Works Published in 2020
Displaying works 81 - 100 of 260 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2020 personal communication
Questioning Existing Cancer Hazard Evaluation Standards in the Name of Statistics
Rusyn, I., Chiu, W. A., & Wright, F. A. (2020, October).
MeSH headings : Biological Assay; Glycine / analogs & derivatives; Humans; Neoplasms / epidemiology; Reference Standards
TL;DR:
This argument sets a potentially far-reaching precedent to revisit decades of standard practice of cancer hazard evaluation performed by national and international agencies, and proposes a very high bar to classify a chemical as positive in a rodent bioassay.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: December 14, 2020
2020 journal article
Effects of Prenatal Exposure to a Mixture of Organophosphhate Flame Ritardants on Placental Gene Expression and Serotonergic Innervaion in the Fetal Rat Brain
TOXICOLOGICAL SCIENCES, 176(1), 203–223.
author keywords: endocrine disruptors; endocrine toxicology; flame retardants; metabolome; neurotoxicity; developmental; neurotoxicology; neurotransmitter; developmental toxicity; prenatal; reproductive and developmental toxicology; developmental/teratology
MeSH headings : Animals; Brain / drug effects; Female; Fetal Development; Fetus; Flame Retardants / toxicity; Gene Expression; Humans; Male; Organophosphates; Organophosphorus Compounds; Placenta / metabolism; Plasticizers; Polybrominated Biphenyls; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Serotonin / metabolism
TL;DR:
Findings suggest that OPFRs have the potential to impact the 5-HTergic system in the fetal forebrain by disrupting placental Trp metabolism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 14, 2020
2020 journal article
Leveraging the Comparative Toxicogenomics Database to Fill in Knowledge Gaps for Environmental Health: A Test Case for Air Pollution-induced Cardiovascular Disease
TOXICOLOGICAL SCIENCES, 177(2), 392–404.
author keywords: environmental health; chemical-induced pathways; air pollution; cardiovascular disease; database
MeSH headings : Air Pollutants / toxicity; Air Pollution; Cardiovascular Diseases / chemically induced; Environmental Exposure; Environmental Health; Humans; Toxicogenetics
TL;DR:
This paper systematically compute the genes, molecular mechanisms, and biological events for the environmental health association linking air pollution toxicants with two cardiovascular diseases as a test case and identifies 19 genes and 96 phenotypes shared between these two air pollutant-induced outcomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 14, 2020
2020 journal article
Measuring Environmental Exposure to Enteric Pathogens in Low-Income Settings: Review and Recommendations of an Interdisciplinary Working Group
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(19), 11673–11691.
MeSH headings : Child; Child, Preschool; Environmental Exposure; Feces; Humans; Hygiene; Poverty; Sanitation
TL;DR:
Current and emerging approaches used to characterize enteric pathogen hazards in different environmental media as well as human interaction with those media and methods that measure human infection with enteric pathogens as a proxy for past exposure are summarized and recommended.
(via Semantic Scholar)
pubs.acs.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 11, 2020
2020 journal article
Treating water containing elevated bromide and iodide levels with granular activated carbon and free chlorine: impacts on disinfection byproduct formation and calculated toxicity
ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY, 6(12), 3460–3475.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 11, 2020
2020 journal article
Transcriptomic and life history responses of the mayfly Neocloeon triangulifer to chronic diel thermal challenge
SCIENTIFIC REPORTS, 10(1).
MeSH headings : Animals; Ephemeroptera / genetics; Ephemeroptera / physiology; Gene Expression Regulation; Heat-Shock Response / genetics; Heat-Shock Response / physiology; Temperature; Transcriptome
TL;DR:
The chronically stressed population had reduced expression of transcripts related to ATP synthesis, mitochondrial electron chain functions, gluconeogenesis and glycolytic processes while transcripts associated with cell adhesion, synaptic vesicle transport, regulation of membrane potential and lipid biosynthesis increased.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: November 30, 2020
2020 journal article
Exploring the Limits of Combined Image/'omics Analysis for Non-cancer Histological Phenotypes
FRONTIERS IN GENETICS, 11.
author keywords: imaging; genomics; pathology; prediction; integration; histology; machine learning; embedding
TL;DR:
This study surveys the evidence for genomic association and prediction of histology, and uses the results to test the limits of prediction accuracy using machine learning methods applied to the imaging data, genomics data, and their combination.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 24, 2020
2020 review
Susceptibility Factors in Chronic Lung Inflammatory Responses to Engineered Nanomaterials
[Review of ]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(19).
