Works Published in 2010
Displaying works 41 - 60 of 135 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2010 journal article
The phylogenetic origins of natural killer receptors and recognition: relationships, possibilities, and realities
Immunogenetics, 63(3), 123–141.
author keywords: Marsupial; Monotreme; Chicken; Xenopus; Zebrafish; Innate immunity; Cytotoxicity
MeSH headings : Animals; Evolution, Molecular; Humans; Immunity, Innate; Killer Cells, Natural / immunology; Mammals / genetics; Mammals / immunology; Phylogeny; Receptors, Natural Killer Cell / genetics; Receptors, Natural Killer Cell / immunology; Receptors, Natural Killer Cell / metabolism; Vertebrates / genetics; Vertebrates / immunology
TL;DR:
Several lines of evidence suggest that NK-type function or its equivalent has sustained a long evolutionary history throughout vertebrate species and likely reflects the influence of pathogens on their evolution.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, NC State University Libraries, Crossref
Added: February 13, 2019
2010 journal article
Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin
Journal of Immunology, 184(12), 7108–7115.
Contributors: G. Cruse* , V. Fernandes *, J. De Salort*, D. Pankhania*, M. Marinas*, H. Brewin*, P. Andrew *, P. Bradding *, A. Kadioglu *
MeSH headings : Bacterial Proteins / immunology; Cell Degranulation / immunology; Cells, Cultured; Coculture Techniques; Humans; Lung / cytology; Lung / immunology; Mast Cells / immunology; Mast Cells / microbiology; Pneumococcal Infections / immunology; Streptococcus pneumoniae / immunology; Streptolysins / immunology
TL;DR:
HLMCs exhibit direct antimicrobial activity to pneumococci through their activation by pneumolysin, and the release of LL-37 from HLMCs suggests that mast cells provide an early warning system and potentially limit pneumococcal dissemination early in the course of invasive pulmonary pneumitiscal disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2010 journal article
Counterregulation of β<inf>2</inf>-adrenoceptor function in human mast cells by stem cell factor
Journal of Allergy and Clinical Immunology, 125(1-3).
Contributors: G. Cruse* , W. Yang*, S. Duffy*, L. Chachi*, M. Leyland*, Y. Amrani*, P. Bradding *
author keywords: beta(2)-Adrenoceptor; albuterol; asthma; mast cell; desensitization
MeSH headings : Albuterol / metabolism; Albuterol / pharmacology; Asthma / drug therapy; Asthma / metabolism; Asthma / physiopathology; Cell Line; Histamine Release; Humans; Lung / cytology; Lung / drug effects; Mast Cells / drug effects; Mast Cells / immunology; Mast Cells / metabolism; Potassium Channels, Calcium-Activated / metabolism; Receptors, Adrenergic, beta-2 / drug effects; Receptors, Adrenergic, beta-2 / metabolism; Stem Cell Factor / metabolism; Stem Cell Factor / pharmacology
TL;DR:
Albuterol actually potentiated IgE-induced histamine release in a dose-dependent manner when both SCF and IgE were present, suggesting the potentially beneficial effects of beta(2)-adrenoceptor agonists in asthmatic airways may be blunted as a result of the high concentrations of SCF present.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2010 journal article
Airway smooth muscle proliferation and survival is not modulated by mast cells
Clinical and Experimental Allergy, 40(2), 279–288.
Contributors: D. Kaur *, F. Hollins*, R. Saunders *, L. Woodman*, A. Sutcliffe*, G. Cruse* , P. Bradding *, C. Brightling *
author keywords: airway smooth muscle; apoptosis; asthma; mast cells; necrosis; proliferation; survival
MeSH headings : Aged; Apoptosis; Asthma / immunology; Asthma / pathology; Cell Proliferation; Cell Survival; Cells, Cultured; Coculture Techniques; Female; Humans; Immunoglobulin E / immunology; Male; Mast Cells / immunology; Mast Cells / physiology; Middle Aged; Muscle, Smooth / metabolism; Muscle, Smooth / pathology
TL;DR:
Background Airway smooth muscle (ASM) hyperplasia and mast cell localization within the ASM bundle are important features of asthma and the cause of this increased ASM mass is uncertain.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2010 journal article
Activation of human mast cells through the platelet-activating factor receptor
Journal of Allergy and Clinical Immunology, 125(5).
