Works Published in 2018
Displaying works 1 - 20 of 37 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 journal article
Mechanism of vaccinia viral protein B14–mediated inhibition of IκB kinase β activation
Journal of Biological Chemistry, 293(26), 10344–10352.
author keywords: molecular docking; autophosphorylation; protein kinase; virus; inhibition mechanism; B14; IKK; protein kinase; trans autophosphorylation; vaccinia virus
MeSH headings : Animals; Enzyme Activation; Humans; I-kappa B Proteins / chemistry; I-kappa B Proteins / metabolism; Models, Molecular; Protein Binding; Protein Domains; Protein Structure, Quaternary; Vaccinia virus; Viral Proteins / metabolism; Xenopus
TL;DR:
The B14–IKKβ interaction sterically hinders direct contact between the kinase domains of IKK β in the IKK complex, containing IKKβ, IKKα, and NEMO in human cells, thereby inhibiting NF-κB signaling.
(via Semantic Scholar)
www.jbc.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: November 30, 2020
2018 chapter
Cassava viruses – host jumps, virus recombination, spread in plant material
In A. Records & J. Ristaino (Eds.), Emerging Plant Diseases and Global Food Security. St. Paul, MN: APS Press.
Ed(s): A. Records & J. Ristaino
Source: NC State University Libraries
Added: September 24, 2020
2018 journal article
Role of the vacuolar ATPase in the Alphavirus replication cycle
Heliyon, 4(7), e00701.
author keywords: Virology; Cell biology
TL;DR:
Results show that a functional V-ATPase is required for efficient virus RNA synthesis and virus maturation in Alphavirus infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: June 6, 2020
2018 journal article
Modulating Enzyme Activity by Altering Protein Dynamics with Solvent
Biochemistry, 57(29), 4263–4275.
MeSH headings : 2-Propanol / metabolism; Crystallography, X-Ray / methods; Enzyme Activation / drug effects; Escherichia coli / chemistry; Escherichia coli / enzymology; Escherichia coli / metabolism; Kinetics; Molecular Dynamics Simulation; Protein Conformation / drug effects; Solvents / metabolism; Static Electricity; Tetrahydrofolate Dehydrogenase / chemistry; Tetrahydrofolate Dehydrogenase / metabolism; Viscosity; Water / metabolism
TL;DR:
An approach that uses an aqueous mixture of organic solvent to control the functionally relevant enzyme dynamics (without changing the structure), which in turn modulates the enzyme activity, providing vital insights that show the altered motions of DHFR cause significant changes in the enzyme's ability to access its functionally relevant conformational substates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 18, 2020
2018 journal article
Cotton Leaf Curl Multan virus C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase
PLOS Pathogens, 14(8), e1007282.
Ed(s): S. Dinesh-Kumar
MeSH headings : Begomovirus / metabolism; Begomovirus / pathogenicity; Down-Regulation / genetics; Gene Expression Regulation, Plant; Gene Silencing; Host-Pathogen Interactions / genetics; Methionine Adenosyltransferase / genetics; Methionine Adenosyltransferase / metabolism; Plants, Genetically Modified; Protein Binding; RNA Interference; Tobacco / genetics; Tobacco / metabolism; Transcription, Genetic; Viral Proteins / metabolism; Viral Proteins / physiology
TL;DR:
It is reported that Cotton Leaf Curl Multan virus (CLCuMuV) C4 protein interacts with S-adenosyl methionine synthetase (SAMS), a core enzyme in the methyl cycle, and inhibits SAMS enzymatic activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 13, 2020
2018 journal article
Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.
FRONTIERS IN MOLECULAR BIOSCIENCES, 5.
author keywords: biofilms; antibiotic resistance; two-component systems; response regulators; Acinetobacter baumannii; Francisella
TL;DR:
This work investigates the response regulator/2-AI interaction and looks at a wider library of 2-AI compounds, and establishes that Francisella tularensis/novicida, encoding for only three known response regulators, can be a model system to study the interaction between 2-AIs and response regulators.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 28, 2019
2018 journal article
Neutron scattering in the biological sciences: progress and prospects
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 74, 1129–1168.
author keywords: neutron scattering; biological systems; structure and dynamics
MeSH headings : Animals; Crystallography / methods; Deuterium / analysis; Deuterium Exchange Measurement / methods; Humans; Models, Molecular; Neutron Diffraction / methods; Neutrons; Proteins / chemistry
TL;DR:
Crystallography, solution scattering, dynamics, membranes, labeling and imaging, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods are examined.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 21, 2019
2018 article
Plant Virus-Based Nanoparticles for the Delivery of Agronomic Compounds as a Suspension Concentrate
VIRUS-DERIVED NANOPARTICLES FOR ADVANCED TECHNOLOGIES: METHODS AND PROTOCOLS, Vol. 1776, pp. 203–214.
