Works Published in 2009
Displaying works 101 - 118 of 118 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2009 journal article
Novel insecticide polymer chemistry to reduce the enzymatic digestion of a protein pesticide, trypsin modulating oostatic factor (TMOF)
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 93(3), 144–152.
author keywords: Insecticide; Protein; Polymer chemistry; Trypsin modulating oostatic factor; TMOF; Polyethylene glycol; Digestion; Protease; Leucine aminopeptidase; Protein delivery
TL;DR:
Structural activity studies demonstrated a correlation between the molecular weight of the PEG polymer and resistance to digestion and show proof of concept that aliphatic-PEG protein polymerization can be used to prevent protease degradation of a protein insecticide.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
'Putting our heads together': insights into genomic conservation between human and canine intracranial tumors
JOURNAL OF NEURO-ONCOLOGY, 94(3), 333–349.
author keywords: Comparative genomic hybridization; Canine; Brain tumor; Chromosome; Microarray
MeSH headings : Animals; Brain Neoplasms / genetics; Brain Neoplasms / pathology; Chromosome Aberrations; Chromosome Mapping; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 22; Cluster Analysis; Dogs; Female; Gene Expression Regulation, Neoplastic; Genome / genetics; Glioma / genetics; Glioma / pathology; Humans; In Situ Hybridization, Fluorescence; Male; Meningeal Neoplasms / genetics; Meningeal Neoplasms / pathology; Meningioma / genetics; Meningioma / pathology
TL;DR:
A microarray-based comparative genomic hybridization analysis of 60 spontaneous canine intracranial tumors was performed to examine the degree to which dog and human patients exhibit aberrations of ancestrally related chromosome regions, consistent with a shared pathogenesis.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
A critical role for DAP10 and DAP12 in CD8(+) T cell-mediated tissue damage in large granular lymphocyte leukemia
BLOOD, 113(14), 3226–3234.
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Adaptor Proteins, Signal Transducing / physiology; CD28 Antigens / metabolism; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; CD8-Positive T-Lymphocytes / pathology; Cytotoxicity, Immunologic / genetics; Endothelial Cells / immunology; Endothelial Cells / pathology; Extracellular Signal-Regulated MAP Kinases / metabolism; Humans; K562 Cells; Leukemia, Large Granular Lymphocytic / genetics; Leukemia, Large Granular Lymphocytic / immunology; Leukemia, Large Granular Lymphocytic / metabolism; Leukemia, Large Granular Lymphocytic / pathology; Membrane Proteins / genetics; Membrane Proteins / metabolism; Membrane Proteins / physiology; Phosphatidylinositol 3-Kinases / metabolism; Pulmonary Artery / immunology; Pulmonary Artery / pathology; Receptors, Immunologic / genetics; Receptors, Immunologic / metabolism; Receptors, Immunologic / physiology; Receptors, Natural Killer Cell / metabolism; Signal Transduction / genetics; Tumor Cells, Cultured
TL;DR:
Results shown suggest that inhibitors of DAP10 and DAP12 or other proteins involved in this signaling pathway will be attractive therapeutic targets for the treatment of LGLL and other autoimmune diseases and syndromes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 journal article
Progesterone and medroxyprogesterone acetate differentially regulate α4 subunit expression of GABAA receptors in the CA1 hippocampus of female rats
Physiology & Behavior, 97(1), 58–61.
author keywords: Allopregnanolone; Neurosteroids; GABA(A) receptors
MeSH headings : Animals; Drug Interactions; Estradiol / administration & dosage; Estradiol / analogs & derivatives; Female; Hippocampus / drug effects; Hippocampus / metabolism; Medroxyprogesterone Acetate / administration & dosage; Medroxyprogesterone Acetate / pharmacology; Ovariectomy; Progesterone / administration & dosage; Progesterone / pharmacology; RNA, Messenger / metabolism; Rats; Rats, Long-Evans; Receptors, GABA-A / metabolism
TL;DR:
MPA, while progestational in terms of its effects in the uterus, is not a simple substitute for P4 in other systems, and the relative impact of these two progestins on neuroendocrine function must be carefully explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2009 review
Heme-binding storage proteins in the Chelicerata
[Review of ]. JOURNAL OF INSECT PHYSIOLOGY, 55(4), 287–296.
