Works Published in 2019
Displaying works 81 - 100 of 113 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2019 journal article
Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing
JOURNAL OF CELL BIOLOGY, 218(6), 1994–2005.
Contributors: K. Sai n, C. Parsons n, J. House n , S. Kathariou n & J. Ninomiya-Tsuji n
MeSH headings : Animals; Female; Humans; Listeria / growth & development; Listeria / immunology; Listeria / metabolism; Listeriosis / metabolism; Listeriosis / microbiology; Listeriosis / pathology; Listeriosis / prevention & control; Mice; Mice, Inbred C57BL; Mice, Knockout; Necroptosis; Protein Kinases / physiology; Receptor-Interacting Protein Serine-Threonine Kinases / genetics; Receptor-Interacting Protein Serine-Threonine Kinases / metabolism; Receptor-Interacting Protein Serine-Threonine Kinases / physiology
TL;DR:
The RIPK3-MLKL pathway protects epithelial cells from Listeria monocytogenes invasion but does not induce its oligomerization or necroptotic cell death, and instead targets intracellular bacteria and suppresses their replication.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 24, 2019
2019 journal article
Inappropriate Citation of Vaccine Article.
The Journal of Infectious Diseases.
MeSH headings : Humans; Smallpox; Vaccination; Vaccines / adverse effects
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: June 19, 2019
2019 journal article
Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women
CANCER MEDICINE, 8(5), 2503–2513.
author keywords: African ancestry risk; genetic association; ovarian cancer; vitamin D pathway
MeSH headings : Black or African American / genetics; Bayes Theorem; Carcinoma, Ovarian Epithelial / genetics; Carcinoma, Ovarian Epithelial / metabolism; Carcinoma, Ovarian Epithelial / pathology; ErbB Receptors / genetics; Female; Genetic Association Studies; Glucuronosyltransferase / genetics; Humans; Logistic Models; Middle Aged; Neoplasm Grading; Ovarian Neoplasms / genetics; Ovarian Neoplasms / metabolism; Ovarian Neoplasms / pathology; Polymorphism, Single Nucleotide; Receptors, Calcitriol / genetics; Vitamin D / biosynthesis
TL;DR:
Genetic variants in the EGFR and UGT2A1/2 may increase susceptibility of EOC in AA women and the Bayesian False Discovery Probability method was used to evaluate statistical significance of selected SNPs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 17, 2019
2019 journal article
Animal production, insecticide use and self-reported symptoms and diagnoses of COPD, including chronic bronchitis, in the Agricultural Health Study
ENVIRONMENT INTERNATIONAL, 127, 764–772.
author keywords: Epidemiology; Occupational health; Environmental health; Pesticide
MeSH headings : Adult; Animal Husbandry; Animals; Bronchitis, Chronic / epidemiology; Farmers; Female; Humans; Insecticides / toxicity; Logistic Models; Male; Middle Aged; Occupational Exposure; Odds Ratio; Prevalence; Pulmonary Disease, Chronic Obstructive / chemically induced; Pulmonary Disease, Chronic Obstructive / epidemiology; Risk Factors; United States / epidemiology
TL;DR:
Animal production work, including insecticide use, was positively associated with chronic bronchitis symptoms; but not consistently with COPD diagnosis alone; the results support the need for further investigation into the role of animal production-related exposures in the etiology of COPD and better respiratory protection for agricultural workers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 17, 2019
2019 journal article
Does Granular Activated Carbon with Chlorination Produce Safer Drinking Water? From Disinfection Byproducts and Total Organic Halogen to Calculated Toxicity
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 53(10), 5987–5999.
Sources: Web Of Science, NC State University Libraries
Added: June 17, 2019
2019 review
Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)
[Review of ]. JOURNAL OF ENDOCRINOLOGY, 241(2), R65–R80.
author keywords: vitamin D deficiency; DOHAD; metabolic disorders; autism; neurobehavioral disorders; animal models
TL;DR:
A detailed review and perspective of evidence for the role of maternal VDD in offspring long term health, particularly as it relates to Developmental Origins of Health and Disease (DOHaD), and evidence implicating epigenetic mechanisms as a mediator of this link is explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 17, 2019
2019 journal article
Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse
CHEMICAL RESEARCH IN TOXICOLOGY, 32(5), 887–898.
