Works Published in 2012
Displaying works 101 - 112 of 112 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 review
Dosing Regimen Matters: the Importance of Early Intervention and Rapid Attainment of the Pharmacokinetic/Pharmacodynamic Target
[Review of ]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 56(6), 2795–2805.
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacokinetics; Anti-Infective Agents / pharmacology; Dose-Response Relationship, Drug; Drug Administration Schedule; Early Medical Intervention; Humans
TL;DR:
This minireview provides an overview of published evidence supporting the positions that, in most situations, it is the exposure achieved during the first dose that is relevant for determining the therapeutic outcome of an infection and therapeutic intervention should be initiated as soon as possible to minimize the size of the bacterial burden at the infection site.
(via Semantic Scholar)
aac.asm.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Ceruloplasmin alters intracellular iron regulated proteins and pathways: Ferritin, transferrin receptor, glutamate and hypoxia-inducible factor-1α
Experimental Eye Research, 97(1), 90–97.
author keywords: ceruloplasmin; iron; lens epithelial cells; retinal pigmented epithelial cells glutamate; hypoxia-inducible factor; transferrin receptor; ferritin
MeSH headings : Animals; Cells, Cultured; Ceruloplasmin / metabolism; Ceruloplasmin / pharmacology; Dogs; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ferritins / metabolism; Fluorescent Antibody Technique, Indirect; Glutamic Acid / metabolism; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Iron Chelating Agents / pharmacology; Lens, Crystalline / cytology; Oxalates / pharmacology; Receptors, Transferrin / metabolism; Retinal Pigment Epithelium / drug effects; Retinal Pigment Epithelium / metabolism
TL;DR:
The Cp increased production and secretion of the neurotransmitter, glutamate, is a substantive finding of clinical relevance because of the neural and retinal degeneration found in aceruloplasminemia patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2012 journal article
CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool for in vitro preclinical studies with primary B-cell malignancies
LEUKEMIA & LYMPHOMA, 53(7), 1390–1398.
author keywords: Diffuse large B-cell lymphoma; CD40L; primary cell culture; canine model; cytotoxicity assay
MeSH headings : Animals; CD40 Ligand / genetics; CD40 Ligand / metabolism; CD40 Ligand / pharmacology; Cell Culture Techniques / methods; Cell Proliferation / drug effects; Cell Survival / drug effects; Coculture Techniques; Dogs; Dose-Response Relationship, Drug; Feeder Cells / metabolism; Gene Expression Profiling; Humans; Lymphoma, Large B-Cell, Diffuse / genetics; Lymphoma, Large B-Cell, Diffuse / metabolism; Lymphoma, Large B-Cell, Diffuse / pathology; Oligonucleotide Array Sequence Analysis; Recombinant Proteins / pharmacology; Tumor Cells, Cultured
TL;DR:
This work used primary canine diffuse large B-cell lymphoma to establish a culture system that reliably supports the growth of these cells in vitro and illustrates the utility of the feeder cell-free culture system for comparable assessment of cytotoxicity using dog and human B- cell malignancies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma
BONE, 50(1), 171–181.
author keywords: Bone neoplasm; cMYC; Osteosarcoma; miR-17-92; 14q32 miRNAs
MeSH headings : Adolescent; Bone Neoplasms / genetics; Bone Neoplasms / pathology; Bone and Bones / anatomy & histology; Bone and Bones / pathology; Bone and Bones / physiology; Cell Line, Tumor; Child; Chromosomes, Human, Pair 14 / genetics; DNA Copy Number Variations; Gene Expression Profiling; Gene Regulatory Networks; Humans; MicroRNAs / genetics; Microarray Analysis; Multigene Family; Osteosarcoma / genetics; Osteosarcoma / pathology; Proto-Oncogene Proteins c-myc / genetics
TL;DR:
It is shown that microRNAs (miRNAs) at the chr.14q32 locus are significantly downregulated in osteosarcoma compared to normal bone tissues, supporting a model where the deregulation of a network involving 14q32 miRNAs, cMYC and miR-17-92 mi RNAs could contribute to osteosARcoma pathogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Neoplastic and Nonneoplastic Liver Lesions Induced by Dimethylnitrosamine in Japanese Medaka Fish
VETERINARY PATHOLOGY, 49(2), 372–385.
author keywords: Japanese medaka; Oryzias latipes; hepatocarcinogenesis; dimethylnitrosamine; aquatic animal models; comparative carcinogenesis; alternative animal models
MeSH headings : Animals; Animals, Genetically Modified; Biliary Tract Neoplasms / chemically induced; Biliary Tract Neoplasms / pathology; Biliary Tract Neoplasms / veterinary; Biomarkers / metabolism; Carcinogenicity Tests; Carcinogens / toxicity; Carcinoma, Hepatocellular / chemically induced; Carcinoma, Hepatocellular / pathology; Carcinoma, Hepatocellular / veterinary; Cell Proliferation / drug effects; Chemical and Drug Induced Liver Injury / pathology; Chemical and Drug Induced Liver Injury / veterinary; Dimethylnitrosamine / toxicity; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fish Diseases / chemically induced; Fish Diseases / pathology; Liver / drug effects; Liver Neoplasms / chemically induced; Liver Neoplasms / pathology; Liver Neoplasms / veterinary; Male; Mutagenicity Tests; Oryzias; Rats; Signal Transduction; Species Specificity; Transforming Growth Factor beta / metabolism
TL;DR:
Small fish models have been used for decades in carcinogenicity testing, but the pre-neoplastic and neoplastic commonalities between the two models are largely unknown, with special emphasis on the TGF-β pathway and its corresponding role in DMN-induced hepatic neoplasia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development
CELL CYCLE, 11(2), 335–342.
