Works Published in 2015
Displaying works 121 - 140 of 154 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
Excretory, Secretory, and Tissue Residues after Label and Extra-label Administration of Flunixin Meglumine to Saline- or Lipopolysaccharide-Exposed Dairy Cows
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63(19), 4893–4901.
author keywords: dairy; extra-label; flunixin; holstein; liver; metabolite ratio; milk; residue
MeSH headings : Adipose Tissue / chemistry; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / analysis; Clonixin / pharmacokinetics; Drug Labeling; Drug Residues / analysis; Drug Residues / pharmacokinetics; Female; Inflammation / chemically induced; Inflammation / drug therapy; Kidney / chemistry; Lipopolysaccharides / adverse effects; Liver / chemistry; Milk / chemistry; Muscle, Skeletal / chemistry; Sodium Chloride / administration & dosage; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR:
Flunixin meglumine administered by either intravenous infusion or intramuscular injection at 24 h intervals may be related to LPS inhibition of flunixIn metabolism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
A Multi-Megabase Copy Number Gain Causes Maternal Transmission Ratio Distortion on Mouse Chromosome 2
PLOS GENETICS, 11(2).
MeSH headings : Alleles; Animals; Chromosomes / genetics; Crosses, Genetic; DNA Copy Number Variations / genetics; Female; Genomics; Genotyping Techniques; Haplotypes / genetics; Inheritance Patterns / genetics; Male; Meiosis / genetics; Mice; Mutation
TL;DR:
It is found that transmission ratios in R2d2WSB heterozygous females vary between Mendelian segregation and complete distortion depending on the genetic background, and that TRD is under genetic control of unlinked distorter loci.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
The importance of retaining a phylogenetic perspective in traits-based community analyses
FRESHWATER BIOLOGY, 60(7), 1330–1339.
author keywords: aquatic insects; metals; physiology; traits; variability
TL;DR:
The findings suggest that lineage provides context for the analysis of species traits, and that failure to consider lineage in community-based analysis of traits may obscure important patterns of species responses to environmental change.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Statistical validation of structured population models for Daphnia magna
Mathematical Biosciences, 266, 73–84.
author keywords: Sensitivity analysis; Structured population model; Uncertainty quantification; Density-dependence; Multi-scale data; Daphnia magna
MeSH headings : Animals; Daphnia; Models, Statistical; Population Dynamics
TL;DR:
This study develops structured population models that exemplify specific mechanisms and uses multi-scale experimental data in order to test their importance, and shows that fecundity and survival rates are affected by both time-varying density-independent factors and density-dependent factors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
SRWC bioenergy productivity and economic feasibility on marginal lands
JOURNAL OF ENVIRONMENTAL MANAGEMENT, 160, 57–66.
author keywords: Abandoned lands; Contaminated lands; Investment analysis; Short-rotation forestry; Sustainable feedstock production
MeSH headings : Agriculture / economics; Biomass; Humans; Pinus taeda / growth & development; Populus / growth & development; Sewage; Southeastern United States; Wood
TL;DR:
Rotation length affected economic outcomes although the returns were poor due to high establishment and maintenance costs, low productivities and low current stumpage values, which are expected to quickly change with development of robust global markets.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Machine learning reveals sex-specific 17β-estradiol-responsive expression patterns in white perch (Morone americana) plasma proteins
PROTEOMICS, 15(15), 2678–2690.
Contributors: J. Schilling n, A. Nepomuceno n, A. Planchart n , J. Yoder n , R. Kelly n , D. Muddiman n , H. Daniels n, N. Hiramatsu*, B. Reading n
author keywords: Animal proteomics; Endocrine disrupting compounds; Machine learning; Plasma; Semiquantitative proteomics; Support vector machines
MeSH headings : Animals; Bass / metabolism; Blood Proteins / metabolism; Blotting, Western; Chromatography, Liquid; Estradiol / pharmacology; Estrogens / pharmacology; Female; Fish Proteins / metabolism; Kininogens / metabolism; Male; Nanotechnology / methods; Proteome / drug effects; Proteome / metabolism; Proteomics / methods; Sex Factors; Support Vector Machine; Tandem Mass Spectrometry; Vitellogenins / metabolism
TL;DR:
This is the first report that Eltd1 and Kng1 may be E2‐responsive proteins in fishes and therefore may be useful indicators of estrogen induction in fishes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Incidence of solid tumours among pesticide applicators exposed to the organophosphate insecticide diazinon in the Agricultural Health Study: an updated analysis
Occupational and Environmental Medicine, 72(7), 496–503.
