Works Published in 2022
Displaying works 41 - 60 of 151 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2022 article
Evaluating the relevance of surgical margins. Part one: The problems with current methodology
Bray, J., Eward, W., & Breen, M. (2022, November 25). VETERINARY AND COMPARATIVE ONCOLOGY.
author keywords: genetics'; pathology; small animal; surgical oncology; tumour biology
MeSH headings : Animals; Margins of Excision; Neoplasm Recurrence, Local / veterinary; Retrospective Studies
TL;DR:
The challenges with defining the true extent of the tumours margin from the perspective of the surgeon, the pathologist and the tumour are described and why current efforts to ensure that all traces of the local tumour have been successfully removed may provide an imperfect assessment of the risk of recurrence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 12, 2022
2022 journal article
A web-based interactive physiologically based pharmacokinetic (iPBPK) model for meloxicam in broiler chickens and laying hens
FOOD AND CHEMICAL TOXICOLOGY, 168.
author keywords: Meloxicam; Food Animal Residue Avoidance Databank (FARAD); Physiologically based pharmacokinetic (PBPK) modeling; Broiler chicken; Laying hen; Food safety
MeSH headings : Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chickens; Eggs; Female; Internet; Meloxicam
TL;DR:
The model provides a useful and flexible tool for risk assessment and management of residues for meat and eggs from chickens treated with meloxicam and will serve as a basis for extrapolation to other NSAID drugs and other poultry species to aid animal-derived food safety assessment.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 12, 2022
2022 journal article
Utilizing a Population-Genetic Framework to Test for Gene-Environment Interactions between Zebrafish Behavior and Chemical Exposure
TOXICS, 10(12).
author keywords: gene-environment interaction; chemical risk-assessment; zebrafish behavior; toxicity screening
TL;DR:
It is demonstrated how standing genetic variation in a heterogeneous population such as the authors' can be leveraged to test for potential GxE by showing evidence that heritable genetics are directly affecting gene expression and behavioral susceptibility of individuals to PFHxA exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 10, 2022
2022 journal article
The acclimatory response of the mayfly Neocloeon triangulifer to dilute conditions is linked to the plasticity of sodium transport
author keywords: mayfly; dilute; ion transport; acclimation; life history; sodium
MeSH headings : Acclimatization; Animals; Ephemeroptera / physiology; Fresh Water; Gills; Ions; Salinity; Sodium; Water Pollutants, Chemical
TL;DR:
A physiological affinity for dilute conditions in this emerging mayfly model is shown, as nymphs acclimated to their dilute exposures by increasing their rates of Na uptake and were able to maintain a relatively narrow range of uptake rates across all treatments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: December 5, 2022
2022 article
Structural and dynamic basis of DNA capture and translocation by mitochondrial Twinkle helicase
Li, Z., Kaur, P., Lo, C.-Y., Chopra, N., Smith, J., Wang, H., & Gao, Y. (2022, November 18). NUCLEIC ACIDS RESEARCH, Vol. 11.
MeSH headings : Humans; Mitochondrial Proteins / metabolism; Cryoelectron Microscopy; DNA Helicases / metabolism; Mitochondria / genetics; Mitochondria / metabolism; DNA Replication; DNA, Mitochondrial / genetics
TL;DR:
Cryo-electron microscopy and high-speed atomic force microscope data obtained the atomic-resolution structure of a vertebrate Twinkle homolog with DNA and captured in real-time how Twinkle is self-loaded onto DNA, highlighting the essential role of the non-catalytic N-terminal domain of Twinkle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 5, 2022
2022 journal article
Impact of Caterpillar Increased Feeding Rates on Reduction of Bt Susceptibility
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(23).
author keywords: tobacco budworm; bollworm; fall armyworm; cotton; Bacillus thuringiensis; MVPII; Cry1Ac; Cry2Ab2; behavioral resistance; increased feeding
MeSH headings : Animals; Hemolysin Proteins / genetics; Hemolysin Proteins / pharmacology; Hemolysin Proteins / metabolism; Endotoxins / genetics; Endotoxins / metabolism; Pest Control, Biological; Plants, Genetically Modified / genetics; Plants, Genetically Modified / metabolism; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bacillus thuringiensis Toxins; Moths / genetics; Bacillus thuringiensis / genetics; Bacillus thuringiensis / metabolism; Insecticide Resistance / genetics; Gossypium / metabolism; Larva / metabolism
TL;DR:
The hypothesis that increased feeding rate is a behavioral mechanism for reducing caterpillar susceptibility to Bt is supported and the literature reviewed support the hypothesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 3, 2022
2022 journal article
A Double Penalty Model for Ensemble Learning
MATHEMATICS, 10(23).
author keywords: double penalty model; interpretability; partially linear model; separability
TL;DR:
By considering ensemble learning for two learning ensemble components as a double penalty model, this work provides a framework to better understand the relative convergence and identifiability of the two components.