MeSH headings : Animals; Butadienes / toxicity; Carcinogens, Environmental / toxicity; DNA Adducts / chemistry; DNA Adducts / genetics; DNA Adducts / metabolism; DNA Methylation / drug effects; Epigenesis, Genetic / drug effects; Guanine / analogs & derivatives; Guanine / chemistry; Histones / metabolism; Kidney / drug effects; Liver / drug effects; Lung / drug effects; Male; Mice; Mutagens / toxicity
TL;DR:
1,3-butadiene is used to demonstrate how the Collaborative Cross mouse population can be used to identify the mechanisms for and quantify the degree of interindividual variability in tissue-specific effects that are relevant to chemically induced carcinogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 17, 2019
2019 journal article
The ubiquitin ligase PHR promotes directional regrowth of spinal zebrafish axons
COMMUNICATIONS BIOLOGY, 2(1).
MeSH headings : Actins / metabolism; Adaptor Proteins, Signal Transducing / metabolism; Alleles; Animals; Animals, Genetically Modified; Axons / metabolism; Cadherins / metabolism; Cytoplasmic Dyneins / metabolism; Disease Models, Animal; Green Fluorescent Proteins / metabolism; Image Processing, Computer-Assisted; Ligases / metabolism; MAP Kinase Kinase 4 / metabolism; Mixed Function Oxygenases / metabolism; Mutation; Nerve Regeneration; Neuronal Outgrowth; Spinal Cord / pathology; Spinal Cord Injuries / metabolism; Transgenes; Ubiquitin / metabolism; Zebrafish; Zebrafish Proteins / metabolism
TL;DR:
It is shown that ubiquitin ligase PHR directs the regrowth of zebrafish Mauthner axons after transection, suggesting an important role for these signaling pathways in spinal axonal regrowth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 17, 2019
2019 journal article
Bisphenol F has different effects on preadipocytes differentiation and weight gain in adult mice as compared with Bisphenol A and S
TOXICOLOGY, 420, 66–72.
author keywords: Bisphenol; Metabolism; Fat; BPF; Alternatives to BPA; Diabetes
MeSH headings : 3T3-L1 Cells; Adipocytes / drug effects; Adipocytes / metabolism; Adipogenesis / drug effects; Adipogenesis / genetics; Animals; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Gene Expression Regulation; Male; Mice; Mice, Inbred ICR; Phenols / toxicity; Sulfones / toxicity; Time Factors; Weight Gain / drug effects
TL;DR:
The results suggest that BPS has a strong potential to be obesogenic while effects of BPF are subtler and potentially in the opposite direction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: June 17, 2019
2019 journal article
Comparative plasma and urine concentrations of flunixin and meloxicam in goats
SMALL RUMINANT RESEARCH, 174, 40–46.
TL;DR:
The information from this study represents a potential worst-case scenario for urine depletion and helps determine the withdrawal intervals needed for flunixin meglumine in show goats when administered in this extra label manner.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 4, 2019
2019 journal article
Associations between Maternal Tobacco Smoke Exposure and the Cord Blood CD4(+) DNA Methylome
ENVIRONMENTAL HEALTH PERSPECTIVES, 127(4).
MeSH headings : Adult; CD4-Positive T-Lymphocytes / chemistry; DNA Methylation / drug effects; Epigenome / drug effects; Female; Fetal Blood / chemistry; Humans; Male; Maternal Exposure; Tobacco Smoke Pollution / analysis; Young Adult
TL;DR:
Maternal tobacco smoke exposure in pregnancy is associated with cord blood CD4+ DNA methylation in key regulatory regions, including enhancers, and a differentially methylated CpG in amino acid transporter SLC7A8 that is highly reproducible, which may be sensitive to cigarette smoke in both cord blood and adultCD4+ cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 28, 2019
2019 journal article
Systematic determination of the relationship between nanoparticle core diameter and toxicity for a series of structurally analogous gold nanoparticles in zebrafish
Nanotoxicology, 4, 1—15.
