Works Published in 2011
Displaying works 161 - 180 of 225 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach
BONE, 49(3), 356–367.
author keywords: Osteosarcoma; Gene expression profiling; Cell cycle; DNA damage checkpoint; Tumor microenvironment; Canine
MeSH headings : Animals; Bone Neoplasms / classification; Bone Neoplasms / genetics; Bone Neoplasms / pathology; Cluster Analysis; Cohort Studies; Cyclin B2 / genetics; Cyclin B2 / metabolism; Dogs; Female; Gene Expression Profiling; Humans; Kaplan-Meier Estimate; Male; Oligonucleotide Array Sequence Analysis / methods; Osteosarcoma / classification; Osteosarcoma / genetics; Osteosarcoma / pathology; Prognosis; Vimentin / genetics; Vimentin / metabolism
TL;DR:
The results indicate that the narrower genetic diversity of dogs can be utilized to group complex human osteosarcoma into biologically and clinically relevant molecular subtypes, which in turn may enhance prognosis and prediction, and identify relevant therapeutic targets.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Effect of shelter on reproduction, growth and longevity of the German cockroach, Blattella germanica (Dictyoptera: Blattellidae)
European Journal of Entomology, 108(2), 205–210.
author keywords: Dictyoptera; Blattellidae; Blattela germanica; cockroach; shelter; fitness; population; aggregation; reproduction; growth; longevity
TL;DR:
When shelters were available in arenas, nymphs developed faster, adults gained more body mass, and females produced more fertile oothecae than when arenas lacked shelters, and reducing or eliminating shelters should affect population growth of B. germanica in residential and industrial settings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Development of a Brain Metastatic Canine Prostate Cancer Cell Line
PROSTATE, 71(12), 1251–1263.
author keywords: prostate cancer; brain metastasis; spinal cord metastasis; dog; canine; bone metastasis
MeSH headings : Adrenal Gland Neoplasms / epidemiology; Adrenal Gland Neoplasms / secondary; Animals; Antineoplastic Agents / pharmacology; Bone Neoplasms / epidemiology; Bone Neoplasms / secondary; Boronic Acids / pharmacology; Bortezomib; Brain Neoplasms / epidemiology; Brain Neoplasms / metabolism; Brain Neoplasms / pathology; Brain Neoplasms / secondary; Carcinogenicity Tests; Carcinoma / epidemiology; Carcinoma / metabolism; Carcinoma / pathology; Carcinoma / secondary; Cell Division; Cell Line, Tumor / drug effects; Cell Line, Tumor / pathology; Dogs; Immunohistochemistry; Incidence; Injections, Subcutaneous; Keratin-18 / metabolism; Keratin-7 / metabolism; Keratin-8 / metabolism; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Connective Tissue / secondary; Parathyroid Hormone-Related Protein / metabolism; Phenylbutyrates / antagonists & inhibitors; Prostatic Neoplasms / pathology; Pyrazines / pharmacology; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord Neoplasms / epidemiology; Spinal Cord Neoplasms / secondary; Subcutaneous Tissue; Transplantation, Heterologous
TL;DR:
The goal of the study was to establish and characterize a new prostate cancer line derived from a dog with spontaneous prostate cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Comparison of stable-isotope labeling with amino acids in cell culture and spectral counting for relative quantification of protein expression
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 25(17), 2524–2532.
MeSH headings : Amino Acid Sequence; Amino Acids / chemistry; Amino Acids / metabolism; Animals; Cell Differentiation; Cell Line; Ectoderm; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Humans; Isotope Labeling / methods; Mass Spectrometry; Mice; Molecular Sequence Data; Peptide Fragments; Peptide Mapping; Proteins / analysis; Proteins / chemistry; Proteins / metabolism; Proteomics / methods; Sensitivity and Specificity; Tandem Mass Spectrometry; Time Factors
TL;DR:
The comparison of stable-isotope labeling of amino acids in cell culture (SILAC) with spectral counting for the quantification of human embryonic stem cells as they differentiate toward the trophectoderm at three time points is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
CD34 antigen: Determination of specific sites of phosphorylation in vitro and in vivo
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 301(1-3), 12–21.
author keywords: CD34; Phosphorylation; PKC kinase; AKT2 kinase; LC/MS/MS
TL;DR:
The identification of the in vitro sites of phosphorylation on the intracellular domain of mouse CD34 following PKC treatment suggests that other kinases, as well as PKC, may have important signaling functions in CD34.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Bayesian Spatial Quantile Regression
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 106(493), 6–20.
author keywords: Climate change; Ozone; Semiparametric Bayesian methods; Spatial data
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Bacteria Stimulate Hatching of Yellow Fever Mosquito Eggs
PLoS ONE, 6(9), e24409.
