Works Published in 2019
Displaying works 41 - 60 of 147 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2019 journal article
Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control
NATURE COMMUNICATIONS, 10.
MeSH headings : Animals; Chlorocebus aethiops / genetics; Chlorocebus aethiops / immunology; Disease Progression; Fibronectins / immunology; Fibronectins / metabolism; Intestinal Mucosa / immunology; Intestinal Mucosa / metabolism; Macaca mulatta / genetics; Macaca mulatta / immunology; Macrophages / immunology; Macrophages / metabolism; Rectum / immunology; Rectum / metabolism; Simian Acquired Immunodeficiency Syndrome / immunology; Simian Immunodeficiency Virus; Systems Biology; Transcriptome; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / immunology; Wound Healing / genetics; Wound Healing / immunology
TL;DR:
It is found that AGMs rapidly activate and maintain evolutionarily conserved regenerative wound healing mechanisms in mucosal tissue, which likely preserves mucosal integrity and prevents inflammatory insults that underlie immune exhaustion in RMs.
(via Semantic Scholar)
www.nature.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 25, 2019
2019 journal article
Measurement of peripheral muscle oxygen saturation in conscious healthy horses using a near-infrared spectroscopy device
VETERINARY ANAESTHESIA AND ANALGESIA, 46(6), 789–795.
author keywords: equine; horse; microcirculation; muscle oxygenation; NIRS; tissue oximetry
MeSH headings : Animals; Female; Horses / physiology; Male; Muscle, Skeletal / physiology; Oximetry / instrumentation; Oximetry / methods; Oximetry / veterinary; Oxygen / chemistry; Oxygen / metabolism; Oxygen Consumption / physiology; Spectroscopy, Near-Infrared / veterinary
TL;DR:
The vastus lateralis and extensor carpi ulnaris muscle sites provided the most reliable and repeatable readings when using the Inspectra m650 machine in horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Source: Web Of Science
Added: November 25, 2019
2019 journal article
Sonographic diagnosis of egg-yolk coelomitis in a domestic chicken (Gallus gallus domesticus).
Journal of Avian Medicine and Surgery.
MeSH headings : Animals; Ascites / diagnostic imaging; Ascites / therapy; Ascites / veterinary; Chickens; Female; Genital Diseases, Female / diagnostic imaging; Genital Diseases, Female / therapy; Genital Diseases, Female / veterinary; Oviducts / diagnostic imaging; Oviducts / pathology; Poultry Diseases / diagnosis; Poultry Diseases / diagnostic imaging; Poultry Diseases / therapy; Rupture, Spontaneous / diagnostic imaging; Rupture, Spontaneous / therapy; Rupture, Spontaneous / veterinary; Ultrasonography / veterinary
TL;DR:
A 3-year-old female chicken presented for a 3week history of progressive coelomic distention, with a decreased body condition score (keel score 2/5) and was 5% dehydrated based on decreased skin turgor; trauma from conspecifics was also considered.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: ORCID
Added: November 21, 2019
2019 journal article
Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (151).
author keywords: Neuroscience; Issue 151; scratching; itch; pain; behavior; histamine; capsaicin
MeSH headings : Animals; Antipruritics / administration & dosage; Behavior, Animal / drug effects; Capsaicin / administration & dosage; Cheek; Disease Models, Animal; Injections; Lysophospholipids / toxicity; Male; Mice; Mice, Inbred C57BL; Pain / chemically induced; Pain / drug therapy; Pain / pathology; Pain / psychology; Pruritus / chemically induced; Pruritus / drug therapy; Pruritus / pathology; Pruritus / psychology
TL;DR:
Investigation into the effects of LPA in a mouse cheek injection model showed that LPA only induced scratching, but not wiping behaviors, which indicates that L PA acts as a pruritogen similarly in mice and humans, and demonstrates the utility of a cheek injections model for itch research.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 18, 2019
2019 journal article
Examining the Dynamics of Cellular Adhesion and Spreading of Epithelial Cells on Fibronectin During Oxidative Stress
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 10(152).
author keywords: Biochemistry; Issue 152; cell adhesion; cellular spreading; oxidative stress; fibronectin; epithelial cells; ATM inhibition; ruffles; stress fibers; cell circularity
MeSH headings : Animals; Cell Adhesion / drug effects; Cell Adhesion / physiology; Cell Count / methods; Cell Culture Techniques / methods; Cell Line; Cell Line, Transformed; Cells, Cultured; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Extracellular Matrix / drug effects; Extracellular Matrix / metabolism; Fibroblasts / drug effects; Fibroblasts / metabolism; Fibronectins / metabolism; Humans; Microscopy, Fluorescence / methods; Morpholines / pharmacology; Oxidative Stress / drug effects; Oxidative Stress / physiology; Pyrones / pharmacology
TL;DR:
A step-wise protocol is described that utilizes an immunofluorescence-based assay to specifically quantify cell adhesion and spreading of immortalized fibroblast cells on fibronectin (FN) in vitro to examine a broad range of biological questions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 18, 2019
2019 journal article
C/EBP beta suppresses keratinocyte autonomous type 1 IFN response and p53 to increase cell survival and susceptibility to UVB-induced skin cancer
CARCINOGENESIS, 40(9), 1099–1109.
