Works Published in 2011
Displaying works 41 - 60 of 127 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
Integrative Deep Sequencing of the Mouse Lung Transcriptome Reveals Differential Expression of Diverse Classes of Small RNAs in Response to Respiratory Virus Infection
MBio, 2(6).
Ed(s): B. Cullen & T. Dermody
MeSH headings : Animals; Coronavirus Infections / immunology; Gene Expression Regulation; High-Throughput Nucleotide Sequencing; Lung / immunology; Lung / virology; Mice; Mice, Inbred C57BL; MicroRNAs / biosynthesis; MicroRNAs / genetics; Orthomyxoviridae Infections / immunology; RNA, Small Nucleolar; Transcriptome
TL;DR:
These findings represent the first integrated sequencing analysis of the response of host small RNAs to virus infection and show that smallRNAs are an integrated component of complex networks involved in regulating the host response to infection.
(via Semantic Scholar)
mbio.asm.org (publisher PDF)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2011 journal article
Lipid resuscitation: a life-saving antidote for local anesthetic toxicity.
Current Pharmaceutical Biotechnology, 12(2), 313–319.
Contributors: S. Bern*, B. Akpa* , I. Kuo* & G. Weinberg
author keywords: Fat emulsion; heart arrest; intravenous; local anesthetics; overdose; resuscitation; toxicity
MeSH headings : Anesthesia, Conduction / adverse effects; Anesthetics, Local / administration & dosage; Anesthetics, Local / adverse effects; Anesthetics, Local / toxicity; Animals; Bupivacaine / administration & dosage; Bupivacaine / adverse effects; Bupivacaine / toxicity; Disease Models, Animal; Fat Emulsions, Intravenous / administration & dosage; Fat Emulsions, Intravenous / pharmacology; Fat Emulsions, Intravenous / therapeutic use; Female; Heart Arrest / chemically induced; Heart Arrest / drug therapy; Humans; Male; Rats
TL;DR:
Increased physician awareness and education, as well as optimized treatment protocols, will significantly reduce the rate of morbidity and mortality from local anesthetic toxicity.
(via Semantic Scholar)
Source: ORCID
Added: May 18, 2019
2011 journal article
Fractional Order Analysis of Sephadex Gel Structures: NMR Measurements Reflecting Anomalous Diffusion.
Communications in Nonlinear Science & Numerical Simulation, 16(12), 4581–4587.
Contributors: R. Magin *, B. Akpa* , T. Neuberger * & A. Webb *
author keywords: Diffusion; Exponential; Fractional derivative; Fractal; Magnetic resonance; Sephadex gel
TL;DR:
The fractional order decay model was fit to the diffusion-weighted signal attenuation for a range of b-values, and the parameters β, μ and D, were found to correlate with the porosity and tortuosity of the gel structure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: May 18, 2019
2011 journal article
A photoactivatable small-molecule inhibitor for light-controlled spatiotemporal regulation of Rho kinase in live embryos
Development, 139(2), 437–442.
author keywords: Small-molecule inhibitor; Rho kinase; Photocaging; Xenopus
MeSH headings : Animals; Body Patterning / drug effects; Dioxoles / metabolism; Dioxoles / pharmacology; Embryo, Nonmammalian / metabolism; Immunohistochemistry; Indoles / metabolism; Indoles / pharmacology; Mice; NIH 3T3 Cells; Pyridines / metabolism; Pyridines / pharmacology; Ultraviolet Rays; Xenopus laevis / embryology; Xenopus laevis / metabolism; rho-Associated Kinases / antagonists & inhibitors; rho-Associated Kinases / metabolism
TL;DR:
A novel pharmacological agent that can be light activated to achieve spatiotemporally limited inhibition of Rho kinase activity in vivo is developed and application to the spatially heterogeneous problem of embryonic left-right asymmetry revealed a differential requirement for Rho signaling on the left and right sides of the primitive gut tube.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, Crossref
Added: May 17, 2019
2011 journal article
Florfenicol pharmacokinetics in healthy adult alpacas after subcutaneous and intramuscular injection
Journal of Veterinary Pharmacology & Therapeutics, 8.
Sources: NC State University Libraries, NC State University Libraries
Added: April 13, 2019
2011 journal article
Distribution of enrofloxacin and its active metabolite, using an in vivo ultrafiltration sampling technique after the injection of enrofloxacin to pigs
Journal of Veterinary Pharmacology & Therapeutics, 9.
Sources: NC State University Libraries, NC State University Libraries
Added: April 13, 2019
2011 journal article
Pharmacokinetics and distribution of minocycline in mature horses after oral administration of multiple doses and comparison with minimum inhibitory concentrations
Equine Veterinary Journal, 9.