author keywords: Heme; Heme-binding; Storage protein; Hematophagy; Arthropoda; Chelicerata
MeSH headings : Amino Acid Sequence; Animals; Arthropods / genetics; Arthropods / metabolism; Carrier Proteins / genetics; Carrier Proteins / metabolism; Computational Biology; Gene Expression Regulation / physiology; Glycoproteins / genetics; Glycoproteins / metabolism; Heme / biosynthesis; Hemeproteins / genetics; Hemeproteins / metabolism; Molecular Sequence Data; Phylogeny; Saliva / metabolism; Sequence Alignment
TL;DR:
Comparisons with non-chelicerate arthropods are made in order to highlight the mechanisms and putative functions of heme-binding storage proteins and their possible critical function in the evolution of hematophagy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 article
Nanoparticle-Mediated Drug Delivery and Pulmonary Hypertension
Bonner, J. C., Card, J. W., & Zeldin, D. C. (2009, May). HYPERTENSION, Vol. 53, pp. 751–753.
MeSH headings : Animals; Drug Delivery Systems; Hypertension, Pulmonary / drug therapy; NF-kappa B / antagonists & inhibitors; NF-kappa B / physiology; Nanoparticles / administration & dosage; Nanoparticles / toxicity; Nanotubes, Carbon; Oligodeoxyribonucleotides / administration & dosage; Rats
TL;DR:
It was speculated by the authors that cellular uptake of the NPs might slowly release encapsulated ODNs, and it was shown that NP-encapsulated NF-κB decoy reached the distal regions of the lungs and was present in alveolar macrophages and small pulmonary arteries for ≤14 days after a single instillation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Inhaled Multiwalled Carbon Nanotubes Potentiate Airway Fibrosis in Murine Allergic Asthma
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 40(3), 349–358.
author keywords: carbon nanotubes; asthma; fibrosis; lung
MeSH headings : Administration, Inhalation; Aerosols; Animals; Asthma / chemically induced; Asthma / immunology; Asthma / pathology; Bronchoalveolar Lavage Fluid / cytology; Fibrosis / chemically induced; Fibrosis / immunology; Fibrosis / pathology; Humans; Interleukin-13 / immunology; Lung / cytology; Lung / immunology; Lung / pathology; Macrophages / cytology; Macrophages / metabolism; Male; Mice; Mice, Inbred C57BL; Nanotubes, Carbon / adverse effects; Nanotubes, Carbon / ultrastructure; Ovalbumin / immunology; Particle Size; Platelet-Derived Growth Factor / immunology; Random Allocation; Transforming Growth Factor beta1 / immunology
TL;DR:
It is indicated that individuals with pre-existing allergic inflammation may be susceptible to airway fibrosis from inhaled multiwalled carbon nanotubes, and combined ovalbumin sensitization and MWCNT inhalation also synergistically increased IL-5 mRNA levels, which could further contribute to airways fibrosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Systemic administration of diarylpropionitrile (DPN) or phytoestrogens does not affect anxiety-related behaviors in gonadally intact male rats
HORMONES AND BEHAVIOR, 55(2), 319–328.
author keywords: DPN; PPT; Estrogen; Soy isoflavones; Testosterone; Anxiety; Endocrine active compound; Resveratrol; Equol; Plus maze; ER beta; Estrogen receptor beta
MeSH headings : Analysis of Variance; Animals; Anti-Anxiety Agents / administration & dosage; Anxiety / drug therapy; Behavior, Animal / drug effects; Equol; Estrogen Receptor alpha / agonists; Isoflavones / administration & dosage; Male; Nitriles / administration & dosage; Nitriles / blood; Phenols; Phytoestrogens / administration & dosage; Propionates / administration & dosage; Propionates / blood; Pyrazoles / administration & dosage; Rats; Rats, Long-Evans; Rats, Wistar; Resveratrol; Stilbenes / administration & dosage; Testosterone / blood
TL;DR:
It is determined that DPN can be successfully administered either orally or by subcutaneous injection, although plasma DPN levels are significantly lower if given orally, and the efficacy of ERbeta agonists may depend on gonadal status, therefore the therapeutic potential of ER beta selective agonists to treat mood disorders may be limited.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Analysis of functional traits in reconfigured channels: implications for the bioassessment and disturbance of river restoration
JOURNAL OF THE NORTH AMERICAN BENTHOLOGICAL SOCIETY, 28(1), 80–92.
