relations of Brook Trout Salvelinus fontinalis, Brown Trout Salmo trutta, and Rainbow Trout Oncorhynchus mykiss that were stocked in southern Appalachian Mountain streams in western North Carolina to provide critical insight on the trophics of stocked trout and may assist in developing and enhancing stream trout fisheries.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 5, 2019
2019 journal article
Safety and efficacy of topically applied 0.5% and 1% pirfenidone in a canine model of subconjunctival fibrosis
VETERINARY OPHTHALMOLOGY, 22(4), 502–509.
MeSH headings : Administration, Topical; Animals; Aqueous Humor / drug effects; Conjunctival Diseases / drug therapy; Conjunctival Diseases / pathology; Conjunctival Diseases / veterinary; Disease Models, Animal; Dogs; Drug Implants; Female; Fibrosis / drug therapy; Fibrosis / veterinary; Pyridones / administration & dosage; Pyridones / therapeutic use; Random Allocation
TL;DR:
Pfenidone may decrease fibrosis following glaucoma shunt surgery and can potentially be used indefinitely due to minimal side effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 5, 2019
2019 article
RW-2018-Research Workshop: The Effect of Nutrition on Epigenetic Status, Growth, and Health
Skinner, M., Lumey, L. H., Fleming, T. P., Sapienza, C., Hoyo, C., Aronica, L., … Nichol, P. F. (2019, July). JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, Vol. 43, pp. 627–637.
author keywords: Avy mouse; DOHaD; epigenetics; hormesis; metabolic syndrome; methylome; nutrition; protein malnutrition; xenobiotics
MeSH headings : Animals; Epigenesis, Genetic / physiology; Health Status; Humans; Mice; Nutritional Physiological Phenomena / physiology; Nutritional Status
TL;DR:
The goal of the 2018 ASPEN Research Workshop was to explore the influence of nutrition and dietary exposure to xenobiotics on the epigenome during critical periods in development and how these exposures influence both disease incidence and severity transgenerationally.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: July 29, 2019
2019 journal article
Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene
ENVIRONMENTAL HEALTH PERSPECTIVES, 127(6).
MeSH headings : Animals; Collaborative Cross Mice; Glutathione / analogs & derivatives; Glutathione / metabolism; Hepatitis A Virus Cellular Receptor 1 / genetics; Hepatitis A Virus Cellular Receptor 1 / metabolism; Kidney / drug effects; Kidney Diseases / chemically induced; Kidney Diseases / metabolism; Liver / drug effects; Male; Risk Assessment / methods; Species Specificity; Tetrachloroethylene / metabolism; Tetrachloroethylene / pharmacokinetics; Tetrachloroethylene / toxicity; Toxicokinetics
TL;DR:
The utility of the CC mouse population is demonstrated in characterizing metabolism–toxicity interactions and quantifying interindividual variability and the default uncertainty factor for human variability may be marginally adequate to protect 95%, but not more, of the population for kidney toxicity mediated by PERC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 29, 2019
2019 journal article
Coordinating Tissue Regeneration Through Transforming Growth Factor-beta Activated Kinase 1 Inactivation and Reactivation
STEM CELLS, 37(6), 766–778.
author keywords: Cellular proliferation; Differentiation; Progenitor cells; Proliferation; Stem; progenitor cell; Tissue regeneration
MeSH headings : Animals; Bone Regeneration / drug effects; Bone Regeneration / genetics; Cell Differentiation / drug effects; Cell Proliferation / drug effects; DNA Nucleotidyltransferases / genetics; DNA Nucleotidyltransferases / metabolism; Female; Founder Effect; Fractures, Bone / drug therapy; Fractures, Bone / enzymology; Fractures, Bone / genetics; Fractures, Bone / pathology; Gene Expression Regulation; Integrases / genetics; Integrases / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / genetics; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / enzymology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Osteoblasts / cytology; Osteoblasts / drug effects; Osteoblasts / enzymology; Primary Cell Culture; Protein Kinase Inhibitors / pharmacology; Signal Transduction; Skull / drug effects; Skull / injuries; Skull / metabolism; Wound Healing / drug effects; Wound Healing / genetics
TL;DR:
It is demonstrated that loss of transforming growth factor‐β activated kinase 1 (TAK1) signaling reduces inappropriate tissue formation (heterotopic ossification) through reduced cellular differentiation, and the importance of both the “drug on” and "drug off" states during regenerative therapy is revealed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 22, 2019
2019 journal article
Vangl2 coordinates cell rearrangements during gut elongation
DEVELOPMENTAL DYNAMICS, 248(7), 569–582.
author keywords: Vangl2; endoderm; gut; Xenopus; morphogenesis; elongation
MeSH headings : Animals; Body Patterning; Cell Adhesion; Cell Movement; Cell Polarity; Endoderm / cytology; Intestines / anatomy & histology; Intestines / growth & development; Membrane Proteins / metabolism; Membrane Proteins / physiology; Morphogenesis; Xenopus Proteins / metabolism; Xenopus Proteins / physiology; Xenopus laevis / growth & development
TL;DR:
The embryonic gut tube undergoes extensive lengthening to generate the surface area required for nutrient absorption across the digestive epithelium in Xenopus, a process that concomitantly opens the gut lumen and facilitates epithelial morphogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 22, 2019
2019 journal article
Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases
Toxicology and Applied Pharmacology, 379, 114674.