Sources: NC State University Libraries, NC State University Libraries
Added: April 13, 2019
2011 journal article
Pharmacokinetics of diminazene diaceturate in healthy cats
Journal of Veterinary Pharmacology & Therapeutics, 12.
Sources: NC State University Libraries, NC State University Libraries
Added: April 13, 2019
2011 journal article
Antimicrobial use guidelines for treatment of urinary tract disease in dogs and cats: antimicrobial guidelines working group of the international society for companion animal infectious diseases
Veterinary Medicine International Epub, 6.
Sources: NC State University Libraries, NC State University Libraries
Added: April 13, 2019
2011 book
Saunders Handbook of Veterinary Drugs
(Third). St. Louis, Missouri: Elsevier-Saunders.
Source: NC State University Libraries
Added: March 29, 2019
2011 journal article
Evolution of networks and sequences in eukaryotic cell cycle control
Philosophical Transactions of the Royal Society B: Biological Sciences, 366(1584), 3532–3544.
Contributors: F. Cross *, N. Buchler* & J. Skotheim *
author keywords: cell cycle; eukaryotes; evolution; opisthokonts; plants
MeSH headings : Amino Acid Sequence; Animals; Cell Cycle Checkpoints; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Conserved Sequence; Eukaryota / classification; Eukaryota / cytology; Eukaryota / genetics; Eukaryota / metabolism; Evolution, Molecular; Mammals; Phylogeny; Plant Cells / metabolism; Plants / classification; Plants / genetics; Plants / metabolism; Sequence Alignment; Yeasts / classification; Yeasts / cytology; Yeasts / genetics; Yeasts / metabolism
TL;DR:
Forward genetics in non-opisthokonts, such as plants or their green algal relatives, will provide direct information on cell cycle control in these organisms, and may elucidate the potentially more complexcell cycle control network of the last common eukaryotic ancestor.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2011 journal article
MeSH headings : Chromatin / metabolism; DNA-Binding Proteins / metabolism; Galactokinase / genetics; Galactokinase / metabolism; Gene Expression Regulation, Fungal / genetics; Gene Expression Regulation, Fungal / physiology; Nucleosomes / metabolism; Promoter Regions, Genetic / genetics; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Transcription Factors / metabolism
TL;DR:
A novel RSC-nucleosome complex is identified that both strongly phases flanking nucleosomes and presents regulatory sites for ready access, and these results challenge several widely held views.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2011 journal article
Imaging diagnosis-ct myelography in a dog with intramedullary intervertebral disc herniation
Veterinary Radiology and Ultrasound, 52(2), 185–187.
Contributors: M. Kent*, S. Holmes*, E. Cohen* , S. Sakals*, W. Roach*, S. Platt *, S. Schatzberg*, E. Howerth *
author keywords: computed tomography; interverebral disc; intramedullary; myelography
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dogs; Female; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Lumbar Vertebrae / diagnostic imaging; Myelography / veterinary; Spinal Cord Injuries / diagnostic imaging; Spinal Cord Injuries / surgery; Spinal Cord Injuries / veterinary; Thoracic Vertebrae / diagnostic imaging; Tomography, X-Ray Computed / veterinary
TL;DR:
Based on the findings in this patient, intramedullary disc herniation should be considered a cause for focal intramingullary contrast medium accumulation.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2011 journal article
Functional K<inf>Ca</inf>3.1 K<sup>+</sup> channels are required for human fibrocyte migration
Journal of Allergy and Clinical Immunology, 128(6).
Contributors: G. Cruse* , S. Singh *, S. Duffy*, C. Doe*, R. Saunders *, C. Brightling *, P. Bradding *
author keywords: Pulmonary fibrosis; asthma; fibrocyte; cell migration; ion channel; K(Ca)3.1; patch clamp electrophysiology
MeSH headings : Airway Remodeling / physiology; Asthma / metabolism; Asthma / pathology; Blotting, Western; Cell Differentiation / physiology; Cell Movement; Connective Tissue Cells / cytology; Connective Tissue Cells / metabolism; Fibrosis / metabolism; Fibrosis / pathology; Humans; Intermediate-Conductance Calcium-Activated Potassium Channels / metabolism; Patch-Clamp Techniques; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
The K+ channel KCa3.1 plays a key role in human fibrocyte migration and might attenuate tissue fibrosis and remodeling in patients with diseases such as asthma and idiopathic pulmonary fibrosis through the inhibition of fibroCyte recruitment.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2011 journal article
Mucin granule-associated proteins in human bronchial epithelial cells: the airway goblet cell "granulome"
RESPIRATORY RESEARCH, 12.
