Works Published in 2009
Displaying works 81 - 100 of 118 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2009 journal article
Selection of Appropriate Training Set of Chemicals for Modeling Dermal Permeability Using Uniform Coverage Design
QSAR & COMBINATORIAL SCIENCE, 28(11-12), 1478–1486.
author keywords: Skin absorption; LSER; Diverse chemical selection; QSAR; Modeling; Medicinal chemistry; Toxicology
TL;DR:
Graphical plot of the principal components demonstrated that currently used training set of chemicals have narrow representation of parent dataset whereas the selected training set have appropriate representation in terms of chemical space.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Predictive Modeling of a Mixture of Thyroid Hormone Disrupting Chemicals That Affect Production and Clearance of Thyroxine
INTERNATIONAL JOURNAL OF TOXICOLOGY, 28(5), 368–381.
author keywords: thyroid hormone disruption; mixture modeling; pronamide; mancozeb; thiram; polyhalogenated aromatic hydrocarbons
MeSH headings : Animals; Cytochrome P-450 CYP1A1 / metabolism; Cytochrome P-450 CYP2B1 / metabolism; Dose-Response Relationship, Drug; Endocrine Disruptors / chemistry; Endocrine Disruptors / toxicity; Female; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Models, Biological; Pesticides / chemistry; Pesticides / toxicity; Predictive Value of Tests; Rats; Rats, Long-Evans; Thyroid Gland / drug effects; Thyroid Gland / metabolism; Thyroxine / biosynthesis; Thyroxine / blood; Thyroxine / metabolism
TL;DR:
The hypothesis that serum T4 concentrations of rodents exposed to a mixture of both TH synthesis inhibitors and stimulators of T4 clearance in the liver could be best predicted by an integrated addition model is tested and the use of dose- and integrated additivity models in predicting the effects of complex mixtures are supported.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Intestinal Epithelial-Derived TAK1 Signaling Is Essential for Cytoprotection against Chemical-Induced Colitis
PLOS ONE, 4(2).
MeSH headings : Animals; Apoptosis; Cell Proliferation; Colitis / chemically induced; Colitis / etiology; Cyclooxygenase 2; Dextran Sulfate; Interleukin-6; Intestinal Mucosa / metabolism; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Knockout; Receptors, Tumor Necrosis Factor, Type I / deficiency; Signal Transduction
TL;DR:
It is shown that TAK1 is essential for interleukin 1- and bacterial components-induced expression of cytoprotective factors and cell proliferation, which is pivotal for protecting the intestinal epithelium against injury.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Influence of genetic background on tumor karyotypes: Evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma
CHROMOSOME RESEARCH, 17(3), 365–377.
author keywords: microarray; comparative genomic hybridization (CGH); canine; osteosarcoma; chromosome
MeSH headings : Animals; Chromosome Aberrations / veterinary; Comparative Genomic Hybridization; Dog Diseases / genetics; Dogs; Genetic Predisposition to Disease / genetics; Karyotyping / veterinary; Osteosarcoma / genetics; Osteosarcoma / veterinary; Species Specificity
TL;DR:
Assessment of a cohort of Golden Retrievers and Rottweilers diagnosed with spontaneous appendicular osteosarcoma reveals significant correlations between breed and tumor karyotypes that are independent of gender, age at diagnosis, and histological classification.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Dermal Permeation of Biocides and Aromatic Chemicals in Three Generic Formulations of Metalworking Fluids
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 72(13), 832–841.
