Center for Human Health and the Environment

Works Published in 2014

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Displaying works 141 - 160 of 259 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2014 journal article

Urinary Tetrabromobenzoic Acid (TBBA) as a Biomarker of Exposure to the Flame Retardant Mixture Firemaster ® 550

Environmental Health Perspectives, 122(9), 963–969.

By: K. Hoffman *, M. Fang *, B. Horman n, H. Patisaul n , S. Garantziotis *, L. Birnbaum *, H. Stapleton *

MeSH headings : Adult; Aged; Animals; Biomarkers / metabolism; Bromobenzoates / urine; Dust / analysis; Environmental Exposure / analysis; Environmental Pollutants / urine; Female; Flame Retardants / metabolism; Hand; Humans; Male; Mass Spectrometry / methods; Middle Aged; Organophosphates / urine; Phthalic Acids / urine; Polybrominated Biphenyls / urine; Rats
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Soy but not bisphenol A (BPA) induces hallmarks of polycystic ovary syndrome (PCOS) and related metabolic co-morbidities in rats

REPRODUCTIVE TOXICOLOGY, 49, 209–218.

By: H. Patisaul n , N. Mabrey n, H. Adewale n & A. Sullivan n

author keywords: Phytoestrogens; Genistein; Endocrine disruptors; Ovary; Development
MeSH headings : Animals; Benzhydryl Compounds / adverse effects; Diet / adverse effects; Endocrine Disruptors / adverse effects; Female; Ovary / drug effects; Ovary / pathology; Phenols / adverse effects; Polycystic Ovary Syndrome / chemically induced; Polycystic Ovary Syndrome / pathology; Pregnancy; Rats; Rats, Wistar; Soy Foods / adverse effects; Testosterone / blood
TL;DR: Lifetime exposure to a soy diet, containing endocrine active phytoestrogens, but not developmental exposure to the endocrine disrupting monomer bisphenol A (BPA), can induce key features of PCOS in the rat, results which support the hypothesis that hormonally active diets may contribute to risk when consumed throughout gestation and post-natal life. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Single-Nucleotide Polymorphism Data Support the General Unrelatedness of the Males in the Agricultural Health Study

Cancer Epidemiology Biomarkers & Prevention, 23(10), 2192–2195.

By: J. Jack n, A. Motsinger-Reif n, S. Koutros *, M. Alavanja*, L. Beane Freeman* & J. Hoppin n 

MeSH headings : Agriculture; Case-Control Studies; Cohort Studies; Consanguinity; Gene-Environment Interaction; Humans; Male; Occupational Exposure; Polymorphism, Single Nucleotide; Principal Component Analysis; Research Design
TL;DR: This analysis rejects the hypothesis that individuals in the case–control study of prostate cancer exhibit cryptic relatedness, and these findings are important for all subsequent analyses of gene–environment interactions in the AHS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Pesticide use and incident diabetes among wives of farmers in the Agricultural Health Study

Occupational and Environmental Medicine, 71(9), 629–635.

By: A. Starling *, D. Umbach *, F. Kamel*, S. Long*, D. Sandler * & J. Hoppin n 

Contributors: A. Starling *, D. Umbach *, F. Kamel*, S. Long*, D. Sandler * & J. Hoppin n 

MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Diabetes Mellitus / epidemiology; Diabetes Mellitus / etiology; Female; Humans; Incidence; Iowa / epidemiology; Middle Aged; North Carolina / epidemiology; Occupational Exposure / adverse effects; Organophosphates / toxicity; Pesticides / toxicity; Proportional Hazards Models; Spouses; Young Adult
TL;DR: Results are consistent with previous studies reporting an association between specific organochlorines and diabetes and add to growing evidence that certain organophosphates also may increase risk, though attenuated compared with separate models. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Metal oxyhydroxide dissolution as promoted by structurally diverse siderophores and oxalate

GEOCHIMICA ET COSMOCHIMICA ACTA, 141, 258–269.

By: M. Akafia n, J. Harrington  n, J. Bargar * & O. Duckworth n 

Contributors: M. Akafia n, J. Harrington  n, J. Bargar * & O. Duckworth n 

UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Incorporation of advanced aerosol activation treatments into CESM/CAM5: model evaluation and impacts on aerosol indirect effects

Atmospheric Chemistry and Physics, 14(14), 7485–7497.

