Works Published in 2000

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Displaying works 21 - 40 of 51 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2000 journal article

Association of the C-514T polymorphism in the hepatic lipase gene with variations in lipoprotein subclass profiles - The Framingham Offspring Study

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 20(3), 815–822.

By: P. Couture*, J. Otvos*, L. Cupples*, C. Lahoz*, P. Wilson*, E. Schaefer*, J. Ordovas*

author keywords: hepatic lipase; HDL; gene polymorphisms; lipoprotein particle size
MeSH headings : Adult; Aged; Apolipoprotein A-I / blood; Cholesterol, HDL / blood; Coronary Disease / enzymology; Coronary Disease / epidemiology; Coronary Disease / genetics; Female; Genetic Predisposition to Disease; Genotype; Humans; Lipase / genetics; Liver / enzymology; Male; Middle Aged; Particle Size; Polymorphism, Single Nucleotide; Risk Factors
TL;DR: The results show that the C-514T polymorphism in the hepatic lipase gene is associated with significant variations in the lipoprotein profile in men and women. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

A geminivirus replication protein interacts with the retinoblastoma protein through a novel domain to determine symptoms and tissue specificity of infection in plants

EMBO JOURNAL, 19(13), 3485–3495.

By: L. Kong n, B. Orozco, J. Roe, S. Nagar, S. Ou, H. Feiler, T. Durfee, A. Miller ...

author keywords: AL1; cell cycle; differentiation; plant DNA virus; pRb
MeSH headings : Antigens, Polyomavirus Transforming / metabolism; Base Sequence; DNA Primers; Geminiviridae / isolation & purification; Geminiviridae / metabolism; Geminiviridae / physiology; Plants / virology; Protein Binding; Retinoblastoma Protein / metabolism; Viral Proteins / metabolism; Virus Replication
TL;DR: The pRBR binding domain of AL1 is mapped between amino acids 101 and 180 and two mutants are identified that are differentially impacted for AL1–pRBR interactions during geminivirus infection of plants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2000 journal article

The surface conformation of sindbis virus glycoproteins E1 and E2 at neutral and low pH, as determined by mass spectrometry-based mapping

JOURNAL OF VIROLOGY, 74(12), 5667–5678.

By: B. Phinney n, K. Blackburn* & D. Brown n

MeSH headings : Capsid / chemistry; Capsid / metabolism; Disulfides / metabolism; Hydrogen-Ion Concentration; Iodine Radioisotopes / metabolism; Membrane Glycoproteins / chemistry; Membrane Glycoproteins / metabolism; Pepsin A / metabolism; Peptide Fragments / chemistry; Peptide Fragments / metabolism; Protein Binding; Protein Structure, Tertiary; Serine Endopeptidases / metabolism; Silver Staining; Sindbis Virus; Software; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Surface Properties; Trypsin / metabolism; Tyrosine / metabolism; Viral Envelope Proteins / chemistry; Viral Envelope Proteins / metabolism
TL;DR: The techniques of limited proteolysis and amino acid chemical modification in combination with mass spectrometry improve the understanding of the structure of the virus membrane and have implications for understanding the protein conformational changes which accompany the process of virus-cell membrane fusion. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Sindbis virus glycoprotein E1 is divided into two discrete domains at amino acid 129 by disulfide bridge connections

JOURNAL OF VIROLOGY, 74(19), 9313–9316.