MeSH headings : Bronchi / chemistry; Bronchi / metabolism; Cells, Cultured; Cytoplasmic Granules / chemistry; Cytoplasmic Granules / metabolism; Cytoplasmic Granules / ultrastructure; Goblet Cells / chemistry; Goblet Cells / metabolism; Humans; Membrane Glycoproteins / chemistry; Membrane Glycoproteins / metabolism; Membrane Glycoproteins / ultrastructure; Mucins / chemistry; Mucins / metabolism; Respiratory Mucosa / chemistry; Respiratory Mucosa / metabolism
TL;DR:
This work isolated mucin granules and granule membranes from primary cultures of well differentiated human bronchial epithelial cells utilizing a novel technique of immuno-isolation, based on the presence of the calcium activated chloride channel hCLCA1 on thegranule membranes, and verified via Western blotting and co-immunoprecipitation that MARCKS, HSP70, CSP and hCL CA1 were present on the granule membrane and associated with each other.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Failure of nebulized irritant, acidic, or hypotonic solutions or external mechanical stimulation of the trachea to consistently induce coughing in healthy, awake dogs
Canadian Journal of Veterinary Research, 75(3), 228–232.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Evaluation of intermittent infusion of bupivacaine into surgical wounds of dogs postoperatively
VETERINARY JOURNAL, 190(2), 287–289.
author keywords: Bupivacaine; Local anesthesia; Wound infusion; Dog; Analgesia; Post-operative pain
MeSH headings : Anesthetics, Local / pharmacokinetics; Anesthetics, Local / therapeutic use; Animals; Bupivacaine / pharmacokinetics; Bupivacaine / therapeutic use; Dogs / surgery; Double-Blind Method; Infusions, Intralesional / veterinary; Pain Measurement / veterinary; Pain, Postoperative / drug therapy; Pain, Postoperative / veterinary; Postoperative Care / veterinary; Prospective Studies; Recovery of Function; Wound Healing
TL;DR:
Bupivacaine infusion into surgical wounds after surgery may improve post-operative recovery, but no effect on wound tenderness was demonstrated in this study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Skp2 Is Necessary for Myc-Induced Keratinocyte Proliferation but Dispensable for Myc Oncogenic Activity in the Oral Epithelium
AMERICAN JOURNAL OF PATHOLOGY, 178(6), 2470–2477.
MeSH headings : Animals; Cell Cycle Proteins / metabolism; Cell Proliferation; Epidermis / metabolism; Epidermis / pathology; Epithelium / metabolism; Epithelium / pathology; Keratinocytes / metabolism; Keratinocytes / pathology; Mice; Mice, Transgenic; Mouth / pathology; Mouth Neoplasms / metabolism; Mouth Neoplasms / pathology; Phenotype; Precancerous Conditions / pathology; Proto-Oncogene Proteins c-myc / metabolism; S-Phase Kinase-Associated Proteins / metabolism
TL;DR:
It is suggested that Skp2 and p27(Kip1) are critical for Myc-driven keratinocyte proliferation; however, MyC-mediated tumorigenesis in the oral epithelium is independent of the Skp 2-p27( Kip 1) axis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration
BRITISH JOURNAL OF OPHTHALMOLOGY, 95(12), 1749–1754.
MeSH headings : Animals; Animals, Genetically Modified; Disease Models, Animal; Electroretinography; Eye Proteins / biosynthesis; Eye Proteins / genetics; Gene Deletion; Immunohistochemistry; Macular Degeneration / metabolism; Macular Degeneration / pathology; Macular Degeneration / physiopathology; Membrane Proteins / biosynthesis; Membrane Proteins / genetics; Microscopy, Fluorescence; Mutation; Retina / metabolism; Retina / pathology; Retina / physiopathology; Swine
TL;DR:
These transgenic pigs provide unique animal models for examining macular degeneration and STGD3 pathogenesis and direct fluorescence microscopy indicated that the Y270terEYFP protein is expressed in photoreceptors and mislocalised within the cell.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Pharmacogenomic characterization of US FDA-approved cytotoxic drugs
PHARMACOGENOMICS, 12(10), 1407–1415.
author keywords: cancer; cell line; chemotherapy; cytotoxicity; pharmacogenetics; pharmacogenomic; QTL
MeSH headings : Antineoplastic Agents / pharmacology; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Approval; Genetic Linkage; Humans; Pharmacogenetics; Quantitative Trait Loci / genetics; United States; United States Food and Drug Administration
TL;DR:
The results of this systematic study highlight the variable role that genetics plays in response to cytotoxic drugs, and inform the prioritization of chemotherapeutic drugs with a sizable genetic response component for future investigation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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