Works Published in 2018
Displaying works 41 - 60 of 141 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 journal article
Individual Variation in Social Behaviours of Male Lab-reared Prairie voles (Microtus ochrogaster) is Non-heritable and Weakly Associated with V1aR Density
Scientific Reports, 8(1).
MeSH headings : Animals; Arvicolinae / physiology; Basal Forebrain / metabolism; Female; Male; Mating Preference, Animal; Pair Bond; Receptors, Vasopressin / metabolism; Social Behavior
TL;DR:
Heritability estimates of variation in partner preference were low, yet heritability estimates for V1aR expression were high, indicating that the extensive variation in Partner preference observed within this population is due largely to environmental plasticity.
(via Semantic Scholar)
www.nature.com (publisher PDF)
Sources: Crossref, NC State University Libraries
Added: August 17, 2019
2018 journal article
Environmental Mechanisms of Neurodevelopmental Toxicity
Current Environmental Health Reports, 5(1), 145–157.
author keywords: Neurodevelopment; Neurotoxicity; Xenobiotic; Neuroendocrine; Neuroimmune
MeSH headings : Brain / drug effects; Brain / growth & development; Environmental Exposure / adverse effects; Humans; Immune System / drug effects; Neurodevelopmental Disorders / chemically induced; Neurosecretory Systems / drug effects; Oxidative Stress / drug effects
TL;DR:
Recent findings regarding novel mechanisms of developmental neurotoxicity are reported on and emerging areas of interest include neuroendocrine and immune disruption, as well as indirect toxicity via actions on other organs such as the gut and placenta are highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: August 17, 2019
2018 journal article
CLARITY-BPA academic laboratory studies identify consistent low-dose Bisphenol A effects on multiple organ systems
Basic & Clinical Pharmacology & Toxicology, 10.
author keywords: Bisphenol A; CLARITY-BPA; endocrine disruptor; endocrine-disrupting chemical; oestrogen
MeSH headings : Animals; Benzhydryl Compounds / toxicity; Congresses as Topic; Disease Models, Animal; Ecotoxicology / methods; Ecotoxicology / standards; Endocrine Disruptors / toxicity; Environmental Exposure / adverse effects; Environmental Pollutants / toxicity; Female; Fetal Development / drug effects; Guidelines as Topic; Humans; National Institute of Environmental Health Sciences (U.S.) / standards; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / prevention & control; Rats, Sprague-Dawley; Risk Assessment / methods; Risk Assessment / standards; Toxicity Tests / methods; Toxicity Tests / standards; United States; United States Food and Drug Administration / standards
TL;DR:
The findings highlighted herein corroborate a significant body of evidence that documents adverse effects of BPA at doses relevant to human exposures and emphasizes the need for updated risk assessment analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: August 17, 2019
2018 journal article
Novel unconditioned prosocial behavior in prairie voles (Microtus ochrogaster) as a model for empathy
BMC Research Notes, 11(1).
MeSH headings : Animals; Arginine Vasopressin / genetics; Arginine Vasopressin / metabolism; Arvicolinae / physiology; Arvicolinae / psychology; Behavior, Animal / physiology; Cooperative Behavior; Dopaminergic Neurons / cytology; Dopaminergic Neurons / metabolism; Empathy / physiology; Female; Gene Expression; Humans; Hypothalamus / cytology; Hypothalamus / metabolism; Male; Models, Animal; Oxytocin / genetics; Oxytocin / metabolism; Paraventricular Hypothalamic Nucleus / cytology; Paraventricular Hypothalamic Nucleus / metabolism; Tyrosine 3-Monooxygenase / genetics; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
The consistency between neuroanatomical mechanisms linked to empathy, and the durations of time spent engaging in empathic contact, support the prediction that the empathy contact in this test is a distinct prosocial behavior, lacking prior behavioral training or the naturally occurring ethological relevance of other prosocial behaviors, and is a measure of empathy.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 17, 2019
2018 journal article
Heavy Metal Exposure and Metabolic Syndrome: Evidence from Human and Model System Studies
Current Environmental Health Reports, 5(1), 110–124.