author keywords: Plant pathogenic nematode; Nematicide; Agrichemical; Plant viral nanoparticle; Nanoparticle formulation
MeSH headings : Ivermectin / analogs & derivatives; Ivermectin / chemistry; Nanoparticles / chemistry; Plant Viruses / chemistry; Tombusviridae / chemistry
TL;DR:
This work describes how to formulate a PVN loaded with the nematicide abamectin (Abm) beginning with the propagation of the virus through the formulation, deactivation, and characterization of the finished product.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 14, 2019
2018 journal article
Cardiac cell-integrated microneedle patch for treating myocardial infarction
SCIENCE ADVANCES, 4(11).
MeSH headings : Animals; Cells, Cultured; Microtechnology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Needles; Rats; Rats, Inbred WKY; Regeneration; Stromal Cells / cytology; Stromal Cells / transplantation; Swine; Tissue Engineering / instrumentation
TL;DR:
The microneedle patch integrated with cardiac stromal cells (MN-CSCs) represents an innovative approach delivering therapeutic cells for heart regeneration and polymeric MNs are used to create “channels” between host myocardium and therapeutic CSCs to promote heart repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 31, 2018
2018 article
Chromatin structure profile data from DNS-seq: Differential nuclease sensitivity mapping of four reference tissues of B73 maize (Zea mays L)
Turpin, Z. M., Vera, D. L., Savadel, S. D., Lung, P.-Y., Wear, E. E., Mickelson-Young, L., … Bass, H. W. (2018, October). DATA IN BRIEF, Vol. 20, pp. 358–363.
TL;DR:
Data from Next-Generation Sequencing of differential micrococcal nuclease digestions of formaldehyde-crosslinked chromatin in selected tissues of maize (Zea mays) inbred line B73 are presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 3, 2018
2018 journal article
Clinical therapeutic efficacy of mycophenolate mofetil in the treatment of SARDS in dogs-a prospective open-label pilot study
VETERINARY OPHTHALMOLOGY, 21(6), 565–576.
author keywords: dog; mycophenolate mofetil; retina; sudden acquired retinal degeneration syndrome; treatment; vision
MeSH headings : Animals; Dog Diseases / drug therapy; Dogs; Female; Immunosuppressive Agents / therapeutic use; Male; Mycophenolic Acid / therapeutic use; Pilot Projects; Prospective Studies; Retinal Degeneration / drug therapy; Retinal Degeneration / veterinary; Vision Tests / veterinary
TL;DR:
The effect of sole-agent treatment with mycophenolate mofetil as a sole agent has no measureable positive effect on physical health, vision, or retinal structure following a 6-week trial period.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 3, 2018
2018 review
The Neutron Macromolecular Crystallography Instruments at Oak Ridge National Laboratory: Advances, Challenges, and Opportunities
[Review of ]. CRYSTALS, 8(10).
author keywords: neutron; crystallography; macromolecules; Laue diffraction; hydrogen; proton; deuteration
Sources: Web Of Science, NC State University Libraries
Added: November 19, 2018
2018 journal article
Neural Net Classification Combined With Movement Analysis to Evaluate Setaria viridis as a Model System for Time of Day of Anther Appearance
FRONTIERS IN PLANT SCIENCE, 9.
author keywords: flower opening time; spikelet opening time; timing of anthesis; setaria; developmental stage; image analysis of plants; biological image classification
TL;DR:
The suitability of Setaria viridis, the model for C4 photosynthesis, for such a role is examined, and an imaging system to monitor the temporal regulation of growth, flower opening time, and other physiological characteristics in Setaria is developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 12, 2018
2018 journal article
Diacylglycerol acyltransferase 1 is activated by phosphatidate and inhibited by SnRK1-catalyzed phosphorylation
PLANT JOURNAL, 96(2), 287–299.
author keywords: triacylglycerol biosynthesis; DGAT; Brassica napus; biochemical regulation; allostery
MeSH headings : Acyl Coenzyme A / metabolism; Brassica napus / enzymology; Brassica napus / genetics; Carbohydrate Metabolism; Catalysis; Diacylglycerol O-Acyltransferase / genetics; Diacylglycerol O-Acyltransferase / metabolism; Energy Metabolism; Homeostasis; Lipids / physiology; Phosphatidic Acids / metabolism; Phosphorylation; Plant Proteins / genetics; Plant Proteins / metabolism; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Triglycerides / biosynthesis
TL;DR:
Phosphatidate (PA) was identified as a feed-forward activator of BnaDGAT1, enabling the final enzyme in the Kennedy pathway to adjust to the incoming flow of carbon leading to TAG, indicating that PA facilitates the transition of the enzyme into the more active state.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 22, 2018
2018 journal article
Prostaglandin A(1) triggers Mayaro virus inhibition and heat shock protein 70 expression in an epithelial cell model
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 51(5), 584–590.
