Works Published in 2017
Displaying works 1 - 20 of 44 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2017 journal article
Impact of Dietary Galacto-Oligosaccharide (GOS) on Chicken’s Gut Microbiota, Mucosal Gene Expression, and Salmonella Colonization
Frontiers in Veterinary Science, 4.
author keywords: chickens; immune; Salmonella; prebiotic; galacto-oligosaccharides
TL;DR:
Investigation of the effect of the prebiotic galacto-oligosaccharide (GOS) on the cecal microbiome and ultimately the carriage of Salmonella demonstrated that treatment with thePrebiotic GOS can modify both c Cecal tonsil gene expression and the cECal microbiome, suggesting that this type of treatment may be useful as a tool for altering the carriage in poultry.
(via Semantic Scholar)
www.frontiersin.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: June 23, 2021
2017 journal article
Foundational and Translational Research Opportunities to Improve Plant Health
Molecular Plant-Microbe Interactions, 30(7), 515–516.
MeSH headings : Agriculture / methods; Biotechnology / methods; Climate Change; Crops, Agricultural / growth & development; Crops, Agricultural / microbiology; Crops, Agricultural / parasitology; Food Supply; Humans; Plant Diseases / microbiology; Plant Diseases / parasitology; Translational Research, Biomedical / methods
TL;DR:
The white paper reports the deliberations of a workshop focused on biotic challenges to plant health held in Washington, D.C. in September 2016, and concludes that data-driven, informed decisions based on knowledge of the variation ofBiotic challenges and of natural and synthetic variation in crop plants will enable deployment of durable interventions throughout the world.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 13, 2020
2017 journal article
An extended N-H bond, driven by a conserved second-order interaction, orients the flavin N5 orbital in cholesterol oxidase
Scientific Reports, 7(1), 40517,
MeSH headings : Amides / chemistry; Binding Sites; Biocatalysis; Cholesterol Oxidase / metabolism; Conserved Sequence; Crystallography, X-Ray; Flavin-Adenine Dinucleotide / metabolism; Flavins / chemistry; Flavins / metabolism; Hydrogen Bonding; Models, Molecular; Oxidation-Reduction; Substrate Specificity
TL;DR:
A novel second-order partial-charge interaction network is proposed which enables the correct orientation of the hydride receiving orbital of N5 and affects the N-H bond length in the region of the flavin reactive center.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: January 6, 2020
2017 journal article
Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase
Angewandte Chemie, 129(3), 785–788.
Source: ORCID
Added: January 6, 2020
2017 journal article
Inside Cover: Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase (Angew. Chem. Int. Ed. 3/2017)
Angewandte Chemie International Edition, 56(3), 658–658.
Source: ORCID
Added: January 6, 2020
2017 journal article
Innentitelbild: Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase (Angew. Chem. 3/2017)
Angewandte Chemie.
Source: ORCID
Added: January 6, 2020
2017 journal article
Improving Gene Regulatory Network Inference by Incorporating Rates of Transcriptional Changes
Scientific Reports.
MeSH headings : Algorithms; Animals; Circadian Clocks / genetics; Computational Biology / methods; Gene Regulatory Networks; Humans; Mice; Transcription Factors / metabolism; Transcription, Genetic
TL;DR:
ExRANGES improved the identification of experimentally validated transcription factor targets for all species tested, even in unevenly spaced and sparse data sets, and enhances the utility of network inference approaches in non-model species where experimental validation is challenging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: ORCID
Added: June 25, 2019
2017 article
The Next Generation of Training for Arabidopsis Researchers: Bioinformatics and Quantitative Biology
Friesner, J., Assmann, S. M., Bastow, R., Bailey-Serres, J., Beynon, J., Brendel, V., … Brady, S. M. (2017, December). PLANT PHYSIOLOGY, Vol. 175, pp. 1499–1509.
MeSH headings : Arabidopsis / genetics; Computational Biology / education; Cooperative Behavior; Faculty; Phenotype; Research / education
TL;DR:
Training for experimental plant biologists needs to combine bioinformatics, quantitative approaches, computational biology, and training in the art of collaboration, best achieved through fully integrated curriculum development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
The Arabidopsis Leucine-Rich Repeat Receptor Kinase BIR3 Negatively Regulates BAK1 Receptor Complex Formation and Stabilizes BAK1
PLANT CELL, 29(9), 2285–2303.