author keywords: Metabolic syndrome; Diabetes; Heavy metals; Cadmium; Pb; Mercury
MeSH headings : Animals; Cadmium / adverse effects; Disease Models, Animal; Humans; Lead / adverse effects; Mercury / adverse effects; Metabolic Syndrome / chemically induced; Metals, Heavy / adverse effects
TL;DR:
Assessment of potential causal links between heavy metal exposure and metabolic syndrome remains challenging as epidemiological data are largely cross-sectional; and variation in study design, including samples used for heavy metal measurements, age of subjects at which MS outcomes are measured, and the population demographics vary widely.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 7, 2019
2018 journal article
Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study
International Journal of Obesity, 42(7), 1285–1295.
Contributors: A. Green n, C. Hoyo n, C. Mattingly n , Y. Luo n, J. Tzeng n, S. Murphy *, D. Buchwalter n, A. Planchart n
MeSH headings : Adipogenesis / drug effects; Animals; Cadmium / adverse effects; Cadmium / analysis; Cadmium / blood; Disease Models, Animal; Environmental Exposure / adverse effects; Environmental Exposure / analysis; Female; Humans; Infant, Newborn; Male; Maternal Exposure / adverse effects; Metals, Heavy / adverse effects; Metals, Heavy / analysis; Pediatric Obesity / blood; Pediatric Obesity / chemically induced; Pediatric Obesity / epidemiology; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects / blood; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / epidemiology; Prospective Studies; Socioeconomic Factors; United States / epidemiology; Zebrafish / metabolism
TL;DR:
The findings identify Cd as a potential human obesogen, suggesting that the underlying mechanisms may be evolutionarily conserved, and that zebrafish may be a valuable model for uncovering pathways leading to Cd-mediated obesity in human populations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 7, 2019
2018 article
Mutational and transcriptomic profiling identify distinct angiogenic and inflammatory subtypes of angiosarcoma
Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Wang, C., Elvers, I., … Modiano, J. F. (2018, July). CANCER RESEARCH, Vol. 78.
Source: Web Of Science
Added: June 24, 2019
2018 article
Comparative genomic analyses of osteosarcoma etiology reveal a chromosomal structural rationale for the increased incidence of osteosarcoma in dogs
Sarver, A. L., Mills, L., Temiz, N., Scott, M. I., Sarver, A., Spector, L., … Largaespada, D. (2018, July). CANCER RESEARCH, Vol. 78.
TL;DR:
It is hypothesized that increased osteosarcoma incidence in dogs is partly due to a syntenic rearrangement of the peri-PTEN locus in the canine genome, which creates a high risk of loss in the context of cytogenetic instability caused by disruption of TP53, thereby providing a structural genetic rational for the higher incidence of osteosARcoma in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: June 24, 2019
2018 journal article
Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure.
Environmental Health Perspectives, 6(6).
Contributors: M. Balik-Meisner n, L. Truong *, E. Scholl n, J. La Du, R. Tanguay * & D. Reif n
MeSH headings : Animals; Embryo, Nonmammalian / drug effects; Embryonic Development / drug effects; Female; Gene-Environment Interaction; Genetic Variation; Genome-Wide Association Study; High-Throughput Screening Assays / methods; Ivermectin / analogs & derivatives; Ivermectin / toxicity; Male; Phenotype; Zebrafish / embryology; Zebrafish / genetics
TL;DR:
The results for Abamectin in zebrafish demonstrate that GxE associated with naturally occurring, population genetic variation play a significant role in mediating individual response to chemical exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 14, 2019
2018 article
EPIGENOMICS AND HUMAN OBESITY
EPIGENETICS IN HUMAN DISEASE, 2ND EDITION, Vol. 6, pp. 409–426.