author keywords: cell cycle; D-type cyclins; skin; carcinogenesis; epidermis
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell / chemically induced; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin D1 / genetics; Cyclin D1 / metabolism; Cyclin D2 / metabolism; Cyclin D3 / genetics; Cyclin D3 / metabolism; Gene Expression Regulation; Mice; Mice, Transgenic; Oncogene Protein p21(ras) / genetics; Papilloma / chemically induced; Papilloma / metabolism; Papilloma / pathology; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tumor Burden
TL;DR:
Modulation of the levels of particular members of the D-type cyclin family could be useful to inhibit tumor development and, in particular, ras-mediated tumorigenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Single-dose pharmacokinetics of ceftazidime and fluconazole during concurrent clinical use in cold-stunned Kemp's ridley turtles (Lepidochelys kempii)
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(1), 82–89.
MeSH headings : Animal Husbandry; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Antifungal Agents / administration & dosage; Antifungal Agents / pharmacokinetics; Ceftazidime / administration & dosage; Ceftazidime / pharmacokinetics; Cold Temperature; Fluconazole / administration & dosage; Fluconazole / pharmacokinetics; Turtles / blood; Turtles / metabolism
TL;DR:
Results indicate that the ceftazidime dose and dosing interval used in this study are likely to be effective in treating susceptible strains of bacteria in Kemp's ridley turtles, but the fluconazole dose andDosing interval are not likely to been effective against filamentous fungal pathogens that are often involved in marine turtle fungal infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Pharmacokinetics of intravenous and intramuscular buprenorphine in the horse
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(1), 52–58.
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Area Under Curve; Buprenorphine / administration & dosage; Buprenorphine / blood; Buprenorphine / pharmacokinetics; Cross-Over Studies; Female; Half-Life; Horses / blood; Horses / metabolism; Injections, Intramuscular; Injections, Intravenous; Male
TL;DR:
Buprenorphine has a moderate T(1/2) in the horse and was detected at concentrations expected to be therapeutic in other species after i.v. and i.m. administration of 0.005 mg/kg.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Biological responses in rats exposed to cigarette smoke and Middle East sand (dust)
INHALATION TOXICOLOGY, 24(2), 109–124.
author keywords: Particle toxicity; nanoparticles; rat; in vivo; in vitro; pulmonary toxicity; cytotoxicity; dust inhalation
MeSH headings : Administration, Inhalation; Air Pollutants / toxicity; Animals; Behavior, Animal / drug effects; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Dust / analysis; Gene Expression / drug effects; Hand Strength; Iraq; Larynx / drug effects; Larynx / pathology; Lung / drug effects; Lung / pathology; Lung / physiology; Male; Metals / analysis; Metals / toxicity; Motor Activity / drug effects; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Respiratory Mucosa / drug effects; Respiratory Mucosa / pathology; Silicon Dioxide / analysis; Silicon Dioxide / toxicity; Tobacco Smoke Pollution / adverse effects; Trachea / drug effects; Trachea / pathology
TL;DR:
The studies show that the respiratory toxicity of IS is qualitatively similar to or less than that seen following short-term silica exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
A photoactivatable small-molecule inhibitor for light-controlled spatiotemporal regulation of Rho kinase in live embryos
DEVELOPMENT, 139(2), 437–442.
author keywords: Small-molecule inhibitor; Rho kinase; Photocaging; Xenopus
MeSH headings : Animals; Body Patterning / drug effects; Dioxoles / metabolism; Dioxoles / pharmacology; Embryo, Nonmammalian / metabolism; Immunohistochemistry; Indoles / metabolism; Indoles / pharmacology; Mice; NIH 3T3 Cells; Pyridines / metabolism; Pyridines / pharmacology; Ultraviolet Rays; Xenopus laevis / embryology; Xenopus laevis / metabolism; rho-Associated Kinases / antagonists & inhibitors; rho-Associated Kinases / metabolism
TL;DR:
A novel pharmacological agent that can be light activated to achieve spatiotemporally limited inhibition of Rho kinase activity in vivo is developed and application to the spatially heterogeneous problem of embryonic left-right asymmetry revealed a differential requirement for Rho signaling on the left and right sides of the primitive gut tube.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Cloning, characterization, and expression analysis of the pig (Sus scrofa) C1q tumor necrosis factor-related protein-5 gene
Molecular Vision, 18(12-14), 92–102.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
A Single-Amino-Acid Polymorphism in Reovirus Protein mu 2 Determines Repression of Interferon Signaling and Modulates Myocarditis
JOURNAL OF VIROLOGY, 86(4), 2302–2311.
MeSH headings : Animals; Cell Line; Cells, Cultured; Down-Regulation; Humans; Interferon-alpha / genetics; Interferon-alpha / metabolism; Interferon-beta / genetics; Interferon-beta / metabolism; Mammalian orthoreovirus 3 / genetics; Mammalian orthoreovirus 3 / metabolism; Mice; Myocarditis / genetics; Myocarditis / metabolism; Myocarditis / virology; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / virology; Orthoreovirus, Mammalian / genetics; Orthoreovirus, Mammalian / metabolism; Polymorphism, Single Nucleotide; Reoviridae Infections / genetics; Reoviridae Infections / metabolism; Reoviridae Infections / virology; Signal Transduction; Viral Proteins / genetics
TL;DR:
It is demonstrated that a single amino acid difference between viruses can dictate virus strain-specific differences in suppression of the host IFN-β response and, consequently, damage to the heart.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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