MeSH headings : Arabidopsis / drug effects; Arabidopsis / metabolism; Arabidopsis Proteins / metabolism; Brassinosteroids / metabolism; Cell Death / drug effects; Flagellin / pharmacology; Leucine-Rich Repeat Proteins; Ligands; Membrane Proteins / metabolism; Mutation / genetics; Pathogen-Associated Molecular Pattern Molecules / metabolism; Phenotype; Protein Binding / drug effects; Protein Serine-Threonine Kinases / metabolism; Protein Stability / drug effects; Proteins / metabolism; Signal Transduction
TL;DR:
It is shown that BAK1-related pathways such as innate immunity and cell death control are affected by BIR3 in Arabidopsis thaliana, and Bir3 also has a strong negative impact on BR signaling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(OpenAlex)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds
MOLECULAR MICROBIOLOGY, 106(2), 223–235.
MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Bacterial Proteins / ultrastructure; Biofilms / drug effects; Francisella tularensis / metabolism; Gene Expression Regulation, Bacterial / genetics; Imidazoles / metabolism; Imidazoles / pharmacology; Protein Binding; Virulence / drug effects; Virulence Factors / genetics; Virulence Factors / metabolism
TL;DR:
It is shown that QseB interacts with 2‐aminoimidazole based compounds that impede its function, and this information will assist in tailoring compounds to act as adjuvants that will enhance the effect of antibiotics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Safety and Efficacy of Allogeneic Lung Spheroid Cells in a Mismatched Rat Model of Pulmonary Fibrosis
STEM CELLS TRANSLATIONAL MEDICINE, 6(10), 1905–1916.
author keywords: Fibrosis; Pulmonary; Syngeneic; Allogeneic; Stem cells
MeSH headings : Animals; Bleomycin / toxicity; Cells, Cultured; Female; Lung / cytology; Pulmonary Fibrosis / etiology; Pulmonary Fibrosis / therapy; Rats; Rats, Wistar; Spheroids, Cellular / transplantation; Stem Cell Transplantation / adverse effects; Stem Cell Transplantation / methods; Transplantation, Homologous / adverse effects; Transplantation, Homologous / methods
TL;DR:
It is found that infusion of allogeneic LSCs reduces the progression of inflammation and fibrotic manifestation and preserves epithelial and endothelial health without eliciting significant immune rejection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Infectivity of Deinbollia mosaic virus, a novel weed-infecting begomovirus in East Africa
ARCHIVES OF VIROLOGY, 162(11), 3439–3445.
MeSH headings : Africa, Eastern; Begomovirus / physiology; Euphorbiaceae / virology; Plant Diseases / virology; Plant Leaves / virology; Plant Weeds / virology; Solanaceae / virology
TL;DR:
The first experimental infectivity analysis of DMV is demonstrated, demonstrating the capacity of DMV to infect a restricted host range of Solanaceae and Euphorbiaceae species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(OpenAlex)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Genomic Analysis of the DNA Replication Timing Program during Mitotic S Phase in Maize (Zea mays) Root Tips
PLANT CELL, 29(9), 2126–2149.
MeSH headings : Base Sequence; Chromosomes, Plant / genetics; DNA Replication Timing / genetics; DNA Transposable Elements / genetics; Genes, Plant; Genomics; Meristem / cytology; Meristem / genetics; Mitosis / genetics; Models, Genetic; S Phase / genetics; Tandem Repeat Sequences / genetics; Time Factors; Transcription, Genetic; Zea mays / cytology; Zea mays / genetics
TL;DR:
A novel adaptation of the “Repli-seq” assay for use in intact root tips of maize (Zea mays) that includes several different cell lineages and present whole-genome replication timing profiles from cells in early, mid, and late S phase of the mitotic cell cycle is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Neutron structure of the T26H mutant of T4 phage lysozyme provides insight into the catalytic activity of the mutant enzyme and how it differs from that of wild type
PROTEIN SCIENCE, 26(10), 1953–1963.
author keywords: lysozyme; hydrolysis; perdeuteration; neutron crystallography
MeSH headings : Bacteriophage T4 / enzymology; Bacteriophage T4 / genetics; Binding Sites / genetics; Crystallography, X-Ray; Hydrolysis; Models, Molecular; Muramidase / chemistry; Muramidase / genetics; Muramidase / metabolism; Muramidase / ultrastructure; Mutation / genetics; Neutrons; Protein Conformation
TL;DR:
The neutron structure of the perdeuterated T26H mutant is determined to clarify the protonation states of Glu11 and the substituted His26, which are key in the retaining reaction of T4 phage lysozyme.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Neutron crystallographic studies of T4 lysozyme at cryogenic temperature
PROTEIN SCIENCE, 26(10), 2098–2104.
