Works Published in 2018
Displaying works 181 - 192 of 192 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 journal article
Spatiotemporal organization of exocytosis emerges during neuronal shape change
JOURNAL OF CELL BIOLOGY, 217(3), 1113–1128.
MeSH headings : Animals; Axon Guidance / drug effects; Axon Guidance / physiology; Carrier Proteins / genetics; Cell Line, Tumor; Cell Shape; Clathrin / genetics; Clathrin / metabolism; Exocytosis / drug effects; Exocytosis / physiology; HEK293 Cells; Humans; Image Processing, Computer-Assisted; Mice; Mice, Knockout; Nerve Tissue Proteins / genetics; Netrin-1 / pharmacology; Neurites / drug effects; Neurites / physiology; Neurogenesis; Neurons / cytology; Neurons / drug effects; Neurons / physiology; Primary Cell Culture; Software; Ubiquitin-Protein Ligases; Vesicle-Associated Membrane Protein 2 / metabolism
TL;DR:
Spatial statistics uncovered distinct spatiotemporal regulation of exocytosis in the soma and neurites of developing neurons that was modulated by developmental stage, exposure to the guidance cue netrin-1, and the brain-enriched ubiquitin ligase tripartite motif 9.
(via Semantic Scholar)
jcb.rupress.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Macrophage-Specific in Vivo Gene Editing Using Cationic Lipid-Assisted Polymeric Nanoparticles
ACS NANO, 12(2), 994–1005.
author keywords: CRISPR/Cas9; specific gene editing; nanomedicine; specific promoter; type 2 diabetes
MeSH headings : Animals; CRISPR-Cas Systems / genetics; Cations / chemistry; Cells, Cultured; Diabetes Mellitus, Experimental / chemically induced; Diabetes Mellitus, Experimental / genetics; Diabetes Mellitus, Experimental / metabolism; Diabetes Mellitus, Type 2 / chemically induced; Diabetes Mellitus, Type 2 / genetics; Diabetes Mellitus, Type 2 / metabolism; Diet, High-Fat; Gene Editing; HEK293 Cells; Humans; Lipids / chemistry; Macrophages / chemistry; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Nanoparticles / chemistry; Netrin-1 / genetics; Netrin-1 / metabolism; Polymers / chemistry; RAW 264.7 Cells
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
In situ formed reactive oxygen species-responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy
SCIENCE TRANSLATIONAL MEDICINE, 10(429).
MeSH headings : Animals; Cell Line, Tumor; Combined Modality Therapy; Deoxycytidine / analogs & derivatives; Deoxycytidine / therapeutic use; Female; Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry; Immunotherapy / methods; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor / metabolism; Gemcitabine
TL;DR:
A ROS-responsive hydrogel scaffold controls release of gemcitabine and immune checkpoint inhibitor for enhanced antitumor activity and promotes an immune-mediated tumor regression in the tumor-bearing mice, with prevention of tumor recurrence after primary resection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Impact of Targeted Assistance of Multiarticular Finger Musculotendons on the Coordination of Finger Muscles During Isometric Force Production
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, 26(3), 619–628.
author keywords: Hand; muscle coordination; targeted assistance; exotendon; intermuscular coherence
MeSH headings : Adult; Algorithms; Biomimetics; Electromyography; Exoskeleton Device; Female; Fingers / innervation; Fingers / physiology; Healthy Volunteers; Humans; Isometric Contraction; Male; Muscle, Skeletal / innervation; Muscle, Skeletal / physiology; Prostheses and Implants; Prosthesis Design; Psychomotor Performance; Stroke Rehabilitation / instrumentation; Tendons / innervation; Tendons / physiology; Young Adult
TL;DR:
The targeted biomimetic assistance may be used to retrain activation patterns post-stroke by effectively modulating connectivity between the muscles in the functional context and could be beneficial to restore hand function and reduce disability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Formation of Human Colonic Crypt Array by Application of Chemical Gradients Across a Shaped Epithelial Monolayer
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 5(2), 113–130.
author keywords: Intestinal Epithelial Cells; Intestine-On-A-Chip; Stem Cell Niche; Polarized Crypt
TL;DR:
In vitro human colon crypt array accurately mimicked the architecture, luminal accessibility, tissue polarity, cell migration, and cellular responses of in vivo intestinal crypts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Enhanced tissue remodelling efficacy of adipose-derived mesenchymal stem cells using injectable matrices in radiation-damaged salivary gland model
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 12(2), E695–E706.