TL;DR:
This chapter summarizes human data on CpG methylation, the most studied epigenetic mechanism in humans, in the context of causal inference, in adults and children, and concludes with a call for sex- and ethnic-specific data, together with data demonstrating that obesity-associated DNA methylation marks identified precede obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 22, 2019
2018 journal article
Role of p53 in the chronic pulmonary immune response to tangled or rod-like multi-walled carbon nanotubes
NANOTOXICOLOGY, 12(9), 975–991.
author keywords: Caron nanotubes; immunotoxicology; cancer; granuloma; p53
MeSH headings : Animals; Dose-Response Relationship, Drug; Granuloma, Respiratory Tract / chemically induced; Granuloma, Respiratory Tract / genetics; Granuloma, Respiratory Tract / immunology; Inhalation Exposure; Lung / drug effects; Lung / immunology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Surface Properties; Tertiary Lymphoid Structures / chemically induced; Tertiary Lymphoid Structures / genetics; Tertiary Lymphoid Structures / immunology; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / physiology
TL;DR:
Findings indicate that a combination of p53 deficiency and physicochemical characteristics including nanotube geometry are factors in susceptibility to MWCNT-induced lymphoid infiltration and granuloma formation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 4, 2019
2018 journal article
Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon
Journal of Biological Chemistry, 293(16), 6187–6200.
MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Azepines / pharmacology; Cell Cycle Proteins; Cell Line, Tumor; Conserved Sequence; Cullin Proteins / metabolism; Humans; Immunologic Factors / metabolism; Immunologic Factors / pharmacology; Lenalidomide / pharmacology; Ligands; Mice; Molecular Probes; Nuclear Proteins / drug effects; Nuclear Proteins / metabolism; Peptide Hydrolases / chemistry; Peptide Hydrolases / metabolism; Proteasome Endopeptidase Complex / metabolism; Proteolysis; T-Lymphocytes / metabolism; Thalidomide / analogs & derivatives; Thalidomide / metabolism; Thalidomide / pharmacology; Transcription Factors / drug effects; Transcription Factors / metabolism; Triazoles / pharmacology; Ubiquitin / metabolism; Ubiquitin-Protein Ligases / metabolism
TL;DR:
It is shown that CRBN sequence variants retain their drug-binding properties to both classical immunomodulatory drugs and dBET1, a chemical compound and targeting ligand designed to degrade bromodomain-containing 4 via a CRBN-dependent mechanism, which provides a new understanding of CRBN's substrate-recruiting function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 13, 2019
2018 journal article
Single-molecule DREEM imaging reveals DNA wrapping around human mitochondrial single-stranded DNA binding protein
NUCLEIC ACIDS RESEARCH, 46(21), 11287–11302.
MeSH headings : DNA, Mitochondrial / chemistry; DNA, Mitochondrial / metabolism; DNA, Single-Stranded / chemistry; DNA, Single-Stranded / metabolism; DNA-Binding Proteins / analysis; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Fluorescence Polarization; Humans; Microscopy, Atomic Force / methods; Mitochondrial Proteins / analysis; Mitochondrial Proteins / chemistry; Mitochondrial Proteins / metabolism; Protein Conformation; Protein Stability; Recombinant Proteins / genetics; Single Molecule Imaging / methods; Static Electricity
TL;DR:
Single-molecule imaging suggests mtSSB may not saturate or fully protect single-stranded replication intermediates during mtDNA synthesis, leaving the mitochondrial genome vulnerable to chemical mutagenesis, deletions driven by primer relocation or other actions consistent with clinically observed deletion biases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 11, 2019
2018 journal article
Periconceptional maternal mediterranean diet is associated with favorable offspring behaviors and altered CpG methylation of imprinted genes
Frontiers in Cell and Developmental Biology, 6(SEP), 107.
