Works Published in 2020
Displaying works 81 - 100 of 131 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2020 journal article
MeSH headings : Animals; Biological Evolution; Cell Cycle; Fungi / classification; Fungi / cytology; Fungi / genetics; Fungi / physiology; Gene Expression Regulation, Fungal
TL;DR:
Medina and Buchler provide an introduction to chytrid fungi, an early diverging fungal lineage exhibiting characteristics found in both animals and fungi.
(via Semantic Scholar)
Source: ORCID
Added: May 25, 2020
2020 journal article
B-type natriuretic peptide is upregulated by c-Jun N-terminal kinase and contributes to septic hypotension
JCI INSIGHT, 5(8).
MeSH headings : Animals; Cell Line; Humans; Hypotension / etiology; Hypotension / metabolism; JNK Mitogen-Activated Protein Kinases / metabolism; Mice; Natriuretic Peptide, Brain / metabolism; Sepsis / complications; Sepsis / metabolism; Up-Regulation
TL;DR:
In conclusion, genetic ablation of BNP, as well as treatment with a potentially novel neutralizing anti-BNP monoclonal antibody (19B3) or suppression of its expression via administration of JNK inhibitor SP600125 improved cardiac output, stabilized blood pressure, and improved survival in mice with polymicrobial sepsis.
(via Semantic Scholar)
insight.jci.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 18, 2020
2020 journal article
In vivo assessment of respiratory burst inhibition by xenobiotic exposure using larval zebrafish
Journal of Immunotoxicology, 17(1), 94–104.
author keywords: Chemical screen; high throughput; phagocyte; reactive oxygen species (ROS); polycyclic aromatic hydrocarbons (PAH); endocrine disrupting compounds (EDC); lead
MeSH headings : Animals; Animals, Genetically Modified; Benzo(a)pyrene / adverse effects; Blood Cell Count; Cytotoxicity Tests, Immunologic / methods; Embryo, Nonmammalian; Estradiol / adverse effects; Feasibility Studies; High-Throughput Screening Assays / methods; Immunity, Innate / drug effects; Macrophages / drug effects; Macrophages / immunology; Methoxychlor / adverse effects; Neutrophils / drug effects; Neutrophils / immunology; Organometallic Compounds / adverse effects; Phenanthrenes / adverse effects; Reactive Oxygen Species / analysis; Reactive Oxygen Species / metabolism; Respiratory Burst / drug effects; Respiratory Burst / immunology; Zebrafish
TL;DR:
The utility of zebrafish larvae as a vertebrate model for identifying compounds that impact innate immune function at non-teratogenic levels is demonstrated and validates measuring ROS production and phagocyte numbers as metrics for monitoring how xenobiotic exposure alters the innate immune system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: May 15, 2020
2020 journal article
Genetic transformation of Spizellomyces punctatus, a resource for studying chytrid biology and evolutionary cell biology
ELife.
Contributors: E. Medinal, K. Robinson*, K. Bellingham-Johnstun n, G. Laniri, C. Laplante n, L. Fritz-Laylin *, N. Buchler n
MeSH headings : Actins / metabolism; Biological Evolution; Cell Cycle; Cell Movement; Chytridiomycota / cytology; Chytridiomycota / genetics; Chytridiomycota / growth & development; Fungal Proteins / metabolism; Genome, Fungal; Microorganisms, Genetically-Modified; Mitosis; Morphogenesis; Spores, Fungal / physiology; Transformation, Genetic
TL;DR:
It is shown that the chytrid undergoes multiple rounds of synchronous nuclear division, followed by cellularization, to create and release many daughter ‘zoospores’, which makes Spizellomyces a genetically tractable model for comparative cell biology and understanding the evolution of fungi and early eukaryotes.
