Works Published in 2014
Displaying works 21 - 40 of 47 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Phosphorylation at Y1065 in Vinculin Mediates Actin Bundling, Cell Spreading, and Mechanical Responses to Force
Biochemistry, 53(34), 5526–5536.
MeSH headings : Actins / chemistry; Animals; Cells, Cultured; Circular Dichroism; Magnetic Resonance Spectroscopy; Mice; Microscopy, Fluorescence; Mutation; Phosphorylation; Protein Binding; Vinculin / chemistry; Vinculin / genetics; Vinculin / physiology
TL;DR:
It is shown that Src phosphorylation of Y1065 within the C-terminal hairpin regulates Vt-mediated actin bundling and provides a detailed characterization of Y 1065 mutations, and thatosphorylation at Y1055 plays a role in cell spreading and the response to the application of mechanical force.
(via Semantic Scholar)
doi.org (publisher)
Source: ORCID
Added: December 10, 2019
2014 journal article
Identification of an Actin Binding Surface on Vinculin that Mediates Mechanical Cell and Focal Adhesion Properties
Structure, 22(5), 697–706.
MeSH headings : Actins / metabolism; Animals; Avian Proteins / chemistry; Avian Proteins / genetics; Avian Proteins / metabolism; Binding Sites; Cells, Cultured; Fibroblasts / cytology; Focal Adhesions; Hydrophobic and Hydrophilic Interactions; Mice; Microscopy, Electron / methods; Models, Molecular; Point Mutation; Rabbits; Vinculin / chemistry; Vinculin / genetics; Vinculin / metabolism
TL;DR:
The identification of actin-binding deficient mutants of vinculin outside sites predicted to bind actin and an alternative model developed provide the molecular basis for elucidating additional roles of this interaction, including act in-induced conformational changes that promote actin bundling.
(via Semantic Scholar)
Source: ORCID
Added: December 10, 2019
2014 journal article
Correction to Phosphorylation at Y1065 in Vinculin Mediates Actin Bundling, Cell Spreading, and Mechanical Responses to Force
Biochemistry, 53(39), 6286–6286.
TL;DR:
This work was supported by National Institutes of Health Grants K.L.C.) and NIH/NIBIB 5P41EB002025 (R.S.).
(via Semantic Scholar)
Source: ORCID
Added: December 10, 2019
2014 journal article
ortho-C–H Activation of Thiobenzoic Acid: Synthesis, Characterization, and Reactivity of Iridium Thiobenzoate Complexes
Organometallics, 34(1), 275–279.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: ORCID, NC State University Libraries
Added: November 12, 2019
2014 journal article
Solvate Structures and Spectroscopic Characterization of LiTFSI Electrolytes
JOURNAL OF PHYSICAL CHEMISTRY B, 118(47), 13601–13608.
TL;DR:
It is found, however, that significant difficulties may be encountered when identifying the distributions of specific forms of TFSI(-) anion coordination present in liquid electrolyte mixtures due to the wide range of T FS(-)···Li(+) cation interactions possible and the overlap of the corresponding spectroscopic data signatures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Modifying Caspase-3 Activity by Altering Allosteric Networks
BIOCHEMISTRY, 53(48), 7582–7595.
MeSH headings : Allosteric Site / genetics; Amino Acid Substitution; Caspase 3 / chemistry; Caspase 3 / genetics; Caspase 3 / metabolism; Crystallography, X-Ray; Humans; Kinetics; Models, Molecular; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Protein Conformation; Protein Multimerization; Protein Structure, Quaternary; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism
TL;DR:
The data show that the caspase-3 native ensemble includes the canonical active state as well as an inactive conformation characterized by an intact substrate-binding pocket, but with an altered helix 3, which reflects the relative population of each species in the native ensemble.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 article
Focus on Advancing High Performance Mass Spectrometry, Honoring Dr. Richard D. Smith, Recipient of the 2013 Award for a Distinguished Contribution in Mass Spectrometry
Baker, E. S., Muddiman, D. C., & Loo, J. A. (2014, December). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 25, pp. 1997–1999.