author keywords: T4-lysozyme; neutron; structure; X-ray; hydrogen
MeSH headings : Cold Temperature; Hydrogen / chemistry; Models, Molecular; Muramidase / chemistry; Neutron Diffraction; Protein Conformation; Water / chemistry
TL;DR:
A near complete atomic structure of T4L is described, which includes the positions of 1737 hydrogen atoms determined by neutron crystallography, which reveals explicit detail of the hydrogen bonding interactions in the protein, in addition to the protonation states of several important residues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Evidence for M1-Linked Polyubiquitin-Mediated Conformational Change in NEMO
JOURNAL OF MOLECULAR BIOLOGY, 429(24), 3793–3800.
author keywords: Innate immune signaling; Small-angle X-ray scattering; Protein biochemistry; Size exclusion chromatography
MeSH headings : Binding Sites; Humans; I-kappa B Kinase / chemistry; I-kappa B Kinase / metabolism; NF-kappa B / metabolism; Polyubiquitin / metabolism; Protein Binding; Protein Conformation; Signal Transduction; Ubiquitination
TL;DR:
Observations suggest that NEMO may be auto-inhibited in the resting state by intramolecular interactions and that during signaling, NEMo may be allosterically activated by binding to long M1-linked polyubiquitin chains.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 article
Covering their bases: The phosphobase methylation pathway in plants
Barycki, J. J. (2017, December 29). JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 292, pp. 21703–21704.
author keywords: Arabidopsis thaliana; methyltransferase; phosphocholine; X-ray crystallography; enzyme kinetics; phosphatidylcholine; plant biochemistry
MeSH headings : Amino Acid Sequence; Crystallography, X-Ray; Methylation; Methyltransferases / metabolism; Methyltransferases / physiology; Phosphatidylcholines / biosynthesis; Phosphorylcholine / metabolism; Plants / metabolism
TL;DR:
New work from Lee and Jez reveals critical domain movements that explain how multiple methylation reactions are uniquely coordinated by plant methyltransferases and provides insights into the evolution of this class of enzymes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Reciprocal cross-regulation of VND and SND multigene TF families for wood formation in Populus trichocarpa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114(45), E9722–E9729.
author keywords: reciprocal cross-regulation; NAC transcription factors; alternative splicing; wood formation; Populus trichocarpa
MeSH headings : Alternative Splicing; Cell Wall / genetics; Cell Wall / metabolism; Cloning, Molecular; DNA, Plant; Gene Expression Regulation, Plant / genetics; Gene Regulatory Networks; Genes, Plant; Homeostasis; Multigene Family; Nuclear Proteins; Plant Leaves / genetics; Plant Leaves / metabolism; Plant Proteins / genetics; Plant Proteins / metabolism; Plant Shoots / genetics; Plant Shoots / metabolism; Populus / genetics; Populus / metabolism; Recombinant Proteins / genetics; Transcription Factors / genetics; Transcription Factors / metabolism; Transcriptional Activation / genetics; Transcriptome; Wood / genetics; Wood / growth & development; Xylem / genetics; Xylem / growth & development
TL;DR:
The results indicate that the splice variants from the PtrVND6 and PtrSND1 family may exert reciprocal cross-regulation for complete transcriptional regulation of these two families in wood formation, suggesting a general mechanism among NAC domain proteins and likely other transcription factors.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Heart Repair Using Nanogel-Encapsulated Human Cardiac Stem Cells in Mice and Pigs with Myocardial Infarction
ACS NANO, 11(10), 9738–9749.
author keywords: cardiac stem cells; nanogel; myocardial infarction; biomaterials; mouse model; pig model
MeSH headings : Acrylamides / chemistry; Acrylates / chemistry; Animals; Disease Models, Animal; Female; Humans; Mice; Myocardial Infarction / metabolism; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Nanogels; Particle Size; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Surface Properties; Swine; Temperature
TL;DR:
In mice and pigs with acute MI, injection of encapsulated hCSCs preserves cardiac function and reduces scar sizes, whereas injection of hC SCs in saline has an adverse effect on heart healing, suggesting thermosensitive nanogels can be used as a stem cell carrier.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Altered acrylic acid concentrations in hard and soft corals exposed to deteriorating water conditions
Facets, 2, 531–544.
TL;DR:
Changes in acrylic acid concentration in polyp tissues free of zooxanthellae suggest that acrylic acid could be a product of animal metabolism and not exclusively a metabolic by-product of the osmolyte dimethylsulfoniopropionate (DMSP) in marine algae or bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
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