Contributors: J. House n , M. Mendez*, R. Maguire n, S. Gonzalez-Nahm *, Z. Huang *, J. Daniels *, S. Murphy *, B. Fuemmeler *, F. Wright n, C. Hoyo n
TL;DR:
In this ethnically diverse cohort, maternal adherence to a Mediterranean diet in early pregnancy was associated with favorable neurobehavioral outcomes in early childhood and with sex-dependent methylation differences of MEG3, IGF2, and SGCE/PEG10 DMRs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: January 21, 2019
2018 journal article
Skin Permeation of Solutes from Metalworking Fluids to Build Prediction Models and Test A Partition Theory
MOLECULES, 23(12).
author keywords: leave-one-solute-out (LOSO) cross-validation; leave-one-out (LOO) cross-validation; linear free-energy relationship (LFER) model; membrane-coated fiber (MCF) approach; partition coefficient; quantitative structure-activity relationship (QSAR); metalworking fluid
MeSH headings : Algorithms; Metals / metabolism; Models, Theoretical; Permeability; Reproducibility of Results; Skin Physiological Phenomena
TL;DR:
Using the membrane-coated fiber as a solid phase membrane extraction (SPME) approach to simulate skin permeation, partition coefficients for 37 solutes under 90 treatment combinations that could broadly represent formulations that could be associated with occupational skin exposure are obtained.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 14, 2019
2018 article
ICONS - Integrated testing strategy for mechanistically assessing the respiratory toxicity of functionalized MWCNTs - Comparative in vitro investigations
Ziemann, C., Reamon-Buettner, S. M., Lison, D., Bonner, J. C., Brule, S., Simon, S., & Creutzenberg, O. H. (2018, October 10). TOXICOLOGY LETTERS, Vol. 295, pp. S213–S213.
Source: Web Of Science
Added: January 7, 2019
2018 journal article
Bacterial microbiome of the chigger mite Leptotrombidium imphalum varies by life stage and infection with the scrub typhus pathogen Orientia tsutsugamushi
PLOS ONE, 13(12).
MeSH headings : Animals; Female; Male; Orientia tsutsugamushi / pathogenicity; RNA, Ribosomal, 16S / genetics; Scrub Typhus / microbiology; Scrub Typhus / transmission; Trombiculidae / microbiology; Trombiculidae / pathogenicity
TL;DR:
The composition of the microbiome in larvae, deutonymphs and adult males and females from laboratory colonies of L. imphalum that were infected as well as uninfected with O. tsutsugamushi were investigated by high-throughput sequencing of the bacterial 16S rRNA gene to determine the influence of the novel Amoebophilaceae species on the bacterial microbiome and on vector susceptibility to and transovarial transmission.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 31, 2018
2018 journal article
The pharmacokinetics of gabapentin in cats
JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(6), 1996–2002.
author keywords: compounded; feline; pain; transdermal
MeSH headings : Analgesics / administration & dosage; Analgesics / blood; Analgesics / pharmacokinetics; Animals; Cats / metabolism; Female; Gabapentin / administration & dosage; Gabapentin / blood; Gabapentin / pharmacokinetics; Half-Life; Injections, Intravenous / veterinary; Male
TL;DR:
Repeated oral dosing of gabapentin did not alter the drug's pharmacokinetics, making dose adjustments unnecessary with long‐term treatment, and the transdermal route is an inappropriate choice for drug administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 31, 2018
2018 journal article
A Comparison of the chemical sensitivities between in vitro and in vivo propagated juvenile freshwater mussels: Implications for standard toxicity testing
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 37(12), 3077–3085.
author keywords: Mussel propagation; Copper; Nickel; Ammonia; Unionid
MeSH headings : Aging / physiology; Animals; Bivalvia / drug effects; Fresh Water; Larva / drug effects; Reference Standards; Toxicity Tests, Acute; Water Pollutants, Chemical / toxicity; Water Quality
TL;DR:
In vitro propagated juvenile mussels may be appropriate for use in ASTM International‐based toxicity testing, and differences in chemical sensitivity exist between in vitro and in vivo propagated juveniles, they are within normal toxicity test variation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 17, 2018
2018 journal article
The Good, the Bad, and the Lethal: Gene Expression and Metabolomics Reveal Physiological Mechanisms Underlying Chronic Thermal Effects in Mayfly Larvae (Neocloeon triangulifer)
FRONTIERS IN ECOLOGY AND EVOLUTION, 6.
author keywords: aquatic insects; mayfly; thermal limits; metabolomics; temperature
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: December 17, 2018
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