TL;DR:
This special focus issue of the Journal of the American Society for Mass spectrometry celebrates the accomplishments of Dr. Richard D. Smith, the recipient of the 2013ASMS Award for a Distinguished Contribution in Mass Spectrometry.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Evaluating nonpolar surface area and liquid chromatography/mass spectrometry response: an application for site occupancy measurements for enzyme intermediates in polyketide biosynthesis
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 28(23), 2511–2522.
MeSH headings : Acyltransferases / metabolism; Chromatography, Liquid / methods; Filtration; Hydrophobic and Hydrophilic Interactions; Mass Spectrometry / methods; Oligopeptides / chemistry; Oligopeptides / metabolism; Peptide Fragments / chemistry; Peptide Fragments / metabolism; Polyketides / chemistry; Polyketides / metabolism
TL;DR:
The MS signal as a function of nonpolar surface area (NPSA) is explored in order to better understand this bias in electrospray response and to determine relative LC/MS response for peptides.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Establishing ion ratio thresholds based on absolute peak area for absolute protein quantification using protein cleavage isotope dilution mass spectrometry
ANALYST, 139(21), 5439–5450.
MeSH headings : Chromatography, Liquid; Isotopes / chemistry; Proteins / analysis; Tandem Mass Spectrometry / methods
TL;DR:
It is suggested that evaluation of the absolute ion abundance for any given transition is necessary in order to effectively implement RA thresholds, and these RA values should be assessed as close as possible to the time at which data is collected for quantification.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Mapping Antiretroviral Drugs in Tissue by IR-MALDESI MSI Coupled to the Q Exactive and Comparison with LC-MS/MS SRM Assay
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 25(12), 2038–2047.
author keywords: IR-MALDESI; Mass spectrometry imaging; LC-MS/MS; Drug distribution
MeSH headings : Adenine / analogs & derivatives; Adenine / analysis; Adenine / chemistry; Adenine / pharmacokinetics; Anti-Retroviral Agents / analysis; Anti-Retroviral Agents / chemistry; Anti-Retroviral Agents / pharmacokinetics; Cervix Uteri / chemistry; Cervix Uteri / metabolism; Chromatography, Liquid / methods; Deoxycytidine / analogs & derivatives; Deoxycytidine / analysis; Deoxycytidine / chemistry; Deoxycytidine / pharmacokinetics; Emtricitabine; Female; Histocytochemistry; Humans; Molecular Imaging / methods; Organophosphonates / analysis; Organophosphonates / chemistry; Organophosphonates / pharmacokinetics; Pyrrolidinones / analysis; Pyrrolidinones / chemistry; Pyrrolidinones / pharmacokinetics; Raltegravir Potassium; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Tandem Mass Spectrometry / methods; Tenofovir; Tissue Distribution
TL;DR:
An agreement between the average intensities from the imaging experiment and the absolute quantities for each drug was observed and this correlation between these two techniques serves as a prerequisite to quantitative IR-MALDESI MSI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Oxyfunctionalization with Cp*Ir-III(NHC)(Me)L Complexes
ORGANOMETALLICS, 33(19), 5081–5084.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Mono-Oxido-Bridged Heterobimetallic and Heterotrimetallic Compounds Containing Titanium(IV) and Chromium(III)
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2014(33), 5662–5674.
author keywords: Chromium; Titanium; Heterometallic complexes; Bridging ligands; Porphyrinoids
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Hierarchical Self-Assembly of Supramolecular Hydrophobic Metallacycles into Ordered Nanostructures
CHEMISTRY-AN ASIAN JOURNAL, 9(10), 2928–2936.
author keywords: metallacycles; noncovalent interactions; nanostructures; self-assembly; supramolecular chemistry
TL;DR:
A new series of well-defined metallacycles decorated with long alkyl chains were obtained through metal-ligand interactions, which were capable of aggregating into ordered fibroid or spherical nanostructures on the surface, mostly driven by hydrophobic interactions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Silver dopants for targeted and untargeted direct analysis of unsaturated lipids via infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI)
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 28(22), 2461–2470.