MeSH headings : Animals; Complex Mixtures / chemistry; Disinfectants / chemistry; Disinfectants / pharmacokinetics; Hydrocarbons, Aromatic / chemistry; Hydrocarbons, Aromatic / pharmacokinetics; Metallurgy; Occupational Exposure; Permeability; Skin Absorption / drug effects; Swine
TL;DR:
Data from this study show that permeation of chemicals is higher in a generic synthetic MWF when compared to a soluble oil MWF, which indicates that a solubleOil MWF may be safer than a syntheticMWF in regard to dermal permeations of chemicals to allow for an increased potential of systemic toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Characterization of vitellin protein in the twospotted spider mite, Tetranychus urticae (Acari: Tetranychidae)
JOURNAL OF INSECT PHYSIOLOGY, 55(7), 655–661.
author keywords: Mite; Spider mite; Tick; American dog tick; Vitellogenin; Vitellin; Yolk protein; Reproduction; Egg
MeSH headings : Animals; Heme / metabolism; Isoelectric Point; Molecular Weight; Protein Stability; Tetranychidae / chemistry; Tetranychidae / metabolism; Ticks / chemistry; Ticks / metabolism; Vitellins / chemistry; Vitellins / metabolism
TL;DR:
Spider mite vitellin weakly bound lipids and carbohydrates compared to the tick, and unlike D. variabilis, the spider mite egg yolk protein does not bind heme.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Heart rate as a sublethal indicator of thermal stress in juvenile freshwater mussels
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 154(3), 347–352.
author keywords: Freshwater mussel; Heart rate; Temperature; Thermal stress; Unionidae
MeSH headings : Acclimatization / physiology; Animals; Bivalvia / physiology; Fresh Water; Heart Rate; Stress, Physiological; Temperature
TL;DR:
The use of heart rate appears to be a suitable indicator of thermal stress in some unionid mussels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity
Molecular Immunology, 46(7), 1505–1516.
author keywords: Zebrafish; Mouse; rag1; Innate immunity; SCID
MeSH headings : Adaptation, Physiological / genetics; Adaptation, Physiological / immunology; Animals; Animals, Genetically Modified; Blood Coagulation Factors / genetics; Blood Coagulation Factors / metabolism; Complement C4 / genetics; Complement C4 / metabolism; Complement System Proteins / genetics; Complement System Proteins / metabolism; Female; Gene Expression Profiling; Genes, RAG-1 / physiology; Immunity / genetics; Immunity / physiology; Intestinal Mucosa / metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Transcription, Genetic; Up-Regulation; Zebrafish
TL;DR:
It is hypothesized that the rag1(-/-) zebrafish may possess an "enhanced" innate immune response to compensate for the lack of an adaptive immune system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Efficacy of the new repellent BioUD(A (R)) against three species of ixodid ticks
EXPERIMENTAL AND APPLIED ACAROLOGY, 48(3), 239–250.
author keywords: Arthropod repellent; BioUD; DEET; Ticks; Undecanone
MeSH headings : Animals; DEET; Insect Repellents; Ixodidae / drug effects; Ketones; Species Specificity
TL;DR:
Based on filter paper head-to-head assays, BioUD® is at least 2–4 times more active as a repellent than DEET against three species of ixodid ticks under the conditions of the authors' laboratory bioassays.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 review
Update on Genomics in Veterinary Oncology
[Review of ]. TOPICS IN COMPANION ANIMAL MEDICINE, 24(3), 113–121.
author keywords: cancer; genomics; oncology; technology; veterinary
MeSH headings : Animals; Cat Diseases / genetics; Cats; Dog Diseases / genetics; Dogs; Genomics / methods; Neoplasms / genetics; Neoplasms / veterinary; Veterinary Medicine / methods
TL;DR:
The release of an annotated human genome sequence assembly and the emergence of genomics technologies have led to significant advances in the authors' understanding of many human diseases including cancers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Pharmacology of tetracycline water medication in swine
JOURNAL OF ANIMAL SCIENCE, 87(10), 3179–3186.
author keywords: pharmacokinetics; plasma concentration; swine; tetracycline; water medication
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Biological Availability; Dose-Response Relationship, Drug; Male; Microbial Sensitivity Tests / veterinary; Random Allocation; Swine / metabolism; Tetracycline / administration & dosage; Tetracycline / blood; Tetracycline / pharmacokinetics; Tetracycline / urine
TL;DR:
The study showed that tetracycline oral bioavailability is very small and the dose response curve shows that concentrations of plasma tetrACYcline increase linearly, yet not in a 1 to 1 ratio, to the direct increase in water medication dose.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Neonatal Bisphenol-A Exposure Alters Rat Reproductive Development and Ovarian Morphology Without Impairing Activation of Gonadotropin-Releasing Hormone Neurons
BIOLOGY OF REPRODUCTION, 81(4), 690–699.