(via Semantic Scholar)
Source: ORCID
Added: May 12, 2020
2020 article
Plasma metabolomic profiling of healthy pregnant mares and mares with experimentally induced placentitis
EQUINE VETERINARY JOURNAL.
author keywords: horse; placentitis; diagnosis; plasma; NMR spectroscopy; metabolomics
MeSH headings : Animals; Female; Horse Diseases; Horses; Metabolomics; Placenta Diseases / veterinary; Plasma; Pregnancy; Streptococcus equi
TL;DR:
Two phases of metabolite changes were noted after experimental infection: An immediate rise in metabolite concentration involved in energy, nitrogen, hydrogen, and oxygen metabolism within 4 hours after inoculation that was followed by a decrease in metabolites involved inenergy and nitrogen metabolism at 4 days, coinciding with ultrasonographic diagnosis of placentitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: April 28, 2020
2020 journal article
Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch
CELL REPORTS, 31(1).
Contributors: S. Mishra n, J. Wheeler n, S. Pitake n, H. Ding *, C. Jiang *, T. Fukuyama n, J. Paps n, P. Ralph n
MeSH headings : Animals; Cell Adhesion Molecules / metabolism; Cell Adhesion Molecules / physiology; Dermatitis, Atopic / etiology; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Dogs; Female; Hypersensitivity / physiopathology; Integrin alpha5 / metabolism; Integrin beta3 / metabolism; Integrins / metabolism; Keratinocytes / metabolism; Male; Mice; Primates; Pruritus / metabolism; Pruritus / pathology; Sensory Receptor Cells / metabolism; Skin / metabolism
TL;DR:
A TSLP-periostin reciprocal activation loop that links the skin to the spinal cord via peripheral sensory neurons is identified and the non-canonical functional role of an integrin in itch is characterized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 27, 2020
2020 article
What Is Your Diagnosis?
Feeman, W. E., III, Wendt, J. A., Salas, E. N., Nelson, N. C., & Lehman, K. M. (2020, April 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 256, pp. 767–769.
MeSH headings : Animals
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 27, 2020
2020 journal article
Multicenter flow cytometry proficiency testing of canine blood and lymph node samples
VETERINARY CLINICAL PATHOLOGY, 49(2), 249–257.
author keywords: assay performance; dog; external laboratory quality assessment; immunophenotyping
MeSH headings : Animals; Cross-Sectional Studies; Dog Diseases / blood; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Flow Cytometry / standards; Flow Cytometry / veterinary; Hematologic Neoplasms / diagnosis; Hematologic Neoplasms / pathology; Hematologic Neoplasms / veterinary; Immunophenotyping / veterinary; Laboratory Proficiency Testing / standards; Lymph Nodes / pathology; Lymphoproliferative Disorders / diagnosis; Lymphoproliferative Disorders / pathology; Lymphoproliferative Disorders / veterinary
TL;DR:
Lymphoproliferations were readily identified by FC, but identification of the categories of hematolymphoid neoplasia in fresh samples or archived files was variable, indicating a need for a more standardized approach to maximize the enormous potential of FC in veterinary medicine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 20, 2020
2020 journal article
Local and regional temporal trends (2013-2019) of canine Ehrlichia spp. seroprevalence in the USA
PARASITES & VECTORS, 13(1).
author keywords: Ehrlichia canis; Ehrlichia chaffeensis; Ehrlichia ewingii; Temporal trends; USA; Vector-borne
MeSH headings : Animals; Antibodies, Bacterial / blood; Appalachian Region; Bayes Theorem; Dog Diseases / epidemiology; Dog Diseases / immunology; Dog Diseases / microbiology; Dogs; Ehrlichia / classification; Ehrlichia / immunology; Ehrlichia canis / immunology; Ehrlichia chaffeensis / immunology; Ehrlichiosis / epidemiology; Ehrlichiosis / immunology; Ehrlichiosis / veterinary; Humans; Seroepidemiologic Studies; United States / epidemiology
TL;DR:
The findings from this study indicate that dogs across a wide area of the USA are at risk of exposure to tick exposure and these results should provide veterinarians and pet owners with the information they need to make informed decisions about prevention of tick exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: April 20, 2020
2020 journal article
Preliminary Pilot Study of Itraconazole After a Single Oral Dose of a Veterinary Formulation Solution in African Penguins (Spheniscus demersus)
JOURNAL OF AVIAN MEDICINE AND SURGERY, 34(1), 52–56.