TL;DR:
A p53-C/E BPβ feedback loop, whereby C/EBPβ a transcriptional target of a p53 pathway, functions as a survival factor by negatively regulating p53 apoptotic activity in response to DNA damage is suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 18, 2019
2019 journal article
Use of Nasal Pathology in the Derivation of Inhalation Toxicity Values for Hydrogen Sulfide
TOXICOLOGIC PATHOLOGY, 47(8), 1043–1048.
author keywords: hydrogen sulfide; nasal toxicity; risk assessment; CFD modeling
MeSH headings : Animals; Dose-Response Relationship, Drug; Humans; Hydrogen Sulfide / toxicity; Inhalation Exposure / adverse effects; Nasal Mucosa / drug effects; Nasal Mucosa / pathology; No-Observed-Adverse-Effect Level; Nose / anatomy & histology; Nose / drug effects; Nose / pathology; Toxicity Tests
TL;DR:
Three major areas of focus for this review include a brief description of nasal anatomy, H 2S-induced ONL in rodents, derivation of a chronic inhalation reference concentration for H2S, and the use of CFD models to derive alternative toxicity values for this gas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 18, 2019
2019 journal article
Investigation of adrenal and thyroid gland dysfunction in dogs with ultrasonographic diagnosis of gallbladder mucocele formation
PLOS ONE, 14(2), e0212638.
Ed(s): J. Loor
MeSH headings : Adrenal Glands / physiopathology; Adrenocortical Hyperfunction / epidemiology; Adrenocortical Hyperfunction / physiopathology; Adrenocortical Hyperfunction / veterinary; Animals; Autoantibodies / blood; Case-Control Studies; Dehydroepiandrosterone / blood; Dog Diseases / diagnosis; Dog Diseases / epidemiology; Dog Diseases / physiopathology; Dogs; Electronic Health Records; Female; Gallbladder / diagnostic imaging; Gallbladder Diseases / blood; Gallbladder Diseases / physiopathology; Gallbladder Diseases / veterinary; Hypothyroidism / epidemiology; Hypothyroidism / physiopathology; Hypothyroidism / veterinary; Male; Mucocele / blood; Mucocele / physiopathology; Mucocele / veterinary; Prevalence; Retrospective Studies; Thyroid Gland / physiopathology; Ultrasonography
TL;DR:
It is suggested that dogs with gallbladder mucocele formation have a greater capacity for cortisol synthesis and pinpoint DHEAS elevations as a potential clue to the underlying pathogenesis of the disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019
2019 journal article
Influence of the intestinal microbiota on disease susceptibility in kittens with experimentally-induced carriage of atypical enteropathogenic Escherichia coli
Veterinary Microbiology, 231, 197–206.
author keywords: aEPEC; Animal model; Feline; Probiotic; Enterococcus hirae
MeSH headings : Age Factors; Animals; Anti-Infective Agents / pharmacology; Asymptomatic Infections; Bacterial Shedding; Cats / microbiology; Diarrhea / microbiology; Disease Models, Animal; Disease Susceptibility / etiology; Disease Susceptibility / microbiology; Enteropathogenic Escherichia coli; Escherichia coli Infections / veterinary; Feces / microbiology; Gastrointestinal Microbiome; Polymerase Chain Reaction; Probiotics
TL;DR:
Enrichment of the intestinal microbiota with a commensal member of the feline mucosa-associated microbiota, Enterococcus hirae, ameliorated the effects of aEPEC experimental infection on intestinal function and water loss and begin to unravel the mechanisms by which aEPec infection may be able to exploit susceptible hosts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019
2019 journal article
Interventions and observations associated with survival of orphaned shelter kittens undergoing treatment for diarrhea
Journal of Feline Medicine and Surgery, 3, 1098612X1984045.