By: B. Gantt, J. He, X. Zhang, Y. Zhang & A. Nenes

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Improvement and further development in CESM/CAM5: gas-phase chemistry and inorganic aerosol treatments

Atmospheric Chemistry and Physics, 14(17), 9171–9200.

By: J. He & Y. Zhang

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

CHROMOSOME RESEARCH, 22(3), 305–319.

By: R. Thomas n, L. Borst n , D. Rotroff n, A. Motsinger-Reif n, K. Lindblad-Toh *, J. Modiano *, M. Breen n

author keywords: canine; chromosome; hemangiosarcoma; comparative genomic hybridization (CGH)
MeSH headings : Animals; Breeding; Comparative Genomic Hybridization; DNA Copy Number Variations / genetics; Dog Diseases / genetics; Dogs; Gene Amplification; Gene Expression Profiling; Genetic Heterogeneity; Genome; Hemangiosarcoma / genetics; Hemangiosarcoma / veterinary; Penetrance; Vascular Endothelial Growth Factor A / genetics
TL;DR: Analysis of genome-wide microarray-based somatic DNA copy number profiling of 75 primary intra-abdominal hemangiosarcomas from five popular dog breeds supports prior transcriptional studies suggesting that the clinical heterogeneity of this cancer may reflect the existence of multiple, molecularly distinct subtypes of canine hemangiusarcoma. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

GENE-LEVEL PHARMACOGENETIC ANALYSIS ON SURVIVAL OUTCOMES USING GENE-TRAIT SIMILARITY REGRESSION

ANNALS OF APPLIED STATISTICS, 8(2), 1232–1255.

By: J. Tzeng n, W. Lu n & F. Hsu *

author keywords: Association study; gene/pathway; pharmacogenetics; similarity regression; survival data; proportional odds model; proportional hazards model
TL;DR: A gene-trait similarity regression for survival analysis to assess the effect of a gene or pathway on time-to-event outcomes and derives the equivalence between the similarity survival regression and a random effects model, which further unifies the current variance-component based methods. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 article

Focus on Advancing High Performance Mass Spectrometry, Honoring Dr. Richard D. Smith, Recipient of the 2013 Award for a Distinguished Contribution in Mass Spectrometry

Baker, E. S., Muddiman, D. C., & Loo, J. A. (2014, December). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 25, pp. 1997–1999.

By: E. Baker *, D. Muddiman n  & J. Loo *

TL;DR: This special focus issue of the Journal of the American Society for Mass spectrometry celebrates the accomplishments of Dr. Richard D. Smith, the recipient of the 2013ASMS Award for a Distinguished Contribution in Mass Spectrometry. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Fertilization of Radishes, Tomatoes, and Marigolds Using a Large-Volume Atmospheric Glow Discharge

PLASMA CHEMISTRY AND PLASMA PROCESSING, 34(6), 1271–1290.

By: A. Lindsay n, B. Byrns n, W. King n, A. Andhvarapou n, J. Fields  n, D. Knappe n , W. Fonteno n, S. Shannon n 

Contributors: A. Lindsay n, B. Byrns n, W. King n, A. Andhvarapou n, J. Fields  n, D. Knappe n , W. Fonteno n, S. Shannon n 

author keywords: Large-volume glow; Atmospheric pressure plasma; Fertilization; Reactive nitrogen and oxygen species
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Evaluating nonpolar surface area and liquid chromatography/mass spectrometry response: an application for site occupancy measurements for enzyme intermediates in polyketide biosynthesis

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 28(23), 2511–2522.

By: S. Randall n, I. Koryakina n, G. Williams n  & D. Muddiman n 

MeSH headings : Acyltransferases / metabolism; Chromatography, Liquid / methods; Filtration; Hydrophobic and Hydrophilic Interactions; Mass Spectrometry / methods; Oligopeptides / chemistry; Oligopeptides / metabolism; Peptide Fragments / chemistry; Peptide Fragments / metabolism; Polyketides / chemistry; Polyketides / metabolism
TL;DR: The MS signal as a function of nonpolar surface area (NPSA) is explored in order to better understand this bias in electrospray response and to determine relative LC/MS response for peptides. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Establishing ion ratio thresholds based on absolute peak area for absolute protein quantification using protein cleavage isotope dilution mass spectrometry

ANALYST, 139(21), 5439–5450.