MeSH headings : Alkenes / chemistry; Dried Blood Spot Testing; Fats, Unsaturated / analysis; Fats, Unsaturated / chemistry; Humans; Male; Silver / chemistry; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR:
Silver cationization has been shown to enhance IR-MALDESI sensitivity and selectivity for unsaturated lipids, even when applied to complex samples, and developed tools for peak assignment and mapping of isotopic patterns will clearly benefit future mass spectrometry imaging studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Crystallization and preliminary X-ray diffraction analysis of Hypocrea jecorina Cel7A in two new crystal forms
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 70, 773–776.
MeSH headings : Cellulose 1,4-beta-Cellobiosidase / chemistry; Crystallization; Crystallography, X-Ray; Electrophoresis, Polyacrylamide Gel; Hypocrea / chemistry
TL;DR:
A preliminary analysis of the electron-density maps suggests that the linker and CBM are disordered in both crystal forms of Cel7A, which consists of a large 434-residue N-terminal catalytic domain capable of cleaving cellulose, a 27-Residue flexible linking module and a small 36- Residue C-Terminal carbohydrate-binding module.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Light-Driven Hydrogen Evolution by BODIPY-Sensitized Cobaloxime Catalysts
INORGANIC CHEMISTRY, 53(9), 4527–4534.
TL;DR:
It is concluded that accessing the photoexcited triplet state of the BODIPY chromophore by introducing heavy atoms is necessary for efficient electron transfer in this system, enabling catalytic hydrogen generation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Regioselective β-pyrrolic electrophilic substitution of hydrodipyrrin–dialkylboron complexes facilitates access to synthetic models for chlorophyll f
New Journal of Chemistry, 38(4), 1717.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2014 journal article
Proportional Accumulation of Yolk Proteins Derived From Multiple Vitellogenins is Precisely Regulated During Vitellogenesis in Striped Bass (Morone saxatilis)
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY, 321(6), 301–315.
Contributors: V. Williams n, B. Reading n , H. Amano*, N. Hiramatsu*, J. Schilling n, S. Salger n, T. Islam Williams n, K. Gross n, C. Sullivan n
MeSH headings : Animals; Bass / metabolism; Blotting, Western; Egg Proteins / analysis; Egg Proteins / biosynthesis; Egg Proteins / metabolism; Egg Proteins / physiology; Electrophoresis, Polyacrylamide Gel; Female; Liver / chemistry; Mass Spectrometry; Ovary / chemistry; Real-Time Polymerase Chain Reaction; Vitellogenesis / physiology; Vitellogenins / analysis; Vitellogenins / biosynthesis; Vitellogenins / metabolism; Vitellogenins / physiology
TL;DR:
The results indicate that proportional accumulation of multiple Vtgs in the yolk may depend both on the precise rates of their hepatic secretion and specific uptake by oocytes, and composition of the Vtg-derived yolk May vary among Acanthomorph fishes, perhaps reflecting their different early life histories and reproductive strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 article
Reply to the Comment on: "Utilizing Artificial Neural Networks in MATLAB to Achieve Parts-Per-Billion Mass Measurement Accuracy with a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer" by D. Keith Williams Jr., Alexander L. Kovach, David C. Muddiman, and Kenneth W. Hanck. J-Am. Soc. Mass Spectrom. 20, 1303-1310 (2009)
Muddiman, D. C. (2014, April). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 25, pp. 697–697.
MeSH headings : Fourier Analysis; Mass Spectrometry / methods; Neural Networks, Computer
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Complete Proteomic-Based Enzyme Reaction and Inhibition Kinetics Reveal How Monolignol Biosynthetic Enzyme Families Affect Metabolic Flux and Lignin in Populus trichocarpa
PLANT CELL, 26(3), 894–914.
MeSH headings : Kinetics; Lignin / metabolism; Mass Spectrometry; Plant Proteins / metabolism; Polymorphism, Single Nucleotide; Populus / metabolism; Proteome
TL;DR:
A proteomic-based predictive kinetic metabolic-flux model was developed for monolignol biosynthesis in Populus trichocarpa and predicts how pathway enzymes affect lignin content and composition, explains a long-standing paradox regarding the regulation of monolIGNol subunit ratios in lignIn, and reveals novel mechanisms involved in theregulation of lign in biosynthesis.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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