author keywords: Animal welfare; mortality; population medicine
MeSH headings : Animals; Animals, Newborn; Cat Diseases / epidemiology; Cat Diseases / therapy; Cats; Diarrhea / epidemiology; Diarrhea / therapy; Diarrhea / veterinary
TL;DR:
Age ⩾4 weeks and treatment of diarrhea with a vitamin and mineral supplement favorably improves survival of orphaned kittens to adoption and application is likely to improve the health and welfare of this population and contribute to a refinement in use of shelter resources.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019
2019 journal article
Excipient-free nanodispersion of 7-ethyl-10-hydroxycamptothecin exerts potent therapeutic effects against pancreatic cancer cell lines and patient-derived xenografts
CANCER LETTERS, 465, 36–44.
author keywords: Excipient-free nanodispersion; Pancreatic cancer; 7-Ethyl-10-hydroxycamptothecin (SN-38); Patient-derived xenograft (PDX); Irinotecan (CPT-11)
MeSH headings : Animals; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Drug Compounding; Excipients / chemistry; Humans; Irinotecan / administration & dosage; Irinotecan / chemistry; Irinotecan / pharmacology; Mice; Nanomedicine; Nanoparticles; Pancreatic Neoplasms / drug therapy; Topoisomerase I Inhibitors / administration & dosage; Topoisomerase I Inhibitors / chemistry; Topoisomerase I Inhibitors / pharmacology; Xenograft Model Antitumor Assays
TL;DR:
SN-38 and CPT-11 showed potent cytotoxicity against PC cells in vitro, slowed tumor growth in vivo, namely subcutaneously and orthotopically xenografted mice, with minimal adverse effects, and prolonged their overall survival.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 11, 2019
2019 journal article
Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging
ACS NANO, 13(10), 11273–11282.
author keywords: needle free injection; dermal fibroblasts; spheroids; exosomes; skin aging; microRNA
MeSH headings : Animals; Biopolymers / metabolism; Cell Proliferation / radiation effects; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Exosomes / metabolism; Fibroblasts / metabolism; Humans; Mice; Mice, Nude; Skin / cytology; Skin / radiation effects; Skin Aging / radiation effects; Spheroids, Cellular / cytology; Spheroids, Cellular / radiation effects; Tissue Inhibitor of Metalloproteinase-1 / metabolism; Transforming Growth Factor beta / metabolism; Tumor Necrosis Factor-alpha / metabolism; Ultraviolet Rays; Wound Healing / radiation effects
TL;DR:
Results indicate that exosomes from 3D cultured HDF spheroids have anti-skin-aging properties and the potential to prevent and treat cutaneous aging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 11, 2019
2019 journal article
Circulating neurohormone imbalances in canine sudden acquired retinal degeneration syndrome and canine pituitary-dependent hypercortisolism
JOURNAL OF VETERINARY INTERNAL MEDICINE, 33(6), 2587–2594.
author keywords: dog; dopamine; melatonin; PDH; retina; SARDS; serotonin
MeSH headings : Animals; Case-Control Studies; Dog Diseases / blood; Dog Diseases / metabolism; Dogs; Dopamine / blood; Melatonin / analogs & derivatives; Melatonin / blood; Melatonin / urine; Pituitary ACTH Hypersecretion / blood; Pituitary ACTH Hypersecretion / metabolism; Pituitary ACTH Hypersecretion / veterinary; Prospective Studies; Retinal Degeneration / blood; Retinal Degeneration / metabolism; Retinal Degeneration / veterinary; Serotonin / blood
TL;DR:
This study has identified neurohormone differences between dogs with SARDS and PDH, although the study was underpowered for detection of significant differences in serum serotonin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 11, 2019
2019 journal article
Fc Gamma Receptor Polymorphisms Modulated the Vaccine Effect on HIV-1 Risk in the HVTN 505 HIV Vaccine Trial
JOURNAL OF VIROLOGY, 93(21).
author keywords: Fc gamma receptor; HIV/AIDS vaccine trial; HVTN 505; genetic polymorphisms
MeSH headings : Antibodies, Monoclonal / immunology; B-Lymphocytes / immunology; B-Lymphocytes / metabolism; B-Lymphocytes / virology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; CD8-Positive T-Lymphocytes / virology; Case-Control Studies; Clinical Trials, Phase II as Topic; Genetic Vectors / administration & dosage; HIV Infections / epidemiology; HIV Infections / genetics; HIV Infections / immunology; HIV Infections / virology; HIV Seropositivity; HIV-1 / genetics; HIV-1 / immunology; Humans; Incidence; Phagocytosis; Polymorphism, Single Nucleotide; Receptors, IgG / genetics; United States / epidemiology; Vaccination; Vaccines, DNA / administration & dosage; env Gene Products, Human Immunodeficiency Virus / immunology
TL;DR:
It is found that host genetics, specifically Fc gamma receptor genetic variations, influenced whether receiving the DNA/rAd5 regimen was beneficial, neutral, or detrimental to an individual with respect to HIV-1 acquisition risk.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 28, 2019
2019 journal article
Shifts in the Composition and Activities of Denitrifiers Dominate CO2 Stimulation of N2O Emissions
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 53(19), 11204–11213.