MeSH headings : Adult; Agricultural Workers' Diseases / epidemiology; Agricultural Workers' Diseases / etiology; Agriculture; Diazinon / adverse effects; Humans; Incidence; Iowa / epidemiology; Kidney Neoplasms / epidemiology; Kidney Neoplasms / etiology; Lung Neoplasms / epidemiology; Lung Neoplasms / etiology; Male; Middle Aged; North Carolina / epidemiology; Occupational Exposure / adverse effects; Organophosphorus Compounds / adverse effects; Pesticides / adverse effects; Prospective Studies; Prostatic Neoplasms / epidemiology; Prostatic Neoplasms / etiology
TL;DR:
The authors' updated evaluation of diazinon provides additional evidence of an association with lung cancer risk and newly identified links to kidney cancer and associations with aggressive prostate cancer require further evaluation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer
Chemical Research in Toxicology, 28(6), 1144–1155.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
IARC monographs: 40 years of evaluating carcinogenic hazards to humans
Environmental Health Perspectives, 123(6), 507–514.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Epigenetic regulation of Newborns' imprinted genes related to gestational growth: patterning by parental race/ethnicity and maternal socioeconomic status
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 69(7), 639–647.
MeSH headings : Birth Weight / genetics; Cohort Studies; DNA Methylation / genetics; Epigenesis, Genetic; Ethnicity / genetics; Fetal Blood / cytology; Fetal Development / genetics; Genomic Imprinting; Humans; Infant, Newborn; North Carolina; Obesity / genetics; Parents; Regression Analysis; Social Class; Time
TL;DR:
The hypothesis that epigenetics may link the observed lower SES during the prenatal period and poor outcomes such as low birth weight is supported; lower birth weight has previously been associated with adult-onset chronic diseases and conditions that include cardiovascular diseases, diabetes, obesity and some cancers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
BRAF Mutations in Canine Cancers
PLOS ONE, 10(6).
MeSH headings : Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Dogs; Exons / genetics; Female; Genetic Predisposition to Disease; Humans; Male; Molecular Sequence Data; Mutation / genetics; Neoplasms / genetics; Neoplasms / veterinary; Proto-Oncogene Proteins B-raf / chemistry; Proto-Oncogene Proteins B-raf / genetics; Sequence Analysis, DNA
TL;DR:
The evolutional conservation of the BRAF V600E mutation highlights the importance of MAPK pathway activation in neoplasia and may offer opportunity for molecular diagnostics and targeted therapeutics for dogs bearing BRAF-mutated cancers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort
EPIGENETICS, 10(7), 597–606.
author keywords: birth weight; epidemiology; epigenetics; imprinted genes; methylation; physical activity
MeSH headings : Adolescent; Birth Weight / physiology; Cell Cycle Proteins / chemistry; Cell Cycle Proteins / genetics; Cohort Studies; DNA Methylation; Female; Genetic Association Studies; Genomic Imprinting; Humans; Infant, Newborn; Male; Motor Activity / genetics; Pregnancy; Transcription Factors / chemistry; Transcription Factors / genetics; Tumor Suppressor Proteins / chemistry; Tumor Suppressor Proteins / genetics; Young Adult
TL;DR:
This first study to support a role for imprinted gene plasticity in these associations between prenatal PA, birth weight, and newborn DNA methylation levels at differentially methylated regions (DMRs) regulating 4 imprinted genes known to be important in fetal development is confirmed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
A Review of Nonoccupational Pathways for Pesticide Exposure in Women Living in Agricultural Areas
Environmental Health Perspectives, 123(6), 515–524.
MeSH headings : Agriculture; Environmental Exposure; Environmental Pollutants / metabolism; Female; Humans; North America; Pesticides / metabolism
TL;DR:
An improved understanding of nonoccupational pesticide exposure pathways in women living in agricultural areas is critical for studying health effects in women and for designing effective exposure-reduction strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Population-Based in Vitro Hazard and Concentration-Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study
ENVIRONMENTAL HEALTH PERSPECTIVES, 123(5), 458–466.