(via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 1, 2022
2022 review
Placing human gene families into their evolutionary context
[Review of ]. HUMAN GENOMICS, 16(1).
MeSH headings : Animals; Humans; Evolution, Molecular; Genomics; Genome; Base Sequence; Phylogeny
TL;DR:
How homology can provide insights into the genes and gene families associated with immune response, cancer biology, vision, chemosensation, and metabolism, by revealing similarity in processes among distant species is shown.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 28, 2022
2022 journal article
Tools for Understanding and Predicting the Affinity of Per- and Polyfluoroalkyl Substances for Anion-Exchange Sorbents br
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 56(22), 15470–15477.
author keywords: per-and polyfluoroalkyl substances; anion exchange; electrostatic potential; liquid chromatography
MeSH headings : Fluorocarbons / analysis; Water Pollutants, Chemical / analysis; Carboxylic Acids / analysis; Water Purification; Anions
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 28, 2022
2022 review
Biology, Systematics, Microbiome, Pathogen Transmission and Control of Chiggers (Acari: Trombiculidae, Leeuwenhoekiidae) with Emphasis on the United States
[Review of ]. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 19(22).
author keywords: chiggers; biology; systematics; microbiome; pathogen transmission; control
MeSH headings : Animals; Humans; Trombiculidae / microbiology; Scrub Typhus / epidemiology; Orientia tsutsugamushi; Acari; Microbiota; Biology
TL;DR:
The role of chiggers in disease transmission in the US is especially understudied, and the role of endosymbionts in Orientia infection are suggested in the scientific literature but not confirmed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 22, 2022
2022 journal article
Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies
AMERICAN JOURNAL OF HUMAN GENETICS, 109(9), 1638–1652.
MeSH headings : Anemia / drug therapy; Anemia / genetics; Coronary Artery Disease / genetics; Genome-Wide Association Study; Humans; Mendelian Randomization Analysis; Myocardial Infarction / genetics; Renal Insufficiency, Chronic / genetics
TL;DR:
A combination of genetic and functional studies provides a powerful approach to investigate the potential therapeutic profile of EPO-increasing therapies for treating anemia in CKD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 21, 2022
2022 journal article
Pleiotropic modifiers of age-related diabetes and neonatal intestinal obstruction in cystic fibrosis
AMERICAN JOURNAL OF HUMAN GENETICS, 109(10), 1894–1908.
MeSH headings : Cystic Fibrosis / complications; Cystic Fibrosis / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Diabetes Mellitus / genetics; Genome-Wide Association Study; Humans; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction / complications; Intestinal Obstruction / genetics
TL;DR:
Different loci modify risk of CFRD and MI; however, a subset exhibit pleiotropic effects indicating etiologic and mechanistic overlap between these two otherwise distinct complications of CF.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 21, 2022
2022 journal article
A cross-species approach using an in vivo evaluation platform in mice demonstrates that sequence variation in human RABEP2 modulates ischemic stroke outcomes
AMERICAN JOURNAL OF HUMAN GENETICS, 109(10), 1814–1827.
MeSH headings : Alleles; Animals; Brain / metabolism; Chromosome Mapping; Humans; Ischemic Stroke; Mice; Vesicular Transport Proteins / genetics; rab GTP-Binding Proteins / genetics; rab GTP-Binding Proteins / metabolism
TL;DR:
This work established an in vivo evaluation platform in mice by using adeno-associated virus (AAV) gene replacement and verified that both mouse and human RABEP2 rescue the mouse Rabep2 knockout ischemic stroke volume and collateral vessel phenotypes, and chose four coding variants from the human population that are predicted by multiple in silico algorithms to be damaging to RAB EP2 function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 21, 2022
2022 journal article
C3NA: correlation and consensus-based cross-taxonomy network analysis for compositional microbial data
BMC BIOINFORMATICS, 23(1).