author keywords: AVPV; corpora lutea; development; disruption; endocrine disruptors; ER alpha; ESR1; estradiol; estradiol receptor; estrogen; estrogen receptor; GnRH; gonad; hypothalamus; lordosis; neuroendocrinology; ovary; PPT; puberty
MeSH headings : Animals; Animals, Newborn; Benzhydryl Compounds; Dose-Response Relationship, Drug; Estrogens, Non-Steroidal / administration & dosage; Estrogens, Non-Steroidal / toxicity; Estrous Cycle / drug effects; Female; Gonadotropin-Releasing Hormone / metabolism; Hypothalamus / drug effects; Hypothalamus / metabolism; Male; Neuroendocrine Cells / drug effects; Ovary / drug effects; Ovary / pathology; Phenols / administration & dosage; Phenols / toxicity; Proto-Oncogene Proteins c-fos / metabolism; Rats; Rats, Long-Evans; Sexual Behavior, Animal / drug effects; Sexual Maturation / drug effects
TL;DR:
The data suggest that BPA disrupts ovarian development but not the ability of GnRH neurons to respond to steroid-positive feedback.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Impact of neonatal exposure to the ERα agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats
NeuroToxicology, 30(3), 350–357.
author keywords: Bisphenol; Phytoestrogens; Soy; Genistein; Equal; Gonadotropins; Development; Disruption; Estrogen; Estrogen receptor; GnRH; KISS
MeSH headings : Animals; Animals, Newborn; Benzhydryl Compounds; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Receptor alpha / agonists; Female; Hypothalamus / anatomy & histology; Kisspeptins; Male; Nerve Fibers / drug effects; Nerve Fibers / metabolism; Ovariectomy; Phenols / pharmacology; Phytoestrogens / pharmacology; Progesterone / pharmacology; Proteins / metabolism; Pyrazoles / pharmacology; Rats; Rats, Long-Evans; Sex Characteristics
TL;DR:
The results suggest that the organization of hypothalamic KISS fibers may be vulnerable to disruption by EDC exposure and that females might be more sensitive than males.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Comparative Efficacy of BioUD to Other Commercially Available Arthropod Repellents against the Ticks Amblyomma americanum and Dermacentor variabilis on Cotton Cloth
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 81(4), 685–690.
MeSH headings : Animals; Cotton Fiber; Insect Repellents / pharmacology; Ixodidae / drug effects; Textiles; Time Factors
TL;DR:
Repellency of BioUD was compared with five commercially available arthropod repellents against the ticks Amblyomma americanum (L.) and Dermacentor variabilis in two-choice bioassays on treated versus untreated cotton cheesecloth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Removal of emerging contaminants of concern by alternative adsorbents
WATER RESEARCH, 43(15), 3787–3796.
Contributors: A. Rossner *, S. Snyder * & D. Knappe n
author keywords: Adsorption; Activated carbon; Zeolites; Emerging contaminants; Drinking water treatment
MeSH headings : Adsorption; Endocrine Disruptors / analysis; Fresh Water / chemistry; Pharmaceutical Preparations / analysis; Water Pollutants, Chemical / analysis; Water Purification / methods; Zeolites / chemistry; Zeolites / classification
TL;DR:
It is demonstrated that effective adsorbents for the removal of a broad spectrum of ECCs from water should exhibit heterogeneity in pore size and shape and a large pore volume in the 6-9A size range.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science; OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Male engorgement factor: Role in stimulating engorgement to repletion in the ixodid tick, Dermacentor variabilis
JOURNAL OF INSECT PHYSIOLOGY, 55(10), 909–918.