author keywords: plasma concentration; itraconazole; avian; African penguin; Spheniscus demersus
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Aspergillosis / drug therapy; Aspergillosis / veterinary; Bird Diseases / drug therapy; Drug Compounding / veterinary; Female; Half-Life; Itraconazole / administration & dosage; Itraconazole / blood; Itraconazole / pharmacokinetics; Male; Pilot Projects; Spheniscidae / metabolism
TL;DR:
Encouraging evidence is demonstrated that the FDA-approved formulation of oral itraconazole solution should be considered for future study as a cost-effective treatment for aspergillosis in African penguins and other avian species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020
2020 journal article
Efficacy of a single session in-series hemoperfusion and hemodialysis in the management of carprofen overdose in two dogs
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 30(2), 226–231.
author keywords: canine; extracorporeal; nonsteroidal anti-inflammatory; toxicosis; veterinary
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / toxicity; Carbazoles / blood; Carbazoles / toxicity; Charcoal / therapeutic use; Dog Diseases / therapy; Dogs; Hemoperfusion / veterinary; Humans; Poisoning / veterinary; Renal Dialysis / veterinary
TL;DR:
It is suggested that the efficacy of hemoperfusion in removing carprofen is short-lived, and extending the treatment beyond the first hour does not produce any therapeutic benefit, and hourly replacement of the charcoal filter should be considered.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: April 20, 2020
2020 journal article
Detection of circulating anti-retinal antibodies in dogs with sudden acquired retinal degeneration syndrome using indirect immunofluorescence: A case control study
EXPERIMENTAL EYE RESEARCH, 193.
author keywords: SARDS; Dog; Retina; Immune-mediated; IgG; IgM
MeSH headings : Animals; Autoantibodies / immunology; Blotting, Western; Case-Control Studies; Disease Models, Animal; Dogs; Fluorescent Antibody Technique, Indirect / methods; Retina / immunology; Retina / metabolism; Retina / pathology; Retinal Degeneration / diagnosis; Retinal Degeneration / immunology; Retinal Degeneration / metabolism; Syndrome
TL;DR:
Despite having decreased serum IgG compared with healthy controls, circulating IgG in dogs with SARDS binds photoreceptor outer segments to a greater extent than matched healthy controls.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 20, 2020
2020 journal article
Ex vivo comparison of the effect of storage temperature on canine intestinal leakage pressures
VETERINARY SURGERY, 49(3), 496–501.
MeSH headings : Animals; Cadaver; Digestive System Surgical Procedures / veterinary; Dogs; Jejunum / surgery; Pressure; Sutures / standards; Sutures / veterinary; Temperature
TL;DR:
Cadaveric canine intestinal specimens tested immediately after collection or after chilling for 24 hours should be recommended for ex vivo burst pressure assessment in dogs and additional studies to evaluate loss in testing viability of chilled intestinal specimens are warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 20, 2020
2020 article
The people behind the papers - Caroline Johnson and Troy Ghashghaei
Johnson, C., & Ghashghaei, T. (2020, February). DEVELOPMENT, Vol. 147.
MeSH headings : Animals; Brain / embryology; Cell Proliferation; Developmental Biology / history; Developmental Biology / methods; History, 21st Century; Mice; Mitosis; Sp2 Transcription Factor / physiology
TL;DR:
This new paper in Development investigates the molecular control of mitosis in these two stages, using simultaneous labelling and gene knockout in clones in the developing mouse brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 20, 2020
2020 journal article
Sp2 regulates late neurogenic but not early expansive divisions of neural stem cells underlying population growth in the mouse cortex
DEVELOPMENT, 147(4).
author keywords: Corticogenesis; Mitosis; MADM; Neurogenesis; Sp2; Neural stem cell
MeSH headings : Alleles; Animals; Cell Differentiation; Cell Division; Cell Lineage; Cell Proliferation; Cerebral Cortex / embryology; Female; Gene Deletion; Genetic Markers; Male; Mice; Mice, Transgenic; Mitosis; Mutation; Neural Stem Cells / cytology; Phenotype; Sp2 Transcription Factor / genetics; Sp2 Transcription Factor / physiology
TL;DR:
It is found that loss of Sp2 in progenitors undergoing neurogenic divisions results in prolonged mitosis due to extension of early mitotic stages, and mechanistic differences between the early expansive and later neurogenic periods of cortical development are revealed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 20, 2020
2020 journal article
Plasma concentrations of itraconazole following a single oral dose in juvenile California sea lions (Zalophus californianus)
Journal of Veterinary Pharmacology and Therapeutics.