By: P. Loziuk n, R. Sederoff n, V. Chiang n & D. Muddiman n 

MeSH headings : Chromatography, Liquid; Isotopes / chemistry; Proteins / analysis; Tandem Mass Spectrometry / methods
TL;DR: It is suggested that evaluation of the absolute ion abundance for any given transition is necessary in order to effectively implement RA thresholds, and these RA values should be assessed as close as possible to the time at which data is collected for quantification. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Atomic Layer Deposition Coating of Carbon Nanotubes with Aluminum Oxide Alters Pro-Fibrogenic Cytokine Expression by Human Mononuclear Phagocytes In Vitro and Reduces Lung Fibrosis in Mice In Vivo

PLOS ONE, 9(9).

By: A. Taylor n, C. McClure n, K. Shipkowski n, E. Thompson n, S. Hussain *, S. Garantziotis *, G. Parsons n , J. Bonner n

MeSH headings : Aluminum Oxide / pharmacology; Animals; Cell Death / drug effects; Cell Line; Cytokines / metabolism; Humans; Inflammation / pathology; Interleukin-1beta / biosynthesis; Interleukin-6 / metabolism; Leukocytes, Mononuclear / drug effects; Leukocytes, Mononuclear / metabolism; Lung / drug effects; Lung / metabolism; Lung / pathology; Macrophages / drug effects; Macrophages / metabolism; Macrophages / ultrastructure; Mice, Inbred C57BL; Nanotechnology / methods; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / ultrastructure; Osteopontin / metabolism; Phagocytes / drug effects; Phagocytes / metabolism; Pulmonary Fibrosis; Soot / pharmacology; Surface Properties; Tumor Necrosis Factor-alpha / metabolism
TL;DR: Findings indicate that ALD thin film coating of MWCNTs with Al2O3 reduces fibrosis in mice and that in vitro phagocyte expression of IL-6, TNF-α, and OPN, but not IL-1β, predict M WCNT-induced fibrosisIn the lungs of mice in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

A Novel Model for Neuroendocrine Toxicology: Neurobehavioral Effects of BPA Exposure in a Prosocial Species, the Prairie Vole (Microtus ochrogaster)

ENDOCRINOLOGY, 155(10), 3867–3881.

By: A. Sullivan n, E. Beach*, L. Stetzik*, A. Perry*, . Alyssa S. D'Addezio n, B. Cushing*, H. Patisaul n 

MeSH headings : Affect / drug effects; Animals; Arvicolinae / physiology; Arvicolinae / psychology; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Defense Mechanisms; Endocrine Disruptors / toxicity; Environmental Exposure; Environmental Pollutants / toxicity; Female; Male; Models, Animal; Motor Activity / drug effects; Neurosecretory Systems / drug effects; Phenols / toxicity; Social Behavior; Toxicity Tests
TL;DR: The hypothesis that BPA alters affective behaviors, potentially via disruption of OT/AVP pathways, is supported in the prairie vole, which is more prosocial than lab rats or mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

2,4-D adsorption to biochars: Effect of preparation conditions on equilibrium adsorption capacity and comparison with commercial activated carbon literature data

WATER RESEARCH, 62, 20–28.

By: J. Kearns *, L. Wellborn*, R. Summers * & D. Knappe  n

Contributors: J. Kearns *, L. Wellborn*, R. Summers * & D. Knappe  n

author keywords: Pesticide; Herbicide; Water treatment; Charcoal; Low-cost adsorbent
TL;DR: Economic analysis showed that high temperature chars can be a cost-effective alternative to ACs for water treatment applications and increase pyrolysis intensity by increasing temperature and duration was found to positively influence adsorption capacity yield. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
6. Clean Water and Sanitation (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Unraveling secrets of telomeres: One molecule at a time

DNA REPAIR, 20, 142–153.