author keywords: Co-occurrence network analysis; Microbiome; R package; Consensus clustering; Module preservation analysis
MeSH headings : Phylogeny; Consensus
TL;DR:
C3NA is presented, a user-friendly R package for investigating compositional microbial sequencing data to identify and compare co-occurrence patterns across different taxonomic levels and discovered clusters of study and disease-dependent taxa that overlap with known functional taxa studied by other discovery studies and differential abundance analyses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 21, 2022
2022 journal article
Endogenous Diurnal Patterns of Adrenal and Gonadal Hormones During a 24-Hour Constant Routine After Simulated Shift Work
JOURNAL OF THE ENDOCRINE SOCIETY, 6(12).
author keywords: circadian misalignment; healthy young adults; internal desynchrony; reproductive health; sex steroids
TL;DR:
Experimental circadian misalignment had minimal effects on steroidogenesis and adrenal steroids, but not gonadal hormones, showed endogenous circadian regulation robust to prior shift schedule, which may predispose night-shift workers to metabolic ill health.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 14, 2022
2022 journal article
CIRCADIAN DYSREGULATION OF HUMAN DNA REPAIR GENES AND ELEVATED DNA DAMAGE IN SIMULATED NIGHT SHIFT SCHEDULE
Sleep. https://publons.com/wos-op/publon/54906417/
Contributors: H. Van Dongen, B. Koritala, K. Porter, O. Arshad, R. Gajula, H. Mitchell, T. Arman, M. Manjanatha
Source: ORCID
Added: November 14, 2022
2022 article
The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease
Riegl, S. D., Starnes, C., Jima, D. D., Baptissart, M., Diehl, A. M., Belcher, S. M., & Cowley, M. (2022, October 6). TOXICOLOGICAL SCIENCES, Vol. 10.
author keywords: nonalcoholic fatty liver disease; developmental toxicology; epigenetics; cadmium; genomic imprinting; developmental programming
MeSH headings : Mice; Animals; Non-alcoholic Fatty Liver Disease / genetics; Non-alcoholic Fatty Liver Disease / metabolism; Cadmium; Cadmium Chloride / toxicity; PPAR gamma; Liver / metabolism; Fibrosis
TL;DR:
It is demonstrated that developmental Cd exposure is sufficient to program NAFLD in later life, and Zac1 and the IGN are established as key regulators of prosteatotic and profibrotic pathways, two of the major pathological hallmarks ofNAFLD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 7, 2022
2022 review
Racial disparities in liver cancer: Evidence for a role of environmental contaminants and the epigenome
[Review of ]. FRONTIERS IN ONCOLOGY, 12.
author keywords: liver cancer; race; epigenetic; contaminants; epigenome
TL;DR:
The hypothesis that epigenetic mediators may provide biomarkers for early detection to support interventions that reduce disparities is discussed and the paucity of mechanistic insights impedes prevention efforts is evaluated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: October 31, 2022
2022 journal article
Densely methylated DNA traps Methyl-CpG-binding domain protein 2 but permits free diffusion by Methyl-CpG-binding domain protein 3
JOURNAL OF BIOLOGICAL CHEMISTRY, 298(10).
MeSH headings : CpG Islands; DNA Methylation; DNA-Binding Proteins / metabolism; Mi-2 Nucleosome Remodeling and Deacetylase Complex / genetics; Mi-2 Nucleosome Remodeling and Deacetylase Complex / metabolism; Nucleosomes; Protein Binding; Transcription Factors / metabolism; Humans; Single Molecule Imaging
TL;DR:
These studies support a model in which MBD2-NuRD strongly localizes to and compacts methylated CpG islands while MBD3-NURD can freely mobilize nucleosomes independent of methylation status.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 24, 2022
2022 journal article
Impact of ozone-biologically active filtration on the breakthrough of Perfluoroalkyl acids during granular activated carbon treatment of municipal wastewater effluent
WATER RESEARCH, 223.
author keywords: Perfluoroalkyl acids; Municipal wastewater effluent; Ozonation; Biologically active filtration; Effluent organic matter; Potable reuse
MeSH headings : Charcoal / chemistry; Fluorocarbons / analysis; Ozone / chemistry; Wastewater / chemistry; Water Pollutants, Chemical / chemistry; Water Purification / methods
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 17, 2022
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