author keywords: California sea lion; itraconazole; pharmacokinetics; Zalophus californianus
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Female; Itraconazole / administration & dosage; Itraconazole / blood; Itraconazole / pharmacokinetics; Male; Sea Lions / blood; Sea Lions / metabolism; Species Specificity
TL;DR:
Data indicate that a single oral dose of itraconazole given as a capsule at 5-10 mg/kg, under the conditions used in this study, does not achieve therapeutic plasma concentrations in California sea lions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: April 15, 2020
2020 journal article
Veterinary Behavior: Assessment of Veterinarians' Training, Experience, and Comfort Level with Cases
JOURNAL OF VETERINARY MEDICAL EDUCATION, 47(2), 158–169.
author keywords: animal behavior; behavioral medicine; animal welfare; shelter medicine; veterinary curriculum
MeSH headings : Animals; Education, Veterinary / standards; Humans; Life Change Events; Veterinarians / statistics & numerical data
TL;DR:
This study explored veterinarians' training in animal behavior and behavioral medicine, along with their level of comfort in treating common behavioral problems, and found that participants felt most comfortable discussing inappropriate elimination and begging for food but were least comfortable treating issues involving aggression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 14, 2020
2020 journal article
The FcεRIβ homologue, MS4A4A, promotes FcεRI signal transduction and store-operated Ca2+ entry in human mast cells
Cellular Signalling, 71, 109617.
Contributors: G. Arthur n, L. Ehrhardt-Humbert n, D. Snider n, C. Jania*, S. Tilley*, D. Metcalfe *, G. Cruse n
author keywords: Mast cell; IgE receptor; MS4A; Allergy; Orai1
MeSH headings : Calcium / metabolism; Calcium Signaling; Cell Degranulation; Cell Line; Cholesterol / metabolism; Fetal Blood / metabolism; Humans; Mast Cells / metabolism; Mast Cells / physiology; Membrane Microdomains / metabolism; Membrane Proteins / metabolism; ORAI1 Protein / metabolism; Phospholipase C gamma / metabolism; Proto-Oncogene Proteins c-kit / metabolism; Receptors, IgE / metabolism; Sequence Homology, Amino Acid; Signal Transduction
TL;DR:
It is established that MS4A4A promotes phosphorylation of PLCγ1, calcium flux and degranulation in response to IgE-mediated crosslinking of FcεRI in human mast cells and thus represents a new target in the regulation of Ig E-mediated mast cell activation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: April 10, 2020
2020 chapter
Utility of stable isotope ratios of tap water and human hair in determining region of origin in Central and Southern Mexico
In Forensic Science and Humanitarian Action.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: April 7, 2020
2020 journal article
Enteroendocrine Progenitor Cell-Enriched mir-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent Manner
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 9(3), 447–464.
author keywords: miR-7; Enteroendocrine Lineage; Small Intestine; Enteroid; Proliferation
MeSH headings : Animals; Cell Lineage / genetics; Cell Proliferation / genetics; Cells, Cultured; Computational Biology; Enteroendocrine Cells / physiology; ErbB Receptors / metabolism; Feeding Behavior / physiology; Female; Inhibitor of Apoptosis Proteins / genetics; Inhibitor of Apoptosis Proteins / metabolism; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Male; Mice; Mice, Transgenic; MicroRNAs / metabolism; Models, Animal; Organoids; Primary Cell Culture; RNA-Seq; Signal Transduction / genetics; Single-Cell Analysis; Stem Cells / physiology
TL;DR:
This study demonstrates for the first time that EEC progenitor cell-enriched miR-7 is altered by dietary perturbations and that it regulates growth in enteroids via intact Xiap and Egfr signaling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 6, 2020
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