By: J. Lin n, P. Kaur n, P. Countryman n, P. Opresko * & H. Wang n 

author keywords: Telomeres; Single-molecule imaging; Atomic force microscopy; Fluorescence microscopy; FRET; Laser tweezers; Magnetic tweezers; Protein DNA interactions
MeSH headings : Animals; Fluorescence Resonance Energy Transfer / methods; Humans; Microscopy, Atomic Force / methods; Microscopy, Fluorescence / methods; Optical Tweezers; Telomere / chemistry; Telomere / metabolism; Telomere-Binding Proteins / chemistry; Telomere-Binding Proteins / metabolism
TL;DR: This review presents a brief overview of the principles of single-molecule imaging and manipulation techniques and highlights results obtained from applying these single- molecule techniques for studying structure, dynamics and functions of G-quadruplexes, telomerase, and shelterin proteins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Synthetic organic water contaminants in developing communities: an overlooked challenge addressed by adsorption with locally generated char

JOURNAL OF WATER SANITATION AND HYGIENE FOR DEVELOPMENT, 4(3), 422–436.

By: J. Kearns *, D. Knappe n  & R. Summers *

Contributors: J. Kearns *, D. Knappe  n & R. Summers *

author keywords: biochar; charcoal; drinking water; herbicide; pesticide; Thailand
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Myristoylated Alanine Rich C Kinase Substrate (MARCKS) is essential to beta 2-integrin dependent responses of equine neutrophils

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 160(3-4), 167–176.

By: M. Sheats* , K. Pescosolido, E. Hefner*, E. Sung, K. Adler* & S. Jones* 

author keywords: Neutrophil; Migration; Adhesion; Respiratory burst; Beta2-integrin; Inflammation
MeSH headings : Amino Acid Sequence; Animals; Antigen-Antibody Complex / physiology; CD18 Antigens / immunology; CD18 Antigens / physiology; Cell Adhesion / drug effects; Cell Adhesion / physiology; Cell Movement / drug effects; Cell Movement / physiology; Conserved Sequence; Horses / immunology; Horses / physiology; In Vitro Techniques; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / genetics; Membrane Proteins / physiology; Molecular Sequence Data; Myristoylated Alanine-Rich C Kinase Substrate; Neutrophil Infiltration / drug effects; Neutrophil Infiltration / immunology; Neutrophil Infiltration / physiology; Peptide Fragments / genetics; Peptide Fragments / pharmacology; Respiratory Burst / drug effects; Sequence Homology, Amino Acid; Tetradecanoylphorbol Acetate / pharmacology
TL;DR: It is demonstrated that inhibition of MARCKS function significantly attenuates β2-integrin-dependent neutrophil functions including migration, adhesion, and immune complex-mediated respiratory burst, and strongly implicate MARC KS as a potential regulator of β 2-integrins in neutrophils. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Mapping Antiretroviral Drugs in Tissue by IR-MALDESI MSI Coupled to the Q Exactive and Comparison with LC-MS/MS SRM Assay

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 25(12), 2038–2047.

By: J. Barry n, G. Robichaud n, M. Bokhart n, C. Thompson*, C. Sykes *, A. Kashuba *, D. Muddiman n 

author keywords: IR-MALDESI; Mass spectrometry imaging; LC-MS/MS; Drug distribution
MeSH headings : Adenine / analogs & derivatives; Adenine / analysis; Adenine / chemistry; Adenine / pharmacokinetics; Anti-Retroviral Agents / analysis; Anti-Retroviral Agents / chemistry; Anti-Retroviral Agents / pharmacokinetics; Cervix Uteri / chemistry; Cervix Uteri / metabolism; Chromatography, Liquid / methods; Deoxycytidine / analogs & derivatives; Deoxycytidine / analysis; Deoxycytidine / chemistry; Deoxycytidine / pharmacokinetics; Emtricitabine; Female; Histocytochemistry; Humans; Molecular Imaging / methods; Organophosphonates / analysis; Organophosphonates / chemistry; Organophosphonates / pharmacokinetics; Pyrrolidinones / analysis; Pyrrolidinones / chemistry; Pyrrolidinones / pharmacokinetics; Raltegravir Potassium; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Tandem Mass Spectrometry / methods; Tenofovir; Tissue Distribution
TL;DR: An agreement between the average intensities from the imaging experiment and the absolute quantities for each drug was observed and this correlation between these two techniques serves as a prerequisite to quantitative IR-MALDESI MSI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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