Contributors: L. Truong *, T. Zaikova*, B. Baldock*, M. Balik-Meisner n, K. To n, D. Reif n , Z. Kennedy *, J. Hutchison *, R. Tanguay *
author keywords: Size-dependency; gold nanoparticles; zebrafish; uptake; ligands
MeSH headings : Animals; Gold / toxicity; Metal Nanoparticles / toxicity; Particle Size; Zebrafish
TL;DR:
The results indicate that larger NPs may be the most toxic on a per particle basis and highlight the importance of using particle number and surface area, in addition to mass, when evaluating the size-dependent bioactivity of NPs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 14, 2019
2019 journal article
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
NATURE COMMUNICATIONS, 10.
MeSH headings : Adolescent; Adult; Birth Weight / genetics; Body Mass Index; Child; CpG Islands; DNA / genetics; DNA / metabolism; DNA Methylation; Epigenesis, Genetic; Female; Fetal Development / genetics; Fetus; Folic Acid / blood; Genome, Human; Genome-Wide Association Study; Humans; Infant, Newborn; Male; Pregnancy; Prenatal Exposure Delayed Effects / blood; Prenatal Exposure Delayed Effects / etiology; Prenatal Exposure Delayed Effects / genetics; Prenatal Exposure Delayed Effects / physiopathology; Smoking / adverse effects; Smoking / blood; Smoking / genetics
TL;DR:
A meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium finds that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from −183 to 178 grams per 10% increase in methylation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 13, 2019
2019 journal article
An algorithm for quantitatively estimating non-occupational pesticide exposure intensity for spouses in the Agricultural Health Study
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, 29(3), 344–357.
MeSH headings : Adult; Agriculture; Algorithms; Environmental Exposure / analysis; Farmers; Female; Humans; Male; Pesticides / analysis; Spouses; Surveys and Questionnaires
TL;DR:
A quantitative, active ingredient-specific algorithm for cumulative (adult, married lifetime) non-occupational pesticide exposure intensity for spouses of farmers who applied pesticides in the Agricultural Health Study (AHS) is developed and will facilitate improved etiologic analyses in the AHS spouses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 6, 2019
2019 journal article
Differential methylation values in differential methylation analysis
BIOINFORMATICS, 35(7), 1094–1097.
MeSH headings : DNA Methylation; Linear Models; Research Design
TL;DR:
It is shown that under the condition that M-value linear regression model is correct, the method M-model-coef is the best among the four methods and the M- model-M-mean method works very well too.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 6, 2019
2019 journal article
Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study
EPIGENETICS, 14(4), 325–340.
author keywords: DNA methylation; epigenome-wide association study; maternal obesity; offspring body mass index; offspring blood pressure; cardiometabolic health; ALSPAC; NEST
MeSH headings : Adult; Blood Pressure; Cardiovascular Diseases / epidemiology; Cardiovascular Diseases / genetics; Child; Child, Preschool; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Genome-Wide Association Study; Humans; Infant, Newborn / blood; Infant, Newborn / growth & development; Male; Membrane Transport Proteins / genetics; Metabolic Syndrome / epidemiology; Metabolic Syndrome / genetics; Obesity / epidemiology; Obesity / genetics
TL;DR:
Findings suggest sex-specific effects at CpG sites of the TAPBP gene were associated with BMI z-score and systolic BP percentile in female and syStolic and diastolicBP percentile in male offspring, which, if causal, may explain observed sex- specific effects of maternal obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 29, 2019
2019 journal article
Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 101, 91–102.