Contributors: N. Kajiwara*, T. Sasaki*, P. Bradding *, G. Cruse* , H. Sagara *, K. Ohmori *, H. Saito *, C. Ra *, Y. Okayama*
author keywords: Anaphylaxis; histamine; human lung mast cells; human peripheral blood-derived mast cells; human skin mast cells; platelet-activating factor receptor
MeSH headings : Anaphylaxis / immunology; Anaphylaxis / physiopathology; Cells, Cultured; Histamine Release; Humans; Lung / cytology; Mast Cells / cytology; Mast Cells / immunology; Mast Cells / metabolism; Platelet Activating Factor / metabolism; Platelet Membrane Glycoproteins / metabolism; Receptors, G-Protein-Coupled / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Skin / cytology
TL;DR:
The findings provide a mechanism whereby PAF mediates an amplification loop for MC activation in the generation of anaphylaxis, and it is shown for the first time that PAF induces histamine release from human lung MCs and PB-derived MCs but not skin MCs.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2010 journal article
A novel FcεRIβ-chain truncation regulates human mast cell proliferation and survival
FASEB Journal, 24(10), 4047–4057.
Contributors: G. Cruse* , D. Kaur *, M. Leyland* & P. Bradding *
author keywords: MS4A2; IgE receptor; cell cycle; G2 phase; cell membrane
MeSH headings : Amino Acid Sequence; Apoptosis; Base Sequence; Blotting, Western; Cell Cycle; Cell Proliferation; Cell Survival / physiology; DNA; DNA Primers; Electrophoresis, Polyacrylamide Gel; Humans; Mast Cells / cytology; Molecular Sequence Data; Receptors, IgE / chemistry; Receptors, IgE / physiology; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
This finding demonstrates that the MS4A2 gene has multiple roles, extending beyond the regulation of acute allergic responses, and might be possible to induce its expression in mast cells in vivo, which could lead to better treatments for diseases such as mastocytosis and asthma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2010 book
Atlas of feline anatomy for veterinarians
Jackson, WY: Teton NewMedia.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Specific Resistance to Pseudomonas aeruginosa Infection in Zebrafish Is Mediated by the Cystic Fibrosis Transmembrane Conductance Regulator
Infection and Immunity, 78(11), 4542–4550.
MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / metabolism; Disease Models, Animal; Humans; Immunity, Innate; Neutrophils / immunology; Pseudomonas Infections / immunology; Pseudomonas Infections / microbiology; Pseudomonas aeruginosa / genetics; Pseudomonas aeruginosa / metabolism; Pseudomonas aeruginosa / pathogenicity; Quorum Sensing; Trans-Activators / genetics; Trans-Activators / metabolism; Virulence; Zebrafish / immunology; Zebrafish / microbiology
TL;DR:
The zebrafish system provides a multitude of advantages for studying the pathogenesis of P. aeruginosa and for understanding the role that innate immune cells, such as neutrophils, play in the host response to acute bacterial infections commonly associated with cystic fibrosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2010 journal article
Pharmacokinetics and toxicity of ciprofloxacin in adult horses
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 33(6), 587–594.
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacokinetics; Anti-Infective Agents / toxicity; Ciprofloxacin / administration & dosage; Ciprofloxacin / pharmacokinetics; Ciprofloxacin / toxicity; Colitis / chemically induced; Colitis / veterinary; Endotoxemia / chemically induced; Endotoxemia / veterinary; Female; Half-Life; Horse Diseases / chemically induced; Horses / metabolism; Injections, Intravenous / veterinary; Male
TL;DR:
Adverse events included mild transient diarrhea to severe colitis, endotoxemia and laminitis necessitating euthanasia of three horses on humane grounds, and the high incidences of adverse events preclude oral and rapid i.v. push administration of ciprofloxacin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Mature Hair Follicles Generated from Dissociated Cells: A Universal Mechanism of Folliculoneogenesis
DEVELOPMENTAL DYNAMICS, 239(10), 2619–2626.
author keywords: hair follicle; morphogenesis; organogenesis
MeSH headings : Animals; Cell Cycle / genetics; Cell Cycle / physiology; Dogs; Hair Follicle / cytology; Hair Follicle / embryology; Humans; Opossums; Organogenesis / genetics; Organogenesis / physiology; Rats; Skin / cytology; Skin / metabolism
TL;DR:
There is essentially one way by which dissociated mammalian skin cells form a new hair follicle in vivo and that this mechanism has been highly conserved, according to Developmental Dynamics 239:2619–2626.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Fluorescence in situ hybridization for identification of Tritrichomonas foetus in formalin-fixed and paraffin-embedded histological specimens of intestinal trichomonosis
VETERINARY PARASITOLOGY, 172(1-2), 139–143.