MeSH headings : Cell Line, Tumor; Genome-Wide Association Study / methods; Genotype; Humans; Risk Assessment; Toxicity Tests / methods
TL;DR:
This experimental approach fills critical gaps unaddressed by recent large-scale toxicity testing programs, providing quantitative, experimentally based estimates of human toxicodynamic variability, and also testable hypotheses about mechanisms contributing to interindividual variation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 article
Peto's paradox and the promise of comparative oncology
Nunney, L., Maley, C. C., Breen, M., Hochberg, M. E., & Schiffman, J. D. (2015, July 19). PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol. 370.
author keywords: Peto's paradox; comparative oncology; evolution; life-history theory; cancer; modelling
MeSH headings : Animals; Biological Evolution; Body Size; Cocarcinogenesis; Female; Humans; Longevity; Male; Mammals; Models, Biological; Neoplasms / etiology
TL;DR:
The history of the field is reviewed and how the contributions use empirical, comparative and theoretical approaches to address the processes and patterns associated with ‘Peto's paradox’, the lack of a statistical relationship of cancer incidence with body size and longevity is outlined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Impact of Gestational Bisphenol A on Oxidative Stress and Free Fatty Acids: Human Association and Interspecies Animal Testing Studies
ENDOCRINOLOGY, 156(3), 911–922.
MeSH headings : Adult; Animals; Benzhydryl Compounds / blood; Benzhydryl Compounds / toxicity; Biomarkers; Environmental Pollutants; Fatty Acids, Nonesterified / metabolism; Female; Fetal Blood / chemistry; Fetus / drug effects; Humans; Hypopituitarism; Maternal Exposure; Mice; Oxidative Stress; Phenols / blood; Phenols / toxicity; Pregnancy; Rats; Species Specificity
TL;DR:
Evidence is provided of the induction of nitrosative stress by prenatal BPA in both the mother and fetus at time of birth and is thus supportive of the use of maternal NY as a biomarker for offspring health.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes
Infectious Agents and Cancer, 10.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Hypothesis testing at the extremes: fast and robust association for high-throughput data
BIOSTATISTICS, 16(3), 611–625.
author keywords: Density approximation; Exact testing; Permutation
MeSH headings : Biostatistics; Breast Neoplasms / genetics; Computer Simulation; Cystic Fibrosis / genetics; Databases, Nucleic Acid / statistics & numerical data; Female; High-Throughput Nucleotide Sequencing / statistics & numerical data; High-Throughput Screening Assays / statistics & numerical data; Humans; Likelihood Functions; Linear Models; Polymorphism, Single Nucleotide; Sample Size; Software
TL;DR:
An approximation to exact association tests of trend that is accurate and fast enough for standard use in high-throughput settings, and can easily provide standard two-sided or doubled [Formula: see text]-values is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2015 journal article
Gene Expression in Transformed Lymphocytes Reveals Variation in Endomembrane and HLA Pathways Modifying Cystic Fibrosis Pulmonary Phenotypes
The American Journal of Human Genetics, 96(2), 318–328.
MeSH headings : Cystic Fibrosis / genetics; Cystic Fibrosis / pathology; Endoplasmic Reticulum Stress / genetics; Gene Expression Profiling; Genes, MHC Class I / genetics; Genetic Variation; Humans; Linear Models; Phenotype; Receptors, Lysophosphatidic Acid / genetics; Sequence Deletion / genetics
TL;DR:
Gene expression provided a powerful tool to identify unrecognized heritable variation, complementing ongoing GWASs in this rare disease and enriched for heritable genetic variation and expression quantitative traits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018
2015 review
Comparative oncology: what dogs and other species can teach us about humans with cancer
author keywords: comparative oncology; genomics; genetics; cancer; canine; human
MeSH headings : Animals; Breeding; Disease Models, Animal; Dog Diseases / etiology; Dogs; Female; Genome-Wide Association Study / veterinary; Genomics; Germ-Line Mutation; Humans; Male; Neoplasms / etiology; Neoplasms / veterinary; Risk Factors; Species Specificity; Translational Research, Biomedical
TL;DR:
This review begins with the genetic origins of canines and their advantage in cancer research, and next focuses on recent findings in comparative oncology related to inherited, or genetic, risk for tumour development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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