author keywords: Mayaro virus; Prostaglandin A; Heat shock proteins
MeSH headings : Alphavirus / drug effects; Alphavirus / ultrastructure; Animals; Antiviral Agents / pharmacology; Blotting, Western; Cattle; Cell Line; Electrophoresis, Polyacrylamide Gel; Epithelial Cells / ultrastructure; Epithelial Cells / virology; HSP70 Heat-Shock Proteins / pharmacology; Humans; Microscopy, Electron, Transmission; Prostaglandins A / pharmacology; Virus Replication / drug effects
TL;DR:
PGA1 inhibits MAYV replication in Hep-2 cells at early stages of viral replication, prior to production of viral structural proteins, possibly via HSP70 induction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 19, 2018
2018 journal article
Proximity to Other Commercial Turkey Farms Affects Colonization Onset, Genotypes, and Antimicrobial Resistance Profiles of Campylobacter spp. in Turkeys: Suggestive Evidence from a Paired-Farm Model
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 84(18).
author keywords: Campylobacter; antimicrobial resistance; colonization; genotype; turkey
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Campylobacter / drug effects; Campylobacter / genetics; Campylobacter / growth & development; Campylobacter / isolation & purification; Campylobacter Infections / economics; Campylobacter Infections / microbiology; Campylobacter Infections / veterinary; Drug Resistance, Bacterial; Farms / economics; Genotype; Models, Biological; Multilocus Sequence Typing; North Carolina; Poultry Diseases / economics; Poultry Diseases / microbiology; Turkeys / microbiology
TL;DR:
A paired-farm design was used to concurrently investigate Campylobacter colonization and strain types in two turkey breeds at two farms in eastern North Carolina, highlighting the need to further characterize the impact of farm-specific factors and host genetics on antimicrobial resistance and genotypes of C. jejuni and C. coli that colonize turkeys.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 19, 2018
2018 journal article
Sucrose Nonfermenting 1-Related Protein Kinase 1 Phosphorylates a Geminivirus Rep Protein to Impair Viral Replication and Infection
PLANT PHYSIOLOGY, 178(1), 372–389.
MeSH headings : Amino Acid Sequence; Begomovirus / genetics; Begomovirus / metabolism; Begomovirus / physiology; Host-Pathogen Interactions; Solanum lycopersicum / enzymology; Solanum lycopersicum / virology; Mutation; Phosphorylation; Plant Diseases / virology; Plant Proteins / genetics; Plant Proteins / metabolism; Protein Binding; Protein Domains; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Sequence Homology, Amino Acid; Serine / genetics; Serine / metabolism; Viral Proteins / chemistry; Viral Proteins / genetics; Viral Proteins / metabolism; Virus Replication
TL;DR:
It is established that SnRK1 phosphorylates Rep and interferes with geminivirus replication and infection, underscoring the emerging role for SnRk1 in the host defense response against plant pathogens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(OpenAlex)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2018
2018 journal article
Next-generation diamond cell and applications to single-crystal neutron diffraction
REVIEW OF SCIENTIFIC INSTRUMENTS, 89(9).
TL;DR:
A diamond cell optimized for single-crystal neutron diffraction is described, made from a copper beryllium alloy and sized to fit into ORNL's magnets for future ultra-low temperature and high-field studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2018
2018 review
A suite-level review of the neutron single-crystal diffraction instruments at Oak Ridge National Laboratory
[Review of ]. REVIEW OF SCIENTIFIC INSTRUMENTS, 89(9).
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 16, 2018
2018 journal article
Pharmacokinetics and pharmacodynamic effects in koi carp (Cyprinus carpio) following immersion in propofol
VETERINARY ANAESTHESIA AND ANALGESIA, 45(4), 529–538.
author keywords: fish; immersion; koi carp; pharmacodynamics; pharmacokinetics; propofol
MeSH headings : Anesthesia Recovery Period; Animals; Carps / metabolism; Chromatography, High Pressure Liquid / veterinary; Deep Sedation / methods; Deep Sedation / veterinary; Heart Rate / drug effects; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / blood; Hypnotics and Sedatives / pharmacokinetics; Hypnotics and Sedatives / pharmacology; Immersion; Propofol / administration & dosage; Propofol / blood; Propofol / pharmacokinetics; Propofol / pharmacology
TL;DR:
Measurable PPCs were achieved in koi carp anesthetized with propofol by immersion, but recovery time was not.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 16, 2018
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