Ed(s): F. Leulier
MeSH headings : Aedes / microbiology; Aedes / physiology; Animals; Bacteria; Female; Male; Ovum / microbiology; Ovum / physiology; Plant Leaves / chemistry; Plant Leaves / microbiology; Quercus / chemistry; Quercus / microbiology; Reproduction / physiology; Yellow Fever / transmission
TL;DR:
There is compelling evidence that bacteria or water-soluble compounds secreted by bacteria, not just low DO concentration, stimulate hatching of Ae.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Surface estimation, variable selection, and the nonparametric oracle property
Statistica Sinica, 21(2), 679–705.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Structure and molecular evolution of the ribosomal DNA external transcribed spacer in the cockroach genus Blattella
Genome, 54(3), 222–234.
Ed(s): A. Civetta
author keywords: cockroach; Blattella; multigene families; ribosomal DNA; concerted evolution; birth-and-death model; saltational evolution
MeSH headings : Animals; Base Sequence; Cockroaches / genetics; Computational Biology; DNA Primers / genetics; DNA, Ribosomal Spacer / genetics; Evolution, Molecular; Gene Components; Models, Genetic; Molecular Sequence Data; Sequence Analysis, DNA; Species Specificity
TL;DR:
A new model is proposed to explain the evolutionary reorganization of the ETS region: evolution of rDNA by "magnification-and-fixation" is characterized by magnification of minor subrepeats, which become adaptive in a new rapidly changed environment, and subsequent fixation of this variant type as a major component of the multigene family of a new species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Specification of a Foxj1-Dependent Lineage in the Forebrain Is Required for Embryonic-to-Postnatal Transition of Neurogenesis in the Olfactory Bulb
JOURNAL OF NEUROSCIENCE, 31(25), 9368–9382.
MeSH headings : Animals; Forkhead Transcription Factors / metabolism; Mice; Mice, Knockout; Neurogenesis / physiology; Neurons / physiology; Olfactory Bulb / embryology; Olfactory Bulb / physiology; Prosencephalon / embryology; Prosencephalon / physiology
TL;DR:
For the first time, this study identifies the time- and region-specific activity of a perinatal progenitor domain that is required for transition and progression of OB neurogenesis from the embryonic-to-postnatal periods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Ronidazole pharmacokinetics after intravenous and oral immediate-release capsule administration in healthy cats
JOURNAL OF FELINE MEDICINE AND SURGERY, 13(4), 244–250.
MeSH headings : Administration, Oral; Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / pharmacokinetics; Biological Availability; Cat Diseases / drug therapy; Cats / metabolism; Cross-Over Studies; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Metabolic Clearance Rate; Protozoan Infections, Animal / drug therapy; Random Allocation; Ronidazole / administration & dosage; Ronidazole / pharmacokinetics; Tritrichomonas foetus / drug effects
TL;DR:
The high oral bioavailability of RDZ and slow elimination may predispose cats to neurotoxicity with twice-daily administration, and less frequent administration should be considered for further study of effective treatment of T foetus-infected cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Non-canonical beta-catenin degradation mediates reactive oxygen species-induced epidermal cell death
ONCOGENE, 30(30), 3336–3344.
author keywords: apoptosis; beta-catenin; caspase; epidermis; reactive oxygen species
MeSH headings : Animals; Apoptosis / drug effects; Caspases / metabolism; Cell Adhesion / drug effects; Enzyme Activation / drug effects; Epidermal Cells; Epidermis / drug effects; Epidermis / enzymology; Epidermis / metabolism; HEK293 Cells; Humans; Mice; Reactive Oxygen Species / pharmacology; beta Catenin / metabolism
TL;DR:
Results indicate that a feed-forward loop consisting of ROS, caspases activation and β-catenin degradation induces epidermal cell death.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat
REPRODUCTIVE TOXICOLOGY, 31(3), 280–289.
author keywords: Soy; Estrogen; Phytoestrogens; Endocrine disruptors; Development; Reproductive; Fertility; Ovary
MeSH headings : Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / metabolism; Arcuate Nucleus of Hypothalamus / pathology; Female; Gene Expression Regulation, Developmental / drug effects; Genistein / toxicity; Hypothalamus / drug effects; Hypothalamus / metabolism; Immunohistochemistry; In Situ Hybridization; Kisspeptins; Midline Thalamic Nuclei / drug effects; Midline Thalamic Nuclei / metabolism; Midline Thalamic Nuclei / pathology; Ovary / drug effects; Ovary / growth & development; Phytoestrogens / toxicity; Proteins / genetics; Proteins / metabolism; RNA, Messenger / analysis; Rats; Rats, Long-Evans; Rats, Wistar; Sex Factors; Sexual Maturation / drug effects; Sexual Maturation / physiology; Signal Transduction / drug effects
TL;DR:
Female rats exposed to the phytoestrogen genistein, estradiol benzoate, or vehicle from post natal day (P) 0-3 via subcutaneous injection were exposed to estrogenic endocrine disrupting compounds to establish sex specific development of KISS gene expression, cell number and neural fiber density across peripuberty.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Increasing proteome coverage with offline RP HPLC coupled to online RP nanoLC-MS
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 879(9-10), 610–614.