MeSH headings : Carbon Dioxide; Denitrification; Nitrogen; Nitrous Oxide; Soil; Soil Microbiology
TL;DR:
The results suggest that effective management of N sources may mitigate N2O emissions by negating eCO2-stimulation of soil denitrifying microbes and their activities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: October 28, 2019
2019 journal article
The effect of enterococci on feline Tritrichomonas foetus infection in vitro
VETERINARY PARASITOLOGY, 273, 90–96.
author keywords: Cats; Enterococcus faecium; Enterococcus hirae; Probiotics
MeSH headings : Animals; Cat Diseases / microbiology; Cat Diseases / parasitology; Cats; Enterococcus / physiology; Fluorescent Antibody Technique, Indirect; Intestinal Mucosa / microbiology; Intestinal Mucosa / parasitology; Microscopy, Electron, Scanning; Probiotics / pharmacology; Protozoan Infections, Animal / microbiology; Protozoan Infections, Animal / parasitology; Tritrichomonas foetus
TL;DR:
In vitro studies performed to evaluate the effect of a probiotic containing Enterococcus faecium and a novel probiotic on the inhibition of T. foetus growth, adhesion to, and cytotoxicity towards the intestinal epithelium support further study into the investigation of a possible benefit of enterococci-containing probiotic treatment for prevention of T., foetus infection in at-risk uninfected cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 14, 2019
2019 journal article
A DESCRIPTIONOFARTERIAL BLOODPRESSUREMEASUREMENT IN TWO SPECIES OF FLYING FOXES (PTEROPUS VAMPYRUS AND PTEROPUS HYPOMELANUS)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 50(3), 665–671.
author keywords: Arterial blood pressure; bat; Chiroptera; flying fox; Pteropus hypomelanus; Pteropus vampyrus
MeSH headings : Animals; Arterial Pressure / physiology; Blood Pressure Determination / methods; Blood Pressure Determination / veterinary; Chiroptera / physiology; Species Specificity
TL;DR:
Arterial catheterization of both the posterior tibial and median arteries in these species was easily performed without major complication, and blood pressure assessment is valuable during management of chronic conditions with increased risk of developing hypertension and as a standard practice for anesthetic monitoring.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 14, 2019
2019 journal article
Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery
NATURE COMMUNICATIONS, 10.
MeSH headings : Anti-Retroviral Agents / pharmacokinetics; Biodegradable Plastics / chemistry; Chemistry, Pharmaceutical; Delayed-Action Preparations / chemistry; Delayed-Action Preparations / pharmacology; Drug Delivery Systems / methods; Drug Liberation; HIV Infections / drug therapy; Humans; Kinetics; Materials Testing; Polymers / metabolism; Pyrrolidinones; Rheology; Solubility
TL;DR:
An ultra-long-acting tunable, biodegradable, and removable polymer-based delivery system that offers sustained drug delivery for up to one year for HIV treatment or prophylaxis and optimize and demonstrate the release of 6 different drugs over a period of up to a year.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 7, 2019
2019 journal article
Inflammation Induced Sensory Nerve Growth and Pain Hypersensitivity Requires the N-Type Calcium Channel Cav2.2
FRONTIERS IN NEUROSCIENCE, 13.
author keywords: Cav2.2; inflammation; pain; nerve growth; hyperalgesia
TL;DR:
A role is uncovered for Cav2.2 during inflammation, demonstrating that VGCC activity can promote thermal hyperalgesia through both changes in firing rates of sensory neurons as well as promotion of new neurite outgrowth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 7, 2019
2019 journal article
Radiographic anatomy and barium sulfate contrast study of the gastrointestinal tract of eastern box turtles (Terrapene carolina carolina)
VETERINARY RADIOLOGY & ULTRASOUND, 60(5), 473–484.
author keywords: cecum; radiology; Testudines
MeSH headings : Animals; Barium Sulfate / analysis; Female; Gastrointestinal Tract / anatomy & histology; Gastrointestinal Tract / diagnostic imaging; Male; Prospective Studies; Radiography / veterinary; Reference Values; Turtles / anatomy & histology
TL;DR:
A novel, horizontal beam, rostrocaudal view for gastrointestinal contrast studies in chelonians is introduced to serve as a reference on the gastrointestinal anatomy, transit, and emptying times in healthy eastern box turtles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 7, 2019
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