author keywords: salivary gland; adipose tissue-derived mesenchymal stem cells; small intestinal submucosa gel; radiation; regeneration; local transplantation
MeSH headings : Bone Morphogenetic Proteins / pharmacology; Embryonic Stem Cells / cytology; Embryonic Stem Cells / drug effects; Gene Expression Regulation / drug effects; Heart, Artificial; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Imaging, Three-Dimensional; Models, Biological; Myocardium / pathology; Neovascularization, Physiologic / drug effects; Wound Healing / drug effects
TL;DR:
A model is proposed of cardiac tissues preconditioned with B MPs that results in stimulation of cardiomyocyte function and diffusion of BMPs able to support angiogenesis and represents a step towards the validation of more complex bioengineered constructs for in vivo applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
A flow bioreactor system compatible with real-time two-photon fluorescence lifetime imaging microscopy
BIOMEDICAL MATERIALS, 13(2).
author keywords: FLIM; HUVEC; multiphoton imaging; endothelial cells; 3D cell culture; 2P-FLIM
MeSH headings : Bioreactors; Cell Culture Techniques; Cell Differentiation; Cell Lineage; Cell Movement; Human Umbilical Vein Endothelial Cells; Humans; Hydrodynamics; Microscopy, Fluorescence / methods; Photons; Shear Strength; Stress, Mechanical; Wound Healing
TL;DR:
A bioreactor that combines high-resolution contact-free imaging and continuous flow in a closed system that is compatible with various types of microscopes is designed and used to investigate the effects of low shear stress on human umbilical vein endothelial cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2018 journal article
Study of Poly(N-isopropylacrylamide-co-acrylic acid) (pNIPAM) Microgel Particle Induced Deformations of Tissue-Mimicking Phantom by Ultrasound Stimulation
LANGMUIR, 34(4), 1457–1465.
MeSH headings : Acrylates / chemistry; Acrylic Resins / chemistry; Drug Delivery Systems; Gels / chemistry; Polymers / chemistry
TL;DR:
It is demonstrated in tissue-mimicking phantoms that using ultrasound insonification causes deformations of ULC microgel particles, and increasing the degree of microgel cross-linking reduces the magnitude of the deformation and increases the optimal concentration required to achieve the largest amount of deformation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
N-Gemini peptides: cytosolic protease resistance via N-terminal dimerization of unstructured peptides
CHEMICAL COMMUNICATIONS, 54(2), 204–207.
MeSH headings : Cell Line; Cytosol / enzymology; Dimerization; HeLa Cells; Humans; Molecular Structure; Peptide Hydrolases / metabolism; Peptides / chemical synthesis; Peptides / chemistry; Peptides / pharmacology; Protease Inhibitors / chemistry; Protease Inhibitors / pharmacology
TL;DR:
A synthetically simple strategy for increasing the lifetime of unstructured peptides in cytosolic environment via dimerization at the N-terminus to block threading into the catalytic cleft of cytosolics proteases is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 review
Leveraging Engineering of Cells for Drug Delivery
[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 51(3), 668–677.
MeSH headings : Animals; Cell Engineering; Drug Delivery Systems; Humans
TL;DR:
This Account summarizes the recent contribution to the field of cell engineering methodologies and exploits a targeted checkpoint antibody delivery strategy for treatment of postsurgical cancer recurrence and metastatic spread by covalent binding of platelets' cell surfaces with a monoclonal antibody against programmed-death ligand 1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 review
Biological responses to immobilized microscale and nanoscale surface topographies
[Review of ]. PHARMACOLOGY & THERAPEUTICS, 182, 33–55.
author keywords: Nanotechnology; Nanostructure; Surface topography; Cell-material interactions; Biomaterial; Medical devices
MeSH headings : Biocompatible Materials; Cell Physiological Phenomena; Humans; Surface Properties; Tissue Engineering / methods; Topography, Medical
TL;DR:
The goal of this work was to review studies investigating the effects of microstructured and nanostructured biomaterials on in vitro biological responses through fabrication of microscale and nanoscale surface topographies, physico‐chemical characterization of material surface properties, investigation of protein adsorption dynamics, and evaluation of cellular responses in specific biomedical applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 article
Fibrin biomaterials for tissue regeneration and repair
PEPTIDES AND PROTEINS AS BIOMATERIALS FOR TISSUE REGENERATION AND REPAIR, pp. 151–173.
TL;DR:
This chapter first provides an overview of the structure and function of fibrin(ogen) and details the role offibrin-cell interactions in wound repair and the design and use of fibin-based materials for promoting tissue repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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