Contributors: F. Grimm*, J. House n , M. Wilson*, O. Sirenko*, Y. Iwata*, F. Wright n, N. Ball, I. Rusyn *
author keywords: New assessment methodologies; Glycol ethers; In vitro; ToxPi; Read-across; Safety assessment
MeSH headings : Animals; Cell Line; Ethers / classification; Ethers / toxicity; Glycols / classification; Glycols / toxicity; Humans; Risk Assessment; Solvents / classification; Solvents / toxicity; Toxicity Tests
TL;DR:
In this study, a suite of organotypic and population‐based in vitro models are applied for comprehensive bioactivity profiling of twenty E‐Series and P‐Series glycol ethers, solvents with a broad variation in toxicity ranging from relatively non‐toxic to reproductive and hematopoetic system toxicants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 22, 2019
2019 journal article
Evidence for Aryl hydrocarbon Receptor-Mediated Inhibition of Osteoblast Differentiation in Human Mesenchymal Stem Cells
TOXICOLOGICAL SCIENCES, 167(1), 145–156.
author keywords: aryl hydrocarbon receptor; 2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD; mesenchymal stem cell; osteoblast differentiation; skeletal toxicity; bone toxicity
MeSH headings : Basic Helix-Loop-Helix Transcription Factors / agonists; Cell Differentiation / drug effects; Fibroblast Growth Factor 9 / genetics; Fibroblast Growth Factors / genetics; Humans; Ligands; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Osteoblasts / cytology; Osteoblasts / drug effects; Osteoblasts / metabolism; Osteogenesis / drug effects; Osteogenesis / genetics; Polychlorinated Dibenzodioxins / toxicity; Receptors, Aryl Hydrocarbon / agonists; Up-Regulation
TL;DR:
Experimental evidence from this study suggests that AhR transactivation likely attenuates osteoblast differentiation in multipotent hBMSCs, and underscores the use of primary human MSCs to evaluate osteoinductive or osteotoxic potential of chemical and pharmacologic agents in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 15, 2019
2019 journal article
Development and application of a population physiologically based pharmacokinetic model for florfenicol and its metabolite florfenicol amine in cattle
FOOD AND CHEMICAL TOXICOLOGY, 126, 285–294.
author keywords: Physiologically based pharmacokinetic (PBPK) model; Withdrawal interval; Florfenicol; Florfenicol amine; Cattle
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Cattle; Cattle Diseases / drug therapy; China; Chromatography, High Pressure Liquid; Drug Administration Routes; Drug Residues / analysis; Drug Residues / metabolism; Drug Residues / pharmacokinetics; Kidney / drug effects; Liver / drug effects; Models, Biological; Thiamphenicol / administration & dosage; Thiamphenicol / analogs & derivatives; Thiamphenicol / analysis; Thiamphenicol / metabolism; Thiamphenicol / pharmacokinetics
TL;DR:
A population physiologically based pharmacokinetic (PBPK) model to predict the concentrations of FF and its metabolite, florfenicol amine, in cattle after four different routes of administration, and to calculate and compare the withdrawal intervals (WDIs) with approved withdrawal times based on different marker residues and their MRLs or tolerances.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 15, 2019
2019 journal article
Associations between access to healthcare, environmental quality, and end-stage renal disease survival time: Proportional-hazards models of over 1,000,000 people over 14 years
PLOS ONE, 14(3).
Contributors: M. Kosnik n, D. Reif n , D. Lobdell*, T. Astell-Burt *, X. Feng *, J. Hader*, J. Hoppin n
Ed(s): W. Cheungpasitporn
MeSH headings : Adolescent; Adult; Aged; Air Pollution / adverse effects; Female; Health Services Accessibility; Humans; Kidney Failure, Chronic / epidemiology; Male; Middle Aged; Prevalence; Proportional Hazards Models; Risk Factors; Socioeconomic Factors; United States / epidemiology; Water Quality; Young Adult
TL;DR:
The results demonstrate the importance of considering multiple factors when studying ESRD survival and future efforts should consider additional components of the broader environment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 9, 2019
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