Works Published in 2021
Displaying works 21 - 29 of 29 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2021 journal article
GlycoHunter: An Open-Source Software for the Detection and Relative Quantification of INLIGHT-Labeled N-Linked Glycans
JOURNAL OF PROTEOME RESEARCH, 20(4), 1855–1863.
author keywords: glycomics; INLIGHT; N-linked glycans; data analysis; open source; software
TL;DR:
GlycoHunter, a user-friendly software created in MATLAB that enables researchers to accurately and efficiently process MS1 glycomics data where a NAT and SIL pair is generated for relative quantification, including but not limited to, INLIGHT.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 3, 2021
2021 journal article
Remodeling hydrogen bond Interactions results in relaxed specificity of Caspase-3
BIOSCIENCE REPORTS, 41(1).
MeSH headings : Amino Acid Sequence; Animals; Aspartic Acid / metabolism; Caspase 3 / chemistry; Caspase 3 / metabolism; Caspase 6 / metabolism; Humans; Hydrogen Bonding; Sequence Homology, Amino Acid; Substrate Specificity; Valine / metabolism; Zebrafish; Zebrafish Proteins / chemistry; Zebrafish Proteins / metabolism
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 12, 2021
2021 book
Development of Peptide Ligands for Targeted Capture of Host Cell Proteins from Cell Culture Production Harvests
In Methods in Molecular Biology (Vol. 2261, pp. 489–506).
Contributors: R. Lavoie n, T. Williams n , R. Blackburn*, R. Carbonell n & S. Menegatti n
author keywords: Proteomics; Mass spectrometry; Host cell proteins; Monoclonal antibodies; Peptide ligands; Flow-through chromatography
MeSH headings : Animals; CHO Cells; Cricetulus; Enzyme-Linked Immunosorbent Assay; Humans; Ligands; Microscopy, Fluorescence; Peptide Library; Peptides / metabolism; Protein Binding; Proteins / isolation & purification; Proteins / metabolism; Proteomics; Solid Phase Extraction; Tandem Mass Spectrometry
TL;DR:
This work describes the development of HCP-binding peptide ligands, especially focusing on the steps of peptide selection via library screening and quantification of H CP removal via proteomics by mass spectrometry.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: April 8, 2021
2021 journal article
Lactobacillus bile salt hydrolase substrate specificity governs bacterial fitness and host colonization
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(6).
author keywords: Lactobacillus; Acidophilus; gasseri; bile salt hydrolase; bile acid
MeSH headings : Amidohydrolases / genetics; Amidohydrolases / metabolism; Ecosystem; Gastrointestinal Microbiome / genetics; Gastrointestinal Microbiome / physiology; Genetic Fitness / genetics; Host-Pathogen Interactions / genetics; Humans; Lactobacillus / enzymology; Lactobacillus / genetics; Probiotics / pharmacology; Substrate Specificity / genetics
TL;DR:
It is shown that BA type and BSH substrate preferences affect in vitro and in vivo growth of both species and that BSH enzymatic preferences and the intrinsic chemical features of various BAs determine the toxicity of these molecules during Lactobacillus growth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 15, 2021
2021 journal article
The mosquito protein AEG12 displays both cytolytic and antiviral properties via a common lipid transfer mechanism.
Proceedings of the National Academy of Sciences of the United States of America, 118(11).
author keywords: antiviral; membrane disruption; cytolysis; insect digestion; insect immune response
MeSH headings : Animals; Antiviral Agents / chemistry; Antiviral Agents / metabolism; Antiviral Agents / pharmacology; Cell Line; Cell Membrane / metabolism; Culicidae; Erythrocytes / drug effects; Fatty Acids, Unsaturated / metabolism; Hemolytic Agents / chemistry; Hemolytic Agents / metabolism; Hemolytic Agents / pharmacology; Humans; Hydrophobic and Hydrophilic Interactions; Insect Proteins / chemistry; Insect Proteins / metabolism; Insect Proteins / pharmacology; Ligands; Lipids / chemistry; Protein Binding; Protein Structure, Tertiary; Viral Envelope / metabolism; Viruses / drug effects; Viruses / metabolism
TL;DR:
The three-dimensional structure of AEG12 is determined and the binding specificity of acyl-chain ligands within its large central hydrophobic cavity is described, enabling it to inhibit replication of enveloped viruses such as Dengue and Zika viruses at low micromolar concentrations.