author keywords: Engorgement factor; Voraxin; Testis; Male accessory gland; Dermacentor variabilis
MeSH headings : Amino Acid Sequence; Animals; Dermacentor / chemistry; Dermacentor / genetics; Dermacentor / physiology; Feeding Behavior; Female; Gonads / chemistry; Gonads / metabolism; Insect Proteins / chemistry; Insect Proteins / genetics; Insect Proteins / metabolism; Male; Molecular Sequence Data; Sequence Alignment; Sex Attractants / chemistry; Sex Attractants / genetics; Sex Attractants / metabolism; Sexual Behavior, Animal; Species Specificity
TL;DR:
Overall, these data suggest that EFalpha in D. variabilis is not an engorgement factor and that EF in ticks is a non-secreted membrane-bound or intracellular protein.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
C/EBP alpha expression is partially regulated by C/EBP beta in response to DNA damage and C/EBP alpha-deficient fibroblasts display an impaired G(1) checkpoint
ONCOGENE, 28(36), 3235–3245.
author keywords: C/EBP; DNA damage response; G(1)/S transition; p53
MeSH headings : Animals; Blotting, Western; CCAAT-Enhancer-Binding Protein-alpha / genetics; CCAAT-Enhancer-Binding Protein-alpha / metabolism; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / metabolism; DNA Damage; Female; Fibroblasts / drug effects; Fibroblasts / metabolism; Fibroblasts / radiation effects; Flow Cytometry; G1 Phase; Gene Expression; Male; Methylnitronitrosoguanidine / toxicity; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; S Phase; Time Factors; Ultraviolet Rays
TL;DR:
This study shows a novel function for C/EBPβ in the regulation of C/N′-nitro-N-nitrosoguanidine-treated fibroblasts and provides definitive genetic evidence that C-EBPα has a critical role in the DNA damage G1 checkpoint.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 article
Update on drugs prohibited from extralabel use in food animals
Davis, J. L., Smith, G. W., Baynes, R. E., Tell, L. A., Webb, A. I., & Riviere, J. E. (2009, September 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 235, pp. 528–534.
MeSH headings : Animals; Animals, Domestic; Food / standards; Legislation, Drug; Legislation, Veterinary; United States; Veterinary Drugs
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP
ONCOGENE, 28(23), 2257–2265.
author keywords: TAK1; TRAIL; reactive oxygen species; cIAP; apoptosis
MeSH headings : Animals; Apoptosis / drug effects; Caspase 3 / metabolism; Cell Line; Cell Line, Tumor; Cell Survival / drug effects; Electrophoretic Mobility Shift Assay; Flow Cytometry; HeLa Cells; Humans; Immunoblotting; Inhibitor of Apoptosis Proteins / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Microscopy, Fluorescence; NF-kappa B / metabolism; RNA, Small Interfering / genetics; Reactive Oxygen Species / metabolism; Recombinant Proteins / pharmacology; TNF-Related Apoptosis-Inducing Ligand / genetics; TNF-Related Apoptosis-Inducing Ligand / pharmacology; Transfection
TL;DR:
It is reported that deletion of TAK1 kinase greatly increased activation of caspase-3 and cell death after TRAIL stimulation in keratinocytes, fibroblasts and cancer cells, and inhibition of Tak1 can be an effective approach to increase TRAIL sensitivity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
ORIGINS AND EVOLUTION OF A TRANSMISSIBLE CANCER
EVOLUTION, 63(9), 2340–2349.
author keywords: Chromosomal evolution; evolutionary genomics; genetic variation; molecular evolution; population genetics; sex
MeSH headings : Animals; Biological Evolution; Comparative Genomic Hybridization / methods; Dog Diseases / genetics; Dogs / classification; Dogs / genetics; Gene Dosage; Genotype; Microarray Analysis; Microsatellite Repeats / genetics; Neoplasms / genetics; Neoplasms / veterinary; Phylogeny; Venereal Tumors, Veterinary / genetics; Wolves / genetics
TL;DR:
The genetic and genomic patterns observed are typical of those expected of asexual pathogens, and the extended time since first origin may explain the many remarkable adaptations that have enabled this mammalian cell lineage to live as a unicellular pathogen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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