MeSH headings : Amino Acid Sequence; Membrane Glycoproteins / chemistry; Molecular Sequence Data; Sindbis Virus / chemistry; Sulfides; Viral Envelope Proteins / chemistry
TL;DR: The E1 membrane glycoprotein of Sindbis virus contains structural and functional domains, which are conformationally dependent on the presence of intramolecular disulfide bridges, which divide the protein into two domains at amino acid 129. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Phospholipid/fatty acid-induced secondary structural change in beta-lactoglobulin during heat-induced gelation

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 48(3), 605–610.

author keywords: beta-lactoglobubin; phosphatidylcholine; fatty acid; gelation; secondary structure; viscoelasticity
MeSH headings : Fatty Acids / chemistry; Gels; Hot Temperature; Humans; Lactoglobulins / chemistry; Phosphatidylcholines / chemistry; Protein Structure, Secondary
TL;DR: Effects of phosphatidylcholine and the predominant fatty acids (FAs) in milk, butyrate, oleate, and palmitate, on secondary structural changes in beta-lactoglobulin (beta-LG) during heat-induced gelation were analyzed on the basis of circular dichroism (CD) spectra. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Modified nucleoside dependent Watson-Crick and wobble codon binding by tRNA(UUU)(Lys) species

BIOCHEMISTRY, 39(44), 13390–13395.

By: C. Yarian n, M. Marszalek n, E. Sochacka n, A. Malkiewicz n, R. Guenther n, A. Miskiewicz n, P. Agris n

MeSH headings : Adenosine / analogs & derivatives; Adenosine / chemistry; Anticodon / chemistry; Binding Sites; Humans; Nucleic Acid Conformation; Protein Binding; Pseudouridine / chemistry; RNA, Ribosomal, 16S / chemistry; RNA, Transfer, Lys / chemistry; Ribosomal Proteins / chemistry; Structure-Activity Relationship; Thermodynamics; Uridine / analogs & derivatives; Uridine / chemistry
TL;DR: The data suggest that tRNA(Lys)(UUU) species require anticodon domain modifications in the loop to impart an ordered structure to the anticodon for ribosomal binding to AAA and require a combination of modified nucleosides to bind AAG. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Functional anticodon architecture of human tRNA(Lys3) includes disruption of intraloop hydrogen bonding by the naturally occurring amino acid modification, t(6)A

BIOCHEMISTRY, 39(44), 13396–13404.

By: J. Stuart n, Z. Gdaniec n, R. Guenther n, M. Marszalek n, E. Sochacka n, A. Malkiewicz n, P. Agris n

MeSH headings : Adenosine / analogs & derivatives; Adenosine / chemistry; Adenosine / metabolism; Amino Acid Substitution; Anticodon / chemical synthesis; Anticodon / chemistry; Crystallography, X-Ray; Humans; Hydrogen Bonding; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular / methods; Nucleic Acid Conformation; Protein Binding; Pseudouridine / chemistry; RNA, Transfer, Lys / chemical synthesis; RNA, Transfer, Lys / chemistry; Ribosomal Proteins / chemistry; Thermodynamics; Threonine / chemistry; Threonine / metabolism
TL;DR: From these results, it is concluded that ribosome binding cannot simply be an induced fit of the anticodon stem and loop, otherwise the unmodified ASL(Lys3)(UUU) would bind as well as ASL (Lys 3)(UU U)-t(6)A(37), and the ionized carboxylic acid moiety of t(6), possibly neutralizes the positive charge of A(+)(38). (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Differential expression of genes encoding cell wall proteins in vascular tissues from vertical and bent loblolly pine trees

Tree Physiology, 20(7), 457–466.

By: Y. Zhang, R. Sederoff & I. Allona

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Control of ethylene responses in avocado fruit with 1-methylcyclopropene

POSTHARVEST BIOLOGY AND TECHNOLOGY, 20(2), 143–150.

By: X. Feng*, A. Apelbaum*, E. Sisler n & R. Goren*

author keywords: 1-methylcyclopropene; avocado fruit; ripening; ethylene; cellulase; polygalacturonase; softening; coloring
TL;DR: It is suggested that 1-MCP is a potent inhibitor of avocado fruit ripening which exerts its effect via inhibition of ethylene action. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 chapter

Structure determination by directed photo-cross-linking in large RNA molecules with site-specific psoralen

In R.W. Skaggs & J. Schilfgaarde (Eds.), RNA-ligland interactions: Part B (Vol. 318, pp. 104–118).