Contributors: M. Kosnik n & D. Reif n
author keywords: Data integration; Risk assessment; New approach methodologies; Gene-environment interactions
MeSH headings : Animals; Databases, Factual; Datasets as Topic; Environmental Exposure / adverse effects; Environmental Exposure / statistics & numerical data; Gene-Environment Interaction; Genetic Predisposition to Disease / etiology; Genetic Predisposition to Disease / genetics; Genetic Variation; High-Throughput Screening Assays; Humans; Information Storage and Retrieval; Risk Assessment / methods; Toxicology / methods
TL;DR:
This work presents an approach that systematically links multiple data sources to relate chemical risk values to diseases and gene-disease variants and develops a new value that estimates the risk of these associations toward differential population responses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: ORCID
Added: July 17, 2019
2019 review
A Review and Tutorial of Machine Learning Methods for Microbiome Host Trait Prediction
[Review of ]. FRONTIERS IN GENETICS, 10.
author keywords: disease; phenotype; modeling; machine learning; prediction
TL;DR:
The most commonly used machine learning methods are explored, and their prediction accuracy as applied to microbiome host trait prediction is evaluated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 15, 2019
2019 journal article
Effects of Co-occurring Species Present in Swine Lagoons on Adsorption of Copper on Eggshell
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH, 13(4), 613–622.
author keywords: Adsorption; Eggshell; Copper; Swine lagoons; Acetate; Ammonia
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 15, 2019
2019 journal article
Association of prenatal antibiotics with measures of infant adiposity and the gut microbiome
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS, 18.
author keywords: Gut microbiome; Pediatric obesity; Antibiotic; Child health; Prenatal exposure; Pregnancy
MeSH headings : Adiposity / drug effects; Adult; Anti-Bacterial Agents / adverse effects; Bacteria / classification; Bacteria / drug effects; Bacteria / genetics; Bacteria / isolation & purification; Female; Gastrointestinal Microbiome / drug effects; Humans; Infant; Male; Obesity / etiology; Obesity / microbiology; Obesity / physiopathology; Pregnancy; Prenatal Exposure Delayed Effects / etiology; Prenatal Exposure Delayed Effects / microbiology; Prenatal Exposure Delayed Effects / physiopathology; Prospective Studies; Young Adult
TL;DR:
Prenatal antibiotic exposure in the second trimester was associated with an altered infant gut microbiome composition at 3 and 12 months and with higher infant WFL-z and subscapular skinfold thickness at 12 months.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 8, 2019
2019 journal article
Smoking-associated AHRR demethylation in cord blood DNA: impact of CD235a+nucleated red blood cells
CLINICAL EPIGENETICS, 11.
MeSH headings : Adult; Basic Helix-Loop-Helix Transcription Factors / genetics; CpG Islands; DNA Demethylation; Epigenesis, Genetic; Erythrocyte Count; Erythrocytes / immunology; Female; Fetal Blood / immunology; Glycophorins / metabolism; Humans; Lipopolysaccharide Receptors / metabolism; Male; Maternal Age; Pregnancy; Prenatal Exposure Delayed Effects / genetics; Repressor Proteins / genetics; Sequence Analysis, DNA; Smoking / adverse effects; Smoking / genetics; Young Adult
TL;DR:
Prenatal smoke exposure was highly significantly associated with AHRR methylation in cord blood, CD14+ monocytes, and CD235a+ nRBCs, andCD14+ cells, and robust linear regression models adjusting for estimated cell type composition outperformed those lacking these covariates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 1, 2019
2019 journal article
High Temperature Co-pyrolysis Thermal Air Activation Enhances Biochar Adsorption of Herbicides from Surface Water
ENVIRONMENTAL ENGINEERING SCIENCE, 36(6), 710–723.
author keywords: 2; 4-D; adsorption; aerobic pyrolysis; biochar; simazine
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 1, 2019
2019 journal article
Epigenome-wide meta-analysis of DNA methylation and childhood asthma
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(6), 2062–2074.
author keywords: Epigenetics; methylation; asthma; childhood; newborn; drug development
MeSH headings : Asthma / genetics; Child; CpG Islands / genetics; Cross-Sectional Studies; DNA Methylation; ERG1 Potassium Channel / genetics; Epigenesis, Genetic; Epigenome / genetics; Genome-Wide Association Study; Humans; Infant, Newborn; Interleukin-5 Receptor alpha Subunit / genetics
TL;DR:
Novel loci differentially methylated in newborns represent potential biomarkers of risk of asthma by school age, and Asthma-related differential methylation in blood in children was substantially replicated in eosinophils and respiratory epithelium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 24, 2019
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