author keywords: Trichomonas; Intestine; Identification; Paraffin; Fluorescence
MeSH headings : Animals; Cats; DNA, Protozoan / chemistry; DNA, Protozoan / genetics; Histocytochemistry; In Situ Hybridization, Fluorescence / methods; Intestinal Diseases / diagnosis; Intestinal Diseases / parasitology; Microscopy, Fluorescence; Polymerase Chain Reaction; RNA, Ribosomal, 18S / chemistry; RNA, Ribosomal, 18S / genetics; Swine; Trichomonas Infections / diagnosis; Tritrichomonas foetus / genetics; Tritrichomonas foetus / isolation & purification
TL;DR:
The FISH assay described here enables simultaneous location and molecular identification of T. foetus in formalin-fixed and paraffin-embedded histological specimens of intestinal trichomoniasis by means of fluorescence in situ hybridization (FISH).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Evaluation of Pharmacokinetic-Pharmacodynamic Relationships for BioRelease Meloxicam Formulations in Horses
JOURNAL OF EQUINE VETERINARY SCIENCE, 30(10), 539–544.
author keywords: Meloxicam; Nonsteroidal anti-inflammatory drugs; Controlled release formulation
TL;DR:
Results from the present study suggest that potential therapeutic advantages of meloxicam may be enhanced by applying recent advances in biodegradable controlled release drug delivery, allowing single administration products to replace multiple daily treatment protocols.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Development of a Model of Sacrocaudal Spinal Cord Injury in Cloned Yucatan MiniPigs for Cellular Transplantation Research
CELLULAR REPROGRAMMING, 12(6), 689–697.
MeSH headings : Animals; Behavior, Animal; Cauda Equina / pathology; Cauda Equina / surgery; Cell Culture Techniques; Cells, Cultured; Cloning, Organism; Green Fluorescent Proteins / metabolism; Humans; Models, Animal; Nerve Regeneration / physiology; Nuclear Transfer Techniques; Recovery of Function / physiology; Sacrum; Spinal Cord / pathology; Spinal Cord / surgery; Spinal Cord Injuries / pathology; Stem Cell Transplantation / methods; Swine; Swine, Miniature / surgery
TL;DR:
It is demonstrated that transection of the sacrocaudal spinal cord in Yucatan SCNT clones produces profound, quantifiable neurological deficits restricted to the tail, which represents a powerful research tool to investigate the effect of cellular transplantation on axonal regeneration and functional recovery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
CHEMOTHERAPY FOLLOWED BY ABDOMINAL CAVITY IRRADIATION FOR FELINE LYMPHOBLASTIC LYMPHOMA
VETERINARY RADIOLOGY & ULTRASOUND, 51(6), 681–687.
author keywords: feline; lymphoma; chemoradiotherapy
MeSH headings : Abdominal Neoplasms / blood; Abdominal Neoplasms / drug therapy; Abdominal Neoplasms / radiotherapy; Abdominal Neoplasms / veterinary; Animals; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cat Diseases / blood; Cat Diseases / drug therapy; Cat Diseases / radiotherapy; Cats; Combined Modality Therapy / veterinary; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood; Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma / veterinary; Radiotherapy Dosage; Remission Induction / methods; Treatment Outcome
TL;DR:
Results of this study suggest that 15 Gy total abdomen fractionated radiation therapy after induction chemotherapy is tolerated satisfactorily, and this protocol is suitable for further testing to quantify efficacy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Pharmacokinetics of meloxicam following intravenous and oral administration in green iguanas (Iguana iguana)
American Journal of Veterinary Research, 71(11), 1277–1283.
MeSH headings : Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / toxicity; Area Under Curve; Blood Cells / drug effects; Blood Cells / physiology; Body Weight; Female; Iguanas / physiology; Injections, Intravenous; Kidney / drug effects; Kidney / pathology; Male; Meloxicam; Pain / drug therapy; Pain / veterinary; Stomach / drug effects; Stomach / pathology; Thiazines / administration & dosage; Thiazines / blood; Thiazines / pharmacokinetics; Thiazines / toxicity; Thiazoles / administration & dosage; Thiazoles / blood; Thiazoles / pharmacokinetics; Thiazoles / toxicity
TL;DR:
Results suggested that administration of meloxicam at a dose of 0.2 mg/kg IV or PO in green iguanas would result in plasma concentrations > 0.1 μg/mL for approximately 24 hours.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2010 journal article
Overexpression of Transcription Factor Sp2 Inhibits Epidermal Differentiation and Increases Susceptibility to Wound- and Carcinogen-Induced Tumorigenesis
CANCER RESEARCH, 70(21), 8507–8516.