By: D. Mundus & P. Wollenzien*

Ed(s): . R.W. Skaggs & J. Schilfgaarde

MeSH headings : Azides / pharmacology; Chromatography, High Pressure Liquid; Cross-Linking Reagents / pharmacology; Cystamine / chemistry; DNA / chemistry; DNA / metabolism; Electrophoresis, Polyacrylamide Gel; Ficusin / pharmacology; Furocoumarins; Genetic Techniques; Models, Chemical; Phosphorylation; Photoaffinity Labels / pharmacology; Photosensitizing Agents / pharmacology; RNA / chemistry; RNA / drug effects; RNA / metabolism; RNA / radiation effects; RNA, Ribosomal, 16S / metabolism; Time Factors; Transcription, Genetic; Ultraviolet Rays
Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Optimization of sample pH and temperature for phosphorus-31 nuclear magnetic resonance spectroscopy of poultry manure extracts

COMMUNICATIONS IN SOIL SCIENCE AND PLANT ANALYSIS, 31(1-2), 229–240.

UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Identification and characterization of the iron regulatory element in the ferritin gene of a plant (soybean)

JOURNAL OF BIOLOGICAL CHEMISTRY, 275(23), 17488–17493.

By: J. Wei n & E. Theil n

MeSH headings : Base Sequence; Ferritins / genetics; Genes, Reporter; Glucuronidase / genetics; Iron / metabolism; Iron-Regulatory Proteins; Iron-Sulfur Proteins / metabolism; Luciferases / genetics; Molecular Sequence Data; Mutagenesis, Insertional; Plant Leaves; Promoter Regions, Genetic; RNA, Messenger / genetics; RNA-Binding Proteins / metabolism; Recombinant Proteins / biosynthesis; Sequence Deletion; Soybeans / genetics
TL;DR: DNA and DNA were used to show that an 86-base pair fragment controlled iron-mediated derepression of the ferritin gene, and FRE/factor binding was abrogated by increased tissue iron, in analogy to mRNA (IRE)/iron regulatory protein in animals. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Geminiviruses - Models for plant DNA replication, transcription and cell cycle regulation ([correction to] vol 35, pg 105, 2000)

Critical Reviews in Biochemistry and Molecular Biology, 35(4), U4.

By: L. Hanley-Bowdoin, S. Settlage, B. Orozco, S. Nagar & D. Robertson

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Apolipoprotein epsilon 2 allele is associated with an anti-atherogenic lipoprotein profile in children: The Columbia University BioMarkers Study

PEDIATRICS, 106(3), 568–575.

By: C. Isasi, S. Shea, R. Deckelbaum*, S. Couch*, T. Starc*, J. Otvos n, L. Berglund

author keywords: apolipoprotein epsilon; children; cholesterol
MeSH headings : Adolescent; Adult; Alleles; Apolipoproteins E / genetics; Arteriosclerosis / genetics; Child; Child, Preschool; Cholesterol, HDL / blood; Cholesterol, LDL / blood; Female; Genotype; Hispanic or Latino / genetics; Humans; Linear Models; Male; Phenotype; White People / genetics
TL;DR: The apo epsilon2 allele is associated with an anti-atherogenic lipid pattern in children and was independently predictive of higher levels of HDL cholesterol and the large HDL subpopulation and of lower level of LDL cholesterol. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Phosphate and potassium retention and release during chrysanthemum production from precharged materials: II. Calcined clays and brick chips

Journal of the American Society for Horticultural Science, 125(6), 757–764.

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Phosphate and potassium retention and release during chrysanthemum production from precharged materials: I. Alumina

Journal of the American Society for Horticultural Science, 125(6), 748–756.

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Box C/D snoRNA-associated proteins: Two pairs of evolutionarily ancient proteins and possible links to replication and transcription

RNA, 6(6), 861–879.