author keywords: engineered nanomaterials; susceptibility; chronic inflammation; lung inflammation
MeSH headings : Animals; Humans; Inflammation / chemically induced; Inflammation / complications; Inflammation / pathology; Inhalation Exposure; Lung / drug effects; Lung / pathology; Nanostructures / adverse effects; Nanostructures / therapeutic use; Pneumonia / complications; Pneumonia / drug therapy; Pneumonia / pathology
TL;DR:
This review will address evidence from experimental animal models that highlights some important issues of susceptibility to chronic lung inflammation and systemic immune dysfunction after pulmonary exposure to ENMs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
9. Industry, Innovation and Infrastructure
(OpenAlex)
Source: Web Of Science
Added: November 24, 2020
2020 chapter
Cockroach and other inhalant insect allergens
In R. Lockey & D. Ledford (Eds.), Allergens and Allergen Immunotherapy: Subcutaneous, Sublingual and Oral (6th ed., pp. 237–255,). Boca Raton, Florida: CRC Press.
Ed(s): R. Lockey & D. Ledford
Source: NC State University Libraries
Added: November 20, 2020
2020 journal article
The GTEx Consortium atlas of genetic regulatory effects across human tissues
SCIENCE, 369(6509), 1318–1330.
MeSH headings : Datasets as Topic; Disease / genetics; Female; Gene Expression Regulation; Genome-Wide Association Study; Humans; Male; Organ Specificity; Quantitative Trait Loci; Sequence Analysis, RNA
TL;DR:
Leveraging the large diversity of tissues, insights are provided into the tissue specificity of genetic effects and it is shown that cell type composition is a key factor in understanding gene regulatory mechanisms in human tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 16, 2020
2020 journal article
Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth
EPIGENETICS, 15(11), 1243–1258.
author keywords: DNA methylation; gene expression; data integration; replication; preterm birth; gestational age at birth; umbilical cord blood; PREG study; NEST study; innate immunity; inflammation
MeSH headings : Adult; CpG Islands; DNA Methylation; Epigenome; Female; Fetal Blood / metabolism; Genetic Loci; Genome-Wide Association Study; Gestational Age; Humans; Immunity, Innate / genetics; Infant, Newborn; Infant, Premature; Male; Premature Birth / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: November 16, 2020
2020 journal article
3D Imaging and metabolomic profiling reveal higher neuroactive kavalactone contents in lateral roots and crown root peels of Piper methysticum (kava)
GIGASCIENCE, 9(9).
author keywords: kava; kavalactones; metabolomics; 3D imaging; mass spectrometry imaging
MeSH headings : Imaging, Three-Dimensional; Kava; Lactones; Metabolomics; X-Ray Microtomography
TL;DR:
Detailed metabolomic profile and spatio-temporal characteristics of tissues from the roots and stems are characterized using cross-platform metabolomics and a 3D imaging approach to provide mechanistic insights into the social and clinical practice of the use of only peeled roots.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 16, 2020
2020 review
The twists and turns of left-right asymmetric gut morphogenesis
[Review of ]. DEVELOPMENT, 147(19).
author keywords: Gut tube; Intestine; Laterality; Left-right asymmetry; Morphogenesis; Stomach
MeSH headings : Animals; Body Patterning / genetics; Body Patterning / physiology; Gastrointestinal Microbiome / genetics; Gastrointestinal Microbiome / physiology; Gene Expression Regulation, Developmental / genetics; Gene Expression Regulation, Developmental / physiology; Humans; Morphogenesis / genetics; Morphogenesis / physiology; Signal Transduction / genetics; Signal Transduction / physiology
TL;DR:
New evidence is summarized challenging century-old ideas about the development of stomach and intestine laterality, challenging classical models of left-right asymmetric gut morphogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 16, 2020
2020 journal article
Advances in point-of-care nucleic acid extraction technologies for rapid diagnosis of human and plant diseases
BIOSENSORS & BIOELECTRONICS, 169.