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Blotting, Western; COS Cells; Carcinogens / toxicity; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cattle; Cell Differentiation; Chlorocebus aethiops; Disease Susceptibility; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Female; Humans; Immunoenzyme Techniques; Keratin-5 / genetics; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Male; Mice; Mice, Transgenic; Promoter Regions, Genetic; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms / etiology; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Sp2 Transcription Factor / physiology; Wounds and Injuries
TL;DR:
It is reported that Sp2 protein abundance in mice increases in concert with the progression of carcinogen-induced murine squamous cell carcinomas, and this results directly support the likelihood that Sp2 overexpression occurring in various human cancers has significant functional effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 review
Magnetic resonance imaging: A potential tool in assessing the addition of hyperthermia to neoadjuvant therapy in patients with locally advanced breast cancer
[Review of ]. INTERNATIONAL JOURNAL OF HYPERTHERMIA, 26(7), 625–637.
author keywords: imaging (DCE-MRI, DW-MRI); locally advanced breast cancer; physiological effects of hyperthermia; prediction and monitoring of tumour response
MeSH headings : Antineoplastic Agents / administration & dosage; Antineoplastic Agents / therapeutic use; Breast Neoplasms / drug therapy; Breast Neoplasms / pathology; Breast Neoplasms / therapy; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Humans; Hyperthermia, Induced; Magnetic Resonance Imaging / methods
TL;DR:
The purpose of this review is to examine the potential role of magnetic resonance imaging (MRI) in early prediction of treatment response and prognosis of overall survival in locally advanced breast cancer patients enrolled on multi modality therapy trials that include hyperthermia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Expression of IL-4/IL-13 receptors in differentiating human airway epithelial cells
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 299(5), L681–L693.
author keywords: interleukin-4; interleukin-13; eotaxin-3; migration
MeSH headings : Animals; Cell Differentiation / physiology; Cell Movement; Cells, Cultured; Chemokine CCL26; Chemokines, CC / genetics; Chemokines, CC / metabolism; Epithelial Cells / cytology; Epithelial Cells / physiology; Humans; Protein Subunits / genetics; Protein Subunits / metabolism; Receptors, Interleukin-13 / genetics; Receptors, Interleukin-13 / metabolism; Receptors, Interleukin-4 / genetics; Receptors, Interleukin-4 / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / physiology; Stress, Mechanical
TL;DR:
Substantial differences in IL-4/IL-13 receptor subunit expression and responsiveness toIL-4 based on the extent of airway epithelial cell differentiation are demonstrated and it is suggested that these differences may have functional consequences in airway inflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Characterization of side population cells in human malignant mesothelioma cell lines
LUNG CANCER, 70(2), 146–151.
author keywords: Mesothelioma; Side population; Cancer stem cell; Hoechst 33342; Tumorigenicity; Flow cytometry
MeSH headings : Animals; Cell Line, Tumor; Cell Proliferation; Cell Separation; Cisplatin / pharmacology; Feasibility Studies; Flow Cytometry; Gene Expression Regulation, Developmental; Humans; Mesothelioma / diagnosis; Mesothelioma / drug therapy; Mesothelioma / pathology; Mice; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells / drug effects; Neoplastic Stem Cells / metabolism; Neoplastic Stem Cells / pathology; Side-Population Cells / drug effects; Side-Population Cells / metabolism; Side-Population Cells / pathology
TL;DR:
The data indicated that SP assay may not be appropriate for enriching putative CSCs in HMM cell lines, and thus warrants the development of a novel tool for mesothelial CSC study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Proteomic Analysis Reveals Virus-Specific Hsp25 Modulation in Cardiac Myocytes
JOURNAL OF PROTEOME RESEARCH, 9(5), 2460–2471.
author keywords: cardiac myocyte; myocarditis; reovirus; Hsp25; Hsp27; proteome; DIGE
MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Cell Nucleus / metabolism; Cells, Cultured; Cytoplasm / metabolism; Electrophoresis, Gel, Two-Dimensional; Fibroblasts / metabolism; Heat-Shock Proteins / metabolism; Interferons / metabolism; Mice; Molecular Chaperones; Myocarditis / metabolism; Myocarditis / virology; Myocardium / cytology; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / virology; Neoplasm Proteins / metabolism; Orthoreovirus, Mammalian; Phosphorylation; Principal Component Analysis; Proteomics / methods; Reoviridae Infections / metabolism; Reoviridae Infections / virology; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
Results here provide the first evidence for a virus-induced decrease in Hsp25/27 and suggest that viruses may have evolved a mechanism to subvert this protective response, as they have for IFN.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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