By: D. Newman n, J. Kuhn n, G. Shanab* & E. Maxwell n

author keywords: intronic snoRNA; snoRNA processing; snoRNP proteins
MeSH headings : Amino Acid Motifs; Amino Acid Sequence; Animals; Conserved Sequence; DNA Replication; Evolution, Molecular; Mice; Molecular Sequence Data; Nuclear Proteins; RNA, Small Nucleolar / genetics; RNA, Small Nucleolar / physiology; Ribonucleoproteins, Small Nucleolar / genetics; Ribonucleoproteins, Small Nucleolar / physiology; Saccharomyces cerevisiae Proteins; Sequence Alignment; Substrate Specificity; Transcription, Genetic
TL;DR: Homologs for both snoRNA-associated protein pairs occur in Archaea, strengthening the hypothesis that the box C/D RNA elements and their interacting proteins are of ancient evolutionary origin. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Synthesis and properties of uniquely modified oligoribonucleotides: Yeast tRNA(Phe) fragments with 6-methyluridine and 5,6-dimethyluridine at site-specific positions

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 19(3), 515–531.

By: E. Sochacka*, G. Czerwinska*, R. Guenther n, R. Cain n, P. Agris n & A. Malkiewicz*

MeSH headings : Anticodon; Magnetic Resonance Spectroscopy; Methylation; Molecular Conformation; Oligoribonucleotides / chemical synthesis; Oligoribonucleotides / chemistry; Organophosphorus Compounds / chemistry; RNA, Transfer, Phe / chemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Uridine / analogs & derivatives; Uridine / chemistry; Yeasts / chemistry
TL;DR: Stability when the modified uridine is in a loop is sequence context dependent, and can not, at this time, be predicted from the location in the loop, but decrease in RNA duplex stability is predictable. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

A single deletion in the membrane-proximal region of the Sindbis virus glycoprotein E2 endodomain blocks virus assembly

JOURNAL OF VIROLOGY, 74(9), 4220–4228.

MeSH headings : Amino Acid Sequence; Animals; Binding Sites; Biological Transport; Cell Line; Cell Membrane / metabolism; Cricetinae; Cytoplasm / metabolism; Humans; Intracellular Fluid / metabolism; Molecular Sequence Data; Mutagenesis; Nucleocapsid / metabolism; Sindbis Virus / genetics; Sindbis Virus / physiology; Sindbis Virus / ultrastructure; Viral Envelope Proteins / genetics; Viral Envelope Proteins / metabolism; Viral Envelope Proteins / physiology; Viral Structural Proteins / metabolism; Virus Assembly / physiology
TL;DR: A deletion mutant is constructed, ΔK391, in which a nonconserved lysine at the membrane-cytoplasm junction of the E2 tail has been deleted and it is proposed that the phenotypic differences displayed by this mutant in the two diverse host cells arise from fundamental differences in the lipid composition of the insect cell membranes. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Absence of association between genetic variation in the promoter of the microsomal triglyceride transfer protein gene and plasma lipoproteins in the Framingham Offspring Study

ATHEROSCLEROSIS, 148(2), 337–343.

author keywords: microsomal triglyceride transfer protein; LDL-cholesterol; lipoprotein subfractions
MeSH headings : Adult; Apolipoproteins / blood; Cardiovascular Diseases / genetics; Carrier Proteins / genetics; Cholesterol Ester Transfer Proteins; Female; Genetic Predisposition to Disease; Genetic Variation; Genotype; Glycoproteins; Humans; Lipids / blood; Lipoproteins / blood; Lipoproteins / classification; Male; Middle Aged; Polymorphism, Genetic / physiology; Promoter Regions, Genetic / genetics; Prospective Studies
TL;DR: The results suggest that the G-493T mutation in the MTP promoter is unlikely to have significant implications for cardiovascular disease in men and women. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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