author keywords: Point-of-care diagnostics; DNA/RNA extraction; Nucleic acid amplification; Raw samples; Infectious diseases; Plant diseases
MeSH headings : Betacoronavirus / isolation & purification; COVID-19; Chemical Fractionation / instrumentation; Chemical Fractionation / methods; Communicable Diseases / diagnosis; Communicable Diseases / microbiology; Communicable Diseases / parasitology; Communicable Diseases / virology; Coronavirus Infections / diagnosis; Coronavirus Infections / virology; Equipment Design; Humans; Lab-On-A-Chip Devices; Nucleic Acid Amplification Techniques / instrumentation; Nucleic Acid Amplification Techniques / methods; Nucleic Acids / blood; Nucleic Acids / isolation & purification; Nucleic Acids / urine; Pandemics; Plant Diseases / microbiology; Plant Diseases / parasitology; Plant Diseases / virology; Pneumonia, Viral / diagnosis; Pneumonia, Viral / virology; Point-of-Care Systems; SARS-CoV-2
TL;DR:
This review focuses on novel devices or methods that have demonstrated applicability and robustness for the isolation of high-quality nucleic acid from complex raw samples, such as human blood, saliva, sputum, nasal swabs, urine, and plant tissues that would pave the road for the “sample-in-result-out” diagnosis of human and plant diseases, especially in remote or resource-limited settings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 16, 2020
2020 journal article
Maternal Employment and Infant BMI z Score in a US Birth Cohort
OBESITY, 28(12), 2389–2396.
MeSH headings : Adult; Anthropometry; Body Mass Index; Cohort Studies; Employment / methods; Female; Humans; Infant, Newborn; Longitudinal Studies; Male; Mothers; United States
TL;DR:
The purpose of this study was to investigate the association between maternal employment and infant BMI z score.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 9, 2020
2020 journal article
Development of a Genome-Wide Oligonucleotide Microarray Platform for Detection of DNA Copy Number Aberrations in Feline Cancers
VETERINARY SCIENCES, 7(3).
author keywords: feline; cat; cancer; genomics; chromosome; comparative genomic hybridization (CGH)
TL;DR:
A microarray platform that allows rapid and sensitive detection of DNA copy number aberrations in feline tumors using comparative genomic hybridization analysis is developed and shown to have diverse potential to incorporate domestic cat cancers into comparative and translational research efforts in molecular oncology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 9, 2020
2020 journal article
Photoexcited state properties and antibacterial activities of carbon dots relevant to mechanistic features and implications
CARBON, 170, 137–145.
author keywords: Carbon dots; Antibacterial; Light activation; Redox species; Photodynamic; Mechanism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 9, 2020
2020 journal article
Sex chromosome complement influences vulnerability to cocaine in mice
HORMONES AND BEHAVIOR, 125.
author keywords: Mice; Cocaine; Self-administration; Sex chromosomes; Locomotor activity; Sex differences; Addiction
MeSH headings : Animals; Behavior, Animal / drug effects; Cocaine / pharmacology; Cocaine-Related Disorders / genetics; Estradiol / physiology; Female; Genetic Predisposition to Disease; Genotype; Gonads / physiology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Sex Characteristics; Sex Chromosomes / physiology
TL;DR:
The data demonstrate that sex chromosome complement alone and/or interacting with gonadal status can modify cocaine's reinforcing and locomotor-activating effects and inform current studies of sex differences in drug use.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 9, 2020
2020 journal article
Human Cerebral Organoids Reveal Early Spatiotemporal Dynamics and Pharmacological Responses of UBE3A
STEM CELL REPORTS, 15(4), 845–854.
MeSH headings : Angelman Syndrome / pathology; Cell Line; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Cerebrum / metabolism; Genomic Imprinting / drug effects; Humans; Neurons / drug effects; Neurons / metabolism; Organoids / drug effects; Organoids / metabolism; Time Factors; Topoisomerase Inhibitors / pharmacology; Ubiquitin-Protein Ligases / metabolism
TL;DR:
Human cerebral organoids are established as an important model for studying UBE3A and motivates their broader use in understanding complex neurodevelopmental disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Source: Web Of Science
Added: November 9, 2020
2020 journal article
Age and Genetic Background Modify Hybrid Male Sterility in House Mice
GENETICS, 216(2), 585–597.
author keywords: hybrid male sterility; aging; genetic background; spermatogenesis; mouse
MeSH headings : Aging / genetics; Aging / physiology; Animals; Female; Genetic Background; Genetic Loci; Hybridization, Genetic; Infertility, Male / genetics; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Multifactorial Inheritance
TL;DR:
Results point to multiple segregating HMS modifier alleles, some of which have age-related modes of action, which will advance understanding both of the genetic architecture of HMS and of how reproductive barriers are maintained between house mouse subspecies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: November 2, 2020
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