author keywords: benthic macroinvertebrate; functional traits; channel reconfiguration; disturbance; bioassessment; river restoration
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Role of the Tumor Suppressor PTEN in Antioxidant Responsive Element-mediated Transcription and Associated Histone Modifications
MOLECULAR BIOLOGY OF THE CELL, 20(6), 1606–1617.
MeSH headings : Antioxidants / metabolism; Apoptosis / drug effects; Cell Line; Ferritins / genetics; Ferritins / metabolism; Histones / metabolism; Humans; Hydrogen Peroxide / pharmacology; Hydroquinones / pharmacology; NAD(P)H Dehydrogenase (Quinone) / genetics; NAD(P)H Dehydrogenase (Quinone) / metabolism; PTEN Phosphohydrolase / genetics; PTEN Phosphohydrolase / metabolism; Protein Binding; Proto-Oncogene Proteins c-akt / metabolism; RNA, Messenger / genetics; Response Elements / genetics; Transcription, Genetic / drug effects; Transcription, Genetic / genetics; Transcriptional Activation / genetics
TL;DR:
It is demonstrated that the status of PTEN determines cellular susceptibility to oxidative stress through antioxidant-responsive element (ARE)-mediated transcription of detoxification genes and ferritin H transcription was robustly induced in tert-butylhydroquinone (t-BHQ)-treated Jurkat cells via an ARE, and it was due to PTEN deficiency.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Mercury(II) Bioaccumulation and Antioxidant Physiology in Four Aquatic Insects
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 43(3), 934–940.
MeSH headings : Animals; Antioxidants / metabolism; Insecta / metabolism; Mercury / metabolism; Species Specificity; Subcellular Fractions / metabolism; Water Pollutants, Chemical / metabolism
TL;DR:
Surprisingly, little Hg (<10%) was found in the heat-stable cytosolic protein subcellular compartment in each of the four species, suggesting that Hg was not well detoxified.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Aquatic animal models of human disease: Selected papers and recommendations from the 4th Conference
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 149(2), 121–128.
MeSH headings : Animals; Disease Models, Animal; Fishes; Humans; Mollusca
TL;DR:
Of increasing importance are contributions of aquatic invertebrates and fishes to the detection of toxic responses from: metal mining and smelting impacts, polycyclic aromatichydrocarbons and persistent organic pollutants and their adverse effects in harbors and coastal estuaries, including the verification of remediation processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2009 journal article
Neonatal agonism of ERα masculinizes serotonergic (5-HT) projections to the female rat ventromedial nucleus of the hypothalamus (VMN) but does not impair lordosis
Behavioural Brain Research, 196(2), 317–322.
author keywords: Estrogen; Development; Hypothalamus; Serotonin; Sex differences; Estrogen receptor; DPN; PPT
MeSH headings : Animals; Animals, Newborn / physiology; Estradiol / administration & dosage; Estradiol / pharmacology; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / physiology; Estrogen Receptor beta / agonists; Female; Male; Neural Pathways / physiology; Nitriles / pharmacology; Phenols / pharmacology; Propionates / pharmacology; Pyrazoles / pharmacology; Rats; Serotonin / physiology; Sex Characteristics; Sexual Behavior, Animal / physiology; Ventromedial Hypothalamic Nucleus / physiology
TL;DR:
Observations show that postnatal estrogens increase the density of 5-HT projections to the VMNvl via an ERalpha dependent mechanism, but that this increased inhibitory input is not sufficient to suppress the lordosis response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Generation and characterization of novel canine malignant mast cell line CL1
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 127(1-2), 114–124.