(via Semantic Scholar)
Source: ORCID
Added: March 14, 2021
2021 journal article
Design, synthesis, and evaluation of substrate - analogue inhibitors of Trypanosoma cruzi ribose 5-phosphate isomerase type B
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 32.
author keywords: Neglected tropical diseases; Chagas' disease; Trypanosoma cruzi; Amastigote; Trypomastigote; Isomerase; Substrate-analogue inhibitors; Competitive inhibition; Trypsin digestion LC-MS/MS
MeSH headings : 3T3 Cells; Aldose-Ketose Isomerases / antagonists & inhibitors; Aldose-Ketose Isomerases / metabolism; Animals; Binding Sites; Catalytic Domain; Drug Design; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Kinetics; Mice; Molecular Dynamics Simulation; Protozoan Proteins / antagonists & inhibitors; Protozoan Proteins / metabolism; Substrate Specificity; Trypanocidal Agents / chemical synthesis; Trypanocidal Agents / metabolism; Trypanocidal Agents / pharmacology; Trypanosoma cruzi / drug effects; Trypanosoma cruzi / enzymology
TL;DR:
The study of Compound B served as a proof-of-concept so that next generation inhibitors can potentially be developed with a focus on using a prodrug group in replacement of the iodoacetamide moiety, thus representing an attractive starting point for the future treatment of Chagas' disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 8, 2021
2021 journal article
Three-dimensional (3D) imaging of lipids in skin tissues with infrared matrix-assisted laser desorption electrospray ionization (MALDESI) mass spectrometry
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 413(10), 2793–2801.
author keywords: 3D; Mass spectrometry imaging; IR-MALDESI; Skin; Lipids
MeSH headings : Animals; Imaging, Three-Dimensional / methods; Lipids / analysis; Mice; Mice, Hairless; Skin / chemistry; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR:
The use of infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) in ablation-based 3D MSI for analyses of lipids within fresh frozen skin tissue is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 25, 2021
2021 journal article
Removal of host cell proteins from cell culture fluids by weak partitioning chromatography using peptide-based adsorbents
SEPARATION AND PURIFICATION TECHNOLOGY, 257.
Contributors: R. Lavoie n, W. Chu n, J. Lavoie n, Z. Hetzler n, T. Williams n , R. Carbonell n, S. Menegatti n
author keywords: Host cell proteins; Monoclonal antibodies; Flow-through chromatography; Weak partitioning mode; Polishing; Proteomics; Peptide ligands
TL;DR:
Proteomic analysis of the effluents demonstrated that 6HP+4MP-Toyopearl adsorbent removes HCPs known for their immunogenicity or IgG co-elution or degradation, demonstrating the potential of these peptide-based resins as HCP scrubbers in mAb purification processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 11, 2021
2021 review
Integration of Sugar Metabolism and Proteoglycan Synthesis by UDP-glucose Dehydrogenase
[Review of ]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 69(1), 13–23.
author keywords: developmental disorders; extracellular matrix; glucuronidation; glycosaminoglycan; hyaluronan; nucleotide sugars; post-translational modifications; proteoglycan; UDP-glucuronate
MeSH headings : Allosteric Regulation; Animals; Biosynthetic Pathways; Humans; Models, Molecular; Neoplasms / metabolism; Protein Processing, Post-Translational; Proteoglycans / metabolism; Sugars / metabolism; Uridine Diphosphate Glucose Dehydrogenase / chemistry; Uridine Diphosphate Glucose Dehydrogenase / metabolism
TL;DR:
The cellular mechanisms that regulate UG DH expression are reviewed, the structural features of the enzyme are discussed, and the structures are used to provide a context for recent studies that link post-translational modifications and allosteric modulators of UGDH to its function in downstream pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 24, 2020
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