author keywords: RP HPLC; Fractionation methods; Proteomics; Mass spectrometry
MeSH headings : Chromatography, High Pressure Liquid / methods; Chromatography, Reverse-Phase / methods; Mass Spectrometry / methods; Nanotechnology; Peptide Fragments / analysis; Peptide Fragments / metabolism; Proteome / analysis; Proteome / metabolism; Proteomics / methods; Saccharomyces cerevisiae Proteins / analysis; Saccharomyces cerevisiae Proteins / metabolism
TL;DR:
The success of performing offline reversed phase high pressure liquid chromatography (HPLC) fractionation on a C18 2.0 mm×150 mm column at the peptide level with microliter per minute flow rates prior to online nano-flow reversed phase liquid Chromatography mass spectrometry (nanoLC-MS) using the well-studied fungus Saccharomyces cerevisiae is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Improving Proteome Coverage on a LTQ-Orbitrap Using Design of Experiments
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 22(4), 773–783.
author keywords: LTQ-Orbitrap XL MS/MS instrument parameters; Design of experiments; Fractional-factorial design; Saccharomyces cerevisiae; Proteomics
MeSH headings : Peptide Fragments; Peptide Mapping; Proteome / chemistry; Proteomics / methods; Research Design; Saccharomyces cerevisiae Proteins / chemistry; Tandem Mass Spectrometry / methods; Temperature
TL;DR:
The DOE approach represents a time- and cost-effective method for empirically optimizing MS-based proteomics workflows including sample preparation, LC conditions, and multiple instrument platforms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Identification of alternative splice variants in Aspergillus flavus through comparison of multiple tandem MS search algorithms
BMC Genomics, 12.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Hydrophobic Derivatization of N-linked Glycans for Increased Ion Abundance in Electrospray Ionization Mass Spectrometry
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 22(8), 1309–1317.
author keywords: Hydrophobic Derivatization; HILIC; nanoESI; N-Linked Glycans; Hydrazone Formation
MeSH headings : Blood Proteins / chemistry; Carbohydrate Sequence; Chromatography, Liquid; Glycoproteins / chemistry; Humans; Hydrazines / chemistry; Hydrophobic and Hydrophilic Interactions; Polysaccharides / chemistry; Small Molecule Libraries; Spectrometry, Mass, Electrospray Ionization / methods; Tandem Mass Spectrometry
TL;DR:
The results of this study will direct the future synthesis of hydrophobic reagents for glycan analysis using the correlation between hydrophobicity and theoretical non-polar surface area calculation to facilitate the development of an optimum tag for gly can derivatization.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Facile Self-Assembly of Supramolecular Hexakisferrocenyl Triangles via Coordination-Driven Self-Assembly and Their Electrochemical Behavior
ORGANOMETALLICS, 30(13), 3637–3642.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 review
Capitalizing on the hydrophobic bias of electrospray ionization through chemical modification in mass spectrometry-based proteomics
[Review of ]. EXPERT REVIEW OF PROTEOMICS, 8(3), 317–323.
author keywords: ALiPHAT; electrospray ionization; hydrophobic tagging; mass spectrometry; quantification
MeSH headings : Humans; Hydrophobic and Hydrophilic Interactions; Proteomics / methods; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
Improvements in targeted, mass spectrometry-based proteomic strategies are achieved by taking advantage of the mechanism of ESI through the use of hydrophobic chemical derivatization.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Architecture of energy balance traits in emerging lines of the Collaborative Cross
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 300(6), E1124–E1134.
author keywords: genetics; wheel running; adiposity; body weight; quantitative trait loci
MeSH headings : Alleles; Analysis of Variance; Animals; Body Fat Distribution; Body Weight / genetics; Body Weight / physiology; Chromosome Mapping; Chromosomes / genetics; Crosses, Genetic; Eating / genetics; Eating / physiology; Energy Metabolism / genetics; Energy Metabolism / physiology; Genotype; Linkage Disequilibrium; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Motor Activity / physiology; Phenotype; Physical Conditioning, Animal / physiology; Quantitative Trait Loci; Running / physiology; Sample Size
TL;DR:
The results suggest that the CC will be a powerful, high-precision tool for examining the genetic architecture of complex traits such as those involved in regulation of energy balance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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