author keywords: Mast cell tumor; KIT; Cell line
MeSH headings : Animals; Base Sequence; Cell Degranulation; Cell Line, Tumor; DNA Primers / genetics; DNA, Neoplasm / genetics; Dog Diseases / genetics; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Female; Genome-Wide Association Study; Immunophenotyping; Mast Cells / immunology; Mast Cells / pathology; Mast Cells / physiology; Mastocytosis, Systemic / genetics; Mastocytosis, Systemic / immunology; Mastocytosis, Systemic / pathology; Mastocytosis, Systemic / veterinary; Proto-Oncogene Proteins c-kit / genetics; Proto-Oncogene Proteins c-kit / metabolism
TL;DR:
A novel mast cell line is generated from an 11-year-old spayed female Labrador retriever diagnosed with systemic mastocytosis and neoplastic effusion that possesses phenotypic and functional properties similar to those found in canine BMCMCs, and will likely be a useful tool to study mast cell biology, factors regulating transformation of mast cells, cytogenetic abnormalities in mast cell tumors, and novel preclinical therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Form, function and phylogenetics of NITRs in bony fish
Developmental & Comparative Immunology, 33(2), 135–144.
author keywords: Teleost; Innate immunity; Natural killer receptors; ITIM; ITSM; DAP12; CD8; KIR
MeSH headings : Animals; DNA, Complementary / genetics; Fishes / genetics; Fishes / immunology; Humans; Immunoglobulins / immunology; Ligands; Phylogeny; Receptors, Immunologic / chemistry; Receptors, Immunologic / genetics; Receptors, Immunologic / immunology
TL;DR:
An analysis of all published NITRs demonstrates the conserved nature of multiple residues within the NITR Ig domains permitting the identification of NITr ESTs from salmon, cod, halibut, lake whitefish and stickleback species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
A physiologically based pharmacokinetic model linking plasma protein binding interactions with drug disposition
RESEARCH IN VETERINARY SCIENCE, 86(2), 293–301.
author keywords: Physiologically based pharmacokinetic; model (PBPK); Drug-drug interaction; Plasma protein binding; Sulfamethazine; Flunixin meglumine
MeSH headings : Animals; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Blood Proteins / metabolism; Chromatography, High Pressure Liquid; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Drug Interactions; Drug Therapy, Combination; Female; Models, Biological; Pharmacokinetics; Protein Binding; Sulfamethazine / blood; Sulfamethazine / pharmacokinetics; Swine / blood; Swine / metabolism; Tissue Distribution
TL;DR:
A physiologically based pharmacokinetic model was developed that links plasma protein binding interactions to drug disposition for SMZ and FLU in swine and predicted a sustained decrease in total drug and a temporary increase in free drug concentration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Light-activation of gene function in mammalian cells via ribozymes
Chem. Commun., (5), 568–570.
MeSH headings : Cell Line; Gene Expression / radiation effects; Humans; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; RNA, Messenger / metabolism; Toyocamycin / chemistry; Toyocamycin / radiation effects; Ultraviolet Rays
TL;DR:
A ribozyme based gene control element enabled the spatio-temporal regulation of gene function in mammalian cell culture with light.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cattle
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 234(2), 245–248.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / pharmacokinetics; Cattle; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Drug Residues / analysis; Female; Infusions, Parenteral / veterinary; Lactation; Mammary Glands, Animal / metabolism; Mastitis, Bovine / drug therapy; Mastitis, Bovine / metabolism; Metabolic Clearance Rate; Milk / chemistry; Prospective Studies; Tylosin / administration & dosage; Tylosin / analogs & derivatives; Tylosin / analysis; Tylosin / pharmacokinetics
TL;DR:
Findings indicated that tilmicosin should not be administered by the intramammary route in lactating dairy cows, and milk from all glands of any cows accidentally treated should be discarded for